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Volumn 6, Issue MAR, 2015, Pages

Tetraspanins as therapeutic targets in hematological malignancy: A concise review

Author keywords

CD37; CD53; Tetraspanin; TSPAN

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; BENDAMUSTINE; CD151 ANTIGEN; CD37 ANTIGEN; CD53 ANTIGEN; CD81 ANTIGEN; CD82 ANTIGEN; CD9 ANTIGEN; IDELALISIB; IMGN 529; MONOCLONAL ANTIBODY 37.1; OTLERTUZUMAB; RITUXIMAB; SMIP 016; TETRASPANIN; TETRASPANIN 32; TETRASPANIN 33; TETULOMAB TETRAXETAN LUTETIUM LU 177; UNCLASSIFIED DRUG;

EID: 84926456125     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2015.00091     Document Type: Review
Times cited : (46)

References (115)
  • 1
    • 0025676566 scopus 로고
    • Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins
    • Amiot, M. (1990). Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins. J. Immunol . 145, 4322-4325.
    • (1990) J. Immunol. , vol.145 , pp. 4322-4325
    • Amiot, M.1
  • 2
    • 33645085833 scopus 로고    scopus 로고
    • Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS
    • Andre, M., Le Caer, J. P., Greco, C., Planchon, S., El Nemer, W., Boucheix, C., et al. (2006). Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS. Proteomics 6, 1437-1449. doi: 10.1002/pmic.200500180
    • (2006) Proteomics , vol.6 , pp. 1437-1449
    • Andre, M.1    Le Caer, J.P.2    Greco, C.3    Planchon, S.4    El Nemer, W.5    Boucheix, C.6
  • 3
    • 0028057606 scopus 로고
    • Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins
    • Angelisová, P., Hilgert, I., and Horejsí, V. (1994). Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins. Immunogenetics 39, 249-256. doi: 10.1007/BF00188787
    • (1994) Immunogenetics , vol.39 , pp. 249-256
    • Angelisová, P.1    Hilgert, I.2    Horejsí, V.3
  • 4
    • 33746791465 scopus 로고    scopus 로고
    • Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression
    • Bandyopadhyay, S., Zhan, R., Chaudhuri, A., Watabe, M., Pai, S. K., Hirota, S., et al. (2006). Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat. Med . 12, 933-938. doi: 10.1038/nm1444
    • (2006) Nat. Med. , vol.12 , pp. 933-938
    • Bandyopadhyay, S.1    Zhan, R.2    Chaudhuri, A.3    Watabe, M.4    Pai, S.K.5    Hirota, S.6
  • 5
    • 15944361837 scopus 로고    scopus 로고
    • Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation
    • Barreiro, O., Yanez-Mo, M., Sala-Valdes, M., Gutierrez-Lopez, M. D., Ovalle, S., Higginbottom, A., et al. (2005). Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation. Blood 105, 2852-2861. doi: 10.1182/blood-2004-09-3606
    • (2005) Blood , vol.105 , pp. 2852-2861
    • Barreiro, O.1    Yanez-Mo, M.2    Sala-Valdes, M.3    Gutierrez-Lopez, M.D.4    Ovalle, S.5    Higginbottom, A.6
  • 6
    • 23744514951 scopus 로고    scopus 로고
    • Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation
    • Barrena, S., Almeida, J., Yunta, M., Lopez, A., Fernandez-Mosteirin, N., Giralt, M., et al. (2005). Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation. Leukemia 19, 1376-1383. doi: 10.1038/sj.leu.2403822
    • (2005) Leukemia , vol.19 , pp. 1376-1383
    • Barrena, S.1    Almeida, J.2    Yunta, M.3    Lopez, A.4    Fernandez-Mosteirin, N.5    Giralt, M.6
  • 7
    • 34249978469 scopus 로고    scopus 로고
    • Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins
    • Beckmann, J., Scheitza, S., Wernet, P., Fischer, J. C., and Giebel, B. (2007). Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins. Blood 109, 5494-5501. doi: 10.1182/blood-2006-11-055921
    • (2007) Blood , vol.109 , pp. 5494-5501
    • Beckmann, J.1    Scheitza, S.2    Wernet, P.3    Fischer, J.C.4    Giebel, B.5
  • 8
    • 84904071256 scopus 로고    scopus 로고
    • The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model
    • Beckwith, K. A., Frissora, F. W., Stefanovski, M. R., Towns, W. H., Cheney, C., Mo, X., et al. (2014). The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. Leukemia 28, 1501-1510. doi: 10.1038/leu.2014.32
    • (2014) Leukemia , vol.28 , pp. 1501-1510
    • Beckwith, K.A.1    Frissora, F.W.2    Stefanovski, M.R.3    Towns, W.H.4    Cheney, C.5    Mo, X.6
  • 9
    • 0026585492 scopus 로고
    • The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line
    • Bell, G. M., Seaman, W. E., Niemi, E. C., and Imboden, J. B. (1992). The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. J. Exp. Med . 175, 527-536. doi: 10.1084/jem.175.2.527
    • (1992) J. Exp. Med. , vol.175 , pp. 527-536
    • Bell, G.M.1    Seaman, W.E.2    Niemi, E.C.3    Imboden, J.B.4
  • 10
    • 0037020085 scopus 로고    scopus 로고
    • Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling
    • Berditchevski, F., Odintsova, E., Sawada, S., and Gilbert, E. (2002). Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling. J. Biol. Chem . 277, 36991-37000. doi: 10.1074/jbc.M205265200
    • (2002) J. Biol. Chem. , vol.277 , pp. 36991-37000
    • Berditchevski, F.1    Odintsova, E.2    Sawada, S.3    Gilbert, E.4
  • 11
    • 0031018172 scopus 로고    scopus 로고
    • A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase
    • Berditchevski, F., Tolias, K. F., Wong, K., Carpenter, C. L., and Hemler, M. E. (1997). A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J. Biol. Chem . 272, 2595-2598. doi: 10.1074/jbc.272.5.2595
    • (1997) J. Biol. Chem. , vol.272 , pp. 2595-2598
    • Berditchevski, F.1    Tolias, K.F.2    Wong, K.3    Carpenter, C.L.4    Hemler, M.E.5
  • 13
    • 0028295237 scopus 로고
    • Induction of nitric oxide release by MRC OX-44 (anti-CD53) through a protein kinase C-dependent pathway in rat macrophages
    • Bosca, L., and Lazo, P. A. (1994). Induction of nitric oxide release by MRC OX-44 (anti-CD53) through a protein kinase C-dependent pathway in rat macrophages. J. Exp. Med . 179, 1119-1126. doi: 10.1084/jem.179.4.1119
    • (1994) J. Exp. Med. , vol.179 , pp. 1119-1126
    • Bosca, L.1    Lazo, P.A.2
  • 14
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd, J. C., Murphy, T., Howard, R. S., Lucas, M. S., Goodrich, A., Park, K., et al. (2001). Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J. Clin. Oncol . 19, 2153-2164.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3    Lucas, M.S.4    Goodrich, A.5    Park, K.6
  • 15
    • 84896619061 scopus 로고    scopus 로고
    • A phase 1 study evaluating the safety and tolerability of otlertuzumab, an anti-CD37 mono-specific ADAPTIR therapeutic protein in chronic lymphocytic leukemia
    • Byrd, J. C., Pagel, J. M., Awan, F. T., Forero, A., Flinn, I. W., Deauna-Limayo, D. P., et al. (2014). A phase 1 study evaluating the safety and tolerability of otlertuzumab, an anti-CD37 mono-specific ADAPTIR therapeutic protein in chronic lymphocytic leukemia. Blood 123, 1302-1308. doi: 10.1182/blood-2013-07-512137
    • (2014) Blood , vol.123 , pp. 1302-1308
    • Byrd, J.C.1    Pagel, J.M.2    Awan, F.T.3    Forero, A.4    Flinn, I.W.5    Deauna-Limayo, D.P.6
  • 16
    • 0029067385 scopus 로고
    • Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity
    • Carmo, A. M., and Wright, M. D. (1995). Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity. Eur. J. Immunol . 25, 2090-2095. doi: 10.1002/eji.1830250743
    • (1995) Eur. J. Immunol. , vol.25 , pp. 2090-2095
    • Carmo, A.M.1    Wright, M.D.2
  • 17
    • 0042847300 scopus 로고    scopus 로고
    • EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells
    • Charrin, S., Le Naour, F., Labas, V., Billard, M., Le Caer, J. P., Emile, J. F., et al. (2003). EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. Biochem. J . 373, 409-421. doi: 10.1042/BJ20030343
    • (2003) Biochem. J. , vol.373 , pp. 409-421
    • Charrin, S.1    Le Naour, F.2    Labas, V.3    Billard, M.4    Le Caer, J.P.5    Emile, J.F.6
  • 18
    • 0035958026 scopus 로고    scopus 로고
    • The major CD9 and CD81 molecular partner. Identification and characterization of the complexes
    • Charrin, S., Le Naour, F., Oualid, M., Billard, M., Faure, G., Hanash, S. M., et al. (2001). The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. J. Biol. Chem . 276, 14329-14337. doi: 10.1074/jbc.M011297200
    • (2001) J. Biol. Chem. , vol.276 , pp. 14329-14337
    • Charrin, S.1    Le Naour, F.2    Oualid, M.3    Billard, M.4    Faure, G.5    Hanash, S.M.6
  • 19
    • 66549084069 scopus 로고    scopus 로고
    • Lateral organization of membrane proteins: tetraspanins spin their web
    • Charrin, S., Le Naour, F., Silvie, O., Milhiet, P. E., Boucheix, C., and Rubinstein, E. (2009). Lateral organization of membrane proteins: tetraspanins spin their web. Biochem. J . 420, 133-154. doi: 10.1042/BJ20082422
    • (2009) Biochem. J. , vol.420 , pp. 133-154
    • Charrin, S.1    Le Naour, F.2    Silvie, O.3    Milhiet, P.E.4    Boucheix, C.5    Rubinstein, E.6
  • 20
    • 0037051906 scopus 로고    scopus 로고
    • Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation
    • Charrin, S., Manie, S., Oualid, M., Billard, M., Boucheix, C., and Rubinstein, E. (2002). Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. FEBS Lett . 516, 139-144. doi: 10.1016/S0014-5793(02)02522-X
    • (2002) FEBS Lett. , vol.516 , pp. 139-144
    • Charrin, S.1    Manie, S.2    Oualid, M.3    Billard, M.4    Boucheix, C.5    Rubinstein, E.6
  • 21
    • 26444534322 scopus 로고    scopus 로고
    • The human Penumbra gene is mapped to a region on chromosome 7 frequently deleted in myeloid malignancies
    • Chen, Z., Pasquini, M., Hong, B., Dehart, S., Heikens, M., and Tsai, S. (2005). The human Penumbra gene is mapped to a region on chromosome 7 frequently deleted in myeloid malignancies. Cancer Genet. Cytogenet . 162, 95-98. doi: 10.1016/j.cancergencyto.2005.03.017
    • (2005) Cancer Genet. Cytogenet. , vol.162 , pp. 95-98
    • Chen, Z.1    Pasquini, M.2    Hong, B.3    Dehart, S.4    Heikens, M.5    Tsai, S.6
  • 22
    • 0035896648 scopus 로고    scopus 로고
    • Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts
    • Claas, C., Stipp, C. S., and Hemler, M. E. (2001). Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts. J. Biol. Chem . 276, 7974-7984. doi: 10.1074/jbc.M008650200
    • (2001) J. Biol. Chem. , vol.276 , pp. 7974-7984
    • Claas, C.1    Stipp, C.S.2    Hemler, M.E.3
  • 23
    • 2442450501 scopus 로고    scopus 로고
    • CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner
    • Clark, K. L., Oelke, A., Johnson, M. E., Eilert, K. D., Simpson, P. C., and Todd, S. C. (2004). CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner. J. Biol. Chem . 279, 19401-19406. doi: 10.1074/jbc.M312626200
    • (2004) J. Biol. Chem. , vol.279 , pp. 19401-19406
    • Clark, K.L.1    Oelke, A.2    Johnson, M.E.3    Eilert, K.D.4    Simpson, P.C.5    Todd, S.C.6
  • 24
    • 84873027242 scopus 로고    scopus 로고
    • Evaluating antigen targeting and anti-tumor activity of a new anti-CD37 radioimmunoconjugate against non-Hodgkin's lymphoma
    • Dahle, J., Repetto-Llamazares, A. H., Mollatt, C. S., Melhus, K. B., Bruland, O. S., Kolstad, A., et al. (2013). Evaluating antigen targeting and anti-tumor activity of a new anti-CD37 radioimmunoconjugate against non-Hodgkin's lymphoma. Anticancer Res . 33, 85-95.
    • (2013) Anticancer Res. , vol.33 , pp. 85-95
    • Dahle, J.1    Repetto-Llamazares, A.H.2    Mollatt, C.S.3    Melhus, K.B.4    Bruland, O.S.5    Kolstad, A.6
  • 25
    • 49649122294 scopus 로고    scopus 로고
    • Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival
    • De Bruyne, E., Bos, T. J., Asosingh, K., Vande Broek, I., Menu, E., Van Valckenborgh, E., et al. (2008). Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival. Clin. Cancer Res . 14, 2918-2926. doi: 10.1158/1078-0432.CCR-07-4489
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2918-2926
    • De Bruyne, E.1    Bos, T.J.2    Asosingh, K.3    Vande Broek, I.4    Menu, E.5    Van Valckenborgh, E.6
  • 26
    • 84888250428 scopus 로고    scopus 로고
    • A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies
    • Deckert, J., Park, P. U., Chicklas, S., Yi, Y., Li, M., Lai, K. C., et al. (2013). A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies. Blood 122, 3500-3510. doi: 10.1182/blood-2013-05-505685
    • (2013) Blood , vol.122 , pp. 3500-3510
    • Deckert, J.1    Park, P.U.2    Chicklas, S.3    Yi, Y.4    Li, M.5    Lai, K.C.6
  • 27
    • 84926467909 scopus 로고    scopus 로고
    • Preclinical mechanistic studies investigating neutrophil and lymphoid cell depletion by IMGN529, a CD37-targeting antibody-drug conjugate (ADC)
    • #3119 56th Annual Meeting of the American Society of Hematology (San Francisco, CA).
    • Deckert, J., Ponte, J. F., Coccia, J. A., Lanieri, L., Chicklas, S., Yi, Y., et al. (2014). "Preclinical mechanistic studies investigating neutrophil and lymphoid cell depletion by IMGN529, a CD37-targeting antibody-drug conjugate (ADC)," in Abstract #3119, 56th Annual Meeting of the American Society of Hematology (San Francisco, CA).
    • (2014)
    • Deckert, J.1    Ponte, J.F.2    Coccia, J.A.3    Lanieri, L.4    Chicklas, S.5    Yi, Y.6
  • 28
    • 78649885553 scopus 로고    scopus 로고
    • A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity
    • Gartlan, K. H., Belz, G. T., Tarrant, J. M., Minigo, G., Katsara, M., Sheng, K. C., et al. (2010). A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. J. Immunol . 185, 3158-3166. doi: 10.4049/jimmunol.0902867
    • (2010) J. Immunol. , vol.185 , pp. 3158-3166
    • Gartlan, K.H.1    Belz, G.T.2    Tarrant, J.M.3    Minigo, G.4    Katsara, M.5    Sheng, K.C.6
  • 29
    • 84876869737 scopus 로고    scopus 로고
    • Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration
    • Gartlan, K. H., Wee, J. L., Demaria, M. C., Nastovska, R., Chang, T. M., Jones, E. L., et al. (2013). Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration. Eur. J. Immunol . 43, 1208-1219. doi: 10.1002/eji.201242730
    • (2013) Eur. J. Immunol. , vol.43 , pp. 1208-1219
    • Gartlan, K.H.1    Wee, J.L.2    Demaria, M.C.3    Nastovska, R.4    Chang, T.M.5    Jones, E.L.6
  • 30
    • 84938689653 scopus 로고    scopus 로고
    • Phase 1b study of otlertuzumab (TRU-016), an anti-CD37 monospecific ADAPTIR therapeutic protein, in combination with rituximab and bendamustine in relapsed indolent lymphoma patients
    • Gopal, A. K., Tarantolo, S. R., Bellam, N., Green, D. J., Griffin, M., Feldman, T., et al. (2014). Phase 1b study of otlertuzumab (TRU-016), an anti-CD37 monospecific ADAPTIR therapeutic protein, in combination with rituximab and bendamustine in relapsed indolent lymphoma patients. Invest. New Drugs 32, 1213-1225. doi: 10.1007/s10637-014-0125-2
    • (2014) Invest. New Drugs , vol.32 , pp. 1213-1225
    • Gopal, A.K.1    Tarantolo, S.R.2    Bellam, N.3    Green, D.J.4    Griffin, M.5    Feldman, T.6
  • 31
    • 33748697411 scopus 로고    scopus 로고
    • Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice
    • Goschnick, M. W., Lau, L. M., Wee, J. L., Liu, Y. S., Hogarth, P. M., Robb, L. M., et al. (2006). Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice. Blood 108, 1911-1918. doi: 10.1182/blood-2006-02-004267
    • (2006) Blood , vol.108 , pp. 1911-1918
    • Goschnick, M.W.1    Lau, L.M.2    Wee, J.L.3    Liu, Y.S.4    Hogarth, P.M.5    Robb, L.M.6
  • 32
    • 0347297508 scopus 로고    scopus 로고
    • A functionally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated beta1 integrin
    • Gutierrez-Lopez, M. D., Ovalle, S., Yanez-Mo, M., Sanchez-Sanchez, N., Rubinstein, E., Olmo, N., et al. (2003). A functionally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated beta1 integrin. J. Biol. Chem . 278, 208-218. doi: 10.1074/jbc.M207805200
    • (2003) J. Biol. Chem. , vol.278 , pp. 208-218
    • Gutierrez-Lopez, M.D.1    Ovalle, S.2    Yanez-Mo, M.3    Sanchez-Sanchez, N.4    Rubinstein, E.5    Olmo, N.6
  • 33
    • 84869211737 scopus 로고    scopus 로고
    • The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression
    • Haining, E. J., Yang, J., Bailey, R. L., Khan, K., Collier, R., Tsai, S., et al. (2012). The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. J. Biol. Chem . 287, 39753-39765. doi: 10.1074/jbc.M112.416503
    • (2012) J. Biol. Chem. , vol.287 , pp. 39753-39765
    • Haining, E.J.1    Yang, J.2    Bailey, R.L.3    Khan, K.4    Collier, R.5    Tsai, S.6
  • 34
    • 80054115014 scopus 로고    scopus 로고
    • A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies
    • Heider, K. H., Kiefer, K., Zenz, T., Volden, M., Stilgenbauer, S., Ostermann, E., et al. (2011). A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies. Blood 118, 4159-4168. doi: 10.1182/blood-2011-04-351932
    • (2011) Blood , vol.118 , pp. 4159-4168
    • Heider, K.H.1    Kiefer, K.2    Zenz, T.3    Volden, M.4    Stilgenbauer, S.5    Ostermann, E.6
  • 35
    • 34147128271 scopus 로고    scopus 로고
    • Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis
    • Heikens, M. J., Cao, T. M., Morita, C., Dehart, S. L., and Tsai, S. (2007). Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis. Blood 109, 3244-3252. doi: 10.1182/blood-2006-09-046672
    • (2007) Blood , vol.109 , pp. 3244-3252
    • Heikens, M.J.1    Cao, T.M.2    Morita, C.3    Dehart, S.L.4    Tsai, S.5
  • 36
    • 28444441957 scopus 로고    scopus 로고
    • Tetraspanin functions and associated microdomains
    • Hemler, M. E. (2005). Tetraspanin functions and associated microdomains. Nat. Rev. Mol. Cell Biol . 6, 801-811. doi: 10.1038/nrm1736
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 801-811
    • Hemler, M.E.1
  • 37
    • 84890933854 scopus 로고    scopus 로고
    • Tetraspanin proteins promote multiple cancer stages
    • Hemler, M. E. (2014). Tetraspanin proteins promote multiple cancer stages. Nat. Rev. Cancer 14, 49-60. doi: 10.1038/nrc3640
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 49-60
    • Hemler, M.E.1
  • 38
    • 0032514919 scopus 로고    scopus 로고
    • CD19 Is Linked to the Integrin-associated Tetraspans CD9, CD81, and CD82
    • Horváth, G., Serru, V., Clay, D., Billard, M., Boucheix, C., and Rubinstein, E. (1998). CD19 Is Linked to the Integrin-associated Tetraspans CD9, CD81, and CD82. J. Biol. Chem . 273, 30537-30543. doi: 10.1074/jbc.273.46.30537
    • (1998) J. Biol. Chem. , vol.273 , pp. 30537-30543
    • Horváth, G.1    Serru, V.2    Clay, D.3    Billard, M.4    Boucheix, C.5    Rubinstein, E.6
  • 39
    • 84900438005 scopus 로고    scopus 로고
    • Down-regulation of CD9 by methylation decreased bortezomib sensitivity in multiple myeloma.
    • Hu, X., Xuan, H., Du, H., Jiang, H., and Huang, J. (2014). Down-regulation of CD9 by methylation decreased bortezomib sensitivity in multiple myeloma. PLoS ONE 9:e95765. doi: 10.1371/journal.pone.0095765
    • (2014) PLoS ONE , vol.9
    • Hu, X.1    Xuan, H.2    Du, H.3    Jiang, H.4    Huang, J.5
  • 40
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn, D., Von Schilling, C., Wilhelm, M., Ho, A. D., Hallek, M., Kuse, R., et al. (2001). Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood 98, 1326-1331. doi: 10.1182/blood.V98.5.1326
    • (2001) Blood , vol.98 , pp. 1326-1331
    • Huhn, D.1    Von Schilling, C.2    Wilhelm, M.3    Ho, A.D.4    Hallek, M.5    Kuse, R.6
  • 41
    • 0029112968 scopus 로고
    • Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82
    • Imai, T., Mayumi, K., Nishimura, M., and Yoshie, O. (1995). Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. J. Immunol . 155, 1229-1239.
    • (1995) J. Immunol. , vol.155 , pp. 1229-1239
    • Imai, T.1    Mayumi, K.2    Nishimura, M.3    Yoshie, O.4
  • 42
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating, M. J., O'Brien, S., Albitar, M., Lerner, S., Plunkett, W., Giles, F., et al. (2005). Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J. Clin. Oncol . 23, 4079-4088. doi: 10.1200/JCO.2005.12.051
    • (2005) J. Clin. Oncol. , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3    Lerner, S.4    Plunkett, W.5    Giles, F.6
  • 43
    • 0035862964 scopus 로고    scopus 로고
    • CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs
    • Kitadokoro, K., Bordo, D., Galli, G., Petracca, R., Falugi, F., Abrignani, S., et al. (2001). CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. EMBO J . 20, 12-18. doi: 10.1093/emboj/20.1.12
    • (2001) EMBO J. , vol.20 , pp. 12-18
    • Kitadokoro, K.1    Bordo, D.2    Galli, G.3    Petracca, R.4    Falugi, F.5    Abrignani, S.6
  • 44
    • 0033910657 scopus 로고    scopus 로고
    • Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions
    • Knobeloch, K. P., Wright, M. D., Ochsenbein, A. F., Liesenfeld, O., Lohler, J., Zinkernagel, R. M., et al. (2000). Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol. Cell. Biol . 20, 5363-5369. doi: 10.1128/MCB.20.15.5363-5369.2000
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5363-5369
    • Knobeloch, K.P.1    Wright, M.D.2    Ochsenbein, A.F.3    Liesenfeld, O.4    Lohler, J.5    Zinkernagel, R.M.6
  • 45
    • 84926467908 scopus 로고    scopus 로고
    • A phase i study of 177 lu-DOTA-HH1 (Betalutin) radioimmunotherapy for patients with relapsed CD37+ Non-Hodgkin's B cell lymphoma
    • #3094 56th Annual Meeting of the American Society of Hematology (San Francisco, CA).
    • Kolstad, A., Madsbu, U., Dahle, J., Stokke, C., Bach-Gansmo, T., Løndalen, A. M., et al. (2014). "A phase i study of 177 lu-DOTA-HH1 (Betalutin) radioimmunotherapy for patients with relapsed CD37+ Non-Hodgkin's B cell lymphoma," in Abstract #3094, 56th Annual Meeting of the American Society of Hematology (San Francisco, CA).
    • (2014)
    • Kolstad, A.1    Madsbu, U.2    Dahle, J.3    Stokke, C.4    Bach-Gansmo, T.5    Løndalen, A.M.6
  • 46
    • 84857996061 scopus 로고    scopus 로고
    • Action of novel CD37 antibodies on chronic lymphocytic leukemia cells
    • Krause, G., Patz, M., Isaeva, P., Wigger, M., Baki, I., Vondey, V., et al. (2012). Action of novel CD37 antibodies on chronic lymphocytic leukemia cells. Leukemia 26, 546-549. doi: 10.1038/leu.2011.233
    • (2012) Leukemia , vol.26 , pp. 546-549
    • Krause, G.1    Patz, M.2    Isaeva, P.3    Wigger, M.4    Baki, I.5    Vondey, V.6
  • 47
    • 84861415717 scopus 로고    scopus 로고
    • Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals
    • Lapalombella, R., Yeh, Y. Y., Wang, L., Ramanunni, A., Rafiq, S., Jha, S., et al. (2012). Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals. Cancer Cell 21, 694-708. doi: 10.1016/j.ccr.2012.03.040
    • (2012) Cancer Cell , vol.21 , pp. 694-708
    • Lapalombella, R.1    Yeh, Y.Y.2    Wang, L.3    Ramanunni, A.4    Rafiq, S.5    Jha, S.6
  • 48
    • 33645218704 scopus 로고    scopus 로고
    • Engineered antibody Fc variants with enhanced effector function
    • Lazar, G. A., Dang, W., Karki, S., Vafa, O., Peng, J. S., Hyun, L., et al. (2006). Engineered antibody Fc variants with enhanced effector function. Proc. Natl. Acad. Sci. U.S.A . 103, 4005-4010. doi: 10.1073/pnas.0508123103
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 4005-4010
    • Lazar, G.A.1    Dang, W.2    Karki, S.3    Vafa, O.4    Peng, J.S.5    Hyun, L.6
  • 49
    • 33845975257 scopus 로고    scopus 로고
    • Membrane microdomains and proteomics: lessons from tetraspanin microdomains and comparison with lipid rafts
    • Le Naour, F., Andre, M., Boucheix, C., and Rubinstein, E. (2006a). Membrane microdomains and proteomics: lessons from tetraspanin microdomains and comparison with lipid rafts. Proteomics 6, 6447-6454. doi: 10.1002/pmic.200600282
    • (2006) Proteomics , vol.6 , pp. 6447-6454
    • Le Naour, F.1    Andre, M.2    Boucheix, C.3    Rubinstein, E.4
  • 51
    • 79951485609 scopus 로고    scopus 로고
    • The tetraspanin CD9 regulates migration, adhesion, and homing of human cord blood CD34+ hematopoietic stem and progenitor cells
    • Leung, K. T., Chan, K. Y., Ng, P. C., Lau, T. K., Chiu, W. M., Tsang, K. S., et al. (2011). The tetraspanin CD9 regulates migration, adhesion, and homing of human cord blood CD34+ hematopoietic stem and progenitor cells. Blood 117, 1840-1850. doi: 10.1182/blood-2010-04-281329
    • (2011) Blood , vol.117 , pp. 1840-1850
    • Leung, K.T.1    Chan, K.Y.2    Ng, P.C.3    Lau, T.K.4    Chiu, W.M.5    Tsang, K.S.6
  • 52
    • 84901586550 scopus 로고    scopus 로고
    • Function of the tetraspanin molecule CD81 in B and T cells
    • Levy, S. (2014). Function of the tetraspanin molecule CD81 in B and T cells. Immunol. Res . 58, 179-185. doi: 10.1007/s12026-014-8490-7
    • (2014) Immunol. Res. , vol.58 , pp. 179-185
    • Levy, S.1
  • 53
    • 0031895778 scopus 로고    scopus 로고
    • CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system
    • Levy, S., Todd, S. C., and Maecker, H. T. (1998). CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu. Rev. Immunol . 16, 89-109. doi: 10.1146/annurev.immunol.16.1.89
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 89-109
    • Levy, S.1    Todd, S.C.2    Maecker, H.T.3
  • 54
    • 0023001672 scopus 로고
    • A unique antigen on mature B cells defined by a monoclonal antibody
    • Link, M. P., Bindl, J., Meeker, T. C., Carswell, C., Doss, C. A., Warnke, R. A., et al. (1986). A unique antigen on mature B cells defined by a monoclonal antibody. J. Immunol . 137, 3013-3018.
    • (1986) J. Immunol. , vol.137 , pp. 3013-3018
    • Link, M.P.1    Bindl, J.2    Meeker, T.C.3    Carswell, C.4    Doss, C.A.5    Warnke, R.A.6
  • 55
    • 2342653563 scopus 로고    scopus 로고
    • Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association
    • Little, K. D., Hemler, M. E., and Stipp, C. S. (2004). Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. Mol. Biol. Cell 15, 2375-2387. doi: 10.1091/mbc.E03-12-0886
    • (2004) Mol. Biol. Cell , vol.15 , pp. 2375-2387
    • Little, K.D.1    Hemler, M.E.2    Stipp, C.S.3
  • 57
    • 0030948267 scopus 로고    scopus 로고
    • Normal lymphocyte development but delayed humoral immune response in CD81-null mice
    • Maecker, H. T., and Levy, S. (1997). Normal lymphocyte development but delayed humoral immune response in CD81-null mice. J. Exp. Med . 185, 1505-1510. doi: 10.1084/jem.185.8.1505
    • (1997) J. Exp. Med. , vol.185 , pp. 1505-1510
    • Maecker, H.T.1    Levy, S.2
  • 58
    • 0030947554 scopus 로고    scopus 로고
    • The tetraspanin superfamily: molecular facilitators
    • Maecker, H. T., Todd, S. C., and Levy, S. (1997). The tetraspanin superfamily: molecular facilitators. FASEB J . 11, 428-442.
    • (1997) FASEB J. , vol.11 , pp. 428-442
    • Maecker, H.T.1    Todd, S.C.2    Levy, S.3
  • 59
    • 0030239653 scopus 로고    scopus 로고
    • Transmembrane-4 Superfamily Proteins CD81 (TAPA-1), CD82, CD63, and CD53 Specifically Associate with lntegrin α4Β1 (CD49d/CD29)
    • Mannion, B. A., Berditchevski, F., Kraeft, S., Chen, L. B., and Hemler, M. E. (1996). Transmembrane-4 Superfamily Proteins CD81 (TAPA-1), CD82, CD63, and CD53 Specifically Associate with lntegrin α4Β1 (CD49d/CD29). J. Immunol . 157, 2039-2047.
    • (1996) J. Immunol. , vol.157 , pp. 2039-2047
    • Mannion, B.A.1    Berditchevski, F.2    Kraeft, S.3    Chen, L.B.4    Hemler, M.E.5
  • 60
    • 0028270041 scopus 로고
    • CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin
    • Masellis-Smith, A., and Shaw, A. R. (1994). CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin. J. Immunol . 152, 2768-2777.
    • (1994) J. Immunol. , vol.152 , pp. 2768-2777
    • Masellis-Smith, A.1    Shaw, A.R.2
  • 61
    • 84875538701 scopus 로고    scopus 로고
    • The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling
    • Mattila, P. K., Feest, C., Depoil, D., Treanor, B., Montaner, B., Otipoby, K. L., et al. (2013). The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. Immunity 38, 461-474. doi: 10.1016/j.immuni.2012.11.019
    • (2013) Immunity , vol.38 , pp. 461-474
    • Mattila, P.K.1    Feest, C.2    Depoil, D.3    Treanor, B.4    Montaner, B.5    Otipoby, K.L.6
  • 62
    • 33845915636 scopus 로고    scopus 로고
    • Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production
    • Meyer-Wentrup, F., Figdor, C. G., Ansems, M., Brossart, P., Wright, M. D., Adema, G. J., et al. (2007). Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production. J. Immunol . 178, 154-162. doi: 10.4049/jimmunol.178.1.154
    • (2007) J. Immunol. , vol.178 , pp. 154-162
    • Meyer-Wentrup, F.1    Figdor, C.G.2    Ansems, M.3    Brossart, P.4    Wright, M.D.5    Adema, G.J.6
  • 63
    • 33745235141 scopus 로고    scopus 로고
    • Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution
    • Min, G., Wang, H., Sun, T. T., and Kong, X. P. (2006). Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution. J. Cell Biol . 173, 975-983. doi: 10.1083/jcb.200602086
    • (2006) J. Cell Biol. , vol.173 , pp. 975-983
    • Min, G.1    Wang, H.2    Sun, T.T.3    Kong, X.P.4
  • 65
    • 2642642091 scopus 로고    scopus 로고
    • Physiological activation of human neutrophils down-regulates CD53 cell surface antigen
    • Mollinedo, F., Martin-Martin, B., Gajate, C., and Lazo, P. A. (1998). Physiological activation of human neutrophils down-regulates CD53 cell surface antigen. J. Leukoc. Biol . 63, 699-706.
    • (1998) J. Leukoc. Biol. , vol.63 , pp. 699-706
    • Mollinedo, F.1    Martin-Martin, B.2    Gajate, C.3    Lazo, P.A.4
  • 67
    • 0034662761 scopus 로고    scopus 로고
    • Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7
    • Nicholson, R. H., Pantano, S., Eliason, J. F., Galy, A., Weiler, S., Kaplan, J., et al. (2000). Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. Genomics 68, 13-21. doi: 10.1006/geno.2000.6277
    • (2000) Genomics , vol.68 , pp. 13-21
    • Nicholson, R.H.1    Pantano, S.2    Eliason, J.F.3    Galy, A.4    Weiler, S.5    Kaplan, J.6
  • 68
    • 0027181572 scopus 로고
    • CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells
    • Olweus, J., Lund-Johansen, F., and Horejsi, V. (1993). CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells. J. Immunol . 151, 707-716.
    • (1993) J. Immunol. , vol.151 , pp. 707-716
    • Olweus, J.1    Lund-Johansen, F.2    Horejsi, V.3
  • 69
    • 0033563253 scopus 로고    scopus 로고
    • Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylation
    • Ono, M., Handa, K., Withers, D. A., and Hakomori, S. (1999). Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylation. Cancer Res . 59, 2335-2339.
    • (1999) Cancer Res. , vol.59 , pp. 2335-2339
    • Ono, M.1    Handa, K.2    Withers, D.A.3    Hakomori, S.4
  • 70
    • 0034731368 scopus 로고    scopus 로고
    • Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells
    • Ono, M., Handa, K., Withers, D. A., and Hakomori, S. (2000). Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells. Biochem. Biophys. Res. Commun . 279, 744-750. doi: 10.1006/bbrc.2000.4030
    • (2000) Biochem. Biophys. Res. Commun. , vol.279 , pp. 744-750
    • Ono, M.1    Handa, K.2    Withers, D.A.3    Hakomori, S.4
  • 71
    • 84915788744 scopus 로고    scopus 로고
    • Otlertuzumab (TRU-016), an anti-CD37 monospecific ADAPTIR therapeutic protein, for relapsed or refractory NHL patients
    • Pagel, J. M., Spurgeon, S. E., Byrd, J. C., Awan, F. T., Flinn, I. W., Lanasa, M. C., et al. (2015). Otlertuzumab (TRU-016), an anti-CD37 monospecific ADAPTIR therapeutic protein, for relapsed or refractory NHL patients. Br. J. Haematol . 168, 38-45. doi: 10.1111/bjh.13099
    • (2015) Br. J. Haematol. , vol.168 , pp. 38-45
    • Pagel, J.M.1    Spurgeon, S.E.2    Byrd, J.C.3    Awan, F.T.4    Flinn, I.W.5    Lanasa, M.C.6
  • 73
    • 0024321013 scopus 로고
    • Treatment of refractory non-Hodgkin's lymphoma with radiolabeled MB-1 (anti-CD37) antibody
    • Press, O. W., Eary, J. F., Badger, C. C., Martin, P. J., Appelbaum, F. R., Levy, R., et al. (1989). Treatment of refractory non-Hodgkin's lymphoma with radiolabeled MB-1 (anti-CD37) antibody. J. Clin. Oncol . 7, 1027-1038.
    • (1989) J. Clin. Oncol. , vol.7 , pp. 1027-1038
    • Press, O.W.1    Eary, J.F.2    Badger, C.C.3    Martin, P.J.4    Appelbaum, F.R.5    Levy, R.6
  • 74
    • 0028096216 scopus 로고
    • Retention of B-cell-specific monoclonal antibodies by human lymphoma cells.
    • Press, O. W., Howell-Clark, J., Anderson, S., and Bernstein, I. (1994). Retention of B-cell-specific monoclonal antibodies by human lymphoma cells. Blood 83, 1390-1397.
    • (1994) Blood , vol.83 , pp. 1390-1397
    • Press, O.W.1    Howell-Clark, J.2    Anderson, S.3    Bernstein, I.4
  • 75
    • 30144435055 scopus 로고    scopus 로고
    • Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor
    • Qi, J. C., Wang, J., Mandadi, S., Tanaka, K., Roufogalis, B. D., Madigan, M. C., et al. (2006). Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor. Blood 107, 135-142. doi: 10.1182/blood-2005-03-1312
    • (2006) Blood , vol.107 , pp. 135-142
    • Qi, J.C.1    Wang, J.2    Mandadi, S.3    Tanaka, K.4    Roufogalis, B.D.5    Madigan, M.C.6
  • 76
    • 84883883781 scopus 로고    scopus 로고
    • Glycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies
    • Rafiq, S., Siadak, A., Butchar, J. P., Cheney, C., Lozanski, G., Jacob, N. K., et al. (2013). Glycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies. MAbs 5, 723-735. doi: 10.4161/mabs.25282
    • (2013) MAbs , vol.5 , pp. 723-735
    • Rafiq, S.1    Siadak, A.2    Butchar, J.P.3    Cheney, C.4    Lozanski, G.5    Jacob, N.K.6
  • 77
    • 84904878044 scopus 로고    scopus 로고
    • 177Lu-DOTA-HH1, a novel anti-CD37 radio-immunoconjugate: a study of toxicity in nude mice.
    • Repetto-Llamazares, A. H., Larsen, R. H., Giusti, A. M., Riccardi, E., Bruland, O. S., Selbo, P. K., et al. (2014). 177Lu-DOTA-HH1, a novel anti-CD37 radio-immunoconjugate: a study of toxicity in nude mice. PLoS ONE 9:e103070. doi: 10.1371/journal.pone.0103070
    • (2014) PLoS ONE , vol.9
    • Repetto-Llamazares, A.H.1    Larsen, R.H.2    Giusti, A.M.3    Riccardi, E.4    Bruland, O.S.5    Selbo, P.K.6
  • 78
    • 84926467907 scopus 로고    scopus 로고
    • Phase 2 study of otlertuzumab (TRU-016), an anti-CD37 ADAPTIRTM protein, in combination with bendamustine vs bendamustine alone in patients with relapsed chronic lymphocytic leukemia (CLL)
    • #2860 55th Annual Meeting of the American Society of Hematology (New Orleans, LA).
    • Robak, T., Hellman, A., Kloczko, J., Loscertales, J., Lech-Maranda, E. J., Pagel, J. M., et al. (2013). "Phase 2 study of otlertuzumab (TRU-016), an anti-CD37 ADAPTIRTM protein, in combination with bendamustine vs bendamustine alone in patients with relapsed chronic lymphocytic leukemia (CLL)," in Abstract #2860, 55th Annual Meeting of the American Society of Hematology (New Orleans, LA).
    • (2013)
    • Robak, T.1    Hellman, A.2    Kloczko, J.3    Loscertales, J.4    Lech-Maranda, E.J.5    Pagel, J.M.6
  • 79
    • 0035846450 scopus 로고    scopus 로고
    • Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs
    • Robb, L., Tarrant, J., Groom, J., Ibrahim, M., Li, R., Borobakas, B., et al. (2001). Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. Biochim. Biophys. Acta 1522, 31-41. doi: 10.1016/S0167-4781(01)00306-2
    • (2001) Biochim. Biophys. Acta , vol.1522 , pp. 31-41
    • Robb, L.1    Tarrant, J.2    Groom, J.3    Ibrahim, M.4    Li, R.5    Borobakas, B.6
  • 80
    • 78650023067 scopus 로고    scopus 로고
    • Tetraspanins in human epithelial malignancies
    • Romanska, H. M., and Berditchevski, F. (2011). Tetraspanins in human epithelial malignancies. J. Pathol . 223, 4-14. doi: 10.1002/path.2779
    • (2011) J. Pathol. , vol.223 , pp. 4-14
    • Romanska, H.M.1    Berditchevski, F.2
  • 81
    • 0023870925 scopus 로고
    • The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein
    • Schwartz-Albiez, R., Dorken, B., Hofmann, W., and Moldenhauer, G. (1988). The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein. J. Immunol . 140, 905-914.
    • (1988) J. Immunol. , vol.140 , pp. 905-914
    • Schwartz-Albiez, R.1    Dorken, B.2    Hofmann, W.3    Moldenhauer, G.4
  • 82
    • 84858785688 scopus 로고    scopus 로고
    • Antibody therapy of cancer
    • Scott, A. M., Wolchok, J. D., and Old, L. J. (2012). Antibody therapy of cancer. Nat. Rev. Cancer 12, 278-287. doi: 10.1038/nrc3236
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 278-287
    • Scott, A.M.1    Wolchok, J.D.2    Old, L.J.3
  • 83
    • 84864008966 scopus 로고    scopus 로고
    • Gene Expression Commons: an open platform for absolute gene expression profiling.
    • Seita, J., Sahoo, D., Rossi, D. J., Bhattacharya, D., Serwold, T., Inlay, M. A., et al. (2012). Gene Expression Commons: an open platform for absolute gene expression profiling. PLoS ONE 7:e40321. doi: 10.1371/journal.pone.0040321
    • (2012) PLoS ONE , vol.7
    • Seita, J.1    Sahoo, D.2    Rossi, D.J.3    Bhattacharya, D.4    Serwold, T.5    Inlay, M.A.6
  • 84
    • 0034234662 scopus 로고    scopus 로고
    • CD9 expression enhances the susceptibility of myeloma cell lines to cell-mediated cytolysis.
    • Shallal, S., and Kornbluth, J. (2000). CD9 expression enhances the susceptibility of myeloma cell lines to cell-mediated cytolysis. Blood 96, 224-233.
    • (2000) Blood , vol.96 , pp. 224-233
    • Shallal, S.1    Kornbluth, J.2
  • 85
    • 60549086478 scopus 로고    scopus 로고
    • Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC
    • Sheng, K. C., Van Spriel, A. B., Gartlan, K. H., Sofi, M., Apostolopoulos, V., Ashman, L., et al. (2009). Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC. Eur. J. Immunol . 39, 50-55. doi: 10.1002/eji.200838798
    • (2009) Eur. J. Immunol. , vol.39 , pp. 50-55
    • Sheng, K.C.1    Van Spriel, A.B.2    Gartlan, K.H.3    Sofi, M.4    Apostolopoulos, V.5    Ashman, L.6
  • 86
    • 0037474276 scopus 로고    scopus 로고
    • The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity
    • Shinkawa, T., Nakamura, K., Yamane, N., Shoji-Hosaka, E., Kanda, Y., Sakurada, M., et al. (2003). The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity. J. Biol. Chem . 278, 3466-3473. doi: 10.1074/jbc.M210665200
    • (2003) J. Biol. Chem. , vol.278 , pp. 3466-3473
    • Shinkawa, T.1    Nakamura, K.2    Yamane, N.3    Shoji-Hosaka, E.4    Kanda, Y.5    Sakurada, M.6
  • 87
    • 32044459101 scopus 로고    scopus 로고
    • Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments
    • Shoham, T., Rajapaksa, R., Kuo, C. C., Haimovich, J., and Levy, S. (2006). Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments. Mol. Cell. Biol . 26, 1373-1385. doi: 10.1128/MCB.26.4.1373-1385.2006
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 1373-1385
    • Shoham, T.1    Rajapaksa, R.2    Kuo, C.C.3    Haimovich, J.4    Levy, S.5
  • 88
    • 84926467906 scopus 로고    scopus 로고
    • A Phase I study of IMGN529, an antibody-drug conjugate (ADC) targeting CD37, in adult patients with relapsed or refractory b-cell non-hodgkin's lymphoma (NHL)
    • #1760 56th Annual Meeting of the American Society of Hematology (San Francisco, CA).
    • Stathis, A., Freedman, A. S., Flinn, I. W., Maddocks, K. J., Weitman, S., Berdeja, J. G., et al. (2014). "A Phase I study of IMGN529, an antibody-drug conjugate (ADC) targeting CD37, in adult patients with relapsed or refractory b-cell non-hodgkin's lymphoma (NHL)," in Abstract #1760, 56th Annual Meeting of the American Society of Hematology (San Francisco, CA).
    • (2014)
    • Stathis, A.1    Freedman, A.S.2    Flinn, I.W.3    Maddocks, K.J.4    Weitman, S.5    Berdeja, J.G.6
  • 89
    • 0035983648 scopus 로고    scopus 로고
    • Signals mediated by FcgammaRIIA suppress the growth of B-lineage acute lymphoblastic leukemia cells
    • Suzuki, T., Coustan-Smith, E., Mihara, K., and Campana, D. (2002). Signals mediated by FcgammaRIIA suppress the growth of B-lineage acute lymphoblastic leukemia cells. Leukemia 16, 1276-1284. doi: 10.1038/sj.leu.2402523
    • (2002) Leukemia , vol.16 , pp. 1276-1284
    • Suzuki, T.1    Coustan-Smith, E.2    Mihara, K.3    Campana, D.4
  • 90
    • 0030267031 scopus 로고    scopus 로고
    • Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY
    • Szöllósi, J., Horejsí, V., Bene, L., Angelisová, P., and Damjanovich, S. (1996). Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. J. Immunol . 157, 2939-2946.
    • (1996) J. Immunol. , vol.157 , pp. 2939-2946
    • Szöllósi, J.1    Horejsí, V.2    Bene, L.3    Angelisová, P.4    Damjanovich, S.5
  • 91
    • 10144245925 scopus 로고    scopus 로고
    • A role for CD9 molecules in T cell activation
    • Tai, X. G., Yashiro, Y., Abe, R., Toyooka, K., Wood, C. R., Morris, J., et al. (1996). A role for CD9 molecules in T cell activation. J. Exp. Med . 184, 753-758. doi: 10.1084/jem.184.2.753
    • (1996) J. Exp. Med. , vol.184 , pp. 753-758
    • Tai, X.G.1    Yashiro, Y.2    Abe, R.3    Toyooka, K.4    Wood, C.R.5    Morris, J.6
  • 92
    • 0036291471 scopus 로고    scopus 로고
    • The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses
    • Tarrant, J. M., Groom, J., Metcalf, D., Li, R., Borobokas, B., Wright, M. D., et al. (2002). The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses. Mol. Cell. Biol . 22, 5006-5018. doi: 10.1128/MCB.22.14.5006-5018.2002
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5006-5018
    • Tarrant, J.M.1    Groom, J.2    Metcalf, D.3    Li, R.4    Borobokas, B.5    Wright, M.D.6
  • 93
    • 0242302578 scopus 로고    scopus 로고
    • Tetraspanins: molecular organisers of the leukocyte surface
    • Tarrant, J. M., Robb, L., Van Spriel, A. B., and Wright, M. D. (2003). Tetraspanins: molecular organisers of the leukocyte surface. Trends Immunol . 24, 610-617. doi: 10.1016/j.it.2003.09.011
    • (2003) Trends Immunol. , vol.24 , pp. 610-617
    • Tarrant, J.M.1    Robb, L.2    Van Spriel, A.B.3    Wright, M.D.4
  • 94
    • 84869395208 scopus 로고    scopus 로고
    • The tetraspanin CD37 orchestrates the alpha(4)beta(1) integrin-Akt signaling axis and supports long-lived plasma cell survival
    • Van Spriel, A. B., De Keijzer, S., Van Der Schaaf, A., Gartlan, K. H., Sofi, M., Light, A., et al. (2012). The tetraspanin CD37 orchestrates the alpha(4)beta(1) integrin-Akt signaling axis and supports long-lived plasma cell survival. Sci. Signal 5, ra82. doi: 10.1126/scisignal.2003113
    • (2012) Sci. Signal , vol.5 , pp. ra82
    • Van Spriel, A.B.1    De Keijzer, S.2    Van Der Schaaf, A.3    Gartlan, K.H.4    Sofi, M.5    Light, A.6
  • 97
    • 79959546895 scopus 로고    scopus 로고
    • Tetraspanins in the immune response against cancer
    • Veenbergen, S., and Van Spriel, A. B. (2011). Tetraspanins in the immune response against cancer. Immunol. Lett . 138, 129-136. doi: 10.1016/j.imlet.2011.03.010
    • (2011) Immunol. Lett. , vol.138 , pp. 129-136
    • Veenbergen, S.1    Van Spriel, A.B.2
  • 98
    • 0034646232 scopus 로고    scopus 로고
    • Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis
    • Voehringer, D. W., Hirschberg, D. L., Xiao, J., Lu, Q., Roederer, M., Lock, C. B., et al. (2000). Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proc. Natl. Acad. Sci. U.S.A . 97, 2680-2685. doi: 10.1073/pnas.97.6.2680
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 2680-2685
    • Voehringer, D.W.1    Hirschberg, D.L.2    Xiao, J.3    Lu, Q.4    Roederer, M.5    Lock, C.B.6
  • 99
    • 0037148519 scopus 로고    scopus 로고
    • Murine CD9 is the receptor for pregnancy-specific glycoprotein 17
    • Waterhouse, R., Ha, C., and Dveksler, G. S. (2002). Murine CD9 is the receptor for pregnancy-specific glycoprotein 17. J. Exp. Med . 195, 277-282. doi: 10.1084/jem.20011741
    • (2002) J. Exp. Med. , vol.195 , pp. 277-282
    • Waterhouse, R.1    Ha, C.2    Dveksler, G.S.3
  • 100
    • 0032543716 scopus 로고    scopus 로고
    • Frequent downregulation of the KAI1(CD82) metastasis suppressor protein in human cancer cell lines
    • White, A., Lamb, P. W., and Barrett, J. C. (1998). Frequent downregulation of the KAI1(CD82) metastasis suppressor protein in human cancer cell lines. Oncogene 16, 3143-3149. doi: 10.1038/sj.onc.1201852
    • (1998) Oncogene , vol.16 , pp. 3143-3149
    • White, A.1    Lamb, P.W.2    Barrett, J.C.3
  • 101
    • 0034663818 scopus 로고    scopus 로고
    • CD81 and CD28 costimulate T cells through distinct pathways
    • Witherden, D. A., Boismenu, R., and Havran, W. L. (2000). CD81 and CD28 costimulate T cells through distinct pathways. J. Immunol . 165, 1902-1909. doi: 10.4049/jimmunol.165.4.1902
    • (2000) J. Immunol. , vol.165 , pp. 1902-1909
    • Witherden, D.A.1    Boismenu, R.2    Havran, W.L.3
  • 102
    • 0025038080 scopus 로고
    • Platelet activation by CD9 monoclonal antibodies is mediated by the Fc gamma II receptor
    • Worthington, R. E., Carroll, R. C., and Boucheix, C. (1990). Platelet activation by CD9 monoclonal antibodies is mediated by the Fc gamma II receptor. Br. J. Haematol . 74, 216-222. doi: 10.1111/j.1365-2141.1990.tb02568.x
    • (1990) Br. J. Haematol. , vol.74 , pp. 216-222
    • Worthington, R.E.1    Carroll, R.C.2    Boucheix, C.3
  • 103
    • 2942744486 scopus 로고    scopus 로고
    • Characterization of mice lacking the tetraspanin superfamily member CD151
    • Wright, M. D., Geary, S. M., Fitter, S., Moseley, G. W., Lau, L. M., Sheng, K. C., et al. (2004). Characterization of mice lacking the tetraspanin superfamily member CD151. Mol. Cell. Biol . 24, 5978-5988. doi: 10.1128/MCB.24.13.5978-5988.2004
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 5978-5988
    • Wright, M.D.1    Geary, S.M.2    Fitter, S.3    Moseley, G.W.4    Lau, L.M.5    Sheng, K.C.6
  • 104
    • 0036198534 scopus 로고    scopus 로고
    • Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology
    • Yang, X., Claas, C., Kraeft, S. K., Chen, L. B., Wang, Z., Kreidberg, J. A., et al. (2002). Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. Mol. Biol. Cell 13, 767-781. doi: 10.1091/mbc.01-05-0275
    • (2002) Mol. Biol. Cell , vol.13 , pp. 767-781
    • Yang, X.1    Claas, C.2    Kraeft, S.K.3    Chen, L.B.4    Wang, Z.5    Kreidberg, J.A.6
  • 105
    • 11244304502 scopus 로고    scopus 로고
    • Palmitoylation supports assembly and function of integrin-tetraspanin complexes
    • Yang, X., Kovalenko, O. V., Tang, W., Claas, C., Stipp, C. S., and Hemler, M. E. (2004). Palmitoylation supports assembly and function of integrin-tetraspanin complexes. J. Cell Biol . 167, 1231-1240. doi: 10.1083/jcb.200404100
    • (2004) J. Cell Biol. , vol.167 , pp. 1231-1240
    • Yang, X.1    Kovalenko, O.V.2    Tang, W.3    Claas, C.4    Stipp, C.S.5    Hemler, M.E.6
  • 106
    • 0031660652 scopus 로고    scopus 로고
    • Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration
    • Yauch, R. L., Berditchevski, F., Harler, M. B., Reichner, J., and Hemler, M. E. (1998). Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol. Biol. Cell 9, 2751-2765. doi: 10.1091/mbc.9.10.2751
    • (1998) Mol. Biol. Cell , vol.9 , pp. 2751-2765
    • Yauch, R.L.1    Berditchevski, F.2    Harler, M.B.3    Reichner, J.4    Hemler, M.E.5
  • 107
    • 0034737471 scopus 로고    scopus 로고
    • Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151
    • Yauch, R. L., Kazarov, A. R., Desai, B., Lee, R. T., and Hemler, M. E. (2000). Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J. Biol. Chem . 275, 9230-9238. doi: 10.1074/jbc.275.13.9230
    • (2000) J. Biol. Chem. , vol.275 , pp. 9230-9238
    • Yauch, R.L.1    Kazarov, A.R.2    Desai, B.3    Lee, R.T.4    Hemler, M.E.5
  • 108
    • 84878654009 scopus 로고    scopus 로고
    • Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells
    • Yu, B., Mao, Y., Yuan, Y., Yue, C., Wang, X., Mo, X., et al. (2013). Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells. Biomaterials 34, 6185-6193. doi: 10.1016/j.biomaterials.2013.04.063
    • (2013) Biomaterials , vol.34 , pp. 6185-6193
    • Yu, B.1    Mao, Y.2    Yuan, Y.3    Yue, C.4    Wang, X.5    Mo, X.6
  • 109
    • 0037468262 scopus 로고    scopus 로고
    • Apoptosis protection and survival signal by the CD53 tetraspanin antigen
    • Yunta, M., and Lazo, P. A. (2003). Apoptosis protection and survival signal by the CD53 tetraspanin antigen. Oncogene 22, 1219-1224. doi: 10.1038/sj.onc.1206183
    • (2003) Oncogene , vol.22 , pp. 1219-1224
    • Yunta, M.1    Lazo, P.A.2
  • 110
    • 79953203957 scopus 로고    scopus 로고
    • Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated by alpha3beta1 versus alpha6beta4 integrin
    • Zevian, S., Winterwood, N. E., and Stipp, C. S. (2011). Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated by alpha3beta1 versus alpha6beta4 integrin. J. Biol. Chem . 286, 7496-7506. doi: 10.1074/jbc.M110.173583
    • (2011) J. Biol. Chem. , vol.286 , pp. 7496-7506
    • Zevian, S.1    Winterwood, N.E.2    Stipp, C.S.3
  • 111
    • 0035816663 scopus 로고    scopus 로고
    • Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins
    • Zhang, X. A., Bontrager, A. L., and Hemler, M. E. (2001). Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. J. Biol. Chem . 276, 25005-25013. doi: 10.1074/jbc.M102156200
    • (2001) J. Biol. Chem. , vol.276 , pp. 25005-25013
    • Zhang, X.A.1    Bontrager, A.L.2    Hemler, M.E.3
  • 112
    • 34948858867 scopus 로고    scopus 로고
    • Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical
    • Zhao, X., Lapalombella, R., Joshi, T., Cheney, C., Gowda, A., Hayden-Ledbetter, M. S., et al. (2007). Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. Blood 110, 2569-2577. doi: 10.1182/blood-2006-12-062927
    • (2007) Blood , vol.110 , pp. 2569-2577
    • Zhao, X.1    Lapalombella, R.2    Joshi, T.3    Cheney, C.4    Gowda, A.5    Hayden-Ledbetter, M.S.6
  • 113
    • 39849083927 scopus 로고    scopus 로고
    • The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151
    • Zijlstra, A., Lewis, J., Degryse, B., Stuhlmann, H., and Quigley, J. P. (2008). The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell 13, 221-234. doi: 10.1016/j.ccr.2008.01.031
    • (2008) Cancer Cell , vol.13 , pp. 221-234
    • Zijlstra, A.1    Lewis, J.2    Degryse, B.3    Stuhlmann, H.4    Quigley, J.P.5
  • 114
    • 57749169272 scopus 로고    scopus 로고
    • Tetraspanins: push and pull in suppressing and promoting metastasis
    • Zoller, M. (2009). Tetraspanins: push and pull in suppressing and promoting metastasis. Nat. Rev. Cancer 9, 40-55. doi: 10.1038/nrc2543
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 40-55
    • Zoller, M.1
  • 115
    • 84897023823 scopus 로고    scopus 로고
    • Microdomains in the membrane landscape shape antigen-presenting cell function
    • Zuidscherwoude, M., De Winde, C. M., Cambi, A., and Van Spriel, A. B. (2014). Microdomains in the membrane landscape shape antigen-presenting cell function. J. Leukoc. Biol . 95, 251-263. doi: 10.1189/jlb.0813440
    • (2014) J. Leukoc. Biol. , vol.95 , pp. 251-263
    • Zuidscherwoude, M.1    De Winde, C.M.2    Cambi, A.3    Van Spriel, A.B.4


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