Role of polymorphisms of inducible nitric oxide synthase and endothelial nitric oxide synthase in idiopathic environmental intolerances

Mediators of Inflammation

Volumn 2015, Issue , 2015, Pages

  De Luca, Chiara ^a,b   Gugliandolo, Agnese ^c   Calabrò, Carlo ^c   Currò, Monica ^c   Ientile, Riccardo ^c   Raskovic, Desanka ^d   Korkina, Ludmila ^a   Caccamo, Daniela ^c  

^a Centre of Innovative Biotechnological Investigations Nanolab   (Russian Federation)

^b Active Longevity Clinic Institut Krasoty Na Arbate   (Russian Federation)

^c UNIVERSITY OF MESSINA   (Italy)

^d LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRATE; NITRITE; MICROSATELLITE DNA; NITRIC ACID DERIVATIVE; NOS2 PROTEIN, HUMAN; NOS3 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CHRONIC FATIGUE SYNDROME; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFERENTIAL DIAGNOSIS; FEMALE; FIBROMYALGIA; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIPLE CHEMICAL SENSITIVITY; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; GENETICS;

ADULT; FATIGUE SYNDROME, CHRONIC; FEMALE; FIBROMYALGIA; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MULTIPLE CHEMICAL SENSITIVITY; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84927127650     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2015/245308     Document Type: Article

References (36)

1. C. de Luca, G. Scordo, E. Cesareo, D. Raskovic, G. Genovesi, and L. Korkina, "Idiopathic environmental intolerances (IEI): from molecular epidemiology tomolecular medicine," Indian Journal of Experimental Biology, vol. 48, no. 7, pp. 625-635, 2010.
2. L. Korkina, M. G. Scordo, I. Deeva, E. Cesareo, and C. de Luca, "The chemical defensive system in the pathobiology of idiopathic environment-associated diseases," Current Drug Metabolism, vol. 10, no. 8, pp. 914-931, 2009.
3. H. M. Kipen and N. Fiedler, "Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge," Environmental Health Perspectives, vol. 110, supplement 4, pp. 597-599, 2002.
4. L. H. Hetherington and J. M. Battershill, "Review of evidence for a toxicological mechanism of idiopathic environmental intolerance," Human & Experimental Toxicology, vol. 32, no. 1, pp. 3-17, 2013.
5. S. J. Genuis, "Chemical sensitivity: pathophysiology or pathopsychology?" Clinical Therapeutics, vol. 35, no. 5, pp. 572-577, 2013.
6. G. McKeown-Eyssen, C. Baines, D. E. C. Cole et al., "Casecontrol study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR," International Journal of Epidemiology, vol. 33, no. 5, pp. 971-978, 2004.
7. D. Caccamo, E. Cesareo, S. Mariani et al., "Xenobiotic sensor-and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population," Oxidative Medicine and Cellular Longevity, vol. 2013,Article ID 831969, 9 pages, 2013.
8. X. Cui, X. Lu, M. Hiura, M. Oda, W. Miyazaki, and T. Katoh, "Evaluation of genetic polymorphisms in patients withmultiple chemical sensitivity," PLoS ONE, vol. 8, no. 8,Article IDe73708, 2013.
9. C. de Luca, J. C. S. Thai, D. Raskovic et al., "Metabolic and genetic screening of electromagnetic hypersensitive subjects as a feasible tool for diagnostics and intervention," Mediators of Inflammation, vol. 2014, Article ID 924184, 14 pages, 2014.
10. C. De Luca, M. G. Scordo, E. Cesareo et al., "Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobioticmetabolizing enzymes," Toxicology and Applied Pharmacology, vol. 248, no. 3, pp. 285-292, 2010.
11. C. de Luca, D. Raskovic, V. Pacifico, J. C. S. Thai, and L. Korkina, "The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances," International Journal of Environmental Research and Public Health, vol. 8, no. 7, pp. 2770-2797, 2011.
12. M. L. Pall, "NMDA sensitization and stimulation by peroxynitrite, nitric oxide, and organic solvents as the mechanism of chemical sensitivity inmultiple chemical sensitivity,"TheFASEB Journal, vol. 16, no. 11, pp. 1407-1417, 2002.
13. Y. Vodovotz, P. K. M. Kim, E. Z. Bagci et al., "nflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, invitro, and in silico studies," Current Molecular Medicine, vol. 4, no. 7, pp. 753-762, 2004.
14. M. L. Pall and J. D. Satterlee, "Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder," Annals of the New York Academy of Sciences, vol. 933, pp. 323-329, 2001.
15. M. L. Pall, "Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: central role of N-methyl-D-aspartate receptors in the sensitivity mechanism," Environmental Health Perspectives, vol. 111, no. 12, pp. 1461-1464, 2003.
16. L. I. Holla, A. Stejskalova, V. Znojil, and A. Vasku, "Analysis of the inducible nitric oxide synthase gene polymorphisms in Czech patients with atopic diseases," Clinical & Experimental Allergy, vol. 36, no. 12, pp. 1592-1601, 2006.
17. S. Konno, N. Hizawa, E. Yamaguchi, E. Jinushi, and M. Nishimura, "(CCTTT)n repeat polymorphism in the NOS2 gene promoter is associated with atopy," Journal of Allergy and Clinical Immunology, vol. 108, no. 5, pp. 810-814, 2001.
18. J. Batra, T. P. Singh, U. Mabalirajan, A. Sinha, R. Prasad, and B. Ghosh, "Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels," Thorax, vol. 62, no. 1, pp. 16-22, 2007.
19. F. M. Gonçalves, M. R. Luizon, J. G. Speciali, A. Martins-Oliveira, F. Dach, and J. E. Tanus-Santos, "Interaction among nitric oxide (NO)-related genes in migraine susceptibility," Molecular and Cellular Biochemistry, vol. 370, no. 1-2, pp. 183-189, 2012.
20. S. S. Dhillon, L. A. Mastropaolo, R. Murchie et al., "Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease," Clinical and Translational Gastroenterology, vol. 5, no. 1, article e46, 2014.
21. Y.Miyamoto, Y. Saito, M. Nakayama et al., "Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a-786TαC mutation associated with coronary spastic angina," Human Molecular Genetics, vol. 9, no. 18, pp. 2629-2637, 2000.
22. C. S. Miller and T. J. Prihoda, "The environmental exposure and sensitivity inventory (EESI): a standardized approach for measuring chemical intolerances for research and clinical applications," Toxicology and Industrial Health, vol. 15, no. 3-4, pp. 370-385, 1999.
23. G. E. Brown, G. M. Silver, J. Reiff, R. C. Allen, and M. P. Fink, "Polymorphonuclear neutrophil chemiluminescence in whole blood fromblunt trauma patients withmultiple injuries," Journal of Trauma, vol. 46, no. 2, pp. 297-305, 1999.
24. E. Schnakenberg, K.-R. Fabig, M. Stanulla et al., "A crosssectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes," Environmental Health, vol. 6, article 6, 2007.
25. G. A. Wiesmüller, H. Niggemann, W. Weißbach et al., "Sequence variations in subjects with self-reported multiple chemical sensitivity (sMCS): a case-control study," Journal of Toxicology and EnvironmentalHealth Part A: Current Issues, vol. 71, no. 11-12, pp. 786-794, 2008.
26. N. D. Berg, H. Berg Rasmussen, A. Linneberg et al., "Genetic susceptibility factors formultiple chemical sensitivity revisited," International Journal of Hygiene and Environmental Health, vol. 213, no. 2, pp. 131-139, 2010.
27. E. Bouzigon, F. Monier, M. Boussaha et al., "Associations between nitric oxide synthase genes and exhaled NO-related phenotypes according to asthma status," PLoS ONE, vol. 7, no. 5, Article ID e36672, 2012.
28. C. H. Sponton, R. Esposti, C. M. Rodovalho et al., "Thepresence of theNOS3 gene polymorphism for intron 4 mitigates the beneficial effects of exercise training on ambulatory blood pressure monitoring in adults," The American Journal of Physiology-Heart and Circulatory Physiology, vol. 306, no. 12, pp. H1679-H1691, 2014.
29. M. A. Gonzalez-Gay, J. Llorca, E. Sanchez et al., "Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain," Rheumatology, vol. 43, no. 9, pp. 1182-1185, 2004.
30. M. C. Martín, A. Martinez, J. L. Mendoza et al., "Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility," Immunogenetics, vol. 59, no. 11, pp. 833-837, 2007.
31. M. Pascual, M. A. López-Nevot, R. Cáliz et al., "Genetic determinants of rheumatoid arthritis:Theinducible nitric oxide synthase (NOS2) gene promoter polymorphism," Genes & Immunity, vol. 3, no. 5, pp. 299-301, 2002.
32. T. D. O. S. Mansur, F. M. Gonçalves, A. Martins-Oliveira et al., "Inducible nitric oxide synthase haplotype associated with migraine and aura," Molecular and Cellular Biochemistry, vol. 364, no. 1-2, pp. 303-308, 2012.
33. R. Eröz, A. Bahadir, S. Dikici, and S. Tasdemir, "Association of endothelial nitric oxide synthase gene polymorphisms (894G/T,-786T/C, G10T) and clinical findings in patients with migraine," NeuroMolecular Medicine, vol. 16, no. 3, pp. 587-593, 2014.
34. K. M. Warpeha,W. Xu, L. Liu et al., "Genotyping and functional analysis of a polymorphic (CCTTT)(n) repeat of NOS2A in diabetic retinopathy," The FASEB Journal, vol. 13, no. 13, pp. 1825-1832, 1999.
35. W. Xu, S. Humphries, M. Tomita et al., "Survey of the allelic frequency of a NOS2A promoter microsatellite in human populations: Assessment of theNOS2Agene and predisposition to infectious disease," Nitric Oxide-Biology and Chemistry, vol. 4, no. 4, pp. 379-383, 2000.
36. M. Pascual, C. Sanz, M. Isidoro-García et al., "(CCTTT)n polymorphism of NOS2 Ain nasal polyposis and asthma: a casecontrol study," Journal of Investigational Allergology and Clinical Immunology, vol. 18, no. 4, pp. 239-244, 2008.