Altered pattern of major histocompatibility complex expression in renal carcinoma: Tumor-specific expression of the nonclassical human leukocyte antigen-G molecule is restricted to clear cell carcinoma while up-regulation of other major histocompatibility complex antigens is primarily distributed in all subtypes of renal carcinoma

American Journal of Pathology

Volumn 162, Issue 2, 2003, Pages 501-508

  Ibrahim, El Chérif ^a,c   Allory, Yves ^a   Commo, Frédéric ^a   Gattegno, Bernard ^a   Callard, Patrice ^a   Paul, Pascale ^b,d  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^c HARVARD MEDICAL SCHOOL   (United States)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 1B; HLA ANTIGEN CLASS 2; HUMAN LEUKOCYTE ANTIGEN G; LEUKOCYTE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; PARAFFIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER CLASSIFICATION; CELL LINEAGE; CELLULAR DISTRIBUTION; CHROMOPHOBE ADENOMA; CLEAR CELL CARCINOMA; CLINICAL ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; KIDNEY CARCINOMA; KIDNEY CELL; KIDNEY COLLECTING TUBULE; KIDNEY EPITHELIUM; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MALIGNANT TRANSFORMATION; OBSERVATION; ONCOCYTOMA; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROCESS CONTROL; PROTEIN EXPRESSION; TISSUE SPECIFICITY;

EID: 0037331563     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63844-8     Document Type: Article

References (47)

1. Le Bouteiller P, Blaschitz A: The functionality of HLA-G is emerging. Immunol Rev 1999, 167:233-244
2. Rebmann V, Pfeiffer K, Pässler M, Ferrone S, Maier S, Weiss E, Grosse-Wilde H: Detection of soluble HLA-G molecules in plasma and amniotic fluid. Tissue Antigens 1999, 53:14-22
3. Kovats S, Main EK, Librach C, Stubblebine M, Fisher SJ, DeMars R: A class I antigen, HLA-G, expressed in human trophoblasts. Science 1990, 248:220-223
4. Navarro F, Llano M, Bellon T, Colonna M, Geraghty DE, Lopez-Botet M: The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. Eur J Immunol 1999, 29:277-283
5. Ponte M, Cantoni C, Biassoni R, Tradori-Cappai A, Bentivoglio G, Vitale C, Bertone S, Moretta A, Moretta L, Mingari MC: Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94/NKG2A and acquire p49, an HLA-G1-specific receptor. Proc Natl Acad Sci USA 1999, 96:5674-5679
6. Rajagopalan S, Long EO: A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells. J Exp Med 1999, 189:1093-1100
7. + NK cell clones. Int Immunol 1999, 11:29-35
8. Saverino D, Fabbi M, Ghiotto F, Merlo A, Bruno S, Zarcone D, Tenca C, Tiso M, Santoro G, Anastasi G, Cosman D, Grossi CE, Ciccone E: The CD85/LIR-1/ILT2 inhibitory receptor is expressed by all human T lymphocytes and down-regulates their functions. J Immunol 2000, 165:3742-3755
9. Riteau B, Menier C, Khalil-Daher I, Martinozzi S, Pla M, Dausset J, Carosella ED, Rouas-Freiss N: HLA-G1 co-expression boosts the HLA class I-mediated NK lysis inhibition. Int Immunol 2001, 13:193-201
10. Colonna M, Navarro F, Bellon T, Llano M, Garcià P, Samaridis J, Angman L, Cella M, Lopez-Botet M: A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 1997, 186:1809-1818
11. Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, Dunbar R, Ogg GS, Cerundolo V, Rolink A: Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol 1998, 160:3096-3100
12. Allan DS, Colonna M, Lanier LL, Churakova TD, Abrams JS, Ellis SA, McMichael AJ, Braud VM: Tetrameric complexes of human histocompatibility leukocyte antigen (HLA-G) bind to peripheral blood myelomonocytic cells. J Exp Med 1999, 189:1149-1156
13. Llano M, Lee N, Navarro F, Garcia P, Pablo Albar J, Geraghty DE, Lopez-Botet M: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer. Eur J Immunol 1998, 28:2854-2863
14. Valés-Gomez M, Reyburn HT, Erskine RA, Lopez-Botet M, Strominger JL: Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. EMBO J 1999, 18:4250-4260
15. Marincola FM, Jaffee EM, Hicklin DJ, Ferrone S: Escape of human solid tumours from T-cell recognition: molecular mechanisms and functional significance. Adv Immunol 2000, 74:181-263
16. Paul P, Adrian-Cabestre F, Le Gal FA, Khalil-Daher I, Le Danff C, Schmid M, Mercier S, Avril MF, Dausset J, Guillet J-G, Carosella ED: Heterogeneity of HLA-G gene transcription and protein expression in malignant melanoma biopsies. Cancer Res 1999, 59:1954-1960
17. Wagner SN, Rebmann V, Willers CP, Grosse-Wilde H, Goos M: Expression analysis of classic and non-classic HLA molecules before interferon alfa-2b treatment of melanoma. Lancet 2000, 356:220-221
18. Urosevic M, Kurrer MO, Kamarashev J, Mueller B, Weder W, Burg G, Stahel RA, Dummer R, Trojan A: Human leukocyte antigen up-regulation in lung cancer associates with high-grade histology, human leukocyte antigen class I loss and interleukin-10 production. Am J Pathol 2001, 159:817-824
19. Urosevic M, Willers J, Mueller B, Kempf W, Burg G, Dummer R: HLA-G protein up-regulation in primary cutaneous lymphoma is associated with interleukin-10 expression in large cell T-cell lymphomas and indolent B-cell lymphomas. Blood 2002, 99:609-617
20. Lefebvre S, Antoine M, Uzan S, McMaster M, Dausset J, Carosella ED, Paul P: Specific activation of the non-classical class I histocompatibility HLA-G antigen and expression of the ILT2 inhibitory receptor in human breast cancer. J Pathol 2002, 196:266-274
21. Ibrahim EC, Guerra N, Terrier Lacombe M-J, Angevin E, Chouaib S, Carosella ED, Caignard A, Paul P: Tumor-specific up-regulation of the nonclassical class I HLA-G antigen expression in renal carcinoma. Cancer Res 2001, 61:6838-6845
22. Lefebvre S, Berrih-Aknin S, Adrian F, Moreau P, Poea S, Gourand L, Dausset J, Carosella ED, Paul P: A specific ISRE of the distal HLA-G promoter binds IRF-1 and mediates enhancement of this nonclassical histocompatibility class I gene by IFN-beta. J Biol Chem 2001, 276:6133-6139
23. Kovacs G, Akhtar M, Beckwith BJ, Bugert P, Cooper CS, Delahunt B, Eble JN, Fleming S, Ljunberg B, Medeiros LJ, Moch H, Reuter VE, Ritz E, Roos G, Schmidt D, Srigley JR, Storkel S, van den Berg E, Zbar B: The Heidelberg classification of renal cell tumours. J Pathol 1997, 183:131-133
24. Storkel S, Eble JN, Adlakha K, Amin M, Blute ML, Bostwick DG, Darson M, Delahunt B, Iczkowski K: Classification of renal cell carcinoma: Workgroup No. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). Cancer 1997, 80:987-989
25. Reuter VE, Presti Jr JC: Contemporary approach to the classification of renal epithelial tumors. Semin Oncol 2000, 27:124-137
26. Sobin LH, Witteking CH: International Union Against Cancer. TNM Classification of Malignant Tumors, ed 5. New York, Wiley-Liss, 1997
27. Fuhrman SA, Lasky LC, Limas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982, 6:655-663
28. McMaster M, Zhou Y, Shorter S, Kapasi K, Geraghty D, Lim K-H, Fisher S: HLA-G isoforms produced by placental cytotrophoblasts and found in amniotic fluid are due to unusual glycosylation. J Immunol 1998, 160:5922-5928
29. Stam NJ, Spits H, Ploegh HL: Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products. J Immunol 1986, 137:2299-2306
30. Lan HY, Mu W, Nikolic-Paterson DJ, Atkins RC: A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J Histochem Cytochem 1995, 43:97-102
31. Helbert MJF, Dauwe SEH, De Broe ME: Flow cytometric immunodissection of the human distal tubule and cortical collecting duct system. Kidney Int 2001, 59:554-564
32. Debiec H, Christensen EI, Ronco PM: The cell adhesion molecule L1 is developmentally regulated in the renal epithelium and is involved in kidney branching morphogenesis. J Cell Biol 1998, 143:2067-2079
33. Natali PG, Nicotra MR, Bigotti A, Venturo I, Marcenaro L, Giacomini P, Russo C: Selective changes in expression of HLA class I polymorphic determinants in human solid tumors. Proc Natl Acad Sci USA 1989, 86:6719-6723
34. Luboldt H-J, Kubens BS, Rübben H, Grosse-Wilde H: Selective loss of human leukocyte antigen class I allele expression in advanced renal cell carcinoma. Cancer Res 1996, 56:826-830
35. Natali PG, Bigotti A, Nicotra MR, Viora M, Manfredi D, Ferrone S: Distribution of human class I (HLA-A, B, C) histocompatibility antigens in normal and malignant tissues of nonlymphoid origin. Cancer Res 1984, 44:4679-4687
36. Droz D, Zachar D, Charbit L, Gogusev J, Chrétien Y, Iris L: Expression of the human nephron differentiation molecules in renal cell carcinomas. Am J Pathol 1990, 137:895-905
37. Cordon-Cardo C, Fuks Z, Drobnjak M, Moreno C, Eisenbach L, Feldman M: Expression of HLA-A, B, C antigens on primary and metastatic tumor cell populations of human carcinomas. Cancer Res 1991, 51:6372-6380
38. Buszello H, Ackermann R: Immunohistochemical studies on the expression of HLA class I antigens in renal cell carcinoma: comparison of primary and metastatic tumor tissue. Eur Urol 1994, 25:158-163
39. Ohmori T, Okada K, Arita N, Watanabe Y, Miyazaki T, Tabei R: Characteristics of MHC antigen expression and tumor-infiltrating mononuclear cells in renal cell adenomas and carcinomas. Histol Histopathol 1995, 10:789-794
40. lck in T-cell infiltrating human renal cell carcinoma. Cancer Res 1993, 53:5613-5616
41. Uzzo RG, Rayman P, Kolenko V, Clark PE, Bloom T, Ward AM, Molto L, Tannenbaum C, Worford LJ, Bukowski RM, Tubbs R, Hsi ED, Bander NH, Novick AC, Finke JH: Mechanisms of apoptosis in T cells from patients with renal cell carcinoma. Clin Cancer Res 1999, 5:1219-1229
42. Guerra N, Guillard M, Angevin E, Echchakir H, Escudier B, Moretta A, Chouaib S, Caignard A: Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas. Blood 2000, 95:2883-2889
43. + T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res 2001, 61:5132-5136
44. Edidin M: MHC antigens and non-immune functions. Immunol Today 1983, 4:269-270
45. Borthwick GM, Hughes L, Holmes CH, Davis SJ, Stirrat GM: Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney. Br J Cancer 1988, 58:753-761
46. Young AN, Amin MB, Moreno CS, Dug Lim S, Cohen C, Petros JA, Marshall FF, Neish AS: Expression profiling of renal epithelial neoplasms. A method for tumor classification and discovery of diagnostic molecular markers. Am J Pathol 2001, 158:1639-1651
47. Störkel S: Pathology of renal cell carcinomas. Urologic Cancer. Edited by MS Ernstoff, JA Heaney, RF Peschel. London, Blackwell Science, 1997, pp 357-375