The role of HLA-G molecule and HLA-G gene polymorphisms in tumors, viral hepatitis, and parasitic diseases

Frontiers in Immunology

Volumn 6, Issue FEB, 2015, Pages

  Dias, Fabrício C ^a   Castelli, Erick C ^b   Collares, Cristhianna V A ^a   Moreau, Philippe ^c   Donadi, Eduardo A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c SAINT LOUIS HOSPITAL   (France)

Author keywords

HLA G; Parasitic disorders; Polymorphism; Tumors; Viral hepatitis

Indexed keywords

CD45 ANTIGEN;

AFRICAN TRYPANOSOMIASIS; ALLELE; CANCER SUSCEPTIBILITY; CHAGAS DISEASE; DNA POLYMORPHISM; GENE EXPRESSION; HAPLOTYPE; HUMAN; IMMUNE RESPONSE; MALARIA; NEOPLASM; PARASITOSIS; REVIEW; VIRUS HEPATITIS;

EID: 84926641260     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00009     Document Type: Review

References (107)

1. Geraghty DE, Koller BH, Orr HT. A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment. Proc Natl Acad Sci U S A (1987) 84(24):9145-9. doi:10.1073/pnas.84.24.9145
2. Donadi EA, Castelli EC, Arnaiz-Villena A, Roger M, Rey D, Moreau P. Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association. Cell Mol Life Sci (2011) 68(3):369-95. doi:10.1007/s00018-010-0580-7
3. Rouas-Freiss N, Goncalves RM, Menier C, Dausset J, Carosella ED. Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis. Proc Natl Acad Sci U S A (1997) 94(21):11520-5. doi:10.1073/pnas.94.21.11520
4. Naji A, Menier C, Morandi F, Agaugue S, Maki G, Ferretti E, et al. Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses. J Immunol (2014) 192(4):1536-46. doi:10.4049/jimmunol.1300438
5. Horuzsko A, Lenfant F, Munn DH, Mellor AL. Maturation of antigen-presenting cells is compromised in HLA-G transgenic mice. Int Immunol (2001) 13(3):385-94. doi:10.1093/intimm/13.3.385
6. Le Discorde M, Moreau P, Sabatier P, Legeais JM, Carosella ED. Expression of HLA-G in human cornea, an immune-privileged tissue. Hum Immunol (2003) 64(11):1039-44. doi:10.1016/j.humimm.2003.08.346
7. Lefebvre S, Adrian F, Moreau P, Gourand L, Dausset J, Berrih-Aknin S, et al. Modulation of HLA-G expression in human thymic and amniotic epithelial cells. Hum Immunol (2000) 61(11):1095-101. doi:10.1016/S0198-8859(00)00192-0
8. Menier C, Rabreau M, Challier JC, Le Discorde M, Carosella ED, Rouas-Freiss N. Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis. Blood (2004) 104(10):3153-60. doi:10.1182/blood-2004-03-0809
9. Tan Z, Shon AM, Ober C. Evidence of balancing selection at the HLA-G promoter region. Hum Mol Genet (2005) 14(23):3619-28. doi:10.1093/hmg/ddi389
10. Castelli EC, Mendes-Junior CT, Veiga-Castelli LC, Roger M, Moreau P, Donadi EA. A comprehensive study of polymorphic sites along the HLA-G gene: implication for gene regulation and evolution. Mol Biol Evol (2011) 28(11):3069-86. doi:10.1093/molbev/msr138
11. Sabbagh A, Luisi P, Castelli EC, Gineau L, Courtin D, Milet J, et al. Worldwide genetic variation at the 3' untranslated region of the HLA-G gene: balancing selection influencing genetic diversity. Genes Immun (2014) 15(2):95-106. doi:10.1038/gene.2013.67
12. Santos KE, Lima TH, Felicio LP, Massaro JD, Palomino GM, Silva AC, et al. Insights on the HLA-G evolutionary history provided by a nearby Alu insertion. Mol Biol Evol (2013) 30(11):2423-34. doi:10.1093/molbev/mst142
13. Castelli EC, Veiga-Castelli LC, Yaghi L, Moreau P, Donadi EA. Transcriptional and posttranscriptional regulations of the HLA-G gene. J Immunol Res (2014) 2014:734068. doi:10.1155/2014/734068
14. Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, et al. Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet (2007) 81(4):829-34. doi:10.1086/521200
15. Manaster I, Goldman-Wohl D, Greenfield C, Nachmani D, Tsukerman P, Hamani Y, et al. MiRNA-mediated control of HLA-G expression and function. PLoS One (2012) 7(3):e33395. doi:10.1371/journal.pone.0033395
16. Castelli EC, Moreau P, Oya e Chiromatzo A, Mendes-Junior CT, Veiga-Castelli LC, Yaghi L, et al. In silico analysis of microRNAS targeting the HLA-G 3' untranslated region alleles and haplotypes. Hum Immunol (2009) 70(12):1020-5. doi:10.1016/j.humimm.2009.07.028
17. Martelli-Palomino G, Pancotto JA, Muniz YC, Mendes-Junior CT, Castelli EC, Massaro JD, et al. Polymorphic sites at the 3' untranslated region of the HLA-G gene are associated with differential HLA-G soluble levels in the Brazilian and French population. PLoS One (2013) 8(10):e71742. doi:10.1371/journal.pone.0071742
18. Castelli EC, Ramalho J, Porto IO, Lima TH, Felicio LP, Sabbagh A, et al. Insights into HLA-G genetics provided by worldwide haplotype diversity. Front Immunol (2014) 5:476. doi:10.3389/fimmu.2014.00476
19. Rouas-Freiss N, Moreau P, Ferrone S, Carosella ED. HLA-G proteins in cancer: do they provide tumor cells with an escape mechanism? Cancer Res (2005) 65(22):10139-44. doi:10.1158/0008-5472.CAN-05-0097
20. Carosella ED, Moreau P, Lemaoult J, Rouas-Freiss N. HLA-G: from biology to clinical benefits. Trends Immunol (2008) 29(3):125-32. doi:10.1016/j.it.2007.11.005
21. Bukur J, Jasinski S, Seliger B. The role of classical and non-classical HLA class I antigens in human tumors. Semin Cancer Biol (2012) 22(4):350-8. doi:10.1016/j.semcancer.2012.03.003
22. Lefebvre S, Antoine M, Uzan S, McMaster M, Dausset J, Carosella ED, et al. Specific activation of the non-classical class I histocompatibility HLA-G antigen and expression of the ILT2 inhibitory receptor in human breast cancer. J Pathol (2002) 196(3):266-74. doi:10.1002/path.1039
23. Chen HX, Lin A, Shen CJ, Zhen R, Chen BG, Zhang X, et al. Upregulation of human leukocyte antigen-G expression and its clinical significance in ductal breast cancer. Hum Immunol (2010) 71(9):892-8. doi:10.1016/j.humimm.2010.06.009
24. He X, Dong DD, Yie SM, Yang H, Cao M, Ye SR, et al. HLA-G expression in human breast cancer: implications for diagnosis and prognosis, and effect on allocytotoxic lymphocyte response after hormone treatment in vitro. Ann Surg Oncol (2010) 17(5):1459-69. doi:10.1245/s10434-009-0891-9
25. Sayed D, Badr G, Maximous D, Mikhail NN, Abu-Tarboush F, Alhazza IM. HLA-G and its relation to proliferation index in detection and monitoring breast cancer patients. Tissue Antigens (2010) 75(1):40-7. doi:10.1111/j.1399-0039.2009.01393.x
26. Ramos CS, Goncalves AS, Marinho LC, Gomes Avelino MA, Saddi VA, Lopes AC, et al. Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma. Hum Immunol (2014) 75(7):667-72. doi:10.1016/j.humimm.2014.04.005
27. de Kruijf EM, Sajet A, van Nes JG, Natanov R, Putter H, Smit VT, et al. HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients. J Immunol (2010) 185(12):7452-9. doi:10.4049/jimmunol.1002629
28. Elliott RL, Jiang XP, Phillips JT, Barnett BG, Head JF. Human leukocyte antigen G expression in breast cancer: role in immunosuppression. Cancer Biother Radiopharm (2011) 26(2):153-7. doi:10.1089/cbr.2010.0924
29. da Silva GB, Silva TG, Duarte RA, Neto NL, Carrara HH, Donadi EA, et al. Expression of the classical and nonclassical HLA molecules in breast cancer. Int J Breast Cancer (2013) 2013:250435. doi:10.1155/2013/250435
30. Cai MY, Xu YF, Qiu SJ, Ju MJ, Gao Q, Li YW, et al. Human leukocyte antigen-G protein expression is an unfavorable prognostic predictor of hepatocellular carcinoma following curative resection. Clin Cancer Res (2009) 15(14):4686-93. doi:10.1158/1078-0432.CCR-09-0463
31. Lin A, Chen HX, Zhu CC, Zhang X, Xu HH, Zhang JG, et al. Aberrant human leukocyte antigen-G expression and its clinical relevance in hepatocellular carcinoma. J Cell Mol Med (2010) 14(8):2162-71. doi:10.1111/j.1582-4934.2009.00917.x
32. Wang Y, Ye Z, Meng XQ, Zheng SS. Expression of HLA-G in patients with hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int (2011) 10(2):158-63. doi:10.1016/S1499-3872(11)60025-8
33. Park Y, Park Y, Lim HS, Kim YS, Hong DJ, Kim HS. Soluble human leukocyte antigen-G expression in hepatitis B virus infection and hepatocellular carcinoma. Tissue Antigens (2012) 79(2):97-103. doi:10.1111/j.1399-0039.2011.01814.x
34. Nunes LM, Ayres FM, Francescantonio IC, Saddi VA, Avelino MA, Alencar Rde C, et al. Association between the HLA-G molecule and lymph node metastasis in papillary thyroid cancer. Hum Immunol (2013) 74(4):447-51. doi:10.1016/j.humimm.2012.12.012
35. de Figueiredo Feitosa NL, Crispim JC, Zanetti BR, Magalhaes PK, Soares CP, Soares EG, et al. HLA-G is differentially expressed in thyroid tissues. Thyroid (2014) 24(3):585-92. doi:10.1089/thy.2013.0246
36. Cai MB, Han HQ, Bei JX, Liu CC, Lei JJ, Cui Q, et al. Expression of human leukocyte antigen G is associated with prognosis in nasopharyngeal carcinoma. Int J Biol Sci (2012) 8(6):891-900. doi:10.7150/ijbs.4383
37. Morandi F, Levreri I, Bocca P, Galleni B, Raffaghello L, Ferrone S, et al. Human neuroblastoma cells trigger an immunosuppressive program in monocytes by stimulating soluble HLA-G release. Cancer Res (2007) 67(13):6433-41. doi:10.1158/0008-5472.CAN-06-4588
38. Gan LH, Huang LF, Zhang X, Lin A, Xu DP, Wang Q, et al. Tumor-specific upregulation of human leukocyte antigen-G expression in bladder transitional cell carcinoma. Hum Immunol (2010) 71(9):899-904. doi:10.1016/j.humimm.2010.06.012
39. Ugurel S, Rebmann V, Ferrone S, Tilgen W, Grosse-Wilde H, Reinhold U. Soluble human leukocyte antigen-G serum level is elevated in melanoma patients and is further increased by interferon-alpha immunotherapy. Cancer (2001) 92(2):369-76. doi:10.1002/1097-0142(20010715)92:2<369::AID-CNCR1332>3.0.CO;2-U
40. Ibrahim EC, Aractingi S, Allory Y, Borrini F, Dupuy A, Duvillard P, et al. Analysis of HLA antigen expression in benign and malignant melanocytic lesions reveals that upregulation of HLA-G expression correlates with malignant transformation, high inflammatory infiltration and HLA-A1 genotype. Int J Cancer (2004) 108(2):243-50. doi:10.1002/ijc.11456
41. Bezuhly M, Howlett A, Colp P, Conrad DM, Walsh N, Rowden G, et al. Quantitative HLA-G expression in metastasising and non-metastasising primary thin cutaneous melanomas. Dermatology (2008) 217(3):281-3. doi:10.1159/000150602
42. Fang X, Zhang X, Li J. Up-regulation of human leukocyte antigen G expression in primary cutaneous malignant melanoma associated with host-vs-tumor immune response. J Huazhong Univ Sci Technolog Med Sci (2008) 28(2):219-21. doi:10.1007/s11596-008-0227-1
43. Fukushima Y, Oshika Y, Nakamura M, Tokunaga T, Hatanaka H, Abe Y, et al. Increased expression of human histocompatibility leukocyte antigen-G in colorectal cancer cells. Int J Mol Med (1998) 2(3):349-51.
44. Ye SR, Yang H, Li K, Dong DD, Lin XM, Yie SM. Human leukocyte antigen G expression: as a significant prognostic indicator for patients with colorectal cancer. Mod Pathol (2007) 20(3):375-83. doi:10.1038/modpathol.3800751
45. Zeestraten EC, Reimers MS, Saadatmand S, Dekker JW, Liefers GJ, van den Elsen PJ, et al. Combined analysis of HLA class I, HLA-E and HLA-G predicts prognosis in colon cancer patients. Br J Cancer (2014) 110(2):459-68. doi:10.1038/bjc.2013.696
46. Yie SM, Yang H, Ye SR, Li K, Dong DD, Lin XM. Expression of human leukocyte antigen G (HLA-G) correlates with poor prognosis in gastric carcinoma. Ann Surg Oncol (2007) 14(10):2721-9. doi:10.1245/s10434-007-9464-y
47. Du L, Xiao X, Wang C, Zhang X, Zheng N, Wang L, et al. Human leukocyte antigen-G is closely associated with tumor immune escape in gastric cancer by increasing local regulatory T cells. Cancer Sci (2011) 102(7):1272-80. doi:10.1111/j.1349-7006.2011.01951.x
48. Tuncel T, Karagoz B, Haholu A, Ozgun A, Emirzeoglu L, Bilgi O, et al. Immunoregulatory function of HLA-G in gastric cancer. Asian Pac J Cancer Prev (2013) 14(12):7681-4. doi:10.7314/APJCP.2013.14.12.7681
49. Cao M, Yie SM, Liu J, Ye SR, Xia D, Gao E. Plasma soluble HLA-G is a potential biomarker for diagnosis of colorectal, gastric, esophageal and lung cancer. Tissue Antigens (2011) 78(2):120-8. doi:10.1111/j.1399-0039.2011.01716.x
50. Lin A, Zhang X, Zhou WJ, Ruan YY, Xu DP, Wang Q, et al. Human leukocyte antigen-G expression is associated with a poor prognosis in patients with esophageal squamous cell carcinoma. Int J Cancer (2011) 129(6):1382-90. doi:10.1002/ijc.25807
51. Zheng J, Xu C, Chu D, Zhang X, Li J, Ji G, et al. Human leukocyte antigen G is associated with esophageal squamous cell carcinoma progression and poor prognosis. Immunol Lett (2014) 161(1):13-9. doi:10.1016/j.imlet.2014.04.007
52. Yie SM, Yang H, Ye SR, Li K, Dong DD, Lin XM. Expression of HLA-G is associated with prognosis in esophageal squamous cell carcinoma. Am J Clin Pathol (2007) 128(6):1002-9. doi:10.1309/JNCW1QLDFB6AM9WE
53. Hu J, Li L, Liu Y, Chen Y, Liu C, Liang W, et al. Overexpression of HLA-G Is positively associated with Kazakh esophageal squamous cell carcinoma in Xinjiang, China. Viral Immunol (2013) 26(3):180-4. doi:10.1089/vim.2012.0085
54. Lin A, Zhu CC, Chen HX, Chen BF, Zhang X, Zhang JG, et al. Clinical relevance and functional implications for human leukocyte antigen-g expression in non-small-cell lung cancer. J Cell Mol Med (2010) 14(9):2318-29. doi:10.1111/j.1582-4934.2009.00858.x
55. Schutt P, Schutt B, Switala M, Bauer S, Stamatis G, Opalka B, et al. Prognostic relevance of soluble human leukocyte antigen-G and total human leukocyte antigen class I molecules in lung cancer patients. Hum Immunol (2010) 71(5):489-95. doi:10.1016/j.humimm.2010.02.015
56. Urosevic M, Kurrer MO, Kamarashev J, Mueller B, Weder W, Burg G, et al. Human leukocyte antigen G up-regulation in lung cancer associates with high-grade histology, human leukocyte antigen class I loss and interleukin-10 production. Am J Pathol (2001) 159(3):817-24. doi:10.1016/S0002-9440(10)61756-7
57. Yie SM, Yang H, Ye SR, Li K, Dong DD, Lin XM. Expression of human leukocyte antigen G (HLA-G) is associated with prognosis in non-small cell lung cancer. Lung Cancer (2007) 58(2):267-74. doi:10.1016/j.lungcan.2007.06.011
58. Hanak L, Slaby O, Lauerova L, Kren L, Nenutil R, Michalek J. Expression pattern of HLA class I antigens in renal cell carcinoma and primary cell line cultures: methodological implications for immunotherapy. Med Sci Monit (2009) 15(12):CR638-43.
59. Ibrahim EC, Guerra N, Lacombe MJ, Angevin E, Chouaib S, Carosella ED, et al. Tumor-specific up-regulation of the nonclassical class I HLA-G antigen expression in renal carcinoma. Cancer Res (2001) 61(18):6838-45.
60. Ibrahim EC, Allory Y, Commo F, Gattegno B, Callard P, Paul P. Altered pattern of major histocompatibility complex expression in renal carcinoma: tumor-specific expression of the nonclassical human leukocyte antigen-G molecule is restricted to clear cell carcinoma while up-regulation of other major histocompatibility complex antigens is primarily distributed in all subtypes of renal carcinoma. Am J Pathol (2003) 162(2):501-8. doi:10.1016/S0002-9440(10)63844-8
61. Kren L, Valkovsky I, Dolezel J, Capak I, Pacik D, Poprach A, et al. HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma. Diagn Pathol (2012) 7:58. doi:10.1186/1746-1596-7-58
62. Li BL, Lin A, Zhang XJ, Zhang X, Zhang JG, Wang Q, et al. Characterization of HLA-G expression in renal cell carcinoma. Tissue Antigens (2009) 74(3):213-21. doi:10.1111/j.1399-0039.2009.01302.x
63. Wiendl H, Mitsdoerffer M, Hofmeister V, Wischhusen J, Bornemann A, Meyermann R, et al. A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape. J Immunol (2002) 168(9):4772-80. doi:10.4049/jimmunol.168.9.4772
64. Kren L, Muckova K, Lzicarova E, Sova M, Vybihal V, Svoboda T, et al. Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity? J Neuroimmunol (2010) 220(1-2):131-5. doi:10.1016/j.jneuroim.2010.01.014
65. Kren L, Slaby O, Muckova K, Lzicarova E, Sova M, Vybihal V, et al. Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: an unexpected prognostic significance? Neuropathology (2011) 31(2):129-34. doi:10.1111/j.1440-1789.2010.01149.x
66. Wastowski IJ, Simoes RT, Yaghi L, Donadi EA, Pancoto JT, Poras I, et al. Human leukocyte antigen-G is frequently expressed in glioblastoma and may be induced in vitro by combined 5-aza-2'-deoxycytidine and interferon-gamma treatments: results from a multicentric study. Am J Pathol (2013) 182(2):540-52. doi:10.1016/j.ajpath.2012.10.021
67. Guo QY, Chen BG, Ruan YY, Lin A, Yan WH. HLA-G expression is irrelevant to prognosis in patients with acute myeloid leukemia. Leuk Res (2011) 35(10):1350-4. doi:10.1016/j.leukres.2011.05.036
68. Locafaro G, Amodio G, Tomasoni D, Tresoldi C, Ciceri F, Gregori S. HLA-G expression on blasts and tolerogenic cells in patients affected by acute myeloid leukemia. J Immunol Res (2014) 2014:636292. doi:10.1155/2014/636292
69. Nuckel H, Rebmann V, Durig J, Duhrsen U, Grosse-Wilde H. HLA-G expression is associated with an unfavorable outcome and immunodeficiency in chronic lymphocytic leukemia. Blood (2005) 105(4):1694-8. doi:10.1182/blood-2004-08-3335
70. Rebmann V, Nuckel H, Duhrsen U, Grosse-Wilde H. HLA-G in B-chronic lymphocytic leukaemia: clinical relevance and functional implications. Semin Cancer Biol (2007) 17(6):430-5. doi:10.1016/j.semcancer.2007.06.011
71. Giannopoulos K, Dmoszynska A, Bojarska-Junak A, Schmitt M, Rolinski J. Expression of HLA-G in patients with B-cell chronic lymphocytic leukemia (B-CLL). Folia Histochem Cytobiol (2008) 46(4):457-60. doi:10.2478/v10042-008-0072-x
72. Erikci AA, Karagoz B, Ozyurt M, Ozturk A, Kilic S, Bilgi O. HLA-G expression in B chronic lymphocytic leukemia: a new prognostic marker? Hematology (2009) 14(2):101-5. doi:10.1179/102453309X385197
73. Attia MA, Nosair NA, Gawally A, Elnagar G, Elshafey EM. HLA-G expression as a prognostic indicator in B-cell chronic lymphocytic leukemia. Acta Haematol (2014) 132(1):53-8. doi:10.1159/000353757
74. Kleinberg L, Florenes VA, Skrede M, Dong HP, Nielsen S, McMaster MT, et al. Expression of HLA-G in malignant mesothelioma and clinically aggressive breast carcinoma. Virchows Arch (2006) 449(1):31-9. doi:10.1007/s00428-005-0144-7
75. Provatopoulou X, Kalogera E, Sagkriotis A, Zagouri F, Nonni A, Zografos GC, et al. Soluble human leukocyte antigen-G expression in patients with ductal and lobular breast malignancy. Anticancer Res (2012) 32(3):1021-6.
76. Dardano A, Rizzo R, Polini A, Stignani M, Tognini S, Pasqualetti G, et al. Soluble human leukocyte antigen-g and its insertion/deletion polymorphism in papillary thyroid carcinoma: novel potential biomarkers of disease? J Clin Endocrinol Metab (2012) 97(11):4080-6. doi:10.1210/jc.2012-2231
77. Zhu CB, Wang CX, Zhang X, Zhang J, Li W. Serum sHLA-G levels: a useful indicator in distinguishing colorectal cancer from benign colorectal diseases. Int J Cancer (2011) 128(3):617-22. doi:10.1002/ijc.25372
78. Gros F, Sebti Y, de Guibert S, Branger B, Bernard M, Fauchet R, et al. Soluble HLA-G molecules increase during acute leukemia, especially in subtypes affecting monocytic and lymphoid lineages. Neoplasia (2006) 8(3):223-30. doi:10.1593/neo.05703
79. Morandi F, Scaruffi P, Gallo F, Stigliani S, Moretti S, Bonassi S, et al. Bone marrow-infiltrating human neuroblastoma cells express high levels of calprotectin and HLA-G proteins. PLoS One (2012) 7(1):e29922. doi:10.1371/journal.pone.0029922
80. Eskandari-Nasab E, Hashemi M, Hasani SS, Omrani M, Taheri M, Mashhadi MA. Association between HLA-G 3'UTR 14-bp ins/del polymorphism and susceptibility to breast cancer. Cancer Biomark (2013) 13(4):253-9. doi:10.3233/CBM-130364
81. Jeong S, Park S, Park BW, Park Y, Kwon OJ, Kim HS. Human leukocyte antigen-G (HLA-G) polymorphism and expression in breast cancer patients. PLoS One (2014) 9(5):e98284. doi:10.1371/journal.pone.0098284
82. Ge YZ, Ge Q, Li MH, Shi GM, Xu X, Xu LW, et al. Association between human leukocyte antigen-G 14-bp insertion/deletion polymorphism and cancer risk: a meta-analysis and systematic review. Hum Immunol (2014) 75(8):827-32. doi:10.1016/j.humimm.2014.06.004
83. Teixeira AC, Mendes-Junior CT, Souza FF, Marano LA, Deghaide NH, Ferreira SC, et al. The 14bp-deletion allele in the HLA-G gene confers susceptibility to the development of hepatocellular carcinoma in the Brazilian population. Tissue Antigens (2013) 81(6):408-13. doi:10.1111/tan.12097
84. Jiang Y, Chen S, Jia S, Zhu Z, Gao X, Dong D, et al. Association of HLA-G 3' UTR 14-bp insertion/deletion polymorphism with hepatocellular carcinoma susceptibility in a Chinese population. DNA Cell Biol (2011) 30(12):1027-32. doi:10.1089/dna.2011.1238
85. Lau DT, Norris MD, Marshall GM, Haber M, Ashton LJ. HLA-G polymorphisms, genetic susceptibility, and clinical outcome in childhood neuroblastoma. Tissue Antigens (2011) 78(6):421-7. doi:10.1111/j.1399-0039.2011.01781.x
86. Castelli EC, Mendes-Junior CT, Deghaide NH, de Albuquerque RS, Muniz YC, Simoes RT, et al. The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes. Genes Immun (2010) 11(2):134-41. doi:10.1038/gene.2009.74
87. Ghandri N, Gabbouj S, Farhat K, Bouaouina N, Abdelaziz H, Nouri A, et al. Association of HLA-G polymorphisms with nasopharyngeal carcinoma risk and clinical outcome. Hum Immunol (2011) 72(2):150-8. doi:10.1016/j.humimm.2010.10.006
88. Castelli EC, Mendes-Junior CT, Viana de Camargo JL, Donadi EA. HLA-G polymorphism and transitional cell carcinoma of the bladder in a Brazilian population. Tissue Antigens (2008) 72(2):149-57. doi:10.1111/j.1399-0039.2008.01091.x
89. Rolfsen GB, Castelli EC, Donadi EA, Duarte RA, Soares CP. HLA-G polymorphism and breast cancer. Int J Immunogenet (2014) 41(2):143-8. doi:10.1111/iji.12092
90. Chen Y, Gao XJ, Deng YC, Zhang HX. Relationship between HLA-G gene polymorphism and the susceptibility of esophageal cancer in Kazakh and Han nationality in Xinjiang. Biomarkers (2012) 17(1):9-15. doi:10.3109/1354750X.2011.633242
91. de Oliveira Crispim JC, Silva TG, Souto FJ, Souza FF, Bassi CL, Soares CP, et al. Upregulation of soluble and membrane-bound human leukocyte antigen G expression is primarily observed in the milder histopathological stages of chronic hepatitis C virus infection. Hum Immunol (2012) 73(3):258-62. doi:10.1016/j.humimm.2011.12.004
92. Amiot L, Vu N, Rauch M, L'Helgoualc'h A, Chalmel F, Gascan H, et al. Expression of HLA-G by mast cells is associated with hepatitis C virus-induced liver fibrosis. J Hepatol (2014) 60(2):245-52. doi:10.1016/j.jhep.2013.09.006
93. Weng PJ, Fu YM, Ding SX, Xu DP, Lin A, Yan WH. Elevation of plasma soluble human leukocyte antigen-G in patients with chronic hepatitis C virus infection. Hum Immunol (2011) 72(5):406-11. doi:10.1016/j.humimm.2011.02.008
94. Souto FJ, Crispim JC, Ferreira SC, da Silva AS, Bassi CL, Soares CP, et al. Liver HLA-G expression is associated with multiple clinical and histopathological forms of chronic hepatitis B virus infection. J Viral Hepat (2011) 18(2):102-5. doi:10.1111/j.1365-2893.2010.01286.x
95. Shi WW, Lin A, Xu DP, Bao WG, Zhang JG, Chen SY, et al. Plasma soluble human leukocyte antigen-G expression is a potential clinical biomarker in patients with hepatitis B virus infection. Hum Immunol (2011) 72(11):1068-73. doi:10.1016/j.humimm.2011.06.012
96. Han Q, Li N, Zhu Q, Li Z, Zhang G, Chen J, et al. Association of serum soluble human leukocyte antigen-G levels with chronic hepatitis B virus infection. Clin Exp Med (2014) 14(1):35-43. doi:10.1007/s10238-012-0214-5
97. Cordero EA, Veit TD, da Silva MA, Jacques SM, Silla LM, Chies JA. HLA-G polymorphism influences the susceptibility to HCV infection in sickle cell disease patients. Tissue Antigens (2009) 74(4):308-13. doi:10.1111/j.1399-0039.2009.01331.x
98. da Silva GK, Vianna P, Veit TD, Crovella S, Catamo E, Cordero EA, et al. Influence of HLA-G polymorphisms in human immunodeficiency virus infection and hepatitis C virus co-infection in Brazilian and Italian individuals. Infect Genet Evol (2014) 21:418-23. doi:10.1016/j.meegid.2013.12.013
99. Kim SK, Chung JH, Jeon JW, Park JJ, Cha JM, Joo KR, et al. Association between HLA-G 14-bp insertion/deletion polymorphism and hepatocellular carcinoma in Korean patients with chronic hepatitis B viral infection. Hepatogastroenterology (2013) 60(124):796-8. doi:10.5754/hge11180
100. Sartelet H, Schleiermacher D, Le-Hesran JY, Graesslin O, Gaillard D, Fe M, et al. Less HLA-G expression in Plasmodium falciparum-infected third trimester placentas is associated with more natural killer cells. Placenta (2005) 26(6):505-11. doi:10.1016/j.placenta.2004.08.006
101. Sadissou I, d'Almeida T, Cottrell G, Luty A, Krawice-Radanne I, Massougbodji A, et al. High plasma levels of HLA-G are associated with low birth weight and with an increased risk of malaria in infancy. Malar J (2014) 13(1):312. doi:10.1186/1475-2875-13-312
102. Garcia A, Milet J, Courtin D, Sabbagh A, Massaro JD, Castelli EC, et al. Association of HLA-G 3'UTR polymorphisms with response to malaria infection: a first insight. Infect Genet Evol (2013) 16:263-9. doi:10.1016/j.meegid.2013.02.021
103. Sabbagh A, Courtin D, Milet J, Massaro JD, Castelli EC, Migot-Nabias F, et al. Association of HLA-G 3' untranslated region polymorphisms with antibody response against Plasmodium falciparum antigens: preliminary results. Tissue Antigens (2013) 82(1):53-8. doi:10.1111/tan.12140
104. Courtin D, Milet J, Sabbagh A, Massaro JD, Castelli EC, Jamonneau V, et al. HLA-G 3' UTR-2 haplotype is associated with human African trypanosomiasis susceptibility. Infect Genet Evol (2013) 17:1-7. doi:10.1016/j.meegid.2013.03.004
105. Ayo CM, Dalalio MM, Visentainer JE, Reis PG, Sippert EA, Jarduli LR, et al. Genetic susceptibility to Chagas disease: an overview about the infection and about the association between disease and the immune response genes. Biomed Res Int (2013) 2013:284729. doi:10.1155/2013/284729
106. Marin-Neto JA, Rassi A Jr. Update on Chagas heart disease on the first centennial of its discovery. Rev Esp Cardiol (2009) 62(11):1211-6. doi:10.1016/S1885-5857(09)73346-8
107. Dias FC, Mendes-Junior CT, da Silva MC, Tristão FSM, Dellalibera-Joviliano R, Moreau P, et al. Human leukocyte antigen-G (HLA-G) and its murine functional homolog Qa2 in the Trypanosoma cruzi infection. Mediators Inflamm (2014) 2014:595289. doi:10.1155/2014/595829