Metabolic and genetic screening of electromagnetic hypersensitive subjects as a feasible tool for diagnostics and intervention

Mediators of Inflammation

Volumn 2014, Issue , 2014, Pages

  De Luca, Chiara ^a,b   Chung Sheun Thai, Jeffrey ^c   Raskovic, Desanka ^d   Cesareo, Eleonora ^d   Caccamo, Daniela ^e   Trukhanov, Arseny ^b   Korkina, Liudmila ^a,b  

^a Centre of Innovative Biotechnological Investigations (Cibi Nanolab)   (Russian Federation)

^b Active Longevity Clinic Institut Krasoty Na Arbate   (Russian Federation)

^c Natural Health Farm   (Malaysia)

^d LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^e UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; CATALASE; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; POLYUNSATURATED FATTY ACID; SUPEROXIDE DISMUTASE; GENETIC MARKER; REACTIVE OXYGEN METABOLITE;

ADULT; AGED; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; DNA POLYMORPHISM; ELECTROMAGNETIC FIELD; ELECTROMAGNETIC HYPERSENSITIVITY; ERYTHROCYTE MEMBRANE; FEMALE; GENETIC SCREENING; GENOTYPE; HAPLOTYPE; HUMAN; HYPERSENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; MULTIPLE CHEMICAL SENSITIVITY; RADIATION EXPOSURE; SELF REPORT; ADOLESCENT; GENETIC MARKER; GENETIC POLYMORPHISM; GENETICS; METABOLISM; MIDDLE AGED; OXIDATION REDUCTION REACTION; PROCEDURES; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ELECTROMAGNETIC PHENOMENA; FEMALE; GENETIC MARKERS; GENETIC TESTING; HUMANS; MALE; MIDDLE AGED; MULTIPLE CHEMICAL SENSITIVITY; OXIDATION-REDUCTION; POLYMORPHISM, GENETIC; REACTIVE OXYGEN SPECIES; YOUNG ADULT;

EID: 84899915612     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2014/924184     Document Type: Article

References (55)

1. Levallois P., Hypersensitivity of human subjects to environmental electric and magnetic field exposure: a review of the literature. Environmental Health Perspectives 2002 110 supplement 4 613 618 2-s2.0-0036676987
2. Genuis S. J., Lipp C. T., Electromagnetic hypersensitivity: fact or fiction? Science of the Total Environment 2012 414 103 112 2-s2.0-84855527902 10.1016/j.scitotenv.2011.11.008
3. Richman R., Munroe A. J., Siddiqui Y., A pilot neighbourhood study towards establishing a benchmark for reducing electromagnetic field levels within single family residential dwellings. Science of the Total Environment 2014 466-467 625 634 10.1016/j.scitotenv.2013.07.010
4. World Health Organization, Electromagnetic Fields. 2011, http://www.who.int/peh-emf/en/
5. Seitz H., Stinner D., Eikmann T., Herr C., Röösli M., Electromagnetic hypersensitivity (EHS) and subjective health complaints associated with electromagnetic fields of mobile phone communication-a literature review published between 2000 and 2004. Science of the Total Environment 2005 349 1-3 45 55 2-s2.0-26444591556 10.1016/j.scitotenv.2005.05. 009 (Pubitemid 41421062)
6. Röösli M., Hug K., Wireless communication fields and non-specific symptoms of ill health: a literature review. Wiener Medizinische Wochenschrift 2011 161 9-10 240 250 2-s2.0-79960072410 10.1007/s10354-011-0883-9
7. de Luca C., Raskovic D., Pacifico V., Thai J. C. S., Korkina L., The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. International Journal of Environmental Research and Public Health 2011 8 7 2770 2797 2-s2.0-79960826649 10.3390/ijerph8072770
8. Gangi S., Johansson O., A theoretical model based upon mast cells and histamine to explain the recently proclaimed sensitivity to electric and/or magnetic fields in humans. Medical Hypotheses 2000 54 4 663 671 2-s2.0-0034063741 10.1054/mehy.1999.0923 (Pubitemid 30311567)
9. Johansson O., Disturbance of the immune system by electromagnetic fields-a potentially underlying cause for cellular damage and tissue repair reduction which could lead to disease and impairment. Pathophysiology 2009 16 2-3 157 177 2-s2.0-67650697485 10.1016/j.pathophys.2009.03.004
10. Röösli M., Radiofrequency electromagnetic field exposure and non-specific symptoms of ill health: a systematic review. Environmental Research 2008 107 2 277 287 2-s2.0-43049183450 10.1016/j.envres.2008.02.003
11. Rubin G. J., Nieto-Hernandez R., Wessely S., Idiopathic environmental intolerance attributed to electromagnetic fields (formerly "electromagnetic hypersensitivity"): an updated systematic review of provocation studies. Bioelectromagnetics 2010 31 1 1 11 2-s2.0-74049115800 10.1002/bem.20536
12. Köteles F., Szemerszky R., Gubányi M., Idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) and electrosensibility (ES)-are they connected? International Journal of Hygiene and Environmental Health 2013 216 3 362 370 10.1016/j.ijheh.2012.05.007
13. Hillert L., Kolmodin-Hedman B., Eneroth P., Arnetz B. B., The effect of supplementary antioxidant therapy in patients who report hypersensitivity to electricity: a randomized controlled trial. Medscape General Medicine 2001 3 2 11 2-s2.0-0035937756
14. Rubin G. J., Das Munshi J., Wessely S., A systematic review of treatments for electromagnetic hypersensitivity. Psychotherapy and Psychosomatics 2006 75 1 12 18 2-s2.0-29144497251 10.1159/000089222 (Pubitemid 41816060)
15. Schröttner J., Leitgeb N., Sensitivity to electricity-temporal changes in Austria. BMC Public Health 2008 8, article 310 7 10.1186/1471-2458-8- 310
16. Hagström M., Auranen J., Ekman R., Electromagnetic hypersensitive Finns: symptoms, perceived sources and treatments, a questionnaire study. Pathophysiology 2013 20 2 117 122 10.1016/j.pathophys.2013.02.001
17. Witthöft M., Rubin G. J., Are media warnings about the adverse health effects of modern life self-fulfilling? An experimental study on idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF). Journal of Psychosomatic Research 2013 74 3 206 212 10.1016/j.jpsychores.2012.12.002
18. World Health Organization, Establishing a Dialogue on Risks from Electromagnetic Fields 2002 Geneva, Switzerland Radiation and Environmental Health Deparment of Protection of the Human Environment, Who Library
19. Korkina L., Scordo M. G., Deeva I., Cesareo E., de Luca C., The chemical defensive system in the pathobiology of idiopathic environment-associated diseases. Current Drug Metabolism 2009 10 8 914 931 2-s2.0-74249117600 10.2174/138920009790274568
20. Palmquist E., Claeson A. S., Neely G., Stenberg B., Nordin S., Overlap in prevalence between various types of environmental intolerance. International Journal of Hygiene and Environmental Health 2013 10.1016/j.ijheh.2013.08.005
21. Genuis S. J., Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity. Science of the Total Environment 2010 408 24 6047 6061 2-s2.0-77958107727 10.1016/j.scitotenv.2010. 08.047
22. de Luca C., Scordo G., Cesareo E., Raskovic D., Genovesi G., Korkina L., Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine. Indian Journal of Experimental Biology 2010 48 7 625 635 2-s2.0-77954264029
23. de Luca C., Scordo M. G., Cesareo E., Pastore S., Mariani S., Maiani G., Stancato A., Loreti B., Valacchi G., Lubrano C., Raskovic D., de Padova L., Genovesi G., Korkina L. G., Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes. Toxicology and Applied Pharmacology 2010 248 3 285 292 2-s2.0-77953511911 10.1016/j.taap.2010.04.017
24. Caccamo D., Cesareo E., Mariani S., Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population. Oxidative Medicine and Cellular Longevity 2013 2013 9 831969 10.1155/2013/831969
25. Cullen M. R., Multiple chemical sensitivities: summary and directions for future investigators. Occupational Medicine 1987 2 4 801 804 2-s2.0-0023433210
26. Miller C. S., Prihoda T. J., The environmental exposure and sensitivity inventory (EESI): a standardized approach for measuring chemical intolerances for research and clinical applications. Toxicology and Industrial Health 1999 15 3-4 370 385 2-s2.0-0033451982 (Pubitemid 30030695)
27. Fabig K. R., Das multiple chemikalien-sensitivität-syndrom (MCS). Können fragebögen, IgE und SPECT zur Diagnostik beitragen? Hamburger Ärzteblatt 2000 12 600 603
28. Brown G. E., Silver G. M., Reiff J., Allen R. C., Fink M. P., Polymorphonuclear neutrophil chemiluminescence in whole blood from blunt trauma patients with multiple injuries. Journal of Trauma 1999 46 2 297 305 2-s2.0-0032995365 (Pubitemid 29102549)
29. Esko T., Mezzavilla M., Nelis M., Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity. European Journal of Human Genetics 2013 21 6 659 665 10.1038/ejhg.2012.229
30. Giovannoni G., Land J. M., Keir G., Thompson E. J., Heales S. J., Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels. Annals of Clinical Biochemistry 1997 34 2 193 198 2-s2.0-0030969993 (Pubitemid 27121044)
31. Miller N. J., Rice-Evans C., Davies M. J., A new method for measuring antioxidant activity. Biochemical Society Transactions 1993 21 2 95S 2-s2.0-0027156905 (Pubitemid 23167763)
32. Reed D. J., Babson J. R., Beatty P. W., Brodie A. E., Ellis W. W., Potter D. W., High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiol and disulfides. Analytical Biochemistry 1980 106 1 55 62 2-s2.0-0019131878 (Pubitemid 11246564)
33. de Luca C., Deeva I., Mariani S., Maiani G., Stancato A., Korkina L., Monitoring antioxidant defenses and free radical production in space-flight, aviation and railway engine operators, for the prevention and treatment of oxidative stress, immunological impairment, and pre-mature cell aging. Toxicology and Industrial Health 2009 25 4-5 259 267 2-s2.0-68849110161 10.1177/0748233709103032
34. Sun Y., Oberley L. W., Li Y., A simple method for clinical assay of superoxide dismutase. Clinical Chemistry 1988 34 3 497 500 2-s2.0-0023952554
35. Aebi H., Catalase in vitro. Methods in Enzymology 1984 105 121 126 2-s2.0-0021318441 10.1016/S0076-6879(84)05016-3
36. Habig W. H., Pabst M. J., Jakoby W. B., Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. The Journal of Biological Chemistry 1974 249 22 7130 7139 2-s2.0-0016275313
37. Paglia D. E., Valentine W. N., Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of Laboratory and Clinical Medicine 1967 70 1 158 169 2-s2.0-0014108436
38. de Luca C., Filosa A., Grandinetti M., Maggio F., Lamba M., Passi S., Blood antioxidant status and urinary levels of catecholamine metabolites in β -thalassemia. Free Radical Research 1999 30 6 453 462 2-s2.0-0032810030 10.1080/10715769900300491 (Pubitemid 29326875)
39. Primavera A., Fustinoni S., Biroccio A., Ballerini S., Urbani A., Bernardini S., Federici G., Capucci E., Manno M., Bello M. L., Glutathione transferases and glutathionylated hemoglobin in workers exposed to low doses of 1,3-butadiene. Cancer Epidemiology Biomarkers & Prevention 2008 17 11 3004 3012 2-s2.0-55849134828 10.1158/1055-9965.EPI-08-0443
40. Leitgeb N., Schröttner J., Electrosensibility and electromagnetic hypersensitivity. Bioelectromagnetics 2003 24 6 387 394 2-s2.0-0142079470 10.1002/bem.10138 (Pubitemid 38622791)
41. Elmas O., Effects of electromagnetic field exposure on the heart: a systematic review. Toxicology and Industrial Health 2013 10.1177/ 0748233713498444
42. Costa A., Branca V., Minoia C., Pigatto P. D., Guzzi G., Heavy metals exposure and electromagnetic hypersensitivity. Science of the Total Environment 2010 408 20 4919 4920 2-s2.0-77955920248 10.1016/j.scitotenv.2010.06.045
43. Österberg K., Persson R., Karlson B., Eek F. C., Ørbæk P., Personality, mental distress, and subjective health complaints among persons with environmental annoyance. Human & Experimental Toxicology 2007 26 3 231 241 2-s2.0-33947433149 10.1177/0960327107070575 (Pubitemid 46456801)
44. Tuengler A., von Klitzing L., Hypothesis on how to measure electromagnetic hypersensitivity. Electromagnetic Biology and Medicine 2013 32 3 281 290 10.3109/15368378.2012.712586
45. Eltiti S., Wallace D., Zougkou K., Russo R., Joseph S., Rasor P., Fox E., Development and evaluation of the electromagnetic hypersensitivity questionnaire. Bioelectromagnetics 2007 28 2 137 151 2-s2.0-33846656567 10.1002/bem.20279 (Pubitemid 46190949)
46. Mueller C. H., Krueger H., Schlerz C., Project NEMESIS: perception of a 50 Hz electric and magnetic field at low intensities (laboratory experiment). Bioelectromagnetics 2002 23 1 26 36 2-s2.0-0036365183 10.1002/bem.95 (Pubitemid 38622917)
47. 10-containing composition (Immugen) protects against occupational and environmental stress in workers of the gas and oil industry. BioFactors 2003 18 1-4 245 254 2-s2.0-0347418167 (Pubitemid 38035138)
48. de Luca C., Valacchi G., Surface lipids as multifunctional mediators of skin responses to environmental stimuli. Mediators of Inflammation 2010 2010 11 2-s2.0-78349285199 10.1155/2010/321494 321494
49. Kostyuk V., Potapovich A., Stancato A., Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes. PLoS ONE 2012 7 8, article e44472 10.1371/journal.pone. 0044472
50. Lubrano C., Genovesi G., Specchia P., Obesity and metabolic comorbidities: environmental diseases? Oxidative Medicine and Cell Longevity 2013 2013 9 640673 10.1155/2013/640673
51. Dahmen N., Ghezel-Ahmadi D., Engel A., Blood laboratory findingsin patients suffering from self-perceived electromagnetic hypersensitivity (EHS). Bioelectromagnetics 2009 30 4 299 306 2-s2.0-66149147118 10.1002/bem.20486
52. International Programme on Chemical Safety/World Health Organization (IPCS/WHO), Conclusion and recommendations of a wokshop on multiple chemical sensitivities (MCS). Regulatory Toxicology and Pharmacology 1996 24 S79 S86
53. McKeown-Eyssen G., Baines C., Cole D. E., Riley N., Tyndale R. F., Marshall L., Jazmaji V., Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR. International Journal of Epidemiology 2004 33 5 971 978 2-s2.0-7244226313 10.1093/ije/dyh251 (Pubitemid 39429989)
54. Schnakenberg E., Fabig K.-R., Stanulla M., Strobl N., Lustig M., Fabig N., Schloot W., A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes. Environmental Health: A Global Access Science Source 2007 6, article 6 2-s2.0-33847184855 10.1186/1476-069X-6-6
55. Berg N. D., Rasmussen H. B., Linneberg A., Brasch-Andersen C., Fenger M., Dirksen A., Vesterhauge S., Werge T., Elberling J., Genetic susceptibility factors for multiple chemical sensitivity revisited. International Journal of Hygiene and Environmental Health 2010 213 2 131 139 2-s2.0-77649238249 10.1016/j.ijheh.2010.02.001