The effect of mosapride on oesophageal motor function and acid reflux in patients with gastro-oesophageal reflux disease

European Journal of Gastroenterology and Hepatology

Volumn 15, Issue 10, 2003, Pages 1115-1121

  Ruth, Magnus ^a   Finizia, Caterina ^a   Cange, Lars ^a   Lundell, Lars ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

24 hour pH metry; Ambulatory manometry; Cisapride; Gastro oesophageal reflux; Mosapride; Oesophageal peristalsis

Indexed keywords

CISAPRIDE; MOSAPRIDE CITRATE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EVALUATION; FEMALE; FLATULENCE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MOTILITY; HEADACHE; HUMAN; LOWER ESOPHAGUS SPHINCTER; MALE; MOTOR PERFORMANCE; NAUSEA; PH MEASUREMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SUPINE POSITION;

ADULT; AGED; BENZAMIDES; CISAPRIDE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ESOPHAGUS; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL AGENTS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MANOMETRY; MIDDLE AGED; MORPHOLINES; PERISTALSIS; RECEPTORS, SEROTONIN, 5-HT3; RECEPTORS, SEROTONIN, 5-HT4;

EID: 0142012129     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200310000-00009     Document Type: Article

References (23)

1. Yoshida N, Omoya H, Oka M, Furukawa K, Ito T, Karasawa T. AS-4370, a novel gastrokinetic agent free of dopamine D2 receptor antagonist properties. Arch Int Pharmacodyn Ther 1989; 300:51-67.
2. Ruth M, Hamelin B, Rohss K, Lundell L. The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 1998; 12:35-40.
3. Yamada M, Hongo M, Okuno Y, Nishimura N, Ueno M, Kawakami H, et al. Effect of AS-4370 on gastric motility in patients with diabetic autonomic neuropathy. J Smooth Muscle Res 1992; 28:153-158.
4. Kanaizumi T, Nakano H, Matsui Y, Ishikawa H, Shimizu R, Park S, et al. Prokinetic effect of AS-4370 on gastric emptying in healthy adults. Eur J Clin Pharmacol 1991; 41:335-337.
5. Mine Y, Yoshikawa T, Oku S, Nagai R, Yoshida N, Hosoki K. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J Pharmacol Exp Ther 1997; 283:1000-1008.
6. Uchiyama-Tsuyuki Y, Saitoh M, Muramatsu M. Identification and characterization of the 5-HT4 receptor in the intestinal tract and striatum of the guinea pig. Life Sci 1996; 59:2129-2137.
7. Yoshida N, Ito T, Karasawa T, Itoh Z. AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs. J Pharmacol Exp Ther 1991; 257:781.
8. Rydberg L, Ruth M, Lundell L. Does oesophageal motor function improve with time after successful antireflux surgery? Results of a prospective, randomised clinical study. Gut 1997; 41:82-86.
9. Galmiche JP, Janssens J. The pathophysiology of gastro-oesophageal reflux disease: an overview. Scand J Gastroenterol Suppl 1995; 211: 7-18.
10. Holloway RH, Kocyan P, Dent J. Provocation of transient lower esophageal sphincter relaxations by meals in patients with symptomatic gastro-esophageal reflux. Dig Dis Sci 1991; 36:1034-1039.
11. Maddern GJ, Jamieson GG, Myers JC, Collins PJ. Effect of cisapride on delayed gastric emptying in gastro-oesophageal reflux disease. Gut 1991; 32:470-474.
12. Stein HJ, Bremner RM, Jamieson J, DeMeester TR. Effect of Nissen fundoplication on esophageal motor function. Arch Surg 1992; 127:788-791.
13. Schoeman MN, Holloway RH. Integrity and characteristics of secondary oesophageal peristalsis in patients with gastro-oesophageal reflux disease. Gut 1995; 36:499-504.
14. Paterson WG, Abdollah H, Beck IT, Da Costa LR. Ambulatory esophageal manometry, pH-metry, and Holter ECG monitoring in patients with atypical chest pain. Dig Dis Sci 1993; 38:795-802.
15. DeMeester TR, Wang CI, Wernly JA, Pellegrini CA, Little AG, Klementschitsch P, et al. Technique, indications, and clinical use of 24 hour esophageal pH monitoring. J Thorac Cardiovasc Surg 1980; 79:656-670.
16. Bradley JV. Distribution-free Statistical Tests. London: Prentice-Hall; 1968.
17. Paterson WG, Wang H, Beck IT. The effect of cisapride in patients with reflux esophagitis: an ambulatory esophageal manometry/pH-metry study. Am J Gastroenterol 1997; 92:226-230.
18. Inauen W, Emde C, Weber B, Armstrong D, Bettschen HU, Huber T, et al. Effects of ranitidine and cisapride on acid reflux and oesophageal motility in patients with reflux oesophagitis: a 24 hour ambulatory combined pH and manometry study. Gut 1993; 34:1025-1031.
19. Van Herwaarden MA, Samsom M, Van Nispen CH, Verlinden M, Smout AJ. The effect of motilin agonist ABT-229 on gastro-oesophageal reflux, oesophageal motility and lower oesophageal sphincter characteristics in GERD patients. Aliment Pharmacol Ther 2000; 14:453-462.
20. Hatlebakk JG, Hyggen A, Madsen PH, Walle PO, Schulz T, Mowinckel P, et al. Heartburn treatment in primary care: randomised, double blind study for 8 weeks. BMJ 1999; 31:550-553.
21. Chen SD, Kao CH, Chang CS, Chen GH. Salivary function in patients with reflux esophagitis: effect of cisapride. J Nucl Med 1998; 39: 1449-1452.
22. Sarosiek J, McCallum RW. Mechanisms of oesophageal mucosal defence. Baillieres Best Pract Res Clin Gastroenterol 2000; 14:701-717.
23. Sjovall H, Abrahamsson H. Mosapride enhances human esophageal motility [Abstract]. Gastroenterology 1996; 110(4):A47.