Activation of the unfolded protein response in aged human lenses

Molecular Medicine Reports

Volumn 12, Issue 1, 2015, Pages 389-393

  Tang, He Zhen ^a   Yang, Li Min ^a  

^a LIAOCHENG PEOPLE'S HOSPITAL   (China)

Author keywords

Age related cataract; Endoplasmic reticulum stress; Human lens epithelial cells; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; BINDING IMMUNOGLOBULIN PROTEIN; CALCIMYCIN; CASPASE 4; CCAAT ENHANCER BINDING PROTEIN; GLUTATHIONE REDUCTASE; INOSITOL REQUIRING ENZYME 1; MESSENGER RNA; PKR LIKE EUKARYOTIC INITIATION FACTOR 2A KINASE; PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ATF6 PROTEIN, HUMAN; CALCIUM IONOPHORE; EIF2AK3 PROTEIN, HUMAN; ERN1 PROTEIN, HUMAN; ERO1L PROTEIN, HUMAN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MEMBRANE PROTEIN; OXIDOREDUCTASE; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE;

APOPTOSIS; ARTICLE; CATARACT; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; LENS; PROTEIN EXPRESSION; PROTEIN FOLDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE; AGED; CELL LINE; CYTOLOGY; DRUG EFFECTS; ENDOPLASMIC RETICULUM STRESS; EPITHELIUM CELL; GENETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VERY ELDERLY;

EUKARYOTA;

ACTIVATING TRANSCRIPTION FACTOR 6; AGED; AGED, 80 AND OVER; APOPTOSIS; CALCIMYCIN; CALCIUM IONOPHORES; CELL LINE; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; EPITHELIAL CELLS; HUMANS; LENS, CRYSTALLINE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; OXIDOREDUCTASES; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

EID: 84926666459     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3417     Document Type: Article

References (32)

1. Kozutsumi Y, Segal M, Normington K, Gething MJ and Sambrook J: The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332: 462-464, 1988.
2. Brewer JW and Diehl JA: PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci USA 97: 12625-12630, 2000.
3. Prostko CR, Brostrom MA, Malara EM and Brostrom CO: Phosphorylation of eukaryotic initiation factor (eIF) 2 alpha and inhibition of eIF-2B in GH3 pituitary cells by perturbants of early protein processing that induce GRP78. J Biol Chem 267: 16751-16754, 1992
4. Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, et al: Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol 18: 7499-7509, 1998.
5. Tirasophon W, Welihinda AA and Kaufman RJ: A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev 12: 1812-1824, 1998.
6. Rao RV, Ellerby HM and Bredesen DE: Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11: 372-380, 2004.
7. Mandic A, Hansson J, Linder S and Shoshan MC: Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 278: 9100-9106, 2003.
8. Tinhofer I, Anether G, Senfter M, Pfaller K, Bernhard D, Hara M, et al: Stressful death of T-ALL tumor cells after treatment with the anti-tumor agent Tetrocarcin-A. FASEB J 16: 1295-1297, 2002.
9. Xie Q, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, et al: Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology 36: 592-601, 2002.
10. Kaufman RJ, Scheuner D, Schroder M, Shen X, Lee K, Liu CY, et al: The unfolded protein response in nutrient sensing and differentiation. Nat Rev Mol Cell Biol 3: 411-421, 2002.
11. Szegezdi E, Fitzgerald U and Samali A: Caspase-12 and ER stress-mediated apoptosis: the story so far. Ann N Y Acad Sci 1010: 186-194, 2003.
12. Ji C, Deng Q and Kaplowitz N: Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology 40: 442-451, 2004.
13. Haynes CM, Titus EA and Cooper AA: Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Mol Cell 15: 767-776, 2004.
14. McCullough KD, Martindale JL, Klotz LO, Aw TY and Holbrook NJ: Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259, 2001.
15. Tu BP, Ho-Schleyer SC, Travers KJ and Weissman JS: Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science 290: 1571-1574, 2000.
16. Ikesugi K, Yamamoto R, Mulhern ML and Shinohara T: Role of the unfolded protein response (UPR) in cataract formation. Exp Eye Res 83: 508-516, 2006.
17. Elanchezhian R, Palsamy P, Madson CJ, et al: Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells. Cell Death Dis 3: e301, 2012.
18. Elanchezhian R, Palsamy P, Madson CJ, Lynch DW and Shinohara T: Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection. Chem Biol Interact 200: 1-10, 2012.
19. Michael R and Bron AJ: The ageing lens and cataract: a model of normal and pathological ageing, Philos Trans R Soc Lond B Biol Sci 366: 1278-1292, 2011.
20. Harding JJ: Free and protein-bound glutathione in normal and cataractous human lense. Biochem J 117: 957-960, 1970.
21. Lou MF: Redox regulation in the lens. Prog Retin Eye Res 22: 657-682, 2003.
22. Ikesugi K, Mulhern ML, Madson CJ, et al: Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation. Curr Eye Res 31: 947-953, 2006.
23. Mulhern ML, Madson CJ, Danford A, Ikesugi K, Kador PF and Shinohara T: The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Invest Ophthalmol Vis Sci 47: 3951-3959, 2006.
24. Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108, 2008.
25. Shichi H: Cataract formation and prevention. Expert Opin Investig Drugs 13: 691-701, 2004.
26. Bloemendal H, de Jong W, Jaenicke R, Lubsen NH, Slingsby C and Tardieu A: Ageing and vision: structure, stability and function of lens crystallins. Prog Biophys Mol Biol 86: 407-485, 2004.
27. Huang L1, Tang D, Yappert MC, Borchman D: Oxidation-induced changes in human lens epithelial cells 2. Mitochondria and the generation of reactive oxygen species. Free Radic Biol Med 41: 926-936, 2006.
28. Ron D and Walter P: Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529, 2007.
29. Schröder M: The unfolded protein response. Mol. Biotechnol 34: 279-290, 2006.
30. Puustjärvi T, Blomster H, KontkanenvM, Punnonen K and Terasvirta M: Plasma and aqueous humour levels of homocysteine in exfoliation syndrome. Graefes Arch Clin Exp Ophthalmol 242: 749-754, 2004.
31. Arap MA, Lahdenranta J, Mintz PJ, Hajitou A, Sarkis AS, Arap W and Pasqualini R: Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell 6: 275-284, 2004.
32. Huang HC, Nguyen T and Pickett CB: Phosphorylation of Nrf2 t Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem 277: 42769-42774, 2002.