TGF-β (transforming growth factor-β) in chronic inflammatory conditions - A new diagnostic and prognostic marker?

Medical Science Monitor

Volumn 8, Issue 7, 2002, Pages

  Marek, Andrzej ^a   Brodzicki, Jacek ^a   Liberek, Anna ^a   Korzon, Maria ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Chronic hepatitis; Inflammatory bowel disease; Transforming growth factor

Indexed keywords

BINDING PROTEIN; CYTOKINE; MESSENGER RNA; PLASMIN; THROMBIN; TRANSFORMING GROWTH FACTOR BETA; BIOLOGICAL MARKER; ISOPROTEIN;

ADULT; CELIAC DISEASE; CHILD; CHRONIC DISEASE; CHRONIC HEPATITIS; CONTROLLED STUDY; CROHN DISEASE; DIAGNOSTIC VALUE; ENTERITIS; HEPATITIS B; HEPATITIS C; HUMAN; INFLAMMATORY DISEASE; NECROTIZING ENTEROCOLITIS; PROGNOSIS; REVIEW; ULCERATIVE COLITIS; VIRUS HEPATITIS; ANIMAL; IMMUNOLOGY; INFLAMMATION; LIVER DISEASE; METABOLISM; PEDIATRICS;

ADULT; ANIMAL; BIOLOGICAL MARKERS; CHILD; HUMAN; INFLAMMATION; LIVER DISEASES; PEDIATRICS; PROGNOSIS; PROTEIN ISOFORMS; TRANSFORMING GROWTH FACTOR BETA; ANIMALS; HUMANS;

EID: 0036324867     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (58)

1. General characterization of cytokines
2. Advances in the therapy for sepsis in children
3. Inhibition of cytokine production by cydosporin A and TGF-b
4. Latent transforming growth factor-b binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-b
5. Requirement for transglutaminase in the activation of latent transforming growth factor-b in bovine endothelial cells
6. TGF-b signaling from cell membrane to nucleus through SMAD proteins
7. SMAD6 inhibits signaling by TGF-b superfamily
8. Identification of SMAD7. A IGF-b - Inducible antagonist of TGF-b signaling
9. Blockade of transforming growth factorb/Smad signalling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity
10. Blocking Smad7 restores TGF-b1 signalling in chronic inflammatory bowel disease
11. Regulation of TGF-b response during T cell activation is modulated by IL-10
12. The interrelated roles of TGF-b and IL-10 in the regulation of experimental colitis
13. Other cytokines
14. Transforming Growth Factor-b1 as a surrogate marker of hepatic dysfunction in chronic liver disease
15. Transforming Growth Factor b1 selectively augments collagen synthesis by human intestinal smooth muscle cells
16. Cytokine modulation of intestinal epithelial cell restitution: Central role of Transforming Growth Factor b
17. Transforming Growth Factor b is an important immunomodulatory protein for human B lymphocytes
18. TGF-b promotes immune deviation by altering accessory signals of antigen-presenting cells
19. A role for TGF-b in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood
20. Food allergy, coeliac disease and chronic inflammatory bowel disease in man
21. Fas-and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-b
22. Immune dysregulation in TGF-b1-deficient mice
23. Blockade of TGF-b signaling in T cells prevents the development of experimental glomerulonephritis
24. Autoantibodies to tissue transglutaminase as predictors of coeliac disease
25. Duration of exposure to gluten and risk for autoimmune disorders with celiac disease
26. Distribution of transforming growth factor b mRNA and protein in the small intestine
27. VEGF, Basic-FGF anf TGF-b in Crolin's disease and ulcerative colitis: A novel mechanism of chronic intestinal inflammation
28. Inflammatory bowel disease: Ethiology and pathogenesis
29. Loss of Transforming Growth Factor b signalling in die intestine contributes to tissue injury in inflammatory bowel disease
30. TGF-b/Smad signalling defects in inflammatory bowel disease: Mechanisms and possible novel therapies for chronic inflammation
31. Transforming Growth Factor bs and their signalling receptors are coexpressed in Crohn's disease
32. Immunohistochemical lacalisation of transforming growth factor-beta receptors I and II in inflammatory bowel diease
33. Differential expression of TGF-b isoforms by normal and inflammatory bowel disease intestinal myofibroblasts
34. Expression of transforming growth factor a and b in colonic mucosa in inflammatory bowel disease
35. Transforming growth factor b and hepatocyte growth factor plasma levels in patients with inflammatory bowel disease
36. Effects of ulcerative colitis activity on plasma concentration of transforming growth factor b1
37. Experimental model of hepatic fibrosis following repeated periportal necrosis induced by allylalcobol
38. Transforming Growth Factors b1 and a in chronic liver disease. Effects of Interferon alfa therapy
39. Analysis of the expression pattern of the transforming growth factor b binding protein isoformas in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region
40. In situ expression of transforming growth factor b1-3, latent transforming growth factor b binding protein and tumor necrosis factor-a in liver tissue from patients with chronic hepatitis C
41. Reduced plasma transforming growth factor b1 levels in patients with chronic hepatitis C after interferon-a therapy: Association with regression of hepatic fibrosis
42. Fibrosis TGF-b1 marker in blood of chronic hepatitis C patients during interferon a-2B therapy
43. Serum concentrations of sIL-2R, IL-6, TGF-b1, neopterin, and zinc in chronic hepatitis C patients treated with interferon-a
44. Circulating transforming growth factor b1 as an indicator of hepatic function impairment in liver cirrhosis
45. Expression of decortin, transforming growth factor b1, tissue inhibitor metalloproteinase 1 and 2, and type IV collagenases in chronic hepatitis
46. Transformujacy czynnik wzrostowy-beta: Nowe spojrzenie na patogenezȩ zapalenia i stwardnienia klȩbków nerkowych
47. Transforming growth factor-beta (TGF-b) in human milk
48. Transforming growth factor-b levels in maternal milk and expression in postnatal rat duodenum and ileum
49. Expression of transforming growth factor b1, transforming growth factor type I and II receptors, and TNF-a in the mucosa of the small intestine in infants with food protein-induced enterocolitis syndrome
50. Atopic dermatitis is associated with a low-producer transforming growth factor b1 cytokine genotype
51. Circulating levels of transforming growth factor-beta 1 and lymphokines among children with hemolytic uremic syndrome
52. Role of TGF-beta 1 in renal parenchymal scarring following childhood urinary tract infection
53. Differing patterns of transforming growth factor-b expression in normal intestinal mucosa and in active celiac disease
54. The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis
55. Site-specyfic changes in transforming growth facto-a and -bl expression in colonic mucosa of adolescents with inflammatory bowel disease
56. Potential biological role of transforming growth factor-b1 in human congenital kidney malformations
57. Transforming growth factor-beta 1 in plasma and liver of children with liver disease
58. Increased transforming growth factor-beta (TGF-b)-secreting T cells and IgA anti-cardiolipin antibody levels during acute stage of childhood Henoch-Schoenlein purpura