Family history of type 2 diabetes increases the risk of both obesity and its complications: Is type 2 diabetes a disease of inappropriate lipid storage?

Journal of Internal Medicine

Volumn 277, Issue 5, 2015, Pages 540-551

  Cederberg, H ^a   Stancakova A ^a   Kuusisto, J ^a   Laakso, M ^a   Smith, U ^b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Diabetes; Family history; Genetics; Insulin resistance; Insulin secretion; Obesity

Indexed keywords

ADULT; ARTICLE; BODY FAT; BODY MASS; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE PREDISPOSITION; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FIRST DEGREE RELATIVE; FOLLOW UP; GENE; GENETIC RISK; HUMAN; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SECOND DEGREE RELATIVE; SUBCUTANEOUS FAT; BODY FAT DISTRIBUTION; DIABETES MELLITUS, TYPE 2; INSULIN RESISTANCE; LIPID METABOLISM DISORDERS; OVERWEIGHT; PATHOLOGY; PEDIGREE; PHYSIOLOGY; SECRETION (PROCESS); WAIST CIRCUMFERENCE;

INSULIN;

BODY FAT DISTRIBUTION; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LIPID METABOLISM DISORDERS; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; PEDIGREE; RISK FACTORS; SUBCUTANEOUS FAT; WAIST CIRCUMFERENCE;

EID: 84927047452     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/joim.12289     Document Type: Article

References (31)

1. Xu Y, Wang L, He J et al. Prevalence and control of diabetes in Chinese adults. JAMA 2013; 310: 948-59.
2. International Diabetes Federation. IDF Diabetes Atlas 2012 Update, 5th edn. www.idf.org/diabetesatlas.
3. Shah NR, Braverman ER. Measuring adiposity in patients: the utility of body mass index (BMI), percent body fat, and leptin. PLoS One 2012; 7: e33308.
4. Alberti KG, Zimmet P, Shaw J, Group IDFETFC. The metabolic syndrome-a new worldwide definition. Lancet 2005; 366: 1059-62.
5. Ruderman N, Chisholm D, Pi-Sunyer X, Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes 1998; 47: 699-713.
6. Kloting N, Fasshauer M, Dietrich A et al. Insulin-sensitive obesity. Am J Physiol Endocrinol Metab 2010; 299: E506-15.
7. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006; 444: 881-7.
8. Gustafson B, Hammarstedt A, Hedjazifar S, Smith U. Restricted adipogenesis in hypertrophic obesity: the role of WISP2, WNT, and BMP4. Diabetes 2013; 62: 2997-3004.
9. Targher G, Byrne CD. Clinical review: nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications. J Clin Endocrinol Metab 2013; 98: 483-95.
10. Britton KA, Massaro JM, Murabito JM, Kreger BE, Hoffmann U, Fox CS. Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality. J Am Coll Cardiol 2013; 62: 921-5.
11. Graner M, Siren R, Nyman K et al. Cardiac steatosis associates with visceral obesity in nondiabetic obese men. J Clin Endocrinol Metab 2013; 98: 1189-97.
12. Neeland IJ, Turer AT, Ayers CR et al. Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA 2012; 308: 1150-9.
13. Kim JY, van de Wall E, Laplante M et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007; 117: 2621-37.
14. Arner E, Westermark PO, Spalding KL et al. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 2010; 59: 105-9.
15. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796-808.
16. InterAct C. The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study. Diabetologia 2013; 56: 60-9.
17. Wagner R, Thorand B, Osterhoff MA et al. Family history of diabetes is associated with higher risk for prediabetes: a multicentre analysis from the German Center for Diabetes Research. Diabetologia 2013; 56: 2176-80.
18. Zeggini E, Scott LJ, Saxena R et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008; 40: 638-45.
19. Qin J, Li Y, Cai Z et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012; 490: 55-60.
20. Arner P, Arner E, Hammarstedt A, Smith U. Genetic predisposition for Type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. PLoS One 2011; 6: e18284.
21. Stancakova A, Javorsky M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M. Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6, 414 Finnish men. Diabetes 2009; 58: 1212-21.
22. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006; 29 (Suppl 1): S43-8.
23. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22: 1462-70.
24. Boesgaard TW, Zilinskaite J, Vanttinen M et al. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients-the EUGENE2 study. Diabetologia 2008; 51: 816-20.
25. Sjostrom L, Kvist H, Cederblad A, Tylen U. Determination of total adipose tissue and body fat in women by computed tomography, 40K, and tritium. Am J Physiol 1986; 250: E736-45.
26. Lyssenko V, Jonsson A, Almgren P et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 2008; 359: 2220-32.
27. Morino K, Petersen KF, Dufour S et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest 2005; 115: 3587-93.
28. Jansson PA, Pellme F, Hammarstedt A et al. A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin. FASEB J 2003; 17: 1434-40.
29. McQuaid SE, Hodson L, Neville MJ et al. Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition? Diabetes 2011; 60: 47-55.
30. van 't Riet E, Dekker JM, Sun Q, Nijpels G, Hu FB, van Dam RM. Role of adiposity and lifestyle in the relationship between family history of diabetes and 20-year incidence of type 2 diabetes in U.S. women. Diabetes Care 2010; 33: 763-7.
31. Vogt MC, Bruning JC. CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age. Trends Endocrinol Metab 2013; 24: 76-84.