Faster onset of antimanic action with haloperidol compared to second-generation antipsychotics. A meta-analysis of randomized clinical trials in acute mania

European Neuropsychopharmacology

Volumn 23, Issue 4, 2013, Pages 305-316

  Goikolea, J M ^a   Colom, F ^a   Capapey, J ^a   Torres, I ^a   Valenti, M ^a   Grande, I ^a   Undurraga, J ^a   Vieta, E ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Antipsychotics; Mania; Meta analysis; Treatment outcome

Indexed keywords

ARIPIPRAZOLE; HALOPERIDOL; LITHIUM; OLANZAPINE; QUETIAPINE; RISPERIDONE; VALPROIC ACID; ZIPRASIDONE;

ARTICLE; DRUG EFFICACY; HUMAN; MANIA; MENTAL PATIENT; META ANALYSIS; MIXED MANIA AND DEPRESSION; MONOTHERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); TRANQUILIZING ACTIVITY; TREATMENT OUTCOME;

EID: 84881546755     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2012.05.017     Document Type: Article

References (41)

1. American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders fourth ed. American Psychiatric Association, Washington, D.C..
2. Belmaker, R.H., 2004. Bipolar disorder. N. Engl. J. Med. 351, 476-486.
3. Cavazzoni, P.A., Berg, P.H., Kryzhanovskaya, L.A., Briggs, S.D., Roddy, T.E., Tohen, M., Kane, J.M., 2006. Comparison of treatment-emergent extrapyramidal symptoms in patients with bipolar mania or schizophrenia during olanzapine clinical trials. J. Clin. Psychiatry 67, 107-113.
4. Cipriani, A., Rendell, J.M., Geddes, J.R, 2006. Haloperidol alone or in combination for acute mania. Cochrane Database Syst. Rev. 19 (3), CD004362.
5. Cipriani, A., Barbui, C., Salanti, G., Rendell, J., Brown, R., Stockton, S., Purgato, M., Spineli, L.M., Goodwin, G.M., Geddes, J.R., 2011. Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet 378, 1306-1315.
6. Clarke, M., Oxman, A.D., 2000. Cochrane collaboration handbook version 4.0 (updated July 2000). The Cochrane Library, Oxford.
7. Der-Simonian, R., Laird, N., 1986. Meta-analysis in clinical trials. Control Clin. Trials 7, 177-188.
8. Goikolea, J.M., Colom, F., Torres, I., Capapey, J., Valentí, M., Undurraga, J., Grande, I., Sanchez-Moreno, J, Vieta, E. Lower rate of depressive switch following antimanic treatment with second generation antipsychotics versus haloperidol. J. Affect. Disord., in press.
9. Goodwin, F.K., Jamison, K.R., 2007. Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression second edition Oxford University Press, New York, pp. 32-64.
10. Grunze, H., Vieta, E., Goodwin, G.M., Bowden, C., Licht, R.W., Moller, H.J., Kasper, S., 2009. The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2009 on the treatment of acute mania. World J. Biol. Psychiatry 10, 85-116.
11. Higgins, J.P., Thompson, S.G., 2002. Quantifying heterogeneity in a meta-analysis. Stat. Med. 21, 1539-1558.
12. Higgins, J.P.T., Altman, D.G., Sterne, J.A.C., 2011. Chapter 8: assessing risk of bias in included studies. In: Higgins, J.P.T., Green, S. (Eds.), Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration Available from (updated March 2011).
13. Janicak, P.G., Newman, R.H., Davis, J.M, 1992. Advances in the treatment of mania and related disorders: a reappraisal. Psychiatr. Ann. 22, 92-103.
14. Keck Jr., P.E., McElroy, S.L., Bennett, J.A., 2000. Pharmacologic loading in the treatment of acute mania. Bipolar Disord. 2, 42-46.
15. Keck, P.E., Orsulak, P.J., Cutler, A.J., Sanchez, R., Torbeyns, A., Marcus, R.N., McQuade, R.D., Carson, W.H., CN138-135 Study Group, 2009. Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placebo- and lithium-controlled study. J. Affect. Disord. 112, 36-49.
16. Large, M.M., Nielssen, O., 2011. People with bipolar disorder and comorbid substance abuse are six times more likely to be convicted of violent crime than the general population. Evid. Based Ment. Health 14, 17.
17. Machado-Vieira, R., Salvadore, G., Luckenbaugh, D.A., Manji, H.K., Zarate Jr., C.A., 2008. Rapid onset of antidepressant action: a new paradigm in the research and treatment of major depressive disorder. J. Clin. Psychiatry 69, 946-958.
18. McIntyre, R., Brecher, M., Paulsson, B., Huizar, K., Mullen, J., 2005. Quetiapine or haloperidol as monotherapy for bipolar mania: a 12 weeks double blind, randomised, parallel group, placebo controlled trial. Eur. Neuropsychopharmacol. 15, 573-585.
19. Moher, D., Cook, D.J., Eastwood, S., Olkin, I., Rennie, D., Stroup, D.F., 1999. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of reporting of meta-analyses. Lancet 354, 1896-1900.
20. Nasrallah, H.A., Churchill, CM., Hamdan-Allan, G.A., 1988. Higher frequency of neuroleptic-induced dystonia in mania than in schizophrenia. Am. J. Psychiatry 145, 1455-1456.
21. Nivoli, A.M., Murru, A., Goikolea, J.M., Crespo, J.M., Montes, J.M., Gonzàlez-Pinto, A., García-Portilla, P., Bobes, J., Sàiz-Ruiz, J., Vieta, E.. New treatment guidelines for acute bipolar mania: a critical review. J. Affect. Disord., in press.
22. Olié, J.P., Lévy, E., 2002. Manic episodes: the direct cost of a three-month period following hospitalisation. Eur. Psychiatry 17, 278-286.
23. Popovic, D., Reinares, M., Goikolea, J.M., Bonnin, CM., Gonzalez-Pinto, A., Vieta, E., 2012. Polarity index of pharmacological agents used for maintenance treatment of bipolar disorder. Eur. Neuropsychopharmacol. 22, 339-346.
24. Review Manager, (RevMan) [Computer program], 2003. Version 4.2 for Windows. Oxford, Cochrane Collaboration.
25. Sachs, G., Grossman, F., Ghaemi, S.N., Okamoto, A., Bowden, C.L., 2002. Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety. Am. J. Psychatry 159, 1146-1154.
26. Scherk, H., Pajonk, F.G., Leucht, S., 2007. Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials. Arch. Gen. Psychiatry 64, 442-455.
27. Segal, J., Berk, M., Brook, S., 1998. Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial. Clin. Neuropharmacol. 21, 176-180.
28. Smulevich, A.B., Khanna, S., Eerdekens, M., Karcher, K., Kramer, M., Grossman, F, 2005. Acute and continuation risperidone monotherapy in bipolar mania: a 3 week placebo controlled trial followed by a 9 week double blind trial of risperidone and haloperidol. Eur. Neuropsychopharmacol. 15, 75-84.
29. Tohen, M., Zarate Jr., C.A., 1998. Antipsychotic agents and bipolar disorder. J. Clin. Psychiatry 59 (Suppl. 1), 38-48.
30. Tohen, M., Jacobs, T.G., Grundy, S.L., McElroy, S.L., Banov, M.C, Janicak, P.G., Sanger, T., Risser, R., Zhang, F, Toma, V, Francis, J., Tollefson, G.D., Breier, A., 2000. Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group. Arch. Gen. Psychiatry 57, 841-849.
31. Tohen, M., Goldberg, J., Gonzalez-Pinto Arrillaga, A., Azorin, J.M., Vieta, E., Hardy-Bayle, M.C, Lawson, W.B., Emsley, R.A., Zhang, F, Baker, R.W., Risser, R.C, Namjoshi, M.A., Evans, A.R., Breier, A., 2003. A 12-week, double-blind comparison of olanzapine vs. haloperidol in the treatment of acute mania. Arch. Gen. Psychiatry 60, 1218-1226.
32. Tohen, M., Vieta, E., 2009. Antipsychotic agents in the treatment of bipolar mania. Bipolar. Disord. 11 (Suppl. 2), 45-54.
33. Vieta, E., Bourin, M., Sanchez, R., Marcus, R., Stock, E., McQuade, R., Carson, W., Abou-Gharbia, N., Swanink, R., Iwamoto, T, Aripiprazole Study Group, 2005. Effectiveness of aripiprazole vs. haloperidol in acute bipolar mania: double blind, randomised, comparative 12 week trial. Br. J. Psychiatry 187, 235-242.
34. Vieta, E., Goikolea, J.M., 2005. Atypical antipsychotics: newer options for mania and maintenance therapy. Bipolar Disord. 7 (Suppl. 4), 21-33.
35. Vieta, E., Angst, J., Reed, C, Bertsch, J., Haro, J.M., EMBLEM advisory board, 2009. Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM). J Affect. Disord. 118, 118-123.
36. Vieta, E., Ramey, T., Keller, D., English, P.A., Loebel, A.D., Miceli, J., 2010. Ziprasidone in the treatment of acute mania: a 12-week, placebo-controlled, haloperidol-referenced study. J. Psy-chopharmacol. 24, 547-558.
37. Vieta, E., Cruz, N., 2011. Head to head comparisons as an alternative to placebo-controlled trials. Eur. Neuropsychophar-macol., 26 (Epub ahead of print).
38. Yatham, L.N., Kennedy, S.H., Schaffer, A., Parikh, S.V., Beaulieu, S., O'Donovan, C., MacQueen, G., McIntyre, R.S., Sharma, V., Ravin-dran, A., Young, L.T., Young, A.H., Alda, M., Milev, R., Vieta, E., Calabrese, J.R., Berk, M., Ha, K., Kapczinski, F., 2009. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009. Bipolar Disord. 11, 225-255.
39. Young, A, H, Oren, D.A., Lowy, A., McQuade, R.D., Marcus, R.N., Carson, W.H., Spiller, N.H., Torbeyns, A.F., Sanchez, R., 2009. Aripiprazole monotherapy in acute mania: 12-week randomised placebo-and haloperidol-controlled study. Br. J. Psychiatry 194, 40-48.
40. Yildiz, A., Vieta, E., Leucht, S., Baldessarini, R.J., 2011. Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials. Neuropsychopharmacology 36, 375-389.
41. Zarate Jr., C.A., Tohen, M., 2004. Double-blind comparison of the continued use of antipsychotic treatment versus its discontinuation in remitted manic patients. Am. J. Psychiatry 161, 169-171.