Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers

Journal of Gastroenterology

Volumn 49, Issue 9, 2014, Pages 1307-1313

  Fukazawa, Kousuke ^a   Furuta, Kenji ^a   Adachi, Kyoichi ^b   Moritou, Yoshiya ^a   Saito, Tsukasa ^a   Kusunoki, Ryusaku ^a   Uno, Goichi ^a   Shimura, Shino ^a   Aimi, Masahito ^a   Ohara, Shunji ^a   Ishihara, Shunji ^a   Kinoshita, Yoshikazu ^a  

^a SHIMANE UNIVERSITY   (Japan)

^b Shimane Environment and Health Public Corporation   (Japan)

Author keywords

Compliance; Esophagogastric junction; Manometry; Mosapride

Indexed keywords

MOSAPRIDE; BENZAMIDE DERIVATIVE; GASTROINTESTINAL AGENT; MORPHOLINE DERIVATIVE;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; ESOPHAGEAL MOTOR ACTIVITY; ESOPHAGUS EXAMINATION; ESOPHAGUS MANOMETRY; ESOPHAGUS MOTILITY; FEASIBILITY STUDY; HUMAN; HUMAN EXPERIMENT; IMPEDANCE; INTRA ESOPHAGEAL IMPEDANCE PLANIMETRY; LOW DRUG DOSE; LOWER ESOPHAGUS SPHINCTER; LOWER ESOPHAGUS SPHINCTER PRESSURE; MALE; MAXIMUM PLASMA CONCENTRATION; MOTOR ACTIVITY; NORMAL HUMAN; PERISTALSIS; PRIORITY JOURNAL; SUPINE POSITION; CLINICAL TRIAL; COMPLIANCE (PHYSICAL); DRUG EFFECTS; ESOPHAGUS; MANOMETRY; METABOLISM; MIDDLE AGED; PRESSURE; YOUNG ADULT;

ADULT; BENZAMIDES; COMPLIANCE; ESOPHAGEAL SPHINCTER, LOWER; ESOPHAGOGASTRIC JUNCTION; ESOPHAGUS; GASTROINTESTINAL AGENTS; HUMANS; MALE; MANOMETRY; MIDDLE AGED; MORPHOLINES; PERISTALSIS; PRESSURE; YOUNG ADULT;

EID: 84926656568     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-013-0876-0     Document Type: Article

References (42)

1. Adachi K, Furuta K, Miwa H, Oshima T, Miki M, Komazawa Y, et al. A study on the efficacy of rebamipide for patients with proton pump inhibitor-refractory non-erosive reflux disease. Dig Dis Sci. 2012;57:1609-17.
2. Fass R. Therapeutic options for refractory gastroesophageal reflux disease. J Gastroenterol Hepatol. 2012;27(Suppl 3):3-7.
3. Hsu YC, Lin HJ. Addition of prokinetic therapy to a PPI in reflux diseases. Aliment Pharmacol Ther. 2011;33:983-4.
4. Miwa H, Inoue K, Ashida K, Kogawa T, Nagahara A, Yoshida S, et al. Randomised clinical trial: efficacy of the addition of a prokinetic, mosapride citrate, to omeprazole in the treatment of patients with non-erosive reflux disease-a double-blind, placebo- controlled study. Aliment Pharmacol Ther. 2011;33: 323-32.
5. Madan K, Ahuja V, Kashyap PC, Sharma MP. Comparison of efficacy of pantoprazole alone versus pantoprazole plus mosapride in therapy of gastroesophageal reflux disease: a randomized trial. Dis Esophagus. 2004;17:274-8.
6. Koshino K, Adachi K, Furuta K, Ohara S, Morita T, Nakata S, et al. Effects of mosapride on esophageal functions and gastroesophageal reflux. J Gastroenterol Hepatol. 2010;25:1066-71.
7. Kwiatek MA, Pandolfino JE, Hirano I, Kahrilas PJ. Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP). Gastrointest Endosc. 2010;72:272-8.
8. Ghosh SK, Kahrilas PJ, Brasseur JG. Liquid in the gastroesophageal segment promotes reflux, but compliance does not: a mathematical modeling study. Am J Physiol Gastrointest Liver Physiol. 2008;295:G920-33.
9. Jenkinson AD, Scott SM, Yazaki E, Fusai G, Walker SM, Kadirkamanathan SS, et al. Compliance measurement of lower esophageal sphincter and esophageal body in achalasia and gastroesophageal reflux disease. Dig Dis Sci. 2001;46:1937-42.
10. Pandolfino JE, Shi G, Curry J, Joehl RJ, Brasseur JG, Kahrilas PJ. Esophagogastric junction distensibility: a factor contributing to sphincter incompetence. Am J Physiol Gastrointest Liver Physiol. 2002;282:G1052-8.
11. Kahrilas PJ, Shi G, Manka M, Joehl RJ. Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. Gastroenterology. 2000;118:688-95.
12. Pandolfino JE, Shi G, Trueworthy B, Kahrilas PJ. Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects. Gastroenterology. 2003;125:1018-24.
13. Pandolfino JE, Curry J, Shi G, Joehl RJ, Brasseur JG, Kahrilas PJ. Restoration of normal distensive characteristics of the esophagogastric junction after fundoplication. Ann Surg. 2005;242:43-8.
14. Nathanson LK, Brunott N, Cavallucci D. Adult esophagogastric junction distensibility during general anesthesia assessed with an endoscopic functional luminal imaging probe (EndoFLIP_). Surg Endosc. 2012;26:1051-5.
15. Rohof WO, Hirsch DP, Kessing BF, Boeckxstaens GE. Efficacy of treatment for patients with achalasia depends on the distensibility of the esophagogastric junction. Gastroenterology. 2012; 143:328-35.
16. Rieder E, Swanström LL, Perretta S, Lenglinger J, Riegler M, Dunst CM. Intraoperative assessment of esophagogastric junction distensibility during per oral endoscopic myotomy (POEM) for esophageal motility disorders. Surg Endosc. 2013;27:400-5.
17. Perretta S, Dallemagne B, McMahon B, D'Agostino J, Marescaux J. Improving functional esophageal surgery with a ''smart'' bougie: Endoflip. Surg Endosc. 2011;25:3109.
18. Bhatia SJ, Shah C. How to perform and interpret upper esophageal sphincter manometry. J Neurogastroenterol Motil. 2013;19: 99-103.
19. Regan J, Walshe M, Rommel N, Tack J, McMahon BP. New measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using Endo- FLIP_. Neurogastroenterol Motil. 2013;25:e25-34.
20. Alqudah MM, Gregersen H, Drewes AM, McMahon BP. Evaluation of anal sphincter resistance and distensibility in healthy controls using EndoFLIP_. Neurogastroenterol Motil. 2012;24: e591-9.
21. Ruth M, Finizia C, Cange L, Lundell L. The effect of mosapride on oesophageal motor function and acid reflux in patients with gastro-oesophageal reflux disease. Eur J Gastroenterol Hepatol. 2003;15:1115-21.
22. Toga T, Kohmura Y, Kawatsu R. The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities. J Pharmacol Sci. 2007;105:207-10.
23. Endo J, Nomura M, Morishita S, Uemura N, Inoue S, Kishi S, et al. Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography. J Gastroenterol. 2002;37:888-95.
24. Yoshida K, Furuta K, Adachi K, Ohara S, Morita T, Tanimura T, et al. Effects of anti-hypertensive drugs on esophageal body contraction. World J Gastroenterol. 2010;16:987-91.
25. Fox MR, Bredenoord AJ. Oesophageal high-resolution manometry: moving from research into clinical practice. Gut. 2008;57:405-23.
26. Salvador R, Dubecz A, Polomsky M, Gellerson O, Jones CE, Raymond DP, et al. A new era in esophageal diagnostics: the image-based paradigm of high-resolution manometry. J Am Coll Surg. 2009;208:1035-44.
27. Clouse RE, Staiano A. Topography of the esophageal peristaltic pressure wave. Am J Physiol. 1991;261:G677-84.
28. Clouse RE, Staiano A. Topography of normal and high-amplitude esophageal peristalsis. Am J Physiol. 1993;265:G1098-107.
29. Dodds WJ, Dent J, Hogan WJ, Helm JF, Hauser R, Patel GK, et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med. 1982;307:1547-52.
30. Dodds WJ. The pathogenesis of gastroesophageal reflux disease. AJR Am J Roentgenol. 1988;151:49-56.
31. Ho SC, Chang CS, Wu CY, Chen GH. Ineffective esophageal motility is a primary motility disorder in gastroesophageal reflux disease. Dig Dis Sci. 2002;47:652-6.
32. Wong WM, Lai KC, Hui WM, Hu WH, Huang JQ, Wong NY, et al. Pathophysiology of gastroesophageal reflux diseases in Chinese-role of transient lower esophageal sphincter relaxation and esophageal motor dysfunction. Am J Gastroenterol. 2004;99:2088-93.
33. Chitkara DK, Fortunato C, Nurko S. Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis. J Pediatr Gastroenterol Nutr. 2005;40:70-5.
34. Iwakiri K, Kawami N, Sano H, Tanaka Y, Umezawa M, Kotoyori M, et al. Mechanisms of excessive esophageal acid exposure in patients with reflux esophagitis. Dig Dis Sci. 2009;54:1686-92.
35. Makimoto N, Sakurai-Yamashita Y, Furuichi A, Kawakami S, Enjoji A, Kanematsu T, et al. In vivo assessment of acceleration of motor activity associated with acetylcholine release via 5-hydroxytryptamine. Jpn J Pharmacol. 2002;90:28-35.
36. Kawamura E, Enomoto M, Kotani K, Hagihara A, Fujii H, Kobayashi S, et al. Effect of mosapride citrate on gastric emptying in interferon-induced gastroparesis. Dig Dis Sci. 2012;57:1510-6.
37. Ruth M, Hamelin B, Röhss K, Lundell L. The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 1998;12:35-40.
38. Kusunoki H, Haruma K, Hata J, Kamada T, Ishii M, Yamashita N, et al. Efficacy of mosapride citrate in proximal gastric accommodation and gastrointestinal motility in healthy volunteers: a double-blind placebo-controlled ultrasonographic study. J Gastroenterol. 2010;45:1228-34.
39. Sakamoto Y, Sekino Y, Yamada E, Ohkubo H, Higurashi T, Sakai E, et al. Mosapride accelerates the delayed gastric emptying of high-viscosity liquids: a crossover study using continuous real-time C breath test (BreathID System). J Neurogastroenterol Motil. 2011;17:395-401.
40. Iida H, Inamori M, Fujii T, Sekino Y, Endo H, Hosono K, et al. Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH. BMC Gastroenterol. 2012;12:25.
41. Takatori K, Yoshida R, Horai A, Satake S, Ose T, Kitajima N, et al. Therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding. J Gastroenterol 2012. [Epub ahead of print].
42. Cho YK, Choi MG, Park EY, Lim CH, Kim JS, Park JM, et al. Effect of mosapride combined with esomeprazole improves esophageal peristaltic function in patients with gastroesophageal reflux disease: a study using high resolution manometry. Dig Dis Sci. 2013;58:1035-41.