Potential role of increased oxygenation in altering perinatal adrenal steroidogenesis

Pediatric Research

Volumn 77, Issue 2, 2015, Pages 298-309

  Agrawal, Vishal ^a   Tee, Meng Kian ^a   Qiao, Jie ^a   Muench, Marcus O ^a,b   Miller, Walter L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; MESSENGER RNA; OXYGEN; STEROID 17ALPHA MONOOXYGENASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; CULTURE MEDIUM; CYP17A1 PROTEIN, HUMAN; PHOSPHOPROTEIN; STEROID;

ADRENAL CELL; ADRENAL CORTEX CARCINOMA; ADRENAL STEROIDOGENESIS; ADRENOCORTICAL CARCINOMA CELL LINE; ARTERIAL OXYGEN TENSION; ARTICLE; BIRTH; CONTROLLED STUDY; FETUS; FETUS CELL; FETUS HYPOXIA; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NCI H295A CELL LINE; OXYGENATION; PERINATAL PERIOD; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STEROIDOGENESIS; ADRENAL GLAND; BIOSYNTHESIS; CHEMISTRY; CULTURE MEDIUM; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NEWBORN; TUMOR CELL LINE;

3-HYDROXYSTEROID DEHYDROGENASES; ADRENAL GLANDS; CELL LINE, TUMOR; CULTURE MEDIA; FETUS; HUMANS; INFANT, NEWBORN; MICROARRAY ANALYSIS; OXYGEN; PHOSPHOPROTEINS; POLYMERASE CHAIN REACTION; STEROID 17-ALPHA-HYDROXYLASE; STEROIDS;

EID: 84927126163     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2014.194     Document Type: Article

References (33)

1. Goto M, Piper Hanley K, Marcos J, et al. In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development. J Clin Invest 2006; 116: 953-60.
2. Voutilainen R, Ilvesmaki V, Miettinen PJ. Low expression of 3 -hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo; adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures. J Clin Endocrinol Metab 1991; 72: 761-7.
3. Kitada M, Kamataki T, Itahashi K, Rikihisa T, Kanakubo Y. P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16-hydroxylase of dehydroepiandrosterone 3-sulfate. J Biol Chem 1987; 262: 13534-7.
4. Miller KK, Cai J, Ripp SL, Pierce WM Jr, Rushmore TH, Prough RA. Stereo- And regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450. Drug Metab Dispos 2004; 32: 305-13.
5. Leeder JS, Gaedigk R, Marcucci KA, et al. Variability of CYP3A7 expression in human fetal liver. J Pharmacol Exp Ther 2005; 314: 626-35.
6. Kari MA, Raivio KO, Stenman UH, Voutilainen R. Serum cortisol, dehydroepiandrosterone sulfate, and steroid-binding globulins in preterm neonates: effect of gestational age and dexamethasone therapy. Pediatr Res 1996; 40: 319-24.
7. Miller WL. Steroid hormone biosynthesis and actions in the materno-fetoplacental unit. Clin Perinatol 1998; 25: 799-817, v.
8. Siiteri PK, MacDonald PC. Placental estrogen biosynthesis during human pregnancy. J Clin Endocrinol Metab 1966; 26: 751-61.
9. Miller WL, Auchus RJ. The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev 2011; 32: 81-151.
10. McMahon SK, Pretorius CJ, Ungerer JP, et al. Neonatal complete generalized glucocorticoid resistance and growth hormone deficiency caused by a novel homozygous mutation in helix 12 of the ligand binding domain of the glucocorticoid receptor gene (NR3C1). J Clin Endocrinol Metab 2010; 95: 297-302.
11. Keene MF. Observations on the development of the human suprarenal gland. J Anat 1927; 61(Pt 3): 302-24.
12. Lanman JT. The fetal zone of the adrenal gland: its developmental course, comparative anatomy, and possible physiologic functions. Medicine (Baltimore) 1953; 32: 389-430.
13. Villee DB. The development of steroidogenesis Am J Med 1972; 53: 533-44.
14. McNutt NS, Jones AL. Observations on the ultrastructure of cytodifferentiation in the human fetal adrenal cortex. Lab Invest 1970; 22: 513-27.
15. Spencer SJ, Mesiano S, Lee JY, Jaffe RB. Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling. J Clin Endocrinol Metab 1999; 84: 1110-5.
16. Sucheston ME, Cannon MS. Development of zonular patterns in the human adrenal gland. J Morphol 1968; 126: 477-91.
17. Kojima S, Yanaihara T, Nakayama T. Serum steroid levels in children at birth and in early neonatal period Am J Obstet Gynecol 1981; 140: 961-5.
18. Grueters A, Korth-Schutz S. Longitudinal study of plasma dehydroepiandrosterone sulfate in preterm and fullterm infants. J Clin Endocrinol Metab 1982; 55: 314-20.
19. Midgley PC, Russell K, Oates N, Holownia P, Shaw JC, Honour JW Adrenal function in preterm infants: ACTH may not be the sole regulator of the fetal zone. Pediatr Res 1998; 44: 887-93.
20. Ben-David S, Zuckerman-Levin N, Epelman M, et al. Parturition itself is the basis for fetal adrenal involution. J Clin Endocrinol Metab 2007; 92: 93-7.
21. Di Blasio AM, Voutilainen R, Jaffe RB, Miller WL. Hormonal regulation of messenger ribonucleic acids for P450scc (cholesterol side-chain cleavage enzyme) and P450c17 (17 ?-hydroxylase/17, 20-lyase) in cultured human fetal adrenal cells. J Clin Endocrinol Metab 1987; 65: 170-5.
22. Higashimura Y, Nakajima Y, Yamaji R, et al. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells Arch Biochem Biophys 2011; 509: 1-8.
23. Staels B, Hum DW, Miller WL. Regulation of steroidogenesis in NCIH295 cells: a cellular model of the human fetal adrenal. Mol Endocrinol 1993; 7: 423-33.
24. Halle C, Andersen E, Lando M, et al. Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrastenhanced MRI. Cancer Res 2012; 72: 5285-95.
25. Holland RC. The effect of hypoxia on the fetal rat adrenal Anat Rec 1958; 130: 177-95.
26. Myers DA, Hyatt K, Mlynarczyk M, Bird IM, Ducsay CA. Long-Term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-Term ovine fetus Am J Physiol Regul Integr Comp Physiol 2005; 289: R1707-14.
27. Honour JH, Wickramaratne K, Valman HB Adrenal function in preterm infants. Biol Neonate 1992; 61: 214-21.
28. Dunwoodie SL. The role of hypoxia in development of the mammalian embryo. Dev Cell 2009; 17: 755-73.
29. Rudolph AM. Fetal circulation and cardiovascular adjustments after birth. In: Rudolph AM, Hoffman JIE, Rudolph CD, eds. Rudolph's Pediatrics, 20th edn. Stamford, CT: Appleton & Lange, 1996: 1409-13.
30. Park AM, Sanders TA, Maltepe E. Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care. Semin Fetal Neonatal Med 2010; 15: 196-202.
31. Mesiano S, Mellon SH, Jaffe RB. Mitogenic action, regulation, and localization of insulin-like growth factors in the human fetal adrenal gland. J Clin Endocrinol Metab 1993; 76: 968-76.
32. Gazdar AF, Oie HK, Shackleton CH, et al. Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis. Cancer Res 1990; 50: 5488-96.
33. Rodriguez H, Hum DW, Staels B, Miller WL. Transcription of the human genes for cytochrome P450scc and P450c17 is regulated differently in human adrenal NCI-H295 cells than in mouse adrenal Y1 cells. J Clin Endocrinol Metab 1997; 82: 365-71