메뉴 건너뛰기




Volumn 11, Issue 1, 2015, Pages 58-63

GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

6 [[2 [[4 (2,4 DICHLOROPHENYL) 5 (4 METHYL 1H IMIDAZOL 2 YL) 2 PYRIMIDINYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; BETA CATENIN; DASATINIB; ERLOTINIB; GEFITINIB; GLYCOGEN SYNTHASE KINASE 3; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYC PROTEIN; RNA; SMALL INTERFERING RNA; ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; ONCOPROTEIN; POLO-LIKE KINASE 1; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; TARGET OF RAPAMYCIN KINASE;

EID: 84927136638     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1690     Document Type: Article
Times cited : (30)

References (40)
  • 1
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble, B.W. & Woodgett, J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell Sci. 116, 1175-1186 (2003).
    • (2003) J. Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 2
    • 0033851276 scopus 로고    scopus 로고
    • GSK3 a master switch regulating cell-fate specification and tumorigenesis
    • Kim, L. & Kimmel, A.R. GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr. Opin. Genet. Dev. 10, 508-514 (2000).
    • (2000) Curr. Opin. Genet. Dev , vol.10 , pp. 508-514
    • Kim, L.1    Kimmel, A.R.2
  • 3
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
    • Pap, M. & Cooper, G.M. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J. Biol. Chem. 273, 19929-19932 (1998).
    • (1998) J. Biol. Chem , vol.273 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 4
    • 79959233776 scopus 로고    scopus 로고
    • What are the bona fide GSK3 substrates?
    • Sutherland, C. What are the bona fide GSK3 substrates? Int. J. Alzheimers Dis. 2011, 505607 (2011).
    • (2011) Int. J. Alzheimers Dis , vol.2011
    • Sutherland, C.1
  • 5
    • 21344463325 scopus 로고    scopus 로고
    • Kinase-inactive glycogen synthase kinase 3β promotes Wnt signaling and mammary tumorigenesis
    • Farago, M. et al. Kinase-inactive glycogen synthase kinase 3β promotes Wnt signaling and mammary tumorigenesis. Cancer Res. 65, 5792-5801 (2005).
    • (2005) Cancer Res , vol.65 , pp. 5792-5801
    • Farago, M.1
  • 6
    • 37349094929 scopus 로고    scopus 로고
    • GSK-3β targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3β inactivation correlates with Cdc25A overproduction in human cancers
    • Kang, T. et al. GSK-3β targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3β inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell 13, 36-47 (2008).
    • (2008) Cancer Cell , vol.13 , pp. 36-47
    • Kang, T.1
  • 7
    • 0036920227 scopus 로고    scopus 로고
    • Expression localization, and activity of glycogen synthase kinase 3β during mouse skin tumorigenesis
    • Leis, H., Segrelles, C., Ruiz, S., Santos, M. & Paramio, J.M. Expression, localization, and activity of glycogen synthase kinase 3β during mouse skin tumorigenesis. Mol. Carcinog. 35, 180-185 (2002).
    • (2002) Mol. Carcinog , vol.35 , pp. 180-185
    • Leis, H.1    Segrelles, C.2    Ruiz, S.3    Santos, M.4    Paramio, J.M.5
  • 8
    • 33750040886 scopus 로고    scopus 로고
    • S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt
    • Zhang, H.H., Lipovsky, A.I., Dibble, C.C., Sahin, M. & Manning, B.D. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol. Cell 24, 185-197 (2006).
    • (2006) Mol. Cell , vol.24 , pp. 185-197
    • Zhang, H.H.1    Lipovsky, A.I.2    Dibble, C.C.3    Sahin, M.4    Manning, B.D.5
  • 9
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou, B.P. et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6, 931-940 (2004).
    • (2004) Nat. Cell Biol , vol.6 , pp. 931-940
    • Zhou, B.P.1
  • 10
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas N
    • Cancer Genome Atlas, N. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
    • (2012) Nature , vol.487 , pp. 330-337
  • 11
    • 78651287426 scopus 로고    scopus 로고
    • DrugBank 3.0: A comprehensive resource foromics research on drugs
    • Knox, C. et al. DrugBank 3.0: a comprehensive resource foromics research on drugs. Nucleic Acids Res. 39, D1035-D1041 (2011).
    • (2011) Nucleic Acids Res , vol.39
    • Knox, C.1
  • 12
    • 77249105997 scopus 로고    scopus 로고
    • Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro
    • Roig, A.I. et al. Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology 138, 1012-21.e1-1012-21.e5 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 101221e1-101221e5
    • Roig, A.I.1
  • 13
    • 34249311572 scopus 로고    scopus 로고
    • Functional redundancy of GSK-3α and GSK-3β in Wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines
    • Doble, B.W., Patel, S., Wood, G.A., Kockeritz, L.K. & Woodgett, J.R. Functional redundancy of GSK-3α and GSK-3β in Wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev. Cell 12, 957-971 (2007).
    • (2007) Dev. Cell , vol.12 , pp. 957-971
    • Doble, B.W.1    Patel, S.2    Wood, G.A.3    Kockeritz, L.K.4    Woodgett, J.R.5
  • 14
    • 0037163113 scopus 로고    scopus 로고
    • Regulation of Wnt signaling during adipogenesis
    • Bennett, C.N. et al. Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277, 30998-31004 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 30998-31004
    • Bennett, C.N.1
  • 15
    • 84927129668 scopus 로고    scopus 로고
    • US National Cancer Institutes-National Institutes of Health., Developmental Therapeutics Program NCI/NIH
    • US National Cancer Institutes-National Institutes of Health. Synthetics and Pure Natural Products. Developmental Therapeutics Program NCI/NIH, http://dtp.nci.nih.gov/branches/dscb/oncology-drugset-explanation.html (2014).
    • (2014) Synthetics and Pure Natural Products
  • 16
    • 0029683606 scopus 로고    scopus 로고
    • The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
    • Yost, C. et al. The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev. 10, 1443-1454 (1996).
    • (1996) Genes Dev , vol.10 , pp. 1443-1454
    • Yost, C.1
  • 17
    • 0037155691 scopus 로고    scopus 로고
    • Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism
    • Liu, C. et al. Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108, 837-847 (2002).
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1
  • 18
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto, E. et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128 (2004).
    • (2004) Nat. Cell Biol , vol.6 , pp. 1122-1128
    • Jacinto, E.1
  • 19
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D.D. et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302 (2004).
    • (2004) Curr. Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1
  • 20
    • 77951231349 scopus 로고    scopus 로고
    • MTOR and cancer: Many loops in one pathway
    • Efeyan, A. & Sabatini, D.M. mTOR and cancer: many loops in one pathway. Curr. Opin. Cell Biol. 22, 169-176 (2010).
    • (2010) Curr. Opin. Cell Biol , vol.22 , pp. 169-176
    • Efeyan, A.1    Sabatini, D.M.2
  • 21
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: Insights into a complex relationship
    • Sabatini, D.M. mTOR and cancer: insights into a complex relationship. Nat. Rev. Cancer 6, 729-734 (2006).
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 729-734
    • Sabatini D. ., M.1
  • 22
    • 67650228579 scopus 로고    scopus 로고
    • Rapamycin inhibits mTORC1, but not completely
    • Thoreen, C.C. & Sabatini, D.M. Rapamycin inhibits mTORC1, but not completely. Autophagy 5, 725-726 (2009).
    • (2009) Autophagy , vol.5 , pp. 725-726
    • Thoreen, C.C.1    Sabatini, D.M.2
  • 23
    • 32944457518 scopus 로고    scopus 로고
    • MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly, K.E. et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 66, 1500-1508 (2006).
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1
  • 24
    • 79952119614 scopus 로고    scopus 로고
    • ER stress inhibits mTORC2 and Akt signaling through GSK-3beta-mediated phosphorylation of rictor
    • Chen, C.H. et al. ER stress inhibits mTORC2 and Akt signaling through GSK-3beta-mediated phosphorylation of rictor. Sci. Signal. 4, ra10 (2011).
    • (2011) Sci. Signal , vol.4 , pp. ra10
    • Chen, C.H.1
  • 25
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang, J. & Manning, B.D. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 37, 217-222 (2009).
    • (2009) Biochem. Soc. Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 26
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen, C.C. et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284, 8023-8032 (2009).
    • (2009) J. Biol. Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1
  • 27
    • 61349141302 scopus 로고    scopus 로고
    • Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
    • Feldman, M.E. et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 7, e38 (2009).
    • (2009) PLoS Biol , vol.7 , pp. e38
    • Feldman, M.E.1
  • 28
    • 43049151493 scopus 로고    scopus 로고
    • Polo on the rise-from mitotic entry to cytokinesis with Plk1
    • Petronczki, M., Lenart, P. & Peters, J.M. Polo on the rise-from mitotic entry to cytokinesis with Plk1. Dev. Cell 14, 646-659 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 646-659
    • Petronczki, M.1    Lenart, P.2    Peters, J.M.3
  • 29
    • 65649105075 scopus 로고    scopus 로고
    • BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity
    • Rudolph, D. et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clin. Cancer Res. 15, 3094-3102 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 3094-3102
    • Rudolph, D.1
  • 30
    • 79956014825 scopus 로고    scopus 로고
    • Phase i study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies
    • Olmos, D. et al. Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies. Clin. Cancer Res. 17, 3420-3430 (2011).
    • (2011) Clin. Cancer Res , vol.17 , pp. 3420-3430
    • Olmos, D.1
  • 31
    • 68049112546 scopus 로고    scopus 로고
    • Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology
    • Schöffski, P. Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist 14, 559-570 (2009).
    • (2009) Oncologist , vol.14 , pp. 559-570
    • Schöffski, P.1
  • 32
    • 35348953179 scopus 로고    scopus 로고
    • Phosphorylated GSK3β-Ser9 and EGFR are good prognostic factors for lung carcinomas
    • Zheng, H., Saito, H., Masuda, S., Yang, X. & Takano, Y. Phosphorylated GSK3β-Ser9 and EGFR are good prognostic factors for lung carcinomas. Anticancer Res. 27, 3561-3569 (2007).
    • (2007) Anticancer Res , vol.27 , pp. 3561-3569
    • Zheng, H.1    Saito, H.2    Masuda, S.3    Yang, X.4    Takano, Y.5
  • 33
    • 0024233098 scopus 로고
    • Phosphoserine as a recognition determinant for glycogen synthase kinase-3: Phosphorylation of a synthetic peptide based on the G-component of protein phosphatase-1
    • Fiol, C.J. et al. Phosphoserine as a recognition determinant for glycogen synthase kinase-3: phosphorylation of a synthetic peptide based on the G-component of protein phosphatase-1. Arch. Biochem. Biophys. 267, 797-802 (1988).
    • (1988) Arch. Biochem. Biophys , vol.267 , pp. 797-802
    • Fiol, C.J.1
  • 34
    • 0034969088 scopus 로고    scopus 로고
    • A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation
    • Frame, S., Cohen, P. & Biondi, R.M. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol. Cell 7, 1321-1327 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 1321-1327
    • Frame, S.1    Cohen, P.2    Biondi, R.M.3
  • 35
    • 0032821768 scopus 로고    scopus 로고
    • A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and β-catenin
    • Thomas, G.M. et al. A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and β-catenin. FEBS Lett. 458, 247-251 (1999).
    • (1999) FEBS Lett , vol.458 , pp. 247-251
    • Thomas, G.M.1
  • 37
    • 84882754147 scopus 로고    scopus 로고
    • A neo-substrate that amplifies catalytic activity of Parkinson's-disease-related kinase PINK1
    • Hertz, N.T. et al. A neo-substrate that amplifies catalytic activity of Parkinson's-disease-related kinase PINK1. Cell 154, 737-747 (2013).
    • (2013) Cell , vol.154 , pp. 737-747
    • Hertz, N.T.1
  • 38
    • 70149122987 scopus 로고    scopus 로고
    • Direct small-molecule kinase activation: Novel approaches for a new era of drug discovery
    • Simpson, G.L., Hughes, J.A., Washio, Y. & Bertrand, S.M. Direct small-molecule kinase activation: novel approaches for a new era of drug discovery. Curr. Opin. Drug Discov. Devel. 12, 585-596 (2009).
    • (2009) Curr. Opin. Drug Discov. Devel , vol.12 , pp. 585-596
    • Simpson, G.L.1    Hughes, J.A.2    Washio, Y.3    Bertrand, S.M.4
  • 39
    • 77958171338 scopus 로고    scopus 로고
    • Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
    • Thorne, C.A. et al. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nat. Chem. Biol. 6, 829-836 (2010).
    • (2010) Nat. Chem. Biol , vol.6 , pp. 829-836
    • Thorne, C.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.