Japanese herbal medicines shosaikoto, inchinkoto, and juzentaihoto inhibit high-fat diet-induced nonalcoholic steatohepatitis in db/db mice

Pathology International

Volumn 64, Issue 10, 2014, Pages 490-498

  Takahashi, Yoshihisa ^a   Soejima, Yurie ^a   Kumagai, Arisa ^a   Watanabe, Masato ^a   Uozaki, Hiroshi ^a   Fukusato, Toshio ^a  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Animal model; Db db mice; High fat diet; Japanese herbal medicine; Nonalcoholic steatohepatitis

Indexed keywords

INCHINKO TO; KEISHI BUKURYO GAN; SHI QUAN DA BU TANG; XIAO CHAI HU TANG; HERBACEOUS AGENT; INCHINKO-TO; JUZENTAIHOTO; SHOSAIKO-TO;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; LIPID DIET; LIVER FIBROSIS; LIVER HISTOLOGY; MALE; MORPHOMETRICS; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; ADVERSE EFFECTS; ANIMAL; DISEASE MODEL; IMMUNOHISTOCHEMISTRY; MUTANT MOUSE STRAIN; NON-ALCOHOLIC FATTY LIVER DISEASE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, MUTANT STRAINS; NON-ALCOHOLIC FATTY LIVER DISEASE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84926651635     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/pin.12199     Document Type: Article

References (29)

1. Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years. Hepatology 1990; 11: 74-80.
2. Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: Old questions and new insights. Science 2011; 332: 1519-1523.
3. Marchesini G, Bugianesi E, Forlani G etal. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003; 37: 917-923.
4. Machado M, Cortez-Pinto H. Non-alcoholic steatohepatitis and metabolic syndrome. Curr Opin Clin Nutr Metab Care 2006; 9: 637-642.
5. Neuschwander-Tetri BA. Nonalcoholic steatohepatitis and the metabolic syndrome. Am J Med Sci 2005; 330: 326-335.
6. Day CP, James OF. Steatohepatitis: A tale of two 'hits'?. Gastroenterology 1998; 114: 842-845.
7. Tilg H, Moschen AR. Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis. Hepatology 2010; 52: 1836-1846.
8. Takahashi Y, Soejima Y, Fukusato T. Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol 2012; 18: 2300-2308.
9. Handa P, Maliken BD, Nelson JE etal. Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis. Hepatology 2014; 60: 133-145.
10. Motoo Y, Seki T, Tsutani K. Traditional Japanese medicine, Kampo: Its history and current status. Chin J Integr Med 2011; 17: 85-87.
11. Iizuka A, Iijima OT, Kondo K etal. Antioxidative effects of Choi-oki-to and its ability to inhibit the progression of atheroma in KHC rabbits. J Atheroscler Thromb 2000; 6: 49-54.
12. Shiota G, Maeta Y, Mukoyama T etal. Effects of Sho-Saiko-to on hepatocarcinogenesis and 8-hydroxy-2'-deoxyguanosine formation. Hepatology 2002; 35: 1125-1133.
13. Nagai T, Nakao M, Shimizu Y etal. Proteomic analysis of anti-inflammatory effects of a Kampo (Japanese herbal) medicine 'Shoseiryuto (Xiao-qing-long-tang)' on airway inflammation in a mouse model. Evid Based Complement Alternat Med 2011; 2011: 604196.
14. Fujimoto M, Tsuneyama K, Kainuma M etal. Evidence-based efficacy of Kampo formulas in a model of non alcoholic fatty liver. Exp Biol Med 2008; 233: 328-337.
15. Fujimoto M, Tsuneyama K, Kinoshita H etal. The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease. Ann N Y Acad Sci 2010; 1190: 151-158.
16. Ohtake N, Yamamoto M, Takeda S etal. The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation. Eur J Pharmacol 2005; 507: 301-310.
17. Sakaida I, Tsuchiya M, Kawaguchi K, Kimura T, Terai S, Okita K. Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. J Hepatol 2003; 38: 762-769.
18. Tsuchiya M, Kono H, Matsuda M, Fujii H, Rusyn I. Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress. Int J Cancer 2008; 123: 2503-2511.
19. Yoshihisa Y, Furuichi M, Ur Rehman M, Ueda C, Makino T, Shimizu T. The traditional Japanese formula keishibukuryogan inhibits the production of inflammatory cytokines by dermal endothelial cells. Mediators Inflamm 2010; 2010: 804298.
20. Kleiner DE, Brunt EM, Van Natta M etal. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321.
21. Takahashi Y, Soejima Y, Kumagai A, Watanabe M, Uozaki H, Fukusato T. Inhibitory effects of Japanese herbal medicines sho-saiko-to and juzen-taiho-to on nonalcoholic steatohepatitis in mice. PLoS ONE 2014; 9: e87279.
22. Chen H, Charlat O, Tartaglia LA etal. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491-495.
23. Mochiki E, Yanai M, Ohno T, Kuwano H. The effect of traditional Japanese medicine (Kampo) on gastrointestinal function. Surg Today 2010; 40: 1105-1111.
24. Kusunose M, Qiu B, Cui T etal. Effect of Sho-saiko-to extract on hepatic inflammation and fibrosis in dimethylnitrosamine induced liver injury rats. Biol Pharm Bull 2002; 25: 1417-1421.
25. Yamashiki M, Mase A, Arai I etal. Effects of the Japanese herbal medicine 'Inchinko-to' (TJ-135) on concanavalin A-induced hepatitis in mice. Clin Sci (Lond) 2000; 99: 421-431.
26. Asakawa T, Yagi M, Tanaka Y etal. The herbal medicine Inchinko-to reduces hepatic fibrosis in cholestatic rats. Pediatr Surg Int 2012; 28: 379-384.
27. Ramadori G. The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. New insights into pathophysiology of an intriguing cell. Virchows Arch B Cell Pathol Incl Mol Pathol 1991; 61: 147-158.
28. Tojima H, Yamazaki T, Tokudome T. Two cases of pneumonia caused by Sho-saiko-to. Nihon Kyobu Shikkan Gakkai Zasshi 1996; 34: 904-910. (in Japanese).
29. Tomioka H, Hashimoto K, Ohnishi H etal. An autopsy case of interstitial pneumonia probably induced by Sho-saiko-to. Nihon Kokyuki Gakkai Zasshi 1999; 37: 1013-1018. (in Japanese).