Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway

Molecular Medicine Reports

Volumn 12, Issue 1, 2015, Pages 865-870

  Wang, Xu Dong ^a   Wang, Qiang ^a   Chen, Xiao Lin ^a   Huang, Jian Fei ^a   Yin, Yong ^a   Da, Peng ^a   Wu, Hao ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Invasion; Laryngeal carcinoma; Proliferation; Trop2

Indexed keywords

CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN P27; SMALL INTERFERING RNA; TROP2 PROTEIN; UNCLASSIFIED DRUG; CELL ADHESION MOLECULE; MITOGEN ACTIVATED PROTEIN KINASE 1; TACSTD2 PROTEIN, HUMAN; TUMOR ANTIGEN;

ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; HEP 2 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL MOTION; CELL SURVIVAL; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; LARYNX TUMOR; PATHOLOGY; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; TUMOR INVASION;

ANTIGENS, NEOPLASM; CARCINOMA, SQUAMOUS CELL; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN D1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; LARYNGEAL NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEOPLASM INVASIVENESS; SIGNAL TRANSDUCTION;

EID: 84926615913     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3485     Document Type: Article

References (19)

1. Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin 62: 10-29, 2012.
2. Chu EA and Kim YJ: Laryngeal cancer: diagnosis and preoperative work-up. Otolaryngol Clin North Am 41: 673-695, 2008.
3. Dirix P, Lambrecht M and Nuyts S: Radiotherapy for laryngeal squamous cell carcinoma: current standards. Expert Rev Anticancer Ther 10: 1461-1469, 2010.
4. Tsujikawa M, Kurahashi H, Tanaka T, et al: Identification of the gene responsible for gelatinous drop-like corneal dystrophy. Nat Genet 21: 420-423, 1999.
5. Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E and Alberti S: Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. Cytogenet Cell Genet 92: 164-165, 2001.
6. Nakanishi H, Taccioli C, Palatini J, et al: Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway. Oncogene 33: 702-712, 2014.
7. Cubas R, Zhang S, Li M, Chen C and Yao Q: Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer 9: 253, 2010.
8. Kapoor S: TROP2 expression and its evolving role in tumor pathogenesis in systemic tumors. Tumour Biol 34: 1967-1968, 2013.
9. Fong D, Moser P, Krammel C, et al: High expression of TROP2 correlates with poor prognosis in pancreatic cancer. Br J Cancer 99: 1290-1295, 2008.
10. Fong D, Spizzo G, Gostner JM, et al: TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity. Mod Pathol 21: 186-191, 2008.
11. Fang YJ, Lu ZH, Wang GQ, et al: Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. Int J Colorectal Dis 24: 875-884, 2009.
12. Liu T, Liu Y, Bao X, Tian J and Yang X: Overexpression of TROP2 predicts poor prognosis of patients with cervical cancer and promotes the proliferation and invasion of cervical cancer cells by regulating ERK signaling pathway. PLoS One 8: e75864, 2013.
13. Wu H, Xu H, Zhang S, et al: Potential therapeutic target and independent prognostic marker of TROP2 in laryngeal squamous cell carcinoma. Head Neck 35: 1373-1378, 2013.
14. Guerra E, Trerotola M, Aloisi AL, et al: The Trop-2 signalling network in cancer growth. Oncogene 32: 1594-1600, 2013.
15. Cubas R, Li M, Chen C and Yao Q: Trop2: a possible therapeutic target for late stage epithelial carcinomas. Biochim Biophys Acta 1796: 309-314, 2009.
16. Trerotola M, Cantanelli P, Guerra E, et al: Upregulation of Trop-2 quantitatively stimulates human cancer growth. Oncogene 32: 222-233, 2013.
17. Nishi K, Inoue H, Schnier JB and Rice RH: Cyclin D1 downregulation is important for permanent cell cycle exit and initiation of differentiation induced by anchorage-deprivation in human keratinocytes. J Cell Biochem 106: 63-72, 2009.
18. Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL and Dang CV: Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem 276: 7919-7926, 2001.
19. Kolch W: Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351: 289-305, 2000.