The Trop-2 signalling network in cancer growth

Oncogene

Volumn 32, Issue 12, 2013, Pages 1594-1600

  Guerra, E ^a   Trerotola, M ^a,b   Aloisi, A L ^a   Tripaldi, R ^a   Vacca, G ^a   La Sorda, R ^a   Lattanzio, R ^a   Piantelli, M ^a   Alberti, S ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

cell growth; cell signalling; human tumours; Trop 2

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN D1; FORKHEAD BOX M1 PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; GLYCOPROTEIN; GRAINYHEAD LIKE EPITHELIAL TRANSACTIVATOR PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN; PROTEIN P53; STAT1 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GRHL1; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR SPI1; TRANSCRIPTION FACTOR TP53L; TRANSCRIPTION FACTOR TP63; TROP 2 PROTEIN; UNCLASSIFIED DRUG; WILMS TUMOR ASSOCIATED PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; GENE ACTIVATION; GENE INACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GROWTH STIMULATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; CYCLIN D1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; NEOPLASMS; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 84884211535     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.151     Document Type: Article

References (55)

1. Fornaro M, Dell'Arciprete R, Stella M, Bucci C, Nutini M, Capri MG et al. Cloning of the gene encoding TROP-2, a cell-surface glycoprotein expressed by human carcinomas. Int J Cancer 1995; 62: 610-618.
2. El-Sewedy T, Fornaro M, Alberti S. Cloning of the mouse Trop2 gene-Conservation of a PIP2-binding sequence in the cytoplasmic domain of Trop-2. Int J Cancer 1998; 75: 324-331.
3. Linnenbach AJ,Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ et al. Retroposition in a family of carcinoma-associated antigen genes. Mol Cell Biol 1993; 13: 1507-1515.
4. Litvinov SV, Balzar M, Winter MJ, Bakker HA, Briaire-de Bruijn IH, Prins F et al. Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins. J Cell Biol 1997; 139: 1337-1348.
5. Balzar M, Briaire-de Bruijn IH, Rees-Bakker HAM, Prins FA, Helfrich W, Leij LD et al. Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions. Mol Cell Biol 2001; 21: 2570-2580.
6. Aplin AE, Howe A, Alahari SK, Juliano RL. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol Rev 1998; 50: 197-263.
7. Chothia C, Jones EY. The molecular structure of cell adhesion molecules. Annu Rev Biochem 1997; 66: 823-862.
8. Humphries MJ, Newham P. The structure of cell-adhesion molecules. Trends Cell Biol 1998; 8: 78-83.
9. Chong JM, Speicher DW. Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM). J Biol Chem 2001; 276: 5804-5813.
10. Alberti SA. Phosphoinositide-binding sequence is shared by PH domain target molecules.-A model for the binding of PH domains to proteins. Proteins 1998; 31: 1-9.
11. Alberti S. HIKE, a candidate protein binding site for PH domains, is a major regulatory region of Gbeta proteins. Proteins 1999; 35: 360-363.
12. Trerotola M, Cantanelli P, Guerra E, Tripaldi R, Aloisi AL, Bonasera V et al. Upregulation of Trop-2 quantitatively stimulates human cancer growth. Oncogene 2013; 32: 222-233.
13. Shaulian E. AP-1-The Jun proteins: Oncogenes or tumor suppressors in disguise? Cell Signal 2010; 22: 894-899.
14. Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-kappaB as the matchmaker. Nat Immunol 2011; 12: 715-723.
15. Burkhart DL, Sage J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 2008; 8: 671-682.
16. Haura EB, Turkson J, Jove R. Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2005; 2: 315-324.
17. Siu YT, Jin DY. CREB-a real culprit in oncogenesis. FEBS J 2007; 274: 3224-3232.
18. Peiro G, Adrover E, Aranda FI, Peiro FM, Niveiro M, Sanchez-Paya J. Prognostic implications of HER-2 status in steroid receptor-positive, lymph node-negative breast carcinoma. Am J Clin Pathol 2007; 127: 780-786.
19. Biganzoli E, Coradini D, Ambrogi F, Garibaldi JM, Lisboa P, Soria D et al. p53 status identifies two subgroups of triple-negative breast cancers with distinct biological features. Jpn J Clin Oncol 2011; 41: 172-179.
20. Yang A, Zhu Z, Kapranov P, McKeon F, Church GM, Gingeras TR et al. Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell 2006; 24: 593-602.
21. Barbieri CE, Tang LJ, Brown KA, Pietenpol JA. Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis. Cancer Res 2006; 66: 7589-7597.
22. Yuan L, Nikolova-Krstevski V, Zhan Y, Kondo M, Bhasin M, Varghese L et al. Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene. Circ Res 2009; 104: 1049-1057.
23. Yu Z, Lin KK, Bhandari A, Spencer JA, Xu X, Wang N et al. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol 2006; 299: 122-136.
24. Mazumdar J, O'Brien WT, Johnson RS, LaManna JC, Chavez JC, Klein PS et al. O2 regulates stem cells through Wnt/beta-catenin signalling. Nat Cell Biol 2010; 12: 1007-1013.
25. Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science 1997; 275: 1784-1787.
26. Ronneberg JA, Fleischer T, Solvang HK, Nordgard SH, Edvardsen H, Potapenko I et al. Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer. Mol Oncol 2010; 5: 61-76.
27. Loeb DM, Sukumar S. The role of WT1 in oncogenesis: tumor suppressor or oncogene? Int J Hematol 2002; 76: 117-126.
28. Horiuchi K, Umetani M, Minami T, Okayamazzz H, Takada S, Yamamoto M et al. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci USA 2006; 103: 17278-17283.
29. Attanasio M, Uhlenhaut NH, Sousa VH, O'Toole JF, Otto E, Anlag K et al. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat Genet 2007; 39: 1018-1024.
30. Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002; 298: 1395-1401.
31. Merlo A, Casalini P, Carcangiu ML, Malventano C, Triulzi T, Menard S et al. FOXP3 expression and overall survival in breast cancer. J Clin Oncol 2009; 27: 1746-1752.
32. Wonsey DR, Follettie MT. Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe. Cancer Res 2005; 65: 5181-5189.
33. Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S. Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. Cytogenet Cell Genet 2001; 92: 164-165.
34. Zanna P, Trerotola M, Vacca G, Bonasera V, Palombo B, Guerra E et al. Trop-1 is a novel cell growth stimulatory molecule that marks early stages of tumor progression. Cancer 2007; 110: 452-464.
35. Zou Y, Ewton DZ, Deng X, Mercer SE, Friedman E. Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288. J Biol Chem2004; 279: 27790-27798.
36. Cheng C, Li LM, Alves P, Gerstein M. Systematic identification of transcription factors associated with patient survival in cancers. BMC Genomics 2009; 10: 225.
37. Castellone MD, De Falco V, Rao DM, Bellelli R, Muthu M, Basolo F et al. The betacatenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation. Cancer Res 2009; 69: 1867-1876.
38. Bienvenu F, Barre B, Giraud S, Avril S, Coqueret O. Transcriptional regulation by a DNA-associated form of cyclin D1. Mol Biol Cell 2005; 16: 1850-1858.
39. Guerra E, Trerotola M, Dell' Arciprete R, Bonasera V, Palombo B, El-Sewedy T et al. A bi-cistronic CYCLIN D1-TROP2 mRNA chimera demonstrates a novel oncogenic mechanism in human cancer. Cancer Research 2008; 68: 8113-8121.
40. Hinds PW, Dowdy SF, Eaton EN, Arnold A, Weinberg RA. Function of a human cyclin gene as an oncogene. Proc Natl Acad Sci USA 1994; 91: 709-713.
41. Terrinoni A, Dell'Arciprete R, Fornaro M, Stella M, Alberti S. The Cyclin D1 gene contains a cryptic promoter that is functional in human cancer cells. Genes Chromosomes Cancer 2001; 31: 209-220.
42. Cubas R, Zhang S, Li M, Chen C, Yao Q. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer 2010; 9: 253.
43. Ambrogi F, Biganzoli E, Querzoli P, Ferretti S, Boracchi P, Alberti S et al. Molecular subtyping of breast cancer from traditional tumor marker profiles using parallel clustering methods. Clin Cancer Res 2006; 12: 781-790.
44. Alberti S, Miotti S, Stella M, Klein CE, Fornaro M, Ménard S et al. Biochemical characterization of Trop-2, a cell surface molecule expressed by human carcinomas: formal proof that the monoclonal antibodies T16 and MOv-16 recognize Trop-2. Hybridoma 1992; 11: 539-545.
45. Mangino G, Capri MG, Barnaba V, Alberti S. Presentation of native Trop-2 tumor antigens to human cytotoxic T lymphocytes by engineered antigen-presenting cells. Int J Cancer 2002; 101: 353-359.
46. Trerotola M, Guerra E, Alberti S. Letter to the editor: efficacy and safety of anti-Trop antibodies. Biochim Biophys Acta 2010; 1805: 119-120.
47. Varughese J, Cocco E, Bellone S, de Leon M, Bellone M, Todeschini P et al. Uterine serous papillary carcinomas overexpress human trophoblast-cell- surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized anti-Trop-2 monoclonal antibody. Cancer 2011; 117: 3163-3172.
48. Cubas R, Li M, Chen C, Yao Q. Trop2: A possible therapeutic target for late stage epithelial carcinomas. Biochim Biophys Acta 2009; 1796: 309-314.
49. Naquet P, Lepesant H, Luxembourg A, Brekelmans P, Devaux C, Pierres M. Establishment and characterization of mouse thymic epithelial cell lines. Thymus 1989; 13: 217-226.
50. Alberti S, Fornaro M. Higher transfection efficency of genomic DNA purified with a guanidinium-thiocyanate-based procedure. Nucleic Acids Res 1990; 18: 351-353.
51. Orsulic S, Li Y, Soslow RA, Vitale-Crosss LA, Gutkind JS, Varmus HE. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell 2002; 1: 53-62.
52. Querzoli P, Pedriali M, Rinaldi R, Lombardi AR, Biganzoli E, Boracchi P et al. Axillary lymph node nanometastases are prognostic factors for disease-free survival and metastatic relapse in breast cancer patients. Clin Cancer Res 2006; 12: 6696-6701.
53. Alberti S, Herzenberg LA. DNA methylation prevents transfection of genes for specific surface antigens. Proc Natl Acad Sci USA 1988; 85: 8391-8394.
54. Tinari N, Lattanzio R, Natoli C, Cianchetti E, Angelucci D, Ricevuto E et al. Changes of topoisomerase IIalpha expression in breast tumors after neoadjuvant chemotherapy predicts relapse-free survival. Clin Cancer Res 2006; 12: 1501-1506.
55. Su AI, Welsh JB, Sapinoso LM, Kern SG, Dimitrov P, Lapp H et al. Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res 2001; 61: 7388-7393.