Low-dose cyclosporin A microemulsion in children with severe atopic dermatitis: Clinical and immunological effects

Pediatric Allergy and Immunology

Volumn 12, Issue 4, 2001, Pages 216-223

  Bunikowski, Rita ^a   Staab, Doris ^a   Kussebi, Fatima ^a   Bräutigam, Matthias ^b   Weidinger, Gottfried ^b   Renz, Harald ^c   Wahn, Ulrich ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b NOVARTIS PHARMA GMBH   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

CD3+ T ceils; Interleukin 13; Interleukin 4; Low dose cyclosporin A microemulsion; Severe childhood atopic dermatitis; T cell activation

Indexed keywords

CD3 ANTIGEN; CYCLOSPORIN A; CYTOKINE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4;

ADOLESCENT; ARTICLE; ATOPIC DERMATITIS; CELL ACTIVATION; CELL COUNT; CELL SORTER; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FLUORESCENCE; HUMAN; HYPERTENSION; IMMUNOLOGY; MALE; MICROEMULSION; PRIORITY JOURNAL; RELAPSE; T LYMPHOCYTE; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CYCLOSPORINE; DERMATITIS, ATOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; LYMPHOCYTE SUBSETS; MALE; SEVERITY OF ILLNESS INDEX;

EID: 0034885172     PISSN: 09056157     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3038.2001.012004216.x     Document Type: Article

References (36)

1. Pathogenesis of eczema
2. In situ quantification of T-lymphocyte subsets and Langerhans' cells in the inflammatory infiltrate of atopic eczema
3. Th2 cells mediate IL-4-dependent local tissue inflammation
4. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis
5. IL-4 and interferon-γ production in children with atopic diseases
6. Reduced interferon-γ secretion in neonates and subsequent atopy
7. Decreased frequency of interferon-γ- and interleukin-2-producing cells in patients with atopic diseases measured at the single cell level
8. Proliferation and production of interferon-gamma (IFN-γ) and IL-4 in response to Staphylococcus aureus and staphylococcal superantigen in childhood atopic dermatitis
9. Spontaneous expression of IL-4 mRNA in lymphocytes from children with atopic dermatitis
10. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis
11. Interleukin 13 induces interleukin 4-dependent IgG4 and IgE synthesis and CD23 expression by human B cells
12. Practical management of atopic eczema
13. Double blind, controlled, crossover study of cyclosporin in adults with severe refractory atopic dermatits
14. Cyclosporin in atopic dermatitis: A multicentre placebo-controlled study
15. Cyclosporin in atopic dermatitis: Time to relapse and effect of intermittent therapy
16. Antipruritic effect of oral cyclosporin A in atopic dermatitis
17. Cyclosporine in atopic dermatitis. Modulation in the expression of immunologic markers in lesional skin
18. Cyclosporine in severe childhood atopic dermatitis: A multicenter study
19. Cyclosporin A treatment of severe atopic dermatitis in a child
20. A new galenic formulation of cyclosporin (Neoral) effective in the treatment of cyclosporin-resistant dermatoses
21. Treatment of severe atopic dermatitis in childhood with cyclosporin
22. Cyclosporin for severe childhood atopic dermatitis: Short course versus continuous therapy
23. Cyclosporine micro-emulsion in severe atopic dermatitis
24. Cyclosporine in children with severe atopic dermatitis
25. Renal function and blood pressure in psoriatic patients treated with cyclosporin A
26. A critical evaluation of clinical trials in adverse reactions to food in children
27. Severity scoring of atopic dermatitis: The SCORAD Index. Consensus Report of the Task Force on Atopic Dermatitis
28. Clinical validation and guidelines for the SCORAD Index: Consensus report of the European task force on atopic dermatitis
29. + T lymphocytes
30. Cyclosporin A in the treatment of atopic dermatitis: Effects on the immune system and clinical efficacy
31. Cyclosporin A (CyA) reduces sCD30 serum levels in atopic dermatitis: A possible new immune intervention
32. + memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA-memory T cells
33. In vivo expression of IL-12 and IL-13 in atopic dermatitis
34. Cyclosporin-A enhances IFN-gamma, IL-5 and IL-13 production by T cells costimulated through CD28
35. Regulation of antigen-induced human T-lymphocyte responses by calcineurin antagonists
36. All in vitro efficacy of calcineurin antagonists on antigen-driven human Th0, Th1, and Th2 responses