Open challenges in magnetic drug targeting

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volumn 7, Issue 3, 2015, Pages 446-457

  Shapiro, Benjamin ^a   Kulkarni, Sandip ^a   Nacev, Aleksander ^b   Muro, Silvia ^a,c   Stepanov, Pavel Y ^b   Weinberg, Irving N ^b  

^a UNIVERSITY OF MARYLAND   (United States)

^b Weinberg Medical Physics LLC   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; MAGNETISM; MAGNETS; TISSUE;

CLINICAL SETTINGS; HUMAN PATIENTS; MAGNET DESIGNS; MAGNETIC CARRIERS; MAGNETIC DRUG TARGETING; MAGNETIC TARGETING; REGULATORY APPROVALS; WHOLE PROCESS;

DRUG THERAPY;

DRUG CARRIER; DELAYED RELEASE FORMULATION; MAGNETITE NANOPARTICLE; NANOCAPSULE;

ARTICLE; CLINICAL RESEARCH; DRUG DELIVERY SYSTEM; DRUG SAFETY; DRUG TARGETING; HUMAN; IMAGING; MAGNET; MAGNETIC DRUG TARGETING; MAGNETIC FIELD; NANOFABRICATION; NONHUMAN; PRIORITY JOURNAL; TIME; CHEMISTRY; DELAYED RELEASE FORMULATION; MOLECULARLY TARGETED THERAPY; PROCEDURES; RADIATION RESPONSE;

DELAYED-ACTION PREPARATIONS; MAGNETIC FIELDS; MAGNETITE NANOPARTICLES; MOLECULAR TARGETED THERAPY; NANOCAPSULES;

EID: 84927166117     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.1311     Document Type: Article

References (88)

1. Lubbe AS, Bergemann C, Riess H, Schriever F, Reichardt P, Possinger K, Matthias M, Dörken B, Herrmann F, Gürtler R. Clinical experiences with magnetic drug targeting: a phase i study with 4′-epidoxorubicin in 14 patients with advanced solid tumors. Cancer Res 1996, 56:4686-4693.
2. Lemke AJ, von Pilsach MIS, Lubbe A, Bergemann C, Riess H, Felix R. Mri after magnetic drug targeting in patients with advanced solid malignant tumors. Eur Radiol 2004, 14:1949-1955.
3. Voltairas PA, Fotiadis DI, Michalis LK. Hydrodynamics of magnetic drug targeting. J Biomech 2002, 35:813-821.
4. Grief AD, Richardson G. Mathematical modeling of magnetically targeted drug delivery. J Magnetism Mag Mater 2005, 293:455-463.
5. Shapiro B, Dormer K, Rutel IB. A two-magnet system to push therapeutic nanoparticles. AIP Conf Proc 2010, 1311:77-88.
6. Wilson MW, Kerlan RK, Fidelman NA, Venook AP, LaBerge JM, Koda J, Gordon RL. Hepatocellular carcinoma: regional therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/conventional angiography suite-initial experience with four patients. Radiology 2004, 230:287-293.
7. Koda J, Venook A, Walser E, Goodwin S. A multicenter, phase i/ii trial of hepatic intra-arterial delivery of doxorubicin hydrochloride adsorbed to magnetic targeted carriers in patients with hepatocellular carcinoma. Eur J Cancer 2002, 38:S18.
8. Johannsen M, Gneveckow U, Eckelt L, Feussner A, Waldöfner N, Scholz R, Deger S, Wust P, Loening SA, Jordan A. Clinical hyperthermia of prostate cancer using magnetic nanoparticles: presentation of a new interstitial technique. Int J Hyperthermia 2005, 21:637-647.
9. Dobson J. Magnetic micro- and nano-particle-based targeting for drug and gene delivery. Nanomedicine 2006, 1:31-37.
10. Pankhurst QA, Connolly J, Jones SK, Dobson J. Applications of magnetic nanoparticles in biomedicine. J Phys D Appl Phys 2003, 36:R167.
11. Pankhurst QA, Thanh NTK, Jones SK, Dobson J. Progress in applications of magnetic nanoparticles in biomedicine. J Phys D Appl Phys 2009, 42:224001.
12. Sun C, Lee J, Zhang M. Magnetic nanoparticles in mr imaging and drug delivery. Adv Drug Deliv Rev 2008, 60:1252-1265.
13. Villemejane J, Mir LM. Physical methods of nucleic acid transfer: general concepts and applications. Br J Pharmacol 2009, 157:207-219.
14. Berry CC. Progress in functionalization of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 2009, 42:224003-224012.
15. Roca AG, Costo R, Rebolledo AF, Veintemillas-Verdaguer S, Tartaj P, González-Carreño T, Morales MP, Serna CJ. Progress in the preparation of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 2009, 42:224002.
16. McBain SC, Yiu HHP, Dobson J. Magnetic nanoparticles for gene and drug delivery. Int J Nanomedicine 2008, 3:169-180.
17. Veiseh O, Gunn JW, Zhang M. Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev 2010, 62:284-304.
18. Cho K, Wang X, Nie S, Chen Z, Shin DM. Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 2008, 14:1310-1316.
19. Zimmermann U, Pilwat G. Organ specific application of drugs by means of cellular capsule systems. Z Naturforsch C Biosci 1976, 31:732-736.
20. Solanki A, Kim JD, Lee K-B. Nanotechnology for regenerative medicine: nanomaterials for stem cell imaging. Nanomedicine 2008, 3:567-578.
21. Lubbe AS, Alexiou C, Bergemann C. Clinical applications of magnetic drug targeting. J Surg Res 2001, 95:200-206.
22. Nacev A, Komaee A, Sarwar A, Probst R, Kim SH, Lee R, Depireux D, Emmert-Buck M, Shapiro B. Towards control of magnetic fluids in patients: directing therapeutic nanoparticles to disease locations. IEEE Control Syst 2012, 32:32-74.
23. Polyak B, Friedman G. Magnetic targeting for site-specific drug delivery: applications and clinical potential. Expert Opin Drug Deliv 2009, 6:53-70.
24. Bawa R. Nanoparticle-based therapeutics in humans: a survey. Nanotechnol Law Bus 2008, 5:135.
25. Nacev A, Beni C, Bruno O, Shapiro B. Magnetic nanoparticle transport within flowing blood and into surrounding tissue. Nanomedicine 2010, 5:1459-1466.
26. Nacev A, Beni C, Bruno O, Shapiro B. The behaviors of ferro-magnetic nano-particles in and around blood vessels under applied magnetic fields. J Magnetism Mag Mater 2011, 323:651-668.
27. Colombo M, Carregal-Romero S, Casula MF, Gutiérrez L, Morales MP, Bohm IB, Heverhagen JT, Prosperi D, Parak WJ. Biological applications of magnetic nanoparticles. Chem Soc Rev 2012, 41:4306-4334.
28. Puntes VF, Krishnan KM, Alivisatos AP. Colloidal nanocrystal shape and size control: the case of cobalt. Science 2001, 291:2115-2117.
29. Cabot A, Puntes VF, Shevchenko E, Yin Y, Balcells L, Marcus MA, Hughes SM, Alivisatos AP. Vacancy coalescence during oxidation of iron nanoparticles. J Am Chem Soc 2007, 129:10358-10360.
30. Nacev A, Kim SH, Rodriguez-Canales J, Tangrea MA, Shapiro B, Emmert-Buck MR. A dynamic magnetic shift method to increase nanoparticle concentration in cancer metastases: a feasibility study using simulations on autopsy specimens. Int J Nanomedicine 2011, 6:2907-2923.
31. Renkin EM. Filtration, diffusion, and molecular sieving through porous cellulose membranes. J Gen Physiol 1954, 38:225-243.
32. Ogston AG, Preston BN, Wells JD. On the transport of compact particles through solutions of chain-polymers. Proc R Soc Lond A Math Phys Sci 1973, 333:297.
33. Kulkarni, S., Nacev, A, Ramaswamy, B, Depireux, D, Shapiro, B. 2013. Understanding motion of magnetic nanoparticles in tissue.
34. Shapiro B, Depireux D, Sarwar A, Nacev A, Preciado D, Hausfeld J. Pre-clinical development of magnetic delivery of therapy to middle and inner ears. ENT Audiol News 2014, 23:54-56.
35. Shapiro B, Kulkarni S, Nacev A, Sarwar A, Preciado D, Depireux DA. Shaping magnetic fields to direct therapy to ears and eyes. Annu Rev Biomed Eng 2014, 16:455-481.
36. Pardridge WM. Biopharmaceutical drug targeting to the brain. J Drug Target 2010, 18:157-167.
37. Banks WA. Blood-brain barrier as a regulatory interface. Forum Nutr 2010, 63:102-110.
38. Pardridge WM. Blood-brain barrier delivery. Drug Discov Today 2007, 12:54-61.
39. Groothuis DR. The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery. Neuro Oncol 2000, 2:45-59.
40. Lakhal S, Wood MJA. Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of rnai heralds new horizons for drug delivery across biological barriers. Bioessays 2011, 33:737-741.
41. Muro S. Strategies for delivery of therapeutics into the central nervous system for treatment of lysosomal storage disorders. Drug Deliv Transl Res 2012, 2:169-186.
42. Hsu J, Rappaport J, Muro S. Specific binding, uptake, and transport of icam-1-targeted nanocarriers across endothelial and subendothelial cell components of the blood-brain barrier. Pharm Res 2014, 31:1855-1866.
43. Kreuter J. Drug delivery to the central nervous system by polymeric nanoparticles: what do we know? Adv Drug Deliv Rev 2014, 71:2-14.
44. Dilnawaz F, Singh A, Mohanty C, Sahoo SK. Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy. Biomaterials 2010, 31:3694-3706.
45. Shubayev VI, Pisanic TR 2nd, Jin S. Magnetic nanoparticles for theragnostics. Adv Drug Deliv Rev 2009, 61:467-477.
46. Qiao R, Jia Q, Hüwel S, Xia R, Liu T, Gao F, Galla H-J, Gao M. Receptor-mediated delivery of magnetic nanoparticles across the blood-brain barrier. ACS Nano 2012, 6:3304-3310.
47. Saiyed ZM, Gandhi NH, Nair MP. Magnetic nanoformulation of azidothymidine 5′-triphosphate for targeted delivery across the blood-brain barrier. Int J Nanomedicine 2010, 5:157-166.
48. Han L, Zhang A, Wang H, Pu P, Kang C, Chang J. Construction of novel brain-targeting gene delivery system by natural magnetic nanoparticles. J Appl Polym Sci 2011, 121:3446-3454.
49. Kong SD, Lee J, Ramachandran S, Eliceiri BP, Shubayev VI, Lal R, Jin S. Magnetic targeting of nanoparticles across the intact blood-brain barrier. J Control Release 2012, 164:49-57.
50. Wahajuddin AS. Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers. Int J Nanomedicine 2012, 7:3445-3471.
51. Yang H-W, Hua M-Y, Liu H-L, Huang C-Y, Wei K-C. Potential of magnetic nanoparticles for targeted drug delivery. Nanotechnol Sci Appl 2012, 5:73-86.
52. Lai SK, O'Hanlon DE, Harrold S, Man ST, Wang Y-Y, Cone R, Hanes J. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A 2007, 104:1482-1487.
53. Lai SK, Wang Y-Y, Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev 2009, 61:158-171.
54. Kalambur VS, Han B, Hammer BE, Shield TW, Bischof JC. In vitro characterization of movement, heating and visualization of magnetic nanoparticles for biomedical applications. Nanotechnology 2005, 16:1221.
55. Gleich B, Weizenecker J. Tomographic imaging using the nonlinear response of magnetic particles. Nature 2005, 435:1214-1217.
56. Knopp T, Sattel TF, Biederer S, Rahmer J, Weizenecker J, Gleich B, Borgert J, Buzug TM. Model-based reconstruction for magnetic particle imaging. IEEE Trans Med Imaging 2010, 29:12-18.
57. Knopp T, Biederer S, Sattel TF, Rahmer J, Weizenecker J, Gleich B, Borgert J, Buzug TM. 2d model-based reconstruction for magnetic particle imaging. Med Phys 2010, 37:485-491.
58. Biederer S, Knopp T, Sattel TF, Lüdtke-Buzug K, Gleich B, Weizenecker J, Borgert J, Buzug TM. Magnetization response spectroscopy of superparamagnetic nanoparticles for magnetic particle imaging. J Phys D Appl Phys 2009, 42:205007.
59. Weizenecker J, Gleich B, Rahmer J, Dahnke H, Borgert J. Three-dimensional real-time in vivo magnetic particle imaging. Phys Med Biol 2009, 54:L1-L10.
60. Goodwill PW, Conolly SM. The x-space formulation of the magnetic particle imaging process: 1-d signal, resolution, bandwidth, snr, sar, and magnetostimulation. IEEE Trans Med Imaging 2010, 29:1851-1859.
61. Carmi E, Liu S, Alon N, Fiat A, Fiat D. Resolution enhancement in mri. Magn Reson Imaging 2006, 24:133-154.
62. Glover PM. Interaction of mri field gradients with the human body. Phys Med Biol 2009, 54:R99.
63. Weinberg IN, Stepanov PY, Fricke ST, Probst R, Urdaneta M, Warnow D, Sanders H, Glidden SC, McMillan A, Starewicz PM. Increasing the oscillation frequency of strong magnetic fields above 101 khz significantly raises peripheral nerve excitation thresholds. Med Phys 2012, 39:2578-2583.
64. Alexander DC, Hubbard PL, Hall MG, Moore EA, Ptito M, Parker GJ, Dyrby TB. Orientationally invariant indices of axon diameter and density from diffusion MRI. Neuroimage 2010, 52:1374-1389.
65. Takeda S, Mishima F, Fujimoto S, Izumi Y, Nishijima S. Development of magnetically targeted drug delivery system using superconducting magnet. J Magnetism Mag Mater 2007, 311:367-371.
66. Rotariu O, Strachan NJC. Modelling magnetic carrier particle targeting in the tumor microvasculature for cancer treatment. J Magnetism Mag Mater 2005, 293:639-646.
67. Dames P, Gleich B, Flemmer A, Hajek K, Seidl N, Wiekhorst F, Eberbeck D, Bittmann I, Bergemann C, Weyh T. Targeted delivery of magnetic aerosol droplets to the lung. Nat Nano 2007, 2:495-499.
68. Alexiou C, Diehl D, Henninger P, Iro H, Rockelein R, Schmidt W, Weber H. A high field gradient magnet for magnetic drug targeting. IEEE Trans Appl Supercond 2006, 16:1527-1530.
69. Yang Y, Jiang J-S, Du B, Gan Z-F, Qian M, Zhang P. Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting. J Mater Sci Mater Med 2009, 20:301-307.
70. Lohakan M, Junchaichanakun P, Boonsang S, Pintavirooj C. A computational model of magnetic drug targeting in blood vessel using finite element method. In: 2nd IEEE Conference on Industrial Electronics and Applications (ICIEA 2007), 231-234, 2007.
71. Slabu I, Röth A, Schmitz-Rode T, Baumann M. Optimization of magnetic drug targeting by mathematical modeling and simulation of magnetic fields. In: 4th European Conference of the International Federation for Medical and Biological Engineering, 2309-2312, 2009.
72. Creighton FM, Ritter RC, Werp P. Focused magnetic navigation using optimized magnets for medical therapies. In: Magnetics Conference, 2005. INTERMAG Asia 2005. Digests of the IEEE International, 1253-1254, 2005.
73. Creighton FM. Optimal distribution of magnetic material for catheter and guidewire cardiology therapies. In: Magnetics Conference, 2006. INTERMAG 2006. IEEE International, 111-111, 2006.
74. Sarwar A, Nemirovski A, Shapiro B. Optimal halbach permanent magnet designs for maximally pulling and pushing nanoparticles. J Magnetism Mag Mater 2012, 324:742-754.
75. Komaee A, Kim SH, Nacev A, Probst R, Sarwar A, et al. Putting therapeutic nanoparticles where they need to go by magnet systems: design and control. In: Thanh NK, ed. Magnetic Nanoparticles: From Fabrication to Biomedical and Clinical Applications. CRC Press/Taylor and Francis; 2011.
76. Shapiro B. Towards dynamic control of magnetic fields to focus magnetic carriers to targets deep inside the body. J Magnetism Mag Mater 2009, 321:1594.
77. Yesin KB, Vollmers K, Nelson BJ. Modeling and control of untethered biomicrorobots in a fluidic environment using electromagnetic fields. Int J Robot Res 2006, 25:527-536.
78. Bergeles C, Kummer MP, Kratochvil BE, Framme C, Nelson BJ. Steerable intravitreal inserts for drug delivery: in vitro and ex vivo mobility experiments. In: Fichtinger G, Martel A, Peters T, eds. Medical Image Computing and Computer-Assisted Intervention - MICCAI 2011. Berlin, Heidelberg: Springer; 2011, 33-40.
79. Kummer MP, Abbott JJ, Kratochvil BE, Borer R, Sengul A, Nelson BJ. Octomag: an electromagnetic system for 5-dof wireless micromanipulation. IEEE Trans Robot 2010, 26:1006-1017.
80. Tamaz S, Gourdeau R, Chanu A, Mathieu J-B, Martel S. Real-time mri-based control of a ferromagnetic core for endovascular navigation. IEEE Trans BioMed Eng 2008, 55:1854-1863.
81. Grady MS, Howard MA 3rd, Molloy JA, Ritter RC, Quate EG, Gillies GT. Nonlinear magnetic stereotaxis: three-dimensional, in vivo remote magnetic manipulation of a small object in canine brain. Med Phys 1990, 17:405-415.
82. Bauernfeind T, Akca F, Schwagten B, de Groot N, Van Belle Y, Valk S, Ujvari B, Jordaens L, Szili-Torok T. The magnetic navigation system allows safety and high efficacy for ablation of arrhythmias. Europace 2011, 13:1015-1021.
83. Ciuti G, Valdastri P, Menciassi A, Dario P. Robotic magnetic steering and locomotion of capsule endoscope for diagnostic and surgical endoluminal procedures. Robotica 2010, 28(Special Issue 02):199-207.
84. Earnshaw S. On the nature of the molecular forces which regulate the constitution of the luminiferous ether. Trans Cambridge Philos Soc 1842, 7:97-112.
85. Feynman RP, Leighton RB, Sands M. The Feynman Lectures on Physics. Addison-Wesley Publishing Company; 1964.
86. Fleisch DA. A Student's Guide to Maxwell's Equations. Cambridge/New York: Cambridge University Press; 2008.
87. Iacob GH, Rotariu O, Chiriac H. A possibility for local targeting of magnetic carriers. J Optoelectron Adv Mater 2004, 6:713-717.
88. U.S. Department for Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition. 2014. Guidance for industry: safety of nanomaterials in cosmetic products.