메뉴 건너뛰기




Volumn 63, Issue 1, 2014, Pages 53-63

Cyclosporine a regulates pro-inflammatory cytokine production in ulcerative colitis

Author keywords

Apoptosis; Cyclosporine A; IBD; IL 13; Ulcerative colitis

Indexed keywords

ADALIMUMAB; AMINOSALICYLIC ACID; AZATHIOPRINE; CASPASE 8; CORTICOSTEROID; CYCLOSPORIN A; CYTOKINE; GAMMA INTERFERON; INFLIXIMAB; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; NECROSTATIN 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CASP8 PROTEIN, HUMAN; CYCLOSPORIN;

EID: 84926632207     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-014-0309-7     Document Type: Article
Times cited : (14)

References (53)
  • 1
    • 0026513149 scopus 로고
    • Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a singlecell level
    • Andersson J, Nagy S, Groth CG et al (1992) Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a singlecell level. Immunology 75:136-142
    • (1992) Immunology , vol.75 , pp. 136-142
    • Andersson, J.1    Nagy, S.2    Groth, C.G.3
  • 2
    • 81855209849 scopus 로고    scopus 로고
    • Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14? macrophages
    • Atreya R, Zimmer M, Bartsch B et al (2011) Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14? macrophages. Gastroenterology 141:2026-2038
    • (2011) Gastroenterology , vol.141 , pp. 2026-2038
    • Atreya, R.1    Zimmer, M.2    Bartsch, B.3
  • 3
    • 84881030277 scopus 로고    scopus 로고
    • Complex roles of caspases in the pathogenesis of inflammatory bowel disease
    • Becker C, Watson AJ, Neurath MF (2013) Complex roles of caspases in the pathogenesis of inflammatory bowel disease. Gastroenterology 144:283-293
    • (2013) Gastroenterology , vol.144 , pp. 283-293
    • Becker, C.1    Watson, A.J.2    Neurath, M.F.3
  • 4
    • 0029847082 scopus 로고    scopus 로고
    • Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis
    • Boirivant M, Pica R, DeMaria R et al (1996) Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis. J Clin Invest 98:2616-2622
    • (1996) J Clin Invest , vol.98 , pp. 2616-2622
    • Boirivant, M.1    Pica, R.2    Demaria, R.3
  • 5
    • 0025834538 scopus 로고
    • Final report on a placebo-controlled, double-blind, randomized, multicentre trial of cyclosporin treatment in active chronic Crohn’s disease
    • Brynskov J, Freund L, Norby Rasmussen S et al (1991) Final report on a placebo-controlled, double-blind, randomized, multicentre trial of cyclosporin treatment in active chronic Crohn’s disease. Scand J Gastroenterol 26:689-695
    • (1991) Scand J Gastroenterol , vol.26 , pp. 689-695
    • Brynskov, J.1    Freund, L.2    Norby Rasmussen, S.3
  • 6
    • 0034885172 scopus 로고    scopus 로고
    • Low-dose cyclosporin A microemulsion in children with severe atopic dermatitis: Clinical and immunological effects
    • Bunikowski R, Staab D, Kussebi F et al (2001) Low-dose cyclosporin A microemulsion in children with severe atopic dermatitis: clinical and immunological effects. Pediatr Allergy Immunol 12:216-223
    • (2001) Pediatr Allergy Immunol , vol.12 , pp. 216-223
    • Bunikowski, R.1    Staab, D.2    Kussebi, F.3
  • 7
    • 0032199208 scopus 로고    scopus 로고
    • Altered expression of interferon-gamma and interleukin-4 in inflammatory bowel disease
    • Camoglio L, Te Velde AA, Tigges AJ et al (1998) Altered expression of interferon-gamma and interleukin-4 in inflammatory bowel disease. Inflamm Bowel Dis 4:285-290
    • (1998) Inflamm Bowel Dis , vol.4 , pp. 285-290
    • Camoglio, L.1    Te Velde, A.A.2    Tigges, A.J.3
  • 8
    • 84878740844 scopus 로고    scopus 로고
    • Infliximab versus cyclosporine as rescue therapy in acute severe steroid-refractory ulcerative colitis: A systematic review and meta-analysis
    • Chang KH, Burke JP, Coffey JC (2013) Infliximab versus cyclosporine as rescue therapy in acute severe steroid-refractory ulcerative colitis: a systematic review and meta-analysis. Int J Colorectal Dis 28:287-293
    • (2013) Int J Colorectal Dis , vol.28 , pp. 287-293
    • Chang, K.H.1    Burke, J.P.2    Coffey, J.C.3
  • 9
    • 77955645474 scopus 로고    scopus 로고
    • Production of interleukin-17 in Behcet’s disease is inhibited by cyclosporin A
    • Chi W, Yang P, Zhu X et al (2010) Production of interleukin-17 in Behcet’s disease is inhibited by cyclosporin A. Mol Vis 16:880-886
    • (2010) Mol Vis , vol.16 , pp. 880-886
    • Chi, W.1    Yang, P.2    Zhu, X.3
  • 10
    • 65449145198 scopus 로고    scopus 로고
    • Pathogenesis of and unifying hypothesis for idiopathic pouchitis
    • Coffey JC, Rowan F, Burke J et al (2009) Pathogenesis of and unifying hypothesis for idiopathic pouchitis. Am J Gastroenterol 104:1013-1023
    • (2009) Am J Gastroenterol , vol.104 , pp. 1013-1023
    • Coffey, J.C.1    Rowan, F.2    Burke, J.3
  • 11
    • 0141762545 scopus 로고    scopus 로고
    • TGF-beta1 production in inflammatory bowel disease: Differing production patterns in Crohn’s disease and ulcerative colitis
    • Del Zotto B, Mumolo G, Pronio AM et al (2003) TGF-beta1 production in inflammatory bowel disease: differing production patterns in Crohn’s disease and ulcerative colitis. Clin Exp Immunol 134:120-126
    • (2003) Clin Exp Immunol , vol.134 , pp. 120-126
    • Del Zotto, B.1    Mumolo, G.2    Pronio, A.M.3
  • 12
    • 84872482577 scopus 로고    scopus 로고
    • The change of cellular membranes on apoptosis: Fluorescence detection
    • Demchenko AP (2012) The change of cellular membranes on apoptosis: fluorescence detection. Exp Oncol 34:263-268
    • (2012) Exp Oncol , vol.34 , pp. 263-268
    • Demchenko, A.P.1
  • 13
    • 18744425752 scopus 로고    scopus 로고
    • Distinct cytokine patterns in early and chronic ileal lesions of Crohn’s disease
    • Desreumaux P, Brandt E, Gambiez L et al (1997) Distinct cytokine patterns in early and chronic ileal lesions of Crohn’s disease. Gastroenterology 113:118-126
    • (1997) Gastroenterology , vol.113 , pp. 118-126
    • Desreumaux, P.1    Brandt, E.2    Gambiez, L.3
  • 14
    • 0035045816 scopus 로고    scopus 로고
    • Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis
    • D’Haens G, Lemmens L, Geboes K et al (2001) Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis. Gastroenterology 120:1323-1329
    • (2001) Gastroenterology , vol.120 , pp. 1323-1329
    • D’Haens, G.1    Lemmens, L.2    Geboes, K.3
  • 15
    • 7244223147 scopus 로고    scopus 로고
    • Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn’s disease
    • Doering J, Begue B, Lentze MJ et al (2004) Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn’s disease. Gut 53:1632-1638
    • (2004) Gut , vol.53 , pp. 1632-1638
    • Doering, J.1    Begue, B.2    Lentze, M.J.3
  • 16
    • 0028362206 scopus 로고
    • Low-dose cyclosporine for the treatment of Crohn’s disease. The canadian Crohns relapse prevention trial investigators
    • Feagan BG, McDonald JW, Rochon J et al (1994) Low-dose cyclosporine for the treatment of Crohn’s disease. The canadian Crohns relapse prevention trial investigators. N Engl J Med 330:1846-1851
    • (1994) N Engl J Med , vol.330 , pp. 1846-1851
    • Feagan, B.G.1    McDonald, J.W.2    Rochon, J.3
  • 17
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino S, Andoh A, Bamba S et al (2003) Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52:65-70
    • (2003) Gut , vol.52 , pp. 65-70
    • Fujino, S.1    Oh, A.2    Bamba, S.3
  • 18
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4? Lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss IJ, Neurath M, Boirivant M et al (1996) Disparate CD4? lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157:1261-1270
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3
  • 19
    • 0024272439 scopus 로고
    • In situ hybridization for interleukin 2 and interleukin 2 receptor mRNA in T cells activated in the presence or absence of cyclosporin A
    • Granelli-Piperno A (1988) In situ hybridization for interleukin 2 and interleukin 2 receptor mRNA in T cells activated in the presence or absence of cyclosporin A. J Exp Med 168:1649-1658
    • (1988) J Exp Med , vol.168 , pp. 1649-1658
    • Granelli-Piperno, A.1
  • 20
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899-1911
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 21
    • 80052845560 scopus 로고    scopus 로고
    • Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis
    • Gunther C, Martini E, Wittkopf N et al (2011) Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis. Nature 477:335-339
    • (2011) Nature , vol.477 , pp. 335-339
    • Gunther, C.1    Martini, E.2    Wittkopf, N.3
  • 22
    • 0035875516 scopus 로고    scopus 로고
    • Cyclosporin A treatment modulates cytokine mRNA expression by inflammatory cells extracted from the spinal cord of rats with experimental autoimmune encephalomyelitis induced by inoculation with myelin basic protein
    • Harness J, Pender MP, McCombe PA (2001) Cyclosporin A treatment modulates cytokine mRNA expression by inflammatory cells extracted from the spinal cord of rats with experimental autoimmune encephalomyelitis induced by inoculation with myelin basic protein. J Neurol Sci 187:7-16
    • (2001) J Neurol Sci , vol.187 , pp. 7-16
    • Harness, J.1    Pender, M.P.2    McCombe, P.A.3
  • 23
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • Heller F, Florian P, Bojarski C et al (2005) Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 129:550-564
    • (2005) Gastroenterology , vol.129 , pp. 550-564
    • Heller, F.1    Florian, P.2    Bojarski, C.3
  • 24
    • 84857682579 scopus 로고    scopus 로고
    • Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics
    • Hering NA, Fromm M, Schulzke JD (2012) Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics. J Physiol 590(5):1035-1044
    • (2012) J Physiol , vol.590 , Issue.5 , pp. 1035-1044
    • Hering, N.A.1    Fromm, M.2    Schulzke, J.D.3
  • 25
    • 34447621968 scopus 로고    scopus 로고
    • CD44v7 ligation downregulates the inflammatory immune response in Crohn’s disease patients by apoptosis induction in mononuclear cells from the lamina propria
    • Hoffmann U, Heilmann K, Hayford C et al (2007) CD44v7 ligation downregulates the inflammatory immune response in Crohn’s disease patients by apoptosis induction in mononuclear cells from the lamina propria. Cell Death Differ 14:1542-1551
    • (2007) Cell Death Differ , vol.14 , pp. 1542-1551
    • Hoffmann, U.1    Heilmann, K.2    Hayford, C.3
  • 26
    • 20044389090 scopus 로고    scopus 로고
    • Immunomodulatory benefits of cyclosporine A in inflammatory bowel disease
    • Kountouras J, Zavos C, Chatzopoulos D (2004) Immunomodulatory benefits of cyclosporine A in inflammatory bowel disease. J Cell Mol Med 8:317-328
    • (2004) J Cell Mol Med , vol.8 , pp. 317-328
    • Kountouras, J.1    Zavos, C.2    Chatzopoulos, D.3
  • 27
    • 84871426027 scopus 로고    scopus 로고
    • The roles of FADD in extrinsic apoptosis and necroptosis
    • Lee EW, Seo J, Jeong M et al (2012) The roles of FADD in extrinsic apoptosis and necroptosis. BMB Rep 45:496-508
    • (2012) BMB Rep , vol.45 , pp. 496-508
    • Lee, E.W.1    Seo, J.2    Jeong, M.3
  • 28
    • 0028292007 scopus 로고
    • Cyclosporine in severe ulcerative colitis refractory to steroid therapy
    • Lichtiger S, Present DH, Kornbluth A et al (1994) Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med 330:1841-1845
    • (1994) N Engl J Med , vol.330 , pp. 1841-1845
    • Lichtiger, S.1    Present, D.H.2    Kornbluth, A.3
  • 29
    • 0034923470 scopus 로고    scopus 로고
    • IL-12 and Th1immune responses in human Peyer’s patches
    • MacDonald TT, Monteleone G (2001) IL-12 and Th1immune responses in human Peyer’s patches. Trends Immunol 22:244-247
    • (2001) Trends Immunol , vol.22 , pp. 244-247
    • Macdonald, T.T.1    Monteleone, G.2
  • 30
    • 84879215148 scopus 로고    scopus 로고
    • Distinct roles for CXCR6 and CXCR6 CD4 T cells in the pathogenesis of chronic colitis
    • Mandai Y, Takahashi D, Hase K et al (2013) Distinct roles for CXCR6 and CXCR6 CD4 T cells in the pathogenesis of chronic colitis. PLoS ONE 8:e65488
    • (2013) Plos ONE , vol.8
    • Mandai, Y.1    Takahashi, D.2    Hase, K.3
  • 31
    • 84868688331 scopus 로고    scopus 로고
    • Interleukin 13 and its role in gut defence and inflammation
    • Mannon P, Reinisch W (2012) Interleukin 13 and its role in gut defence and inflammation. Gut 61:1765-1773
    • (2012) Gut , vol.61 , pp. 1765-1773
    • Mannon, P.1    Reinisch, W.2
  • 32
    • 0036324867 scopus 로고    scopus 로고
    • TGF-beta (Transforming growth factor-beta) in chronic inflammatory conditions—a new diagnostic and prognostic marker?
    • Marek A, Brodzicki J, Liberek A et al (2002) TGF-beta (transforming growth factor-beta) in chronic inflammatory conditions—a new diagnostic and prognostic marker? Med Sci Monit 8:145-151
    • (2002) Med Sci Monit , vol.8 , pp. 145-151
    • Marek, A.1    Brodzicki, J.2    Liberek, A.3
  • 33
    • 4344591762 scopus 로고    scopus 로고
    • T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn’s disease
    • Matsuoka K, Inoue N, Sato T et al (2004) T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn’s disease. Gut 53:1303-1308
    • (2004) Gut , vol.53 , pp. 1303-1308
    • Matsuoka, K.1    Inoue, N.2    Sato, T.3
  • 34
    • 0032957972 scopus 로고    scopus 로고
    • Effects of cyclosporin A treatment on clinical course and inflammatory cell apoptosis in experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein
    • McCombe PA, Harness J, Pender MP (1999) Effects of cyclosporin A treatment on clinical course and inflammatory cell apoptosis in experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein. J Neuroimmunol 97:60-69
    • (1999) J Neuroimmunol , vol.97 , pp. 60-69
    • McCombe, P.A.1    Harness, J.2    Pender, M.P.3
  • 35
    • 0031868979 scopus 로고    scopus 로고
    • Cyclosporine and inflammatory bowel disease: Buying time
    • Meijssen MA (1998) Cyclosporine and inflammatory bowel disease: buying time. Mediat Inflamm 7:145-147
    • (1998) Mediat Inflamm , vol.7 , pp. 145-147
    • Meijssen, M.A.1
  • 36
    • 0141650591 scopus 로고    scopus 로고
    • Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis
    • Melgar S, Yeung MM, Bas A et al (2003) Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis. Clin Exp Immunol 134:127-137
    • (2003) Clin Exp Immunol , vol.134 , pp. 127-137
    • Melgar, S.1    Yeung, M.M.2    Bas, A.3
  • 37
    • 33847000579 scopus 로고    scopus 로고
    • Apoptosis of T cells and the control of inflammatory bowel disease: Therapeutic implications
    • Mudter J, Neurath MF (2007) Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications. Gut 56:293-303
    • (2007) Gut , vol.56 , pp. 293-303
    • Mudter, J.1    Neurath, M.F.2
  • 38
    • 0034924839 scopus 로고    scopus 로고
    • Regulation of T-cell apoptosis in inflammatory bowel disease: To die or not to die, that is the mucosal question
    • Neurath MF, Finotto S, Fuss I et al (2001) Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question. Trends Immunol 22:21-26
    • (2001) Trends Immunol , vol.22 , pp. 21-26
    • Neurath, M.F.1    Finotto, S.2    Fuss, I.3
  • 39
    • 78650063044 scopus 로고    scopus 로고
    • Cyclosporin A-treated dendritic cells may affect the outcome of organ transplantation by decreasing CD4 ? CD25 ? regulatory T cell proliferation
    • Pino-Lagos K, Michea P, Sauma D et al (2010) Cyclosporin A-treated dendritic cells may affect the outcome of organ transplantation by decreasing CD4 ? CD25 ? regulatory T cell proliferation. Biol Res 43:333-337
    • (2010) Biol Res , vol.43 , pp. 333-337
    • Pino-Lagos, K.1    Michea, P.2    Sauma, D.3
  • 40
    • 0033938680 scopus 로고    scopus 로고
    • Differences in regulatory pathways identify subgroups of T cell-derived Th2 cytokines
    • Rafiq K, Bullens DM, Kasran A et al (2000) Differences in regulatory pathways identify subgroups of T cell-derived Th2 cytokines. Clin Exp Immunol 121:86-93
    • (2000) Clin Exp Immunol , vol.121 , pp. 86-93
    • Rafiq, K.1    Bullens, D.M.2    Kasran, A.3
  • 42
    • 84873616370 scopus 로고    scopus 로고
    • CD4? T-cell subsets in intestinal inflammation
    • Shale M, Schiering C, Powrie F (2013) CD4? T-cell subsets in intestinal inflammation. Immunol Rev 252:164-182
    • (2013) Immunol Rev , vol.252 , pp. 164-182
    • Shale, M.1    Schiering, C.2    Powrie, F.3
  • 43
    • 84887992627 scopus 로고    scopus 로고
    • Pouchitis: What every gastroenterologist needs to know
    • Shen B (2013) Pouchitis: what every gastroenterologist needs to know. Clin Gastroenterol Hepatol 11:1538-1549
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 1538-1549
    • Shen, B.1
  • 44
    • 21744455700 scopus 로고    scopus 로고
    • Review article: Practical management of inflammatory bowel disease patients taking immunomodulators
    • Siegel CA, Sands BE (2005) Review article: practical management of inflammatory bowel disease patients taking immunomodulators. Aliment Pharmacol Ther 22:1-16
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 1-16
    • Siegel, C.A.1    Sands, B.E.2
  • 45
    • 0029150951 scopus 로고
    • European trial of cyclosporine in chronic active Crohn’s disease: A 12-month study. The European Study Group
    • Stange EF, Modigliani R, Pena AS et al (1995) European trial of cyclosporine in chronic active Crohn’s disease: a 12-month study. The European Study Group. Gastroenterology 109:774-782
    • (1995) Gastroenterology , vol.109 , pp. 774-782
    • Stange, E.F.1    Modigliani, R.2    Pena, A.S.3
  • 46
    • 0036151047 scopus 로고    scopus 로고
    • Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn’s disease
    • ten Hove T, van Montfrans C, Peppelenbosch MP et al (2002) Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn’s disease. Gut 50:206-211
    • (2002) Gut , vol.50 , pp. 206-211
    • Ten Hove, T.1    Van Montfrans, C.2    Peppelenbosch, M.P.3
  • 47
    • 0242464926 scopus 로고    scopus 로고
    • CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4? T lymphocytes
    • Tiede I, Fritz G, Strand S et al (2003) CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4? T lymphocytes. J Clin Invest 111:1133-1145
    • (2003) J Clin Invest , vol.111 , pp. 1133-1145
    • Tiede, I.1    Fritz, G.2    Strand, S.3
  • 48
    • 84857124663 scopus 로고    scopus 로고
    • Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naive T cells into cytokine-producing mature T cells
    • Tsuda K, Yamanaka K, Kitagawa H et al (2012) Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naive T cells into cytokine-producing mature T cells. PLoS ONE 7:e31465
    • (2012) Plos ONE , vol.7
    • Tsuda, K.1    Yamanaka, K.2    Kitagawa, H.3
  • 49
    • 10744231879 scopus 로고    scopus 로고
    • Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis
    • Van Assche G, D’Haens G, Noman M et al (2003) Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis. Gastroenterology 125:1025-1031
    • (2003) Gastroenterology , vol.125 , pp. 1025-1031
    • Van Assche, G.1    D’Haens, G.2    Noman, M.3
  • 50
    • 34147211616 scopus 로고    scopus 로고
    • Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn’s disease
    • Van den Brande JM, Koehler TC, Zelinkova Z et al (2007) Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn’s disease. Gut 56:509-517
    • (2007) Gut , vol.56 , pp. 509-517
    • Van Den Brande, J.M.1    Koehler, T.C.2    Zelinkova, Z.3
  • 51
    • 84897985897 scopus 로고    scopus 로고
    • Functional bowel symptoms in quiescent inflammatory bowel diseases: Role of epithelial barrier disruption and low-grade inflammation
    • Vivinus-Nebot M, Frin-Mathy G, Bzioueche H et al (2014) Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation. Gut 63:744-752
    • (2014) Gut , vol.63 , pp. 744-752
    • Vivinus-Nebot, M.1    Frin-Mathy, G.2    Bzioueche, H.3
  • 52
    • 79959707225 scopus 로고    scopus 로고
    • Apoptosis and beyond: Cytometry in studies of programmed cell death
    • Wlodkowic D, Telford W, Skommer J et al (2011) Apoptosis and beyond: cytometry in studies of programmed cell death. Methods Cell Biol 103:55-98
    • (2011) Methods Cell Biol , vol.103 , pp. 55-98
    • Wlodkowic, D.1    Telford, W.2    Skommer, J.3
  • 53
    • 84883721491 scopus 로고    scopus 로고
    • Transcriptional modulation of pattern recognition receptors in acute colitis in mice
    • Zheng B, Morgan ME, van de Kant HJ et al (2013) Transcriptional modulation of pattern recognition receptors in acute colitis in mice. Biochim Biophys Acta 1832:2162-2172
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 2162-2172
    • Zheng, B.1    Morgan, M.E.2    Van De Kant, H.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.