Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults

Experimental Gerontology

Volumn 66, Issue , 2015, Pages 17-20

  Tyrka, Audrey R ^a,b   Carpenter, Linda L ^a,b   Kao, Hung Teh ^a,b   Porton, Barbara ^a,b   Philip, Noah S ^a,b   Ridout, Samuel J ^a,b   Ridout, Kathryn K ^a,b   Price, Lawrence H ^a,b  

^a BUTLER HOSPITAL   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Mitochondria; Mitochondrial biogenesis; Mitochondrial DNA copy number; Telomere

Indexed keywords

MITOCHONDRIAL DNA; PROTEIN P53;

ADULT; AGE; ARTICLE; BODY MASS; CELL FUNCTION; CHROMOSOMAL PARAMETERS; CORRELATIONAL STUDY; FEMALE; GENE DOSAGE; HEALTH STATUS; HUMAN; MALE; MENTAL DISEASE; MITOCHONDRION; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMOKING HABIT; TELOMERE; TELOMERE LENGTH; ADOLESCENT; AGING; CELL AGING; CHILDHOOD TRAUMA SURVIVOR; COPY NUMBER VARIATION; DEMOGRAPHY; DEPRESSION; GENETICS; MIDDLE AGED; SMOKING; TELOMERE SHORTENING; YOUNG ADULT;

ADOLESCENT; ADULT; ADULT SURVIVORS OF CHILD ADVERSE EVENTS; AGING; BODY MASS INDEX; CELL AGING; DEPRESSION; DNA COPY NUMBER VARIATIONS; DNA, MITOCHONDRIAL; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; RESIDENCE CHARACTERISTICS; SMOKING; TELOMERE; TELOMERE SHORTENING; YOUNG ADULT;

EID: 84927130344     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2015.04.002     Document Type: Article

References (27)

1. Ale-Agha N., Dyballa-Rukes N., Jakob S., Altschmied J., Haendeler J. Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase - potential role in senescence and aging. Exp. Gerontol. 2014, 56:189-193.
2. Anglin R.E., Mazurek M.F., Tarnopolsky M.A., Rosebush P.I. The mitochondrial genome and psychiatric illness. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012, 159B(7):749-759.
3. Armanios M., Blackburn E.H. The telomere syndromes. Nat. Rev. Genet. 2012, 13(10):693-704.
4. Bai R.K., Wong L.J. Simultaneous detection and quantification of mitochondrial DNA deletion(s), depletion, and over-replication in patients with mitochondrial disease. J. Mol. Diagn. 2005, 7(5):613-622.
5. Bernstein D.P., Stein J.A., Newcomb M.D., Walker E., Pogge D., Ahluvalia T., Stokes J., Handelsman L., Medrano M., Desmond D., Zule W. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl. 2003, 27(2):169-190.
6. Chan S.W., Chevalier S., Aprikian A., Chen J.Z. Simultaneous quantification of mitochondrial DNA damage and copy number in circulating blood: a sensitive approach to systemic oxidative stress. Biomed. Res. Int. 2013, 2013:157547.
7. First M.B., Spitzer R.L., Williams J.B.W., Gibbon M. Structured Clinical Interview for DSM-IV (SCID) 1997, A.P. Association, Washington, DC.
8. Frenck R.W., Blackburn E.H., Shannon K.M. The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(10):5607-5610.
9. Gredilla R., Bohr V.A., Stevnsner T. Mitochondrial DNA repair and association with aging - an update. Exp. Gerontol. 2010, 45(7-8):478-488.
10. Hekimi S., Guarente L. Genetics and the specificity of the aging process. Science 2003, 299(5611):1351-1354.
11. Kazachkova N., Raposo M., Montiel R., Cymbron T., Bettencourt C., Silva-Fernandes A., Silva S., Maciel P., Lima M. Patterns of mitochondrial DNA damage in blood and brain tissues of a transgenic mouse model of Machado-Joseph disease. Neurodegener. Dis. 2013, 11(4):206-214.
12. Kim J.H., Kim H.K., Ko J.H., Bang H., Lee D.C. The relationship between leukocyte mitochondrial DNA copy number and telomere length in community-dwelling elderly women. PLoS One 2013, 8(6):e67227.
13. Lagouge M., Larsson N.G. The role of mitochondrial DNA mutations and free radicals in disease and ageing. J. Intern. Med. 2013, 273(6):529-543.
14. Liochev S.I. Reactive oxygen species and the free radical theory of aging. Free Radic. Biol. Med. 2013, 60:1-4.
15. Mengel-From J., Thinggaard M., Dalgard C., Kyvik K.O., Christensen K., Christiansen L. Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly. Hum. Genet. 2014, 133(9):1149-1159.
16. O'Callaghan N., Dhillon V., Thomas P., Fenech M. A quantitative real-time PCR method for absolute telomere length. Biotechniques 2008, 44(6):807-809.
17. Osellame L.D., Blacker T.S., Duchen M.R. Cellular and molecular mechanisms of mitochondrial function. Best Pract. Res. Clin. Endocrinol. Metab. 2012, 26(6):711-723.
18. Price L.H., Kao H.T., Burgers D.E., Carpenter L.L., Tyrka A.R. Telomeres and early-life stress: an overview. Biol. Psychiatry 2013, 73(1):15-23.
19. Ridout S.J., Ridout K.K., Kao H.-T., Carpenter L.L., Philip N.S., Tyrka A.R., Price L.H. elomeres, early-life stress, and mental illnessClinical Challenges in the Biopsychosocial Interface: Update on Psychosomatics for the 21st Century 2015, 34:92-108. W. T. Balon R. Basel, Switzerland, S. Karger AG.
20. Rufer N., Brummendorf T.H., Kolvraa S., Bischoff C., Christensen K., Wadsworth L., Schulzer M., Lansdorp P.M. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J. Exp. Med. 1999, 190(2):157-167.
21. Sahin E., Depinho R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464(7288):520-528.
22. Sahin E., DePinho R.A. Axis of ageing: telomeres, p53 and mitochondria. Nat. Rev. Mol. Cell Biol. 2012, 13(6):397-404.
23. Sahin E., Colla S., Liesa M., Moslehi J., Muller F.L., Guo M., Cooper M., Kotton D., Fabian A.J., Walkey C., Maser R.S., Tonon G., Foerster F., Xiong R., Wang Y.A., Shukla S.A., Jaskelioff M., Martin E.S., Heffernan T.P., Protopopov A., Ivanova E., Mahoney J.E., Kost-Alimova M., Perry S.R., Bronson R., Liao R., Mulligan R., Shirihai O.S., Chin L., DePinho R.A. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011, 470(7334):359-365.
24. Shalev I., Moffitt T.E., Braithwaite A.W., Danese A., Fleming N.I., Goldman-Mellor S., Harrington H.L., Houts R.M., Israel S., Poulton R., Robertson S.P., Sugden K., Williams B., Caspi A. Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. Mol. Psychiatry 2014, 19(11):1163-1170.
25. Tyrka A.R., Parade S.H., Price L.H., Kao H.-T., Porton B., Philip N.S., Welch E.S., Carpenter L.L. Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology. Biol. Psychiatry 2015, (1409055 priority communication). 10.1016/j.biopsych.2014.12. 025.
26. Wei Y.H. Oxidative stress and mitochondrial DNA mutations in human aging. Proc. Soc. Exp. Biol. Med. 1998, 217(1):53-63.
27. Xiao J., Chen L., Wang X., Liu M., Xiao Y. eNOS correlates with mitochondrial biogenesis in hearts of congenital heart disease with cyanosis. Arq. Bras. Cardiol. 2012, 99(3):780-788.