Effects of storage-aged red blood cell transfusions on endothelial function in hospitalized patients

Transfusion

Volumn 55, Issue 4, 2015, Pages 782-790

  Neuman, Robert ^a   Hayek, Salim ^a   Rahman, Ayaz ^a   Poole, Joseph C ^a   Menon, Vivek ^a   Sher, Salman ^a   Newman, James L ^a   Karatela, Sulaiman ^a   Polhemus, David ^b   Lefer, David J ^b   De Staercke, Christine ^c   Hooper, Craig ^c   Quyyumi, Arshed A ^a   Roback, John D ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIPHOSPHOGLYCERIC ACID; ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; C REACTIVE PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEMOGLOBIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRATE; NITRIC OXIDE; NITRITE; TUMOR NECROSIS FACTOR ALPHA; ADENOSINE TRIPHOSPHATE; CCL2 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; INTERLEUKIN 2; TUMOR NECROSIS FACTOR;

ADULT; ANEMIA; ARTICLE; BRACHIAL ARTERY; ERYTHROCYTE; ERYTHROCYTE TRANSFUSION; FEMALE; HOSPITAL PATIENT; HUMAN; HYPEREMIA; MAJOR CLINICAL STUDY; MALE; VASCULAR ENDOTHELIUM; VASODILATATION; ADVERSE EFFECTS; AGED; BLOOD; BLOOD STORAGE; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC IMAGING; ECHOGRAPHY; ERYTHROCYTE LIFESPAN; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; TIME FACTOR;

2,3-DIPHOSPHOGLYCERATE; ADENOSINE TRIPHOSPHATE; ADULT; AGED; ANEMIA; BLOOD PRESERVATION; BRACHIAL ARTERY; CHEMOKINE CCL2; ENDOTHELIUM, VASCULAR; ERYTHROCYTE AGING; ERYTHROCYTE TRANSFUSION; FEMALE; HUMANS; INPATIENTS; INTERLEUKIN-2; INTERLEUKIN-6; MALE; NITRIC OXIDE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; ULTRASONOGRAPHY; VASODILATION;

EID: 84926500620     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/trf.12919     Document Type: Article

References (61)

1. Wang R, Mouliswar M, Denman S, et al. Mortality of the institutionalized old-old hospitalized with congestive heart failure. Arch Intern Med 1998; 158: 2464-2468.
2. Tinmouth A, Fergusson D, Yee IC, et al. Clinical consequences of red cell storage in the critically ill. Transfusion 2006; 46: 2014-2027.
3. van de Watering L, Lorinser J, Versteegh M, et al. Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients. Transfusion 2006; 46: 1712-1718.
4. Mou SS, Giroir BP, Molitor-Kirsch EA, et al. Fresh whole blood versus reconstituted blood for pump priming in heart surgery in infants. N Engl J Med 2004; 351: 1635-1644.
5. Weiskopf RB, Feiner J, Hopf H, et al. Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans. Anesthesiology 2006; 104: 911-920.
6. Garcia MG, Duenas E, Sola MC, et al. Epidemiologic and outcome studies of patients who received platelet transfusions in the neonatal intensive care unit. J Perinatol 2001; 21: 415-420.
7. Del Vecchio A, Sola MC, Theriaque DW, et al. Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions. Transfusion 2001; 41: 803-808.
8. Moore FA, Moore EE, Sauaia A,. Blood transfusion. An independent risk factor for postinjury multiple organ failure. Arch Surg 1997; 132: 620-624; discussion 624-5.
9. Gong MN, Thompson BT, Williams P, et al. Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med 2005; 33: 1191-1198.
10. Smith MJ, Le Roux PD, Elliott JP, et al. Blood transfusion and increased risk for vasospasm and poor outcome after subarachnoid hemorrhage. J Neurosurg 2004; 101: 1-7.
11. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999; 340: 409-417.
12. Lacroix J, Hebert PC, Hutchison JS, et al. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 2007; 356: 1609-1619.
13. Kneyber MC, Hersi MI, Twisk JW, et al. Red blood cell transfusion in critically ill children is independently associated with increased mortality. Intensive Care Med 2007; 33: 1414-1422.
14. Reynolds JD, Ahearn GS, Angelo M, et al. S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood. Proc Natl Acad Sci U S A 2007; 104: 17058-17062.
15. Bennett-Guerrero E, Veldman TH, Doctor A, et al. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci U S A 2007; 104: 17063-17068.
16. Ghio M, Contini P, Mazzei C, et al. Soluble HLA class I, HLA class II, and Fas ligand in blood components: a possible key to explain the immunomodulatory effects of allogeneic blood transfusions. Blood 1999; 93: 1770-1777.
17. Corwin HL, Carson JL,. Blood transfusion-when is more really less? N Engl J Med 2007; 356: 1667-1669.
18. Spiess BD,. Transfusion of blood products affects outcome in cardiac surgery. Semin Cardiothorac Vasc Anesth 2004; 8: 267-281.
19. Koch CG, Li L, Sessler DI, et al. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 2008; 358: 1229-1239.
20. Edgren G, Kamper-Jorgensen M, Eloranta S, et al. Duration of red blood cell storage and survival of transfused patients (CME). Transfusion 2010; 50: 1185-1195.
21. Wang D, Sun J, Solomon SB, et al. Transfusion of older stored blood and risk of death: a meta-analysis. Transfusion 2012; 52: 1184-1195.
22. Cortes-Puch I, Wang D, Sun J, et al. Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. Blood 2014; 123: 1403-1411.
23. Solomon SB, Wang D, Sun J, et al. Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood 2013; 121: 1663-1672.
24. Steiner ME, Assmann SF, Levy JH, et al. Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS) (Section 7). Transfus Apher Sci 2010; 43: 107-116.
25. Lacroix J, Hebert P, Fergusson D, et al. The Age of Blood Evaluation (ABLE) randomized controlled trial: study design. Transfus Med Rev 2011; 25: 197-205.
26. Koch CG,. The Red Cell Storage Duration and Outcomes in Cardic Surgery study. Clinical Trialsgov. 2007 [cited 2012 Aug 17]. Available from: http://clinicaltrialsgov/ct2/show/NCT00458783
27. Pereira A,. Will clinical studies elucidate the connection between the length of storage of transfused red blood cells and clinical outcomes? An analysis based on the simulation of randomized controlled trials. Transfusion 2013; 53: 34-40.
28. Yalcin O, Ortiz D, Tsai AG, et al. Microhemodynamic aberrations created by transfusion of stored blood. Transfusion 2014; 54: 1015-1027.
29. Tsai M, Kita A, Leach J, et al. In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology. J Clin Invest 2012; 122: 408-418.
30. Zimring JC, Smith N, Stowell SR, et al. Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. Transfusion 2014; 54: 137-148.
31. Donadee C, Raat NJ, Kanias T, et al. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation 2011; 124: 465-476.
32. Silliman CC, Moore EE, Kelher MR, et al. Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury. Transfusion 2011; 51: 2549-2554.
33. Tissot JD, Rubin O, Canellini G,. Analysis and clinical relevance of microparticles from red blood cells. Curr Opin Hematol 2010; 17: 571-577.
34. Hod EA, Cadwell CM, Liepkalns JS, et al. Cytokine storm in a mouse model of IgG-mediated hemolytic transfusion reactions. Blood 2008; 112: 891-894.
35. Hod EA, Zhang N, Sokol SA, et al. Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. Blood 2010; 115: 4284-4292.
36. Alexander JT, El-Ali AM, Newman JL, et al. Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation. Transfusion 2013; 53: 2619-2628.
37. Stapley R, Owusu BY, Brandon A, et al. Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity. Biochem J 2012; 446: 499-508.
38. Kanias T, Gladwin MT,. Nitric oxide, hemolysis, and the red blood cell storage lesion: interactions between transfusion, donor, and recipient. Transfusion 2012; 52: 1388-1392.
39. Roback JD,. Vascular effects of the red cell storage lesion. Hematology Am Soc Hematol Educ Program 2011; 2011: 475-479.
40. Halcox JP, Nour KR, Zalos G, et al. Endogenous endothelin in human coronary vascular function: differential contribution of endothelin receptor types A and B. Hypertension 2007; 49: 1134-1141.
41. Green DJ, Dawson EA, Groenewoud HM, et al. Is flow-mediated dilation nitric oxide mediated?: a meta-analysis. Hypertension 2014; 63: 376-382.
42. Harris RA, Nishiyama SK, Wray DW, et al. Ultrasound assessment of flow-mediated dilation. Hypertension 2010; 55: 1075-1085.
43. Al Mheid I, Patel R, Murrow J, et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol 2011; 58: 186-192.
44. Atkinson G, Batterham AM,. The percentage flow-mediated dilation index: a large-sample investigation of its appropriateness, potential for bias and causal nexus in vascular medicine. Vasc Med 2013; 18: 354-365.
45. Bryan NS, Calvert JW, Gundewar S, et al. Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice. Free Radic Biol Med 2008; 45: 468-474.
46. Singel DJ, Stamler JS,. Chemical physiology of blood flow regulation by red blood cells: the role of nitric oxide and S-nitrosohemoglobin. Annu Rev Physiol 2005; 67: 99-145.
47. Suematsu M, Suganuma K, Kashiwagi S,. Mechanistic probing of gaseous signal transduction in microcirculation. Antioxid Redox Signal 2003; 5: 485-492.
48. Quyyumi AA, Dakak N, Andrews NP, et al. Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis. J Clin Invest 1995; 95: 1747-1755.
49. Halcox JP, Schenke WH, Zalos G, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002; 106: 653-658.
50. Roback JD, Neuman RB, Quyyumi A, et al. Insufficient nitric oxide bioavailability: a hypothesis to explain adverse effects of red blood cell transfusion. Transfusion 2011; 51: 859-866.
51. Joannides R, Haefeli WE, Linder L, et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 1995; 91: 1314-1319.
52. Berra L, Coppadoro A, Yu B, et al. Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology 2012; 117: 56-63.
53. Roberson RS, Lockhart E, Shapiro NI, et al. Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. Transfusion 2012; 52: 2459-2464.
54. Stewart AD, Millasseau SC, Kearney MT, et al. Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans. Hypertension 2003; 42: 915-918.
55. Weinberg JA, MacLennan PA, Vandromme-Cusick MJ, et al. The deleterious effect of red blood cell storage on microvascular response to transfusion. J Trauma Acute Care Surg 2013; 75: 807-812.
56. Murrow JR, Sher S, Ali S, et al. The differential effect of statins on oxidative stress and endothelial function: atorvastatin versus pravastatin. J Clin Lipidol 2012; 6: 42-49.
57. Keymel S, Heinen Y, Balzer J, et al. Characterization of macro-and microvascular function and structure in patients with type 2 diabetes mellitus. Am J Cardiovasc Dis 2011; 1: 68-75.
58. Inaba Y, Chen JA, Bergmann SR,. Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. Int J Cardiovasc Imaging 2010; 26: 631-640.
59. Schaer DJ, Buehler PW, Alayash AI, et al. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 2013; 121: 1276-1284.
60. Heaton A, Keegan T, Holme S,. In vivo regeneration of red cell 2,3-diphosphoglycerate following transfusion of DPG-depleted AS-1, AS-3 and CPDA-1 red cells. Br J Haematol 1989; 71: 131-136.
61. Correra A, Graziano JH, Seaman C, et al. Inappropriately low red cell 2,3-diphosphoglycerate and p50 in transfused beta-thalassemia. Blood 1984; 63: 803-806.