A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-α levels

European Journal of Human Genetics

Volumn 18, Issue 8, 2010, Pages 953-959

  Bos, Steffan D ^a   Lakenberg, Nico ^a   Van Der Breggen, Ruud ^a   Houwing Duistermaat, Jeanine J ^a   Kloppenburg, Margreet ^a   De Craen, Anton Jm ^a   Beekman, Marian ^a   Meulenbelt, Ingrid ^a   Slagboom, P Eline ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Netherlands Consortium for Healthy Ageing   (Netherlands)

Author keywords

CD53; GARP; immunity; linkage; osteoarthritis; TNF

Indexed keywords

CD53 ANTIGEN; CYTOKINE; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; CD53 PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; IL1RN PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LEUKOCYTE ANTIGEN; MICROSATELLITE DNA; T LYMPHOCYTE ANTIGEN;

ADULT; ARTICLE; COHORT ANALYSIS; CYTOKINE PRODUCTION; FEMALE; GENETIC LINKAGE; GENETIC VARIABILITY; GENOME; HUMAN; INNATE IMMUNITY; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; OSTEOARTHRITIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; CHROMOSOME MAP; GENETIC ASSOCIATION; GENETICS; METABOLISM; MIDDLE AGED; NETHERLANDS; SIBLING; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CHROMOSOME MAPPING; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; HUMANS; IMMUNITY, INNATE; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-10; INTERLEUKIN-1BETA; LINKAGE (GENETICS); MALE; MICROSATELLITE REPEATS; MIDDLE AGED; NETHERLANDS; OSTEOARTHRITIS; POLYMORPHISM, SINGLE NUCLEOTIDE; SIBLINGS; TUMOR NECROSIS FACTOR-ALPHA; ANTIGENS, CD53; GENETIC LINKAGE;

EID: 77954959108     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2010.52     Document Type: Article

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