Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves

Cardiovascular Research

Volumn 106, Issue 1, 2015, Pages 55-66

  Mommersteeg, Mathilda T M ^a   Yeh, Mason L ^a   Parnavelas, John G ^a   Andrews, William D ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Bicuspid aortic valves; Heart development; Membranous ventricular septum defect; Notch signalling pathway; Slit Robo signalling pathway

Indexed keywords

NOTCH RECEPTOR; PROTEIN ROBO 1; PROTEIN ROBO 2; ROUNDABOUT RECEPTOR; SLIT PROTEIN; SLIT2 PROTEIN; SLIT3 PROTEIN; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL CYCLE PROTEIN; HES1 PROTEIN, MOUSE; HEY1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; NERVE PROTEIN; ROBO2 PROTEIN, MOUSE; SIGNAL PEPTIDE; SLIT HOMOLOG 2 PROTEIN; SLIT3 PROTEIN, MOUSE; TRANSCRIPTION FACTOR HES 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BICUSPID AORTIC VALVE; EMBRYO; ENDOCARDIAL CUSHION; GENE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HEART ATRIOVENTRICULAR VALVE; HEART VENTRICLE SEPTUM DEFECT; HES GENE; HEY GENE; IMMUNOHISTOCHEMISTRY; LUCIFERASE ASSAY; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; NOTCH GENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROBO1 GENE; ROBO2 GENE; SIGNAL TRANSDUCTION; SLIT2 GENE; SLIT3 GENE; ABNORMALITIES; ANIMAL; AORTA VALVE; CONGENITAL HEART MALFORMATION; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; INTERVENTRICULAR SEPTUM; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE; VALVULAR HEART DISEASE;

ANIMALS; AORTIC VALVE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE PROTEINS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART DEFECTS, CONGENITAL; HEART VALVE DISEASES; HOMEODOMAIN PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR HES-1; VENTRICULAR SEPTUM;

EID: 84926647742     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv040     Document Type: Article

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