Irisin: A myokine with locomotor activity

Neuroscience Letters

Volumn 595, Issue , 2015, Pages 7-11

  Zhang, Weizhen ^a,b   Chang, Lin ^a   Zhang, Chao ^a   Zhang, Ruthann ^a   Li, Ziru ^a   Chai, Biaoxin ^a   Li, Jiyao ^a   Chen, Eugene ^a   Mulholland, Michael ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Central nervous system; Irisin; Locomotion; Metabolism

Indexed keywords

AMINO ACID; CARBON DIOXIDE; IMMUNOGLOBULIN FC FRAGMENT; IRISIN; PEPTIDE HORMONE; UNCLASSIFIED DRUG; FIBRONECTIN; FNDC5 PROTEIN, RAT;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EXERCISE; LOCOMOTION; NONHUMAN; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; THERMOGENESIS; ANIMAL; DRUG EFFECTS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; METABOLISM; MOTOR ACTIVITY; SPRAGUE DAWLEY RAT;

ANIMALS; CARBON DIOXIDE; FIBRONECTINS; INJECTIONS, INTRAVENTRICULAR; LOCOMOTION; MALE; MOTOR ACTIVITY; OXYGEN CONSUMPTION; RATS, SPRAGUE-DAWLEY;

EID: 84926487800     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.03.069     Document Type: Article

References (13)

1. Yan Z., Okutsu M., Akhtar Y.N., Lira V.A. Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J. Appl. Physiol. (1985) 2011, 110:264-274.
2. Xu X., Ying Z., Cai M., Xu Z., Li Y., Jiang S.Y., Tzan K., Wang A., Parthasarathy S., He G., Rajagopalan S., Sun Q. Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 300:R1115-1125.
3. Bostrom P., Wu J., Jedrychowski M.P., Korde A., Ye L., Lo J.C., Rasbach K.A., Bostrom E.A., Choi J.H., Long J.Z., Kajimura S., Zingaretti M.C., Vind B.F., Tu H., Cinti S., Hojlund K., Gygi S.P., Spiegelman B.M. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012, 481:463-468.
4. Kelly D.P. Medicine. Irisin, light my fire. Science 2012, 336:42-43.
5. Sanchis-Gomar F., Lippi G., Mayero S., Perez-Quilis C., Garcia-Gimenez J.L. Irisin: a new potential hormonal target for the treatment of obesity and type 2 diabetes. J. Diabetes 2012, 4:196.
6. Paxinos G., Watson C.R., Emson P.C. The Rat Brain in Stereotaxic Coordinates 1998, Academic Press, Bowen Hills, Australia. 4th ed.
7. Aydin S., Kuloglu T., Aydin S., Kalayci M., Yilmaz M., Cakmak T., Albayrak S., Gungor S., Colakoglu N., Ozercan I.H. A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues. Peptides 2014, 61:130-136.
8. Hashemi M.S., Ghaedi K., Salamian A., Karbalaie K., Emadi-Baygi M., Tanhaei S., Nasr-Esfahani M.H., Baharvand H. Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells. Neuroscience 2013, 231:296-304.
9. Moon H.S., Dincer F., Mantzoros C.S. Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse h19-7 hippocampal cell lines. Metabolism 2013, 62:1131-1136.
10. Wu J., Boström P., Sparks L.M., Ye L., Choi J.H., Giang A.H., Khandekar M., Virtanen K.A., Nuutila P., Schaart G., Huang K., Tu H., van Marken Lichtenbelt W.D., Hoeks J., Enerbäck S., Schrauwen P., Spiegelman B.M. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012, 150:366-376.
11. Norheim F., Langleite T.M., Hjorth M., Holen T., Kielland A., Stadheim H.K., Gulseth H.L., Birkeland K.I., Jensen J., Drevon C.A. The effects of acute and chronic exercise on pgc-1alpha: irisin and browning of subcutaneous adipose tissue in humans. FEBS J. 2014, 281:739-749.
12. Wrann C.D., White J.P., Salogiannnis J., Laznik-Bogoslavski D., Wu J., Ma D., Lin J.D., Greenberg M.E., Spiegelman B.M. Exercise induces hippocampal BDNF through a PGC-1alpha/FNDC5 pathway. Cell Metab. 2013, 18:649-659.
13. Raschke S., Elsen M., Gassenhuber H., Sommerfeld M., Schwahn U., Brockmann B., Jung R., Wisløff U., Tjønna A.E., Raastad T., Hallén J., Norheim F., Drevon C.A., Romacho T., Eckardt K., Eckel J. Evidence against a beneficial effect of irisin in humans. PLoS One 2013, 8:e73680.