Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism

Molecular Medicine Reports

Volumn 12, Issue 1, 2015, Pages 675-683

  Xiao, Zhibin ^a,b   Ren, Pengcheng ^a   Chao, Yang ^b   Wang, Qianyun ^b   Kuai, Jianke ^a   Lv, Miaomiao ^b   Chen, Lei ^c   Gao, Changjun ^a   Sun, Xude ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Chinese People s Liberation Army 323 Hospital   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Cerebral ischemia; Isoflurane; Protective

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOFLURANE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; MYD88 PROTEIN, RAT; TLR4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN WATER; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; HUMAN; IMMUNOREACTIVITY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PREMEDICATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REPERFUSION INJURY; ANIMAL; BIOSYNTHESIS; BRAIN INJURIES; CEREBRAL ARTERY DISEASE; DISEASE MODEL; DRUG EFFECTS; GENETICS; PATHOLOGY;

RATTUS;

ANIMALS; ASTROCYTES; BRAIN INJURIES; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; ISOFLURANE; MALE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; RATS; TOLL-LIKE RECEPTOR 4;

EID: 84926613554     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3408     Document Type: Article

References (39)

1. Fan H and Cook JA: Molecular mechanisms of endotoxin tolerance. J Endotoxin Res 10: 71-84, 2004.
2. Aderem A and Ulevitch RJ: Toll-like receptors in the induction of the innate immune response. Nature 406: 782-787, 2000.
3. Chakravarty S and Herkenham M: Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines. J Neurosci 25: 1788-1796, 2005.
4. Kaisho T and Akira S: Toll-like receptors as adjuvant receptors. Biochim Biophys Acta 1589: 1-13, 2002.
5. Kilic U, Kilic E, Matter CM, Bassetti CL and Hermann DM: TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration. Neurobiol Dis 31: 33-40, 2008.
6. Kitano H, Young JM, Cheng J, Wang L, Hurn PD and Murphy SJ: Gender-specific response to isoflurane preconditioning in focal cerebral ischemia. J Cereb Blood Flow Metab 27: 1377-1386, 2007.
7. Zhang J, Yang ZJ, Klaus JA, Koehler RC and Huang J: Delayed tolerance with repetitive transient focal ischemic preconditioning in the mouse. Stroke 39: 967-974, 2008.
8. Eilers H and Bickler PE: Hypothermia and isoflurane similarly inhibit glutamate release evoked by chemical anoxia in rat cortical brain slices. Anesthesiology 85: 600-607, 1996.
9. Becker K, Eder M, Ranft A, et al: Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus. PLoS One 7: e39346, 2012.
10. Puil E, El-Beheiry H and Baimbridge KG: Anesthetic effects on glutamate-stimulated increase in intraneuronal calcium. J Pharmacol Exp Ther 255: 955-961, 1990.
11. Puil E and El-Beheiry H: Anaesthetic suppression of transmitter actions in neocortex. Br J Pharmacol 101: 61-66, 1990.
12. Bickler PE, Buck LT and Hansen BM: Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices. Anesthesiology 81: 1461-1469, 1994.
13. Dong Y and Benveniste EN: Immune function of astrocytes. Glia 36: 180-190, 2001.
14. Ladeby R, Wirenfeldt M, Garcia-Ovejero D, et al: Microglial cell population dynamics in the injured adult central nervous system. Brain Res Brain Res Rev 48: 196-206, 2005.
15. Song JH, Bellail A, Tse MC, Yong VW and Hao C: Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. J Neurosci 26: 3299-3308, 2006.
16. Li H, Yin J, Li L, Deng J, Feng C and Zuo Z: Isoflurane postconditioning reduces ischemia-induced nuclear factor-kappaB activation and interleukin 1beta production to provide neuroprotection in rats and mice. Neurobiol Dis 54: 216-224, 2013.
17. Bedirli N, Bagriacik EU, Emmez H, Yilmaz G, Unal Y and Ozkose Z: Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia. J Neurosurg Anesthesiol 24: 336-344, 2012.
18. Chen J, Graham SH, Zhu RL and Simon RP: Stress proteins and tolerance to focal cerebral ischemia. J Cereb Blood Flow Metab 16: 566-577, 1996.
19. Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91, 1989.
20. Shimamura N, Matchett G, Solaroglu I, Tsubokawa T, Ohkuma H and Zhang J: Inhibition of integrin alphavbeta3 reduces blood-brain barrier breakdown in focal ischemia in rats. J Neurosci Res 84: 1837-1847, 2006.
21. Guo W, Wang H, Watanabe M, et al: Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain. J Neurosci 27: 6006-6018, 2007.
22. Tang SC, Arumugam TV, Xu X, et al: Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci USA 104: 13798-13803, 2007.
23. Hua F, Ma J, Ha T, et al: Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion. J Neuroimmunol 190: 101-111, 2007.
24. Xiong L, Zheng Y, Wu M, et al: Preconditioning with isoflurane produces dose-dependent neuroprotection via activation of adenosine triphosphate-regulated potassium channels after focal cerebral ischemia in rats. Anesth Analg 96: 233-237, 2003.
25. Kawaguchi M, Drummond JC, Cole DJ, Kelly PJ, Spurlock MP and Patel PM: Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. Anesth Analg 98: 798-805, 2004.
26. Hanisch UK and Kettenmann H: Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394, 2007.
27. Kapinya KJ, Lowl D, Futterer C, et al: Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. Stroke 33: 1889-1898, 2002.
28. Lee SJ and Lee S: Toll-like receptors and inflammation in the CNS. Curr Drug Targets Inflamm Allergy 1: 181-191, 2002.
29. Beg AA: Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol 23: 509-512, 2002.
30. Doyle SL and O'Neill LA: Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol 72: 1102-1113, 2006.
31. Baeuerle PA and Henkel T: Function and activation of NF-kappaB in the immune system. Annu Rev Immunol 12: 141-179, 1994.
32. Seki E, Tsutsui H, Iimuro Y, et al: Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. Hepatology 41: 443-450, 2005.
33. Farina C, Aloisi F and Meinl E: Astrocytes are active players in cerebral innate immunity. Trends Immunol 28: 138-145, 2007.
34. Glezer I, Simard AR and Rivest S: Neuroprotective role of the innate immune system by microglia. Neuroscience 147: 867-883, 2007.
35. Aloisi F: Immune function of microglia. Glia 36: 165-179, 2001.
36. Streit WJ, Conde JR, Fendrick SE, Flanary BE and Mariani CL: Role of microglia in the central nervous system's immune response. Neurol Res 27: 685-691, 2005.
37. Akira S, Uematsu S and Takeuchi O: Pathogen recognition and innate immunity. Cell 124: 783-801, 2006.
38. Bowman CC, Rasley A, Tranguch SL and Marriott I: Cultured astrocytes express toll-like receptors for bacterial products. Glia 43: 281-291, 2003.
39. Hang CH, Shi JX, Li JS, Wu W and Yin HX: Concomitant upregulation of nuclear factor-κB activity, proinflammatory cytokines and ICAM-1 in the injured brain after cortical contusion trauma in a rat model. Neurol India 53: 312-317, 2005.