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Volumn 14, Issue 1, 2015, Pages

Revisiting loxapine: A systematic review

Author keywords

Agitation; Antipsychotic; Bipolar disorder; Loxapine; Schizophrenia

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; LOXAPINE; PLACEBO;

EID: 84926667044     PISSN: None     EISSN: 1744859X     Source Type: Journal    
DOI: 10.1186/s12991-015-0053-3     Document Type: Review
Times cited : (59)

References (102)
  • 1
    • 0035029416 scopus 로고    scopus 로고
    • Short-term inpatient pharmacotherapy of schizophrenia
    • Osser DN, Sigadel R. Short-term inpatient pharmacotherapy of schizophrenia. Harv Rev Psychiatry. 2001;9:89-104.
    • (2001) Harv Rev Psychiatry , vol.9 , pp. 89-104
    • Osser, D.N.1    Sigadel, R.2
  • 2
    • 0037257591 scopus 로고    scopus 로고
    • Treatment of agitation in bipolar disorder across the life cycle
    • Alderfer BS, Allen MH. Treatment of agitation in bipolar disorder across the life cycle. J Clin Psychiatry. 2003;64 suppl 4:3-9.
    • (2003) J Clin Psychiatry , vol.64 , pp. 3-9
    • Alderfer, B.S.1    Allen, M.H.2
  • 3
    • 84926622389 scopus 로고    scopus 로고
    • The psychopharmacology of violence: making sensible decisions
    • Citrome L, Volavka J. The psychopharmacology of violence: making sensible decisions. CNS Spectr. 2014;26:1-8.
    • (2014) CNS Spectr , vol.26 , pp. 1-8
    • Citrome, L.1    Volavka, J.2
  • 4
    • 84879291163 scopus 로고    scopus 로고
    • Loxapine inhalation powder: a review of its use in the acute treatment of agitation in patients with bipolar disorder or schizophrenia
    • Keating GM. Loxapine inhalation powder: a review of its use in the acute treatment of agitation in patients with bipolar disorder or schizophrenia. CNS Drugs. 2013;27(6):479-89.
    • (2013) CNS Drugs , vol.27 , Issue.6 , pp. 479-489
    • Keating, G.M.1
  • 5
    • 0004031154 scopus 로고    scopus 로고
    • The creation of psychopharmacology
    • Massachusetts London, England: Harvard University Press Cambridge;
    • Healy D. The creation of psychopharmacology. Massachusetts London, England: Harvard University Press Cambridge; 2004.
    • (2004)
    • Healy, D.1
  • 6
    • 78651204419 scopus 로고
    • Traitement des ètats d'excitation et d'agitation par une méthode médicamenteuse dérivè de l'hibernothèrapie
    • Delay J, Deniker P, Harl JM. Traitement des ètats d'excitation et d'agitation par une méthode médicamenteuse dérivè de l'hibernothèrapie. Ann Med Psychol. 1952;110:267-73.
    • (1952) Ann Med Psychol , vol.110 , pp. 267-273
    • Delay, J.1    Deniker, P.2    Harl, J.M.3
  • 9
    • 84897724496 scopus 로고    scopus 로고
    • 'Rapid tranquillisation': an historical perspective on its emergence in the context of the development of antipsychotic medications
    • Allison L, Moncrieff J. 'Rapid tranquillisation': an historical perspective on its emergence in the context of the development of antipsychotic medications. Hist Psychiatry. 2014;25(1):57-69.
    • (2014) Hist Psychiatry , vol.25 , Issue.1 , pp. 57-69
    • Allison, L.1    Moncrieff, J.2
  • 10
    • 0021415382 scopus 로고
    • Was insanity increasing? A response to Edward Hare
    • Scull A. Was insanity increasing? A response to Edward Hare. Brit J Psych. 1984;144:432-6.
    • (1984) Brit J Psych , vol.144 , pp. 432-436
    • Scull, A.1
  • 11
    • 0344540436 scopus 로고
    • Le R1625, nouvelle thérapeutique symptomatique de l'agitation psychomotrice
    • Divry P, Bobon J, Collard J. Le R1625, nouvelle thérapeutique symptomatique de l'agitation psychomotrice. Acta Neurol Psychiatr Belg. 1958;58:878-88.
    • (1958) Acta Neurol Psychiatr Belg , vol.58 , pp. 878-888
    • Divry, P.1    Bobon, J.2    Collard, J.3
  • 12
    • 0016691635 scopus 로고
    • Loxapine succinate: a controlled double-blind study in chronic schizophrenia
    • Schiele BC. Loxapine succinate: a controlled double-blind study in chronic schizophrenia. Dis Nerv Syst. 1975;36(7):361-4.
    • (1975) Dis Nerv Syst , vol.36 , Issue.7 , pp. 361-364
    • Schiele, B.C.1
  • 13
    • 0033815635 scopus 로고    scopus 로고
    • Loxapine intoxication: case report and literature review
    • Mazzola CD, Miron S, Jenkins AJ. Loxapine intoxication: case report and literature review. J Anal Toxicol. 2000;24(7):638-41.
    • (2000) J Anal Toxicol , vol.24 , Issue.7 , pp. 638-641
    • Mazzola, C.D.1    Miron, S.2    Jenkins, A.J.3
  • 14
    • 84879310710 scopus 로고    scopus 로고
    • Adasuve (loxapine) inhalation powder: EU summary of product characteristics;
    • (Accessed 22-Jan-2013)
    • European Medicines Agency. Adasuve (loxapine) inhalation powder: EU summary of product characteristics; 2013. http://ec.europa.eu/health/documents/community-register/html/h823.htm (Accessed 22-Jan-2013)
    • (2013)
  • 15
    • 0030781693 scopus 로고    scopus 로고
    • PET evidence that loxapine is an equipotent blocker of 5-HT2 and D2 receptors: implications for the therapeutics of schizophrenia
    • Kapur S, Zipursky R, Remington G, Jones C, McKay G, Houle S. PET evidence that loxapine is an equipotent blocker of 5-HT2 and D2 receptors: implications for the therapeutics of schizophrenia. Am J Psychiatry. 1997;154(11):1525-9.
    • (1997) Am J Psychiatry , vol.154 , Issue.11 , pp. 1525-1529
    • Kapur, S.1    Zipursky, R.2    Remington, G.3    Jones, C.4    McKay, G.5    Houle, S.6
  • 16
    • 0032961509 scopus 로고    scopus 로고
    • The role of typical and atypical antipsychotic medications in the management of agitation and aggression
    • Buckley PF. The role of typical and atypical antipsychotic medications in the management of agitation and aggression. J Clin Psychiatry. 1999;60:52-60.
    • (1999) J Clin Psychiatry , vol.60 , pp. 52-60
    • Buckley, P.F.1
  • 17
    • 0032961508 scopus 로고    scopus 로고
    • Selecting an atypical antipsychotic by combining clinical experience with guidelines from clinical trials
    • Stahl SM. Selecting an atypical antipsychotic by combining clinical experience with guidelines from clinical trials. J Clin Psychiatry. 1999;60:31-41.
    • (1999) J Clin Psychiatry , vol.60 , pp. 31-41
    • Stahl, S.M.1
  • 18
    • 0032962454 scopus 로고    scopus 로고
    • Does loxapine have "atypical" properties? Clinical evidence
    • Glazer WM. Does loxapine have "atypical" properties? Clinical evidence. J Clin Psychiatry. 1999;60:42-6.
    • (1999) J Clin Psychiatry , vol.60 , pp. 42-46
    • Glazer, W.M.1
  • 19
    • 1842273560 scopus 로고
    • Classification des neuroleptiques
    • In: Achaintre A, Balvet P, Beaujard M, Becache A, Berthier C, Broussolle P, editors. Actualities de therapeutique psychiatrique. Paris: Masson et Cie;
    • Lambert PA. Classification des neuroleptiques. In: Achaintre A, Balvet P, Beaujard M, Becache A, Berthier C, Broussolle P, editors. Actualities de therapeutique psychiatrique. Paris: Masson et Cie; 1963.
    • (1963)
    • Lambert, P.A.1
  • 20
    • 33746768115 scopus 로고    scopus 로고
    • Targeting the dopamine D2 receptor in schizophrenia
    • Seeman P. Targeting the dopamine D2 receptor in schizophrenia. Expert Opin Ther Targets. 2006;10(4):515-31.
    • (2006) Expert Opin Ther Targets , vol.10 , Issue.4 , pp. 515-531
    • Seeman, P.1
  • 21
    • 0028990758 scopus 로고
    • D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs
    • Roth BL, Tandra S, Burgess LH, Sibley DR, Meltzer HY. D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs. Psychopharmacology (Berl). 1995;120(3):365-8.
    • (1995) Psychopharmacology (Berl) , vol.120 , Issue.3 , pp. 365-368
    • Roth, B.L.1    Tandra, S.2    Burgess, L.H.3    Sibley, D.R.4    Meltzer, H.Y.5
  • 23
    • 0032909923 scopus 로고    scopus 로고
    • Pharmacologic and pharmacokinetic considerations in choosing an antipsychotic
    • Ereshefsky L. Pharmacologic and pharmacokinetic considerations in choosing an antipsychotic. J Clin Psychiatry. 1999;60:20-30.
    • (1999) J Clin Psychiatry , vol.60 , pp. 20-30
    • Ereshefsky, L.1
  • 24
    • 0016440232 scopus 로고
    • Psychoactive drugs in mania: a controlled comparison of lithium carbonate, chlorpromazine, and haloperidol
    • Shopsin B, Gershon S, Thompson H, Collins P. Psychoactive drugs in mania: a controlled comparison of lithium carbonate, chlorpromazine, and haloperidol. Arch Gen Psychiatry. 1975;32:34-42.
    • (1975) Arch Gen Psychiatry , vol.32 , pp. 34-42
    • Shopsin, B.1    Gershon, S.2    Thompson, H.3    Collins, P.4
  • 25
    • 0018188765 scopus 로고
    • Loxapine versus perphenazine in psychotic patients: a doubleblind, randomized, multicenter trial
    • Fruensgaard K, Wollenberg J, Hansen KM, Fensbo C, Sihm F. Loxapine versus perphenazine in psychotic patients: a doubleblind, randomized, multicenter trial. Curr Med Res Opin. 1978;5(8):601-7.
    • (1978) Curr Med Res Opin , vol.5 , Issue.8 , pp. 601-607
    • Fruensgaard, K.1    Wollenberg, J.2    Hansen, K.M.3    Fensbo, C.4    Sihm, F.5
  • 26
    • 0017293515 scopus 로고
    • A double-blind comparison of loxapine succinate and trifluoperazine in newly admitted schizophrenic patients
    • Simpson GM, Cuculic Z. A double-blind comparison of loxapine succinate and trifluoperazine in newly admitted schizophrenic patients. J Clin Pharmacol. 1976;16:60-5.
    • (1976) J Clin Pharmacol , vol.16 , pp. 60-65
    • Simpson, G.M.1    Cuculic, Z.2
  • 27
    • 84889000300 scopus 로고    scopus 로고
    • Alternative delivery systems for agents to treat acute agitation: progress to date
    • Nordstrom K, Allen MH. Alternative delivery systems for agents to treat acute agitation: progress to date. Drugs. 2013;73(16):1783-92.
    • (2013) Drugs , vol.73 , Issue.16 , pp. 1783-1792
    • Nordstrom, K.1    Allen, M.H.2
  • 28
    • 33947264305 scopus 로고    scopus 로고
    • Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients
    • Schneeweiss S, Setoguchi S, Brookhart A, Dormuth C, Wang PS. Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ. 2007;176(5):627-32.
    • (2007) CMAJ , vol.176 , Issue.5 , pp. 627-632
    • Schneeweiss, S.1    Setoguchi, S.2    Brookhart, A.3    Dormuth, C.4    Wang, P.S.5
  • 29
    • 84855345321 scopus 로고    scopus 로고
    • The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium
    • Comai S, Tau M, Pavlovic Z, Gobbi G. The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium. J Clin Psychopharmacol. 2012;32(2):237-60.
    • (2012) J Clin Psychopharmacol , vol.32 , Issue.2 , pp. 237-260
    • Comai, S.1    Tau, M.2    Pavlovic, Z.3    Gobbi, G.4
  • 30
    • 67650353988 scopus 로고    scopus 로고
    • Use and safety of antipsychotic drugs during pregnancy
    • Einarson A, Boskovic R. Use and safety of antipsychotic drugs during pregnancy. J Psychiatr Pract. 2009;15(3):183-92.
    • (2009) J Psychiatr Pract , vol.15 , Issue.3 , pp. 183-192
    • Einarson, A.1    Boskovic, R.2
  • 31
    • 3342900250 scopus 로고    scopus 로고
    • Bipolar disorder
    • Belmaker RH. Bipolar disorder. N Engl J Med. 2004;351(5):476-86.
    • (2004) N Engl J Med , vol.351 , Issue.5 , pp. 476-486
    • Belmaker, R.H.1
  • 32
    • 0034157483 scopus 로고    scopus 로고
    • Pharmacologic loading in the treatment of acute mania
    • Keck PE, McElroy SL, Bennett JA. Pharmacologic loading in the treatment of acute mania. Bipolar Disord. 2000;2:42-6.
    • (2000) Bipolar Disord , vol.2 , pp. 42-46
    • Keck, P.E.1    McElroy, S.L.2    Bennett, J.A.3
  • 33
    • 84881546755 scopus 로고    scopus 로고
    • Faster onset of antimanic action with haloperidol compared to second-generation antipsychotics: a meta-analysis of randomized clinical trials in acute mania
    • Goikolea JM, Colom F, Capapey J, Torres I, Valenti M, Grande I. Faster onset of antimanic action with haloperidol compared to second-generation antipsychotics: a meta-analysis of randomized clinical trials in acute mania. Eur Neuropsychopharmacol. 2013;23(4):305-16.
    • (2013) Eur Neuropsychopharmacol , vol.23 , Issue.4 , pp. 305-316
    • Goikolea, J.M.1    Colom, F.2    Capapey, J.3    Torres, I.4    Valenti, M.5    Grande, I.6
  • 34
    • 84870549409 scopus 로고    scopus 로고
    • Lower rate of depressive switch following antimanic treatment with second-generation antipsychotics versus haloperidol
    • Goikolea JM, Colom F, Torres I, Capapey J, Valentí M, Undurraga J, et al. Lower rate of depressive switch following antimanic treatment with second-generation antipsychotics versus haloperidol. J Affect Disord. 2013;144(3):191-8.
    • (2013) J Affect Disord , vol.144 , Issue.3 , pp. 191-198
    • Goikolea, J.M.1    Colom, F.2    Torres, I.3    Capapey, J.4    Valentí, M.5    Undurraga, J.6
  • 35
    • 66649123127 scopus 로고    scopus 로고
    • Antipsychotic agents in the treatment of bipolar mania
    • Tohen M, Vieta E. Antipsychotic agents in the treatment of bipolar mania. Bipolar Disord. 2009;11 Suppl 2:45-54.
    • (2009) Bipolar Disord , vol.11 , pp. 45-54
    • Tohen, M.1    Vieta, E.2
  • 36
    • 0014034485 scopus 로고
    • Importance of psychiatric diagnosis in prediction of clinical drug effects
    • Klein DF. Importance of psychiatric diagnosis in prediction of clinical drug effects. Arch Gen Psychiatry. 1967;16:118-26.
    • (1967) Arch Gen Psychiatry , vol.16 , pp. 118-126
    • Klein, D.F.1
  • 37
    • 21044447164 scopus 로고    scopus 로고
    • Quetiapine or haloperidol as monotherapy for bipolar mania-a 12-week, double-blind, randomised, parallel-group, placebo-controlled trial
    • McIntyre RS, Brecher M, Paulsson B, Huizar K, Mullen J. Quetiapine or haloperidol as monotherapy for bipolar mania-a 12-week, double-blind, randomised, parallel-group, placebo-controlled trial. Eur Neuropsychopharmacol. 2005;15:573-85.
    • (2005) Eur Neuropsychopharmacol , vol.15 , pp. 573-585
    • McIntyre, R.S.1    Brecher, M.2    Paulsson, B.3    Huizar, K.4    Mullen, J.5
  • 38
    • 9644291757 scopus 로고    scopus 로고
    • Acute and continuation risperidone monotherapy in bipolar mania: a 3-week placebo-controlled trial followed by a 9-week double-blind trial of risperidone and haloperidol
    • Smulevich AB, Khanna S, Eerdekens M, Karcher K, Kramer M, Grossman F. Acute and continuation risperidone monotherapy in bipolar mania: a 3-week placebo-controlled trial followed by a 9-week double-blind trial of risperidone and haloperidol. Eur Neuropsychopharmacol. 2005;15:75-84.
    • (2005) Eur Neuropsychopharmacol , vol.15 , pp. 75-84
    • Smulevich, A.B.1    Khanna, S.2    Eerdekens, M.3    Karcher, K.4    Kramer, M.5    Grossman, F.6
  • 39
    • 77950396957 scopus 로고    scopus 로고
    • Ziprasidone in the treatment of acute mania: a 12-week, placebo-controlled, haloperidol-referenced study
    • Vieta E, Ramey T, Keller D, English PA, Loebel AD, Miceli J. Ziprasidone in the treatment of acute mania: a 12-week, placebo-controlled, haloperidol-referenced study. J Psychopharmacol. 2010;24:547-58.
    • (2010) J Psychopharmacol , vol.24 , pp. 547-558
    • Vieta, E.1    Ramey, T.2    Keller, D.3    English, P.A.4    Loebel, A.D.5    Miceli, J.6
  • 40
    • 58149398256 scopus 로고    scopus 로고
    • Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study
    • Young AH, Oren DA, Lowy A, McQuade RD, Marcus RN, Carson WH, et al. Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study. Br J Psychiatry. 2009;194:40-8.
    • (2009) Br J Psychiatry , vol.194 , pp. 40-48
    • Young, A.H.1    Oren, D.A.2    Lowy, A.3    McQuade, R.D.4    Marcus, R.N.5    Carson, W.H.6
  • 42
    • 84856884690 scopus 로고    scopus 로고
    • Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine
    • Kwentus J, Riesenberg RA, Marandi M, Manning RA, Allen MH, Fishman RS, et al. Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine. Bipolar Disord. 2012;14:31-40.
    • (2012) Bipolar Disord , vol.14 , pp. 31-40
    • Kwentus, J.1    Riesenberg, R.A.2    Marandi, M.3    Manning, R.A.4    Allen, M.H.5    Fishman, R.S.6
  • 43
    • 13644262989 scopus 로고    scopus 로고
    • Treatment of acute mania-from clinical trials to recommendations for clinical practice
    • Bourin M, Lambert O, Guitton B. Treatment of acute mania-from clinical trials to recommendations for clinical practice. Hum Psychopharmacol. 2005;20(1):15-26.
    • (2005) Hum Psychopharmacol , vol.20 , Issue.1 , pp. 15-26
    • Bourin, M.1    Lambert, O.2    Guitton, B.3
  • 44
    • 0023698607 scopus 로고
    • Higher frequency of neuroleptic-induced dystonia in mania than in schizophrenia
    • Nasrallah HA, Churchill CM, Hamdan-Allan GA. Higher frequency of neuroleptic-induced dystonia in mania than in schizophrenia. Am J Psychiatry. 1993;145:1455-6.
    • (1993) Am J Psychiatry , vol.145 , pp. 1455-1456
    • Nasrallah, H.A.1    Churchill, C.M.2    Hamdan-Allan, G.A.3
  • 45
    • 0032962302 scopus 로고    scopus 로고
    • Tardive dyskinesia in affective disorders
    • Kane JM. Tardive dyskinesia in affective disorders. J Clin Psychiatry. 1999;60 Suppl 5:43-7.
    • (1999) J Clin Psychiatry , vol.60 , pp. 43-47
    • Kane, J.M.1
  • 46
    • 0017746969 scopus 로고
    • Loxapine versus haloperidol parenterally in acute psychosis with agitation: a double-blind study
    • Fruensgaard K, Korsgaard S, Jorgensen H, Jensen K. Loxapine versus haloperidol parenterally in acute psychosis with agitation: a double-blind study. Acta Psychiatr Scand. 1977;56:256-64.
    • (1977) Acta Psychiatr Scand , vol.56 , pp. 256-264
    • Fruensgaard, K.1    Korsgaard, S.2    Jorgensen, H.3    Jensen, K.4
  • 47
    • 0016715295 scopus 로고
    • A double-blind comparison of loxitane loxapine succinate and trifluoperazine hydrochloride in chronic schizophrenic patients
    • Moyano CZ. A double-blind comparison of loxitane loxapine succinate and trifluoperazine hydrochloride in chronic schizophrenic patients. Dis Nerv Syst. 1975;36:301-4.
    • (1975) Dis Nerv Syst , vol.36 , pp. 301-304
    • Moyano, C.Z.1
  • 48
    • 0017335738 scopus 로고
    • A double-blind comparison between loxapine and haloperidol by parenteral route in acute schizophrenia
    • Paprocki J, Versiani M. A double-blind comparison between loxapine and haloperidol by parenteral route in acute schizophrenia. Curr Ther Res Clin Exp. 1977;21:80-100.
    • (1977) Curr Ther Res Clin Exp , vol.21 , pp. 80-100
    • Paprocki, J.1    Versiani, M.2
  • 49
    • 0017123806 scopus 로고
    • Loxapine succinate: a double-blind comparison with haloperidol and placebo in acute schizophrenics
    • Selman FB, McClure RF, Helwig H. Loxapine succinate: a double-blind comparison with haloperidol and placebo in acute schizophrenics. Curr Ther Res Clin Exp. 1976;19:645-52.
    • (1976) Curr Ther Res Clin Exp , vol.19 , pp. 645-652
    • Selman, F.B.1    McClure, R.F.2    Helwig, H.3
  • 50
    • 0022640794 scopus 로고
    • A comparison of parenteral loxapine and haloperidol in hostile and aggressive acutely schizophrenic patients
    • Tuason VB. A comparison of parenteral loxapine and haloperidol in hostile and aggressive acutely schizophrenic patients. J Clin Psychiatry. 1986;47:126-9.
    • (1986) J Clin Psychiatry , vol.47 , pp. 126-129
    • Tuason, V.B.1
  • 51
    • 0021219334 scopus 로고
    • Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms
    • Anderson LT, Campbell M, Grega DM, Perry R, Small AM, Green WH. Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms. Am J Psychiatry. 1984;141(10):1195-202.
    • (1984) Am J Psychiatry , vol.141 , Issue.10 , pp. 1195-1202
    • Anderson, L.T.1    Campbell, M.2    Grega, D.M.3    Perry, R.4    Small, A.M.5    Green, W.H.6
  • 52
    • 0024402021 scopus 로고
    • The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children
    • Anderson LT, Campbell M, Adams P, Small AM, Perry R, Shell J. The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children. J Autism Dev Disord. 1989;19(2):227-39.
    • (1989) J Autism Dev Disord , vol.19 , Issue.2 , pp. 227-239
    • Anderson, L.T.1    Campbell, M.2    Adams, P.3    Small, A.M.4    Perry, R.5    Shell, J.6
  • 55
    • 33750932192 scopus 로고    scopus 로고
    • Loxapine treatment in an autistic child with aggressive behavior: therapeutic challenges
    • Reinblatt SP, Abanilla PK, Jummani R, Coffey B. Loxapine treatment in an autistic child with aggressive behavior: therapeutic challenges. J Child Adolesc Psychopharmacol. 2006;16(5):639-43.
    • (2006) J Child Adolesc Psychopharmacol , vol.16 , Issue.5 , pp. 639-643
    • Reinblatt, S.P.1    Abanilla, P.K.2    Jummani, R.3    Coffey, B.4
  • 56
    • 0043284302 scopus 로고    scopus 로고
    • Amoxapine treatment of interfering behaviors in autistic disorder
    • Craven-Thuss B, Nicolson R. Amoxapine treatment of interfering behaviors in autistic disorder. J Am Acad Child Adolesc Psychiatry. 2003;42(5):515-6.
    • (2003) J Am Acad Child Adolesc Psychiatry , vol.42 , Issue.5 , pp. 515-516
    • Craven-Thuss, B.1    Nicolson, R.2
  • 57
    • 78651474093 scopus 로고    scopus 로고
    • Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine
    • Lesem MD, Tran-Johnson TK, Riesenberg RA, Feifel D, Allen MH, Fishman R, et al. Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine. Br J Psychiatry. 2011;198(1):51-8.
    • (2011) Br J Psychiatry , vol.198 , Issue.1 , pp. 51-58
    • Lesem, M.D.1    Tran-Johnson, T.K.2    Riesenberg, R.A.3    Feifel, D.4    Allen, M.H.5    Fishman, R.6
  • 58
    • 79958061760 scopus 로고    scopus 로고
    • Efficacy and safety of loxapine for inhalation in the treatment of acute agitation in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial
    • Allen MH, Feifel DA, Lesem MD, Zimbroff DL, Ross R, Spyker DA, et al. Efficacy and safety of loxapine for inhalation in the treatment of acute agitation in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2011;72(10):1313-21.
    • (2011) J Clin Psychiatry , vol.72 , Issue.10 , pp. 1313-1321
    • Allen, M.H.1    Feifel, D.A.2    Lesem, M.D.3    Zimbroff, D.L.4    Ross, R.5    Spyker, D.A.6
  • 59
    • 79951656747 scopus 로고    scopus 로고
    • Aerosolised antipsychotic assuages agitation: inhaled loxapine for agitation associated with schizophrenia or bipolar disorder
    • Citrome L. Aerosolised antipsychotic assuages agitation: inhaled loxapine for agitation associated with schizophrenia or bipolar disorder. Int J Clin Pract. 2011;65(3):330-40.
    • (2011) Int J Clin Pract , vol.65 , Issue.3 , pp. 330-340
    • Citrome, L.1
  • 60
    • 84899799666 scopus 로고    scopus 로고
    • Loxapine delivered as a thermally generated aerosol does not prolong QTc in a thorough QT/QTc study in healthy subjects
    • Spyker DA, Voloshko P, Heyman ER, Cassella JV. Loxapine delivered as a thermally generated aerosol does not prolong QTc in a thorough QT/QTc study in healthy subjects. J Clin Pharmacol. 2014;54(6):665-74.
    • (2014) J Clin Pharmacol , vol.54 , Issue.6 , pp. 665-674
    • Spyker, D.A.1    Voloshko, P.2    Heyman, E.R.3    Cassella, J.V.4
  • 62
    • 84898542844 scopus 로고    scopus 로고
    • The bipolar maze: a roadmap through translational psychopathology
    • Vieta E. The bipolar maze: a roadmap through translational psychopathology. Acta Psychiatr Scand. 2014;129(5):323-7.
    • (2014) Acta Psychiatr Scand , vol.129 , Issue.5 , pp. 323-327
    • Vieta, E.1
  • 64
    • 0028869668 scopus 로고
    • Reduction of suicidality during clozapine treatment of neuroleptic-resistant schizophrenia: impact on risk-benefit assessment
    • Meltzer HY, Okayli G. Reduction of suicidality during clozapine treatment of neuroleptic-resistant schizophrenia: impact on risk-benefit assessment. Am J Psychiatry. 1995;152:183-90.
    • (1995) Am J Psychiatry , vol.152 , pp. 183-190
    • Meltzer, H.Y.1    Okayli, G.2
  • 65
    • 0033288769 scopus 로고    scopus 로고
    • Active monitoring of 12,760 clozapine recipients in the UK and Ireland: beyond pharmacovigilance
    • Munro J, O'sullivan D, Andrews C, Arana A, Mortimer A, Kerwin R. Active monitoring of 12,760 clozapine recipients in the UK and Ireland: beyond pharmacovigilance. Br J Psychiatry. 1999;175:576-80.
    • (1999) Br J Psychiatry , vol.175 , pp. 576-580
    • Munro, J.1    O'sullivan, D.2    Andrews, C.3    Arana, A.4    Mortimer, A.5    Kerwin, R.6
  • 66
    • 0031904437 scopus 로고    scopus 로고
    • Suicide prevention effects associated with clozapine therapy in schizophrenia and schizoaffective disorder
    • Reid WH, Mason M, Hogan T. Suicide prevention effects associated with clozapine therapy in schizophrenia and schizoaffective disorder. Psychiatr Serv. 1998;40:1029-33.
    • (1998) Psychiatr Serv , vol.40 , pp. 1029-1033
    • Reid, W.H.1    Mason, M.2    Hogan, T.3
  • 68
    • 0037227192 scopus 로고    scopus 로고
    • Clozapine treatment for suicidality in schizophrenia: international suicide prevention trial (InterSePT)
    • Meltzer HY, Alphs L, Green A, Altamura AC, Anand R, Bertoldi A, et al. Clozapine treatment for suicidality in schizophrenia: international suicide prevention trial (InterSePT). Arch Gen Psychiatry. 2003;60:82-91.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 82-91
    • Meltzer, H.Y.1    Alphs, L.2    Green, A.3    Altamura, A.C.4    Anand, R.5    Bertoldi, A.6
  • 69
    • 0018836609 scopus 로고
    • A double-blind controlled trial of loxapine and trifluoperazine in adolescent schizophrenia
    • Bagadia VN, Shah LP, Abhyankar RR. A double-blind controlled trial of loxapine and trifluoperazine in adolescent schizophrenia. Curr Ther Res Clin Exp. 1980;27(6):886-96.
    • (1980) Curr Ther Res Clin Exp , vol.27 , Issue.6 , pp. 886-896
    • Bagadia, V.N.1    Shah, L.P.2    Abhyankar, R.R.3
  • 70
    • 0014854594 scopus 로고
    • Loxapine: a controlled evaluation in chronic schizophrenic patients
    • Bishop MP, Gallant DM. Loxapine: a controlled evaluation in chronic schizophrenic patients. Curr Ther Res Clin Exp. 1970;12(9):594-7.
    • (1970) Curr Ther Res Clin Exp , vol.12 , Issue.9 , pp. 594-597
    • Bishop, M.P.1    Gallant, D.M.2
  • 71
    • 0016209526 scopus 로고
    • Loxapine succinate: a controlled double blind study in schizophrenia
    • Charalampous KD, Freemesser GF, Malev J, Ford K. Loxapine succinate: a controlled double blind study in schizophrenia. Curr Ther Res. 1974;6(8):829-37.
    • (1974) Curr Ther Res , vol.6 , Issue.8 , pp. 829-837
    • Charalampous, K.D.1    Freemesser, G.F.2    Malev, J.3    Ford, K.4
  • 74
    • 0017335728 scopus 로고
    • Evaluation of two dose levels of loxapine succinate in chronic schizophrenia
    • Clark ML, Paredes A, Costiloe JP, Fulkerson FG, Wood F. Evaluation of two dose levels of loxapine succinate in chronic schizophrenia. Dis Nerv Syst. 1977;38(1):7-10.
    • (1977) Dis Nerv Syst , vol.38 , Issue.1 , pp. 7-10
    • Clark, M.L.1    Paredes, A.2    Costiloe, J.P.3    Fulkerson, F.G.4    Wood, F.5
  • 75
    • 84926648038 scopus 로고    scopus 로고
    • Control studies on curative effects of loxapine succinate and risperidone in schizophrenics
    • Du B-G, Fang R-L. Control studies on curative effects of loxapine succinate and risperidone in schizophrenics. J Clin Psychosomatic Dis. 2003;9(1):16-9.
    • (2003) J Clin Psychosomatic Dis , vol.9 , Issue.1 , pp. 16-19
    • Du, B.-G.1    Fang, R.-L.2
  • 76
    • 0017147941 scopus 로고
    • Loxapine succinate: a comparative study with chlorpromazine
    • Dube KC, Kumar N. Loxapine succinate: a comparative study with chlorpromazine. Curr Ther Res Clin Exp. 1976;19(6):653-60.
    • (1976) Curr Ther Res Clin Exp , vol.19 , Issue.6 , pp. 653-660
    • Dube, K.C.1    Kumar, N.2
  • 77
    • 0022532439 scopus 로고
    • Rapid tranquilization: a comparison of thiothixene with loxapine
    • Dubin WR, Weiss KJ. Rapid tranquilization: a comparison of thiothixene with loxapine. J Clin Psychiatry. 1986;47(6):294-7.
    • (1986) J Clin Psychiatry , vol.47 , Issue.6 , pp. 294-297
    • Dubin, W.R.1    Weiss, K.J.2
  • 78
    • 84926639204 scopus 로고
    • Oxilapine versus trifluoperazine
    • Gallant B. Oxilapine versus trifluoperazine. Psychopharmacol Bull. 1971;7(1):40-3.
    • (1971) Psychopharmacol Bull , vol.7 , Issue.1 , pp. 40-43
    • Gallant, B.1
  • 79
    • 84926653365 scopus 로고    scopus 로고
    • Study on the efficacy of loxapine in treatment of schizophrenia in comparison with chlorpromazine
    • Huang S, Qin Y, Wang L. Study on the efficacy of loxapine in treatment of schizophrenia in comparison with chlorpromazine. Chinese New Drugs J. 1997;6(3):161-4.
    • (1997) Chinese New Drugs J , vol.6 , Issue.3 , pp. 161-164
    • Huang, S.1    Qin, Y.2    Wang, L.3
  • 80
    • 0017109147 scopus 로고
    • A double-blind comparative trial of loxapine and trifluoperazine in acute and chronic schizophrenic patients
    • Kiloh LG, Williams SE, Grant DA, Whetton PS. A double-blind comparative trial of loxapine and trifluoperazine in acute and chronic schizophrenic patients. J Int Med Res. 1976;4(6):441-8.
    • (1976) J Int Med Res , vol.4 , Issue.6 , pp. 441-448
    • Kiloh, L.G.1    Williams, S.E.2    Grant, D.A.3    Whetton, P.S.4
  • 81
    • 0018179479 scopus 로고
    • Relative efficacy and safety of loxapine succinate (Loxitane) and thioridazine hydrochloride (Mellaril) in the treatment of acute schizophrenia
    • Kramer MR, Thomas SPJ, Zorick FJ, Blackwell B. Relative efficacy and safety of loxapine succinate (Loxitane) and thioridazine hydrochloride (Mellaril) in the treatment of acute schizophrenia. Curr Ther Res. 1978;23(5):619-31.
    • (1978) Curr Ther Res , vol.23 , Issue.5 , pp. 619-631
    • Kramer, M.R.1    Thomas, S.P.J.2    Zorick, F.J.3    Blackwell, B.4
  • 82
    • 84926611895 scopus 로고    scopus 로고
    • Control study of loxapine succinate and clozapine on curative effects in treatment of schizophrenics
    • Li Y, Shang J, Li C. Control study of loxapine succinate and clozapine on curative effects in treatment of schizophrenics. Heath Psychol J. 2004;12(3):202.
    • (2004) Heath Psychol J , vol.12 , Issue.3 , pp. 202
    • Li, Y.1    Shang, J.2    Li, C.3
  • 83
    • 84926612195 scopus 로고    scopus 로고
    • A comparative study of loxapine succinate and risperidone in the treatment of schizophrenia
    • Li L-X, Li C-Y. A comparative study of loxapine succinate and risperidone in the treatment of schizophrenia. Shandong Arch Psychiatry. 2005;18(4):246-7.
    • (2005) Shandong Arch Psychiatry , vol.18 , Issue.4 , pp. 246-247
    • Li, L.-X.1    Li, C.-Y.2
  • 84
    • 84926611092 scopus 로고    scopus 로고
    • Comparative study between loxapine and risperedone in treatment of schizophrenia
    • Z-y L, Rui-fang HE. Comparative study between loxapine and risperedone in treatment of schizophrenia. J Clin Psychol Med. 2005;15(1):11-2.
    • (2005) J Clin Psychol Med , vol.15 , Issue.1 , pp. 11-12
    • Z-y, L.1    Rui-fang, H.E.2
  • 85
    • 44949151728 scopus 로고    scopus 로고
    • Control study of loxapine and chlorpromazine in the treatment of schizophrenia
    • Liu. Control study of loxapine and chlorpromazine in the treatment of schizophrenia. Med J ChinesePeople's Health. 2005;17(9):503-4.
    • (2005) Med J ChinesePeople's Health , vol.17 , Issue.9 , pp. 503-504
  • 86
    • 70249122835 scopus 로고    scopus 로고
    • Control studies of loxapine succinate and clozapine in treatment of schizophrenia
    • Lu X-Q, Zhu G-L. Control studies of loxapine succinate and clozapine in treatment of schizophrenia. J Clin Psychosom Dis. 2003;9(3):157-8.
    • (2003) J Clin Psychosom Dis , vol.9 , Issue.3 , pp. 157-158
    • Lu, X.-Q.1    Zhu, G.-L.2
  • 87
    • 0018829805 scopus 로고
    • Loxapine in adolescent schizophrenia-a comparative study with trifluoperazine
    • Malik SC, Kumar K. Loxapine in adolescent schizophrenia-a comparative study with trifluoperazine. Curr Ther Res Clin Exp. 1980;28(3):432-46.
    • (1980) Curr Ther Res Clin Exp , vol.28 , Issue.3 , pp. 432-446
    • Malik, S.C.1    Kumar, K.2
  • 88
    • 0005399834 scopus 로고
    • Treatment of acute schizophrenia with loxapine succinate (Loxitane) in a controlled study with chlorpromazine
    • Moore DF. Treatment of acute schizophrenia with loxapine succinate (Loxitane) in a controlled study with chlorpromazine. Curr Ther Res. 1975;18(1):172-80.
    • (1975) Curr Ther Res , vol.18 , Issue.1 , pp. 172-180
    • Moore, D.F.1
  • 89
    • 0017235160 scopus 로고
    • A controlled evaluation of loxitane in seventy-five adolescent schizophrenic patients
    • Pool D, Bloom W, Mielke DH, Roniger Jr JJ, Gallant DM. A controlled evaluation of loxitane in seventy-five adolescent schizophrenic patients. Curr Ther Res. 1976;19(1):99-104.
    • (1976) Curr Ther Res , vol.19 , Issue.1 , pp. 99-104
    • Pool, D.1    Bloom, W.2    Mielke, D.H.3    Roniger, J.J.4    Gallant, D.M.5
  • 90
    • 0021219899 scopus 로고
    • Isloxapine more effective than chlorpromazine in paranoid schizophrenia?
    • Rifkin A, Rieder E, Sarantakos S, Saraf K, Kane J. Isloxapine more effective than chlorpromazine in paranoid schizophrenia? Am J Psychiatr. 1984;141(11):1411-3.
    • (1984) Am J Psychiatr , vol.141 , Issue.11 , pp. 1411-1413
    • Rifkin, A.1    Rieder, E.2    Sarantakos, S.3    Saraf, K.4    Kane, J.5
  • 91
    • 0018417810 scopus 로고
    • A double-blind comparative trial of loxapine and trifluperazine in chronic schizophrenic patients
    • Seth S, Mahal AS, Kumar KA. A double-blind comparative trial of loxapine and trifluperazine in chronic schizophrenic patients. Curr Ther Res. 1979;25(2):320-9.
    • (1979) Curr Ther Res , vol.25 , Issue.2 , pp. 320-329
    • Seth, S.1    Mahal, A.S.2    Kumar, K.A.3
  • 92
    • 0015424387 scopus 로고
    • A controlled double-blind comparison between loxapine succinate and chlorpromazine in acute newly hospitalized schizophrenic patients
    • Shopsin B, Pearson E, Gershon S, Collins P. A controlled double-blind comparison between loxapine succinate and chlorpromazine in acute newly hospitalized schizophrenic patients. Curr Ther Res Clin Exp. 1972;14(11):739-48.
    • (1972) Curr Ther Res Clin Exp , vol.14 , Issue.11 , pp. 739-748
    • Shopsin, B.1    Pearson, E.2    Gershon, S.3    Collins, P.4
  • 94
    • 84926627768 scopus 로고    scopus 로고
    • Controlled study of loxapineand chlorpromazine in the treatment of schizophrenia
    • Tu Z-M, Gao S-R, Ye S-N. Controlled study of loxapineand chlorpromazine in the treatment of schizophrenia. Med J Chinese People's Health. 2004;16(7):415-7.
    • (2004) Med J Chinese People's Health , vol.16 , Issue.7 , pp. 415-417
    • Tu, Z.-M.1    Gao, S.-R.2    Ye, S.-N.3
  • 95
    • 0021319522 scopus 로고
    • Loxapine versus chlorpromazine in paranoid schizophrenia: a double-blind study
    • Tuason VB, Escobar JI, Garvey M, Schiele B. Loxapine versus chlorpromazine in paranoid schizophrenia: a double-blind study. J Clin Psychiatry. 1984;45(4):158-63.
    • (1984) J Clin Psychiatry , vol.45 , Issue.4 , pp. 158-163
    • Tuason, V.B.1    Escobar, J.I.2    Garvey, M.3    Schiele, B.4
  • 96
    • 0016434581 scopus 로고
    • Effectiveness of loxapine succinate in acute schizophrenia: a comparative study with thiothixene
    • Van Der Velde CD, Kiltie H. Effectiveness of loxapine succinate in acute schizophrenia: a comparative study with thiothixene. Curr Ther Res. 1975;17(1):1-12.
    • (1975) Curr Ther Res , vol.17 , Issue.1 , pp. 1-12
    • Van Der Velde, C.D.1    Kiltie, H.2
  • 97
    • 0018900770 scopus 로고
    • A six-month double-blind comparison of loxapine succinate and chlorpromazine in chronic schizophrenic patients
    • Vyas BK, Kalla V. A six-month double-blind comparison of loxapine succinate and chlorpromazine in chronic schizophrenic patients. Curr Ther Res Clin Exp. 1980;28(1):16-30.
    • (1980) Curr Ther Res Clin Exp , vol.28 , Issue.1 , pp. 16-30
    • Vyas, B.K.1    Kalla, V.2
  • 98
    • 84926665491 scopus 로고    scopus 로고
    • Using loxapine succinate and chlorpromazine for treating schizophrenia
    • Wang L, Wang Z, Wang Y. Using loxapine succinate and chlorpromazine for treating schizophrenia. Tianjing Med J. 1996;24(11):672-5.
    • (1996) Tianjing Med J , vol.24 , Issue.11 , pp. 672-675
    • Wang, L.1    Wang, Z.2    Wang, Y.3
  • 99
    • 84926643953 scopus 로고    scopus 로고
    • Control study of loxapine and quetiapine treating first onset schizophrenia
    • Wang. Control study of loxapine and quetiapine treating first onset schizophrenia. Chinese J Behav Med Sci. 2005;14(8):752.
    • (2005) Chinese J Behav Med Sci , vol.14 , Issue.8 , pp. 752
  • 100
    • 84926680154 scopus 로고    scopus 로고
    • A comparative study of loxapine and risperidone in the treatment of schizophrenic patients
    • Wang H-Y, Wang G-P, Pei G-X. A comparative study of loxapine and risperidone in the treatment of schizophrenic patients. Shandong Arch Psychiatry. 2005;18(1):28-9.
    • (2005) Shandong Arch Psychiatry , vol.18 , Issue.1 , pp. 28-29
    • Wang, H.-Y.1    Wang, G.-P.2    Pei, G.-X.3
  • 101
    • 84926685351 scopus 로고    scopus 로고
    • A comparison study on loxapine and chlorpromazine in the treatment of schizophrenia
    • Xue S-J, Huang J-M, Yang M-Z. A comparison study on loxapine and chlorpromazine in the treatment of schizophrenia. Med J Chinese People's Health. 2004;16(10):593-4.
    • (2004) Med J Chinese People's Health , vol.16 , Issue.10 , pp. 593-594
    • Xue, S.-J.1    Huang, J.-M.2    Yang, M.-Z.3
  • 102
    • 44949138399 scopus 로고    scopus 로고
    • Control study of loxapine treatment in schizophrenia
    • Zhang. Control study of loxapine treatment in schizophrenia. Sichuan Mental Health. 2005;18(4):222-4.
    • (2005) Sichuan Mental Health , vol.18 , Issue.4 , pp. 222-224


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