Impaired self-awareness in human addiction: Deficient attribution of personal relevance

Trends in Cognitive Sciences

Volumn 18, Issue 12, 2014, Pages 635-641

  Moeller, Scott J ^a   Goldstein, Rita Z ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Addiction; Cortical midline regions; FMRI; Insight; Personal relevance; RDoC criteria; Rostral anterior cingulate cortex; Self awareness; Self processing; Ventromedial prefrontal cortex

Indexed keywords

ADDICTION; ANTERIOR CINGULATE CORTICES; CORTICAL MIDLINE REGIONS; FMRI; INSIGHT; PERSONAL RELEVANCE; PREFRONTAL CORTEX; RDOC CRITERIA; SELF-AWARENESS;

ADAPTIVE BEHAVIOR; COGNITIVE THERAPY; DRUG DEPENDENCE; HUMAN; MENTAL DISEASE; REVIEW; SELF CONCEPT; SELF REPORT; VENTROMEDIAL PREFRONTAL CORTEX; AWARENESS; BRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; SUBSTANCE-RELATED DISORDERS;

AWARENESS; BRAIN; HUMANS; SELF CONCEPT; SUBSTANCE-RELATED DISORDERS;

EID: 84927174042     PISSN: 13646613     EISSN: 1879307X     Source Type: Journal    
DOI: 10.1016/j.tics.2014.09.003     Document Type: Review

References (80)

1. Goldstein R.Z., Volkow N.D. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat. Rev. Neurosci. 2011, 12:652-669.
2. Goldstein R.Z., et al. The neurocircuitry of impaired insight in drug addiction. Trends Cogn. Sci. 2009, 13:372-380.
3. David A.S., et al. Failures of metacognition and lack of insight in neuropsychiatric disorders. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2012, 367:1379-1390.
4. van der Meer L., et al. Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia. Neurosci. Biobehav. Rev. 2010, 34:935-946.
5. Abraham A. The world according to me: personal relevance and the medial prefrontal cortex. Front. Hum. Neurosci. 2013, 7:341.
6. Edwards B.G., et al. Joint ICA of ERP and fMRI during error-monitoring. Neuroimage 2012, 59:1896-1903.
7. Etkin A., et al. Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 2006, 51:871-882.
8. Sturm V.E., et al. Role of right pregenual anterior cingulate cortex in self-conscious emotional reactivity. Soc. Cogn. Affect. Neurosci. 2013, 8:468-474.
9. Mies G.W., et al. The anterior cingulate cortex responds differently to the validity and valence of feedback in a time-estimation task. Neuroimage 2011, 56:2321-2328.
10. Clark L., et al. Gambling near-misses enhance motivation to gamble and recruit win-related brain circuitry. Neuron 2009, 61:481-490.
11. Sui J., et al. Coupling social attention to the self forms a network for personal significance. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:7607-7612.
12. D'Argembeau A. On the role of the ventromedial prefrontal cortex in self-processing: the valuation hypothesis. Front. Hum. Neurosci. 2013, 7:372.
13. Kim K., Johnson M.K. Extended self: medial prefrontal activity during transient association of self and objects. Soc. Cogn. Affect. Neurosci. 2012, 7:199-207.
14. Kim K., Johnson M.K. Extended self: spontaneous activation of medial prefrontal cortex by objects that are 'mine'. Soc. Cogn. Affect. Neurosci. 2014, 9:1006-1012.
15. Abraham A., von Cramon D.Y. Reality = relevance? Insights from spontaneous modulations of the brain's default network when telling apart reality from fiction. PLoS ONE 2009, 4:e4741.
16. Sescousse G., et al. Processing of primary and secondary rewards: a quantitative meta-analysis and review of human functional neuroimaging studies. Neurosci. Biobehav. Rev. 2013, 37:681-696.
17. Litt A., et al. Dissociating valuation and saliency signals during decision-making. Cereb. Cortex 2011, 21:95-102.
18. Levy D.J., Glimcher P.W. Comparing apples and oranges: using reward-specific and reward-general subjective value representation in the brain. J. Neurosci. 2011, 31:14693-14707.
19. van der Meer L., et al. Insight in schizophrenia: involvement of self-reflection networks?. Schizophr. Bull. 2013, 39:1288-1295.
20. Amanzio M., et al. Unawareness of deficits in Alzheimer's disease: role of the cingulate cortex. Brain 2011, 134:1061-1076.
21. Robinson H., et al. Neuroanatomical correlates of executive functions: a neuropsychological approach using the EXAMINER battery. J. Int. Neuropsychol. Soc. 2014, 20:52-63.
22. Eugene F., et al. Neural correlates of inhibitory deficits in depression. Psychiatry Res. 2010, 181:30-35.
23. Blair K.S., et al. Atypical modulation of medial prefrontal cortex to self-referential comments in generalized social phobia. Psychiatry Res. 2011, 193:38-45.
24. Engelmann J.M., et al. Neural substrates of smoking cue reactivity: a meta-analysis of fMRI studies. Neuroimage 2012, 60:252-262.
25. Kuhn S., Gallinat J. Common biology of craving across legal and illegal drugs - a quantitative meta-analysis of cue-reactivity brain response. Eur. J. Neurosci. 2011, 33:1318-1326.
26. Schacht J.P., et al. Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review. Addict. Biol. 2013, 18:121-133.
27. Chase H.W., et al. The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis. Biol. Psychiatry 2011, 70:785-793.
28. Goldstein R.Z., et al. Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:9453-9458.
29. Wilson S.J., et al. Quitting-unmotivated and quitting-motivated cigarette smokers exhibit different patterns of cue-elicited brain activation when anticipating an opportunity to smoke. J. Abnorm. Psychol. 2012, 121:198-211.
30. Goudriaan A.E., et al. Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. Addict. Biol. 2010, 15:491-503.
31. Bolla K., et al. Prefrontal cortical dysfunction in abstinent cocaine abusers. J. Neuropsychiatry Clin. Neurosci. 2004, 16:456-464.
32. Hester R., et al. Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users. Neuropsychopharmacology 2009, 34:2450-2458.
33. Claus E.D., et al. Behavioral control in alcohol use disorders: relationships with severity. J. Stud. Alcohol Drugs 2013, 74:141-151.
34. Moeller S.J., et al. Impaired insight in cocaine addiction: laboratory evidence and effects on cocaine-seeking behaviour. Brain 2010, 133:1484-1493.
35. Moeller S.J., et al. Psychophysiological prediction of choice: relevance to insight and drug addiction. Brain 2012, 135:3481-3494.
36. Moeller S.J., et al. Functional, structural, and emotional correlates of impaired insight in cocaine addiction. JAMA Psychiatry 2014, 71:61-70.
37. Gowin J.L., et al. Altered cingulate and insular cortex activation during risk-taking in methamphetamine dependence: losses lose impact. Addiction 2014, 109:237-247.
38. Wesley M.J., et al. Poor decision-making by chronic marijuana users is associated with decreased functional responsiveness to negative consequences. Psychiatry Res. 2011, 191:51-59.
39. Gowin J.L., et al. Altered risk-related processing in substance users: imbalance of pain and gain. Drug Alcohol Depend. 2013, 132:13-21.
40. Preller K.H., et al. Functional changes of the reward system underlie blunted response to social gaze in cocaine users. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:2842-2847.
41. Connolly C.G., et al. The neurobiology of cognitive control in successful cocaine abstinence. Drug Alcohol Depend. 2012, 121:45-53.
42. Moeller S.J., et al. Enhanced midbrain response at 6-month follow-up in cocaine addiction, association with reduced drug-related choice. Addict. Biol. 2012, 17:1013-1025.
43. Nestor L., et al. Differences in 'bottom-up' and 'top-down' neural activity in current and former cigarette smokers: evidence for neural substrates which may promote nicotine abstinence through increased cognitive control. Neuroimage 2011, 56:2258-2275.
44. Beck A., et al. Effect of brain structure, brain function, and brain connectivity on relapse in alcohol-dependent patients. Arch. Gen. Psychiatry 2012, 69:842-852.
45. Vago D.R., Silbersweig D.A. Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness. Front. Hum. Neurosci. 2012, 6:296.
46. Garland E.L. Trait mindfulness predicts attentional and autonomic regulation of alcohol cue-reactivity. J. Psychophysiol. 2011, 25:180-189.
47. Franklin T., et al. Effects of varenicline on smoking cue-triggered neural and craving responses. Arch. Gen. Psychiatry 2011, 68:516-526.
48. Culbertson C.S., et al. Effect of bupropion treatment on brain activation induced by cigarette-related cues in smokers. Arch. Gen. Psychiatry 2011, 68:505-515.
49. Goldstein R.Z., et al. Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:16667-16672.
50. Chua H.F., et al. Neural correlates of message tailoring and self-relatedness in smoking cessation programming. Biol. Psychiatry 2009, 65:165-168.
51. Chua H.F., et al. Self-related neural response to tailored smoking-cessation messages predicts quitting. Nat. Neurosci. 2011, 14:426-427.
52. Yoshimura S., et al. Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing. Soc. Cogn. Affect. Neurosci. 2014, 9:487-493.
53. Hull J.G., et al. Applications of the self-awareness model of alcohol consumption: predicting patterns of use and abuse. J. Pers. Soc. Psychol. 1986, 51:790-796.
54. Amador X.F., et al. Awareness of illness in schizophrenia and schizoaffective and mood disorders. Arch. Gen. Psychiatry 1994, 51:826-836.
55. Woicik P.A., et al. The neuropsychology of cocaine addiction: recent cocaine use masks impairment. Neuropsychopharmacology 2009, 34:1112-1122.
56. Miller D.T., Ross M. Self-serving biases in the attribution of causality: fact or fiction?. Psychol. Bull. 1975, 82:213-225.
57. Synder M. Self-monitoring of expressive behavior. J. Pers. Soc. Psychol. 1974, 30:526-537.
58. Fenigstein A., et al. Public and private self-consciousness: assessment and theory. J. Consult. Clin. Psychol. 1975, 43:522-527.
59. Vallacher R.R., Wegner D.M. Levels of personal agency: individual variation in action identification. J. Pers. Soc. Psychol. 1989, 57:660-671.
60. Wanner B., et al. Flow and dissociation: examination of mean levels, cross-links, and links to emotional well-being across sports and recreational and pathological gambling. J. Gambl. Stud. 2006, 22:289-304.
61. Murray R.J., et al. Degrees of separation: a quantitative neuroimaging meta-analysis investigating self-specificity and shared neural activation between self- and other-reflection. Neurosci. Biobehav. Rev. 2012, 36:1043-1059.
62. Margulies D.S., et al. Mapping the functional connectivity of anterior cingulate cortex. Neuroimage 2007, 37:579-588.
63. Uddin L.Q., et al. Functional connectivity of default mode network components: correlation, anticorrelation, and causality. Hum. Brain Mapp. 2009, 30:625-637.
64. Grigg O., Grady C.L. The default network and processing of personally relevant information: converging evidence from task-related modulations and functional connectivity. Neuropsychologia 2010, 48:3815-3823.
65. Chavez R.S., Heatherton T.F. Multimodal frontostriatal connectivity underlies individual differences in self-esteem. Soc. Cogn. Affect. Neurosci. 2014, 10.1093/scan/nsu063.
66. Atique B., et al. Task-specific activity and connectivity within the mentalizing network during emotion and intention mentalizing. Neuroimage 2011, 55:1899-1911.
67. Zald D.H., et al. Meta-analytic connectivity modeling reveals differential functional connectivity of the medial and lateral orbitofrontal cortex. Cereb. Cortex 2014, 24:232-248.
68. Gilbert S.J., et al. Distinct functional connectivity associated with lateral versus medial rostral prefrontal cortex: a meta-analysis. Neuroimage 2010, 53:1359-1367.
69. Denny B.T., et al. A meta-analysis of functional neuroimaging studies of self- and other judgments reveals a spatial gradient for mentalizing in medial prefrontal cortex. J. Cogn. Neurosci. 2012, 24:1742-1752.
70. Northoff G., et al. Self-referential processing in our brain - a meta-analysis of imaging studies on the self. Neuroimage 2006, 31:440-457.
71. Ma N., et al. Addiction related alteration in resting-state brain connectivity. Neuroimage 2010, 49:738-744.
72. Gu H., et al. Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity. Neuroimage 2010, 53:593-601.
73. Sutherland M.T., et al. Insula's functional connectivity with ventromedial prefrontal cortex mediates the impact of trait alexithymia on state tobacco craving. Psychopharmacology (Berl.) 2013, 228:143-155.
74. Sutherland M.T., et al. Down-regulation of amygdala and insula functional circuits by varenicline and nicotine in abstinent cigarette smokers. Biol. Psychiatry 2013, 74:538-546.
75. Kirk U., et al. Mindfulness training modulates value signals in ventromedial prefrontal cortex through input from insular cortex. Neuroimage 2014, 100C:254-262.
76. Craig A.D. How do you feel - now? The anterior insula and human awareness. Nat. Rev. Neurosci. 2009, 10:59-70.
77. Verdejo-Garcia A., et al. The role of interoception in addiction: a critical review. Neurosci. Biobehav. Rev. 2012, 36:1857-1869.
78. Naqvi N.H., et al. Damage to the insula disrupts addiction to cigarette smoking. Science 2007, 315:531-534.
79. Malouff J.M., et al. Alcohol involvement and the Five-Factor model of personality: a meta-analysis. J. Drug Educ. 2007, 37:277-294.
80. Kehoe E.G., et al. Personality modulates the effects of emotional arousal and valence on brain activation. Soc. Cogn. Affect. Neurosci. 2012, 7:858-870.