Function of the tetraspanin molecule CD81 in B and T cells

Immunologic Research

Volumn 58, Issue 2-3, 2014, Pages 179-185

  Levy, Shoshana ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibody deficiency; Glycosylation; Mutation; Tetraspanins; Trafficking

Indexed keywords

CD19 ANTIGEN; CD81 ANTIGEN; TETRASPANIN; MEMBRANE PROTEIN;

ADAPTIVE IMMUNITY; ALLELE; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CELL INTERACTION; CELL SURFACE; GENE MUTATION; HEPATITIS C VIRUS; HUMAN; HUMORAL IMMUNE DEFICIENCY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; T LYMPHOCYTE; TH2 CELL; ANIMAL; CELL COMMUNICATION; CHEMISTRY; IMMUNOLOGY; METABOLISM; MOUSE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD81; B-LYMPHOCYTES; CELL COMMUNICATION; HUMANS; MEMBRANE PROTEINS; MICE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84901586550     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-014-8490-7     Document Type: Article

References (59)

1. Oren R, Takahashi S, Doss C, Levy R, Levy S. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol Cell Biol. 1990;10(8):4007-15.
2. Takahashi S, Doss C, Levy S, Levy R. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. J Immunol (Baltimore, MD: 1950). 1990;145(7):2207-13.
3. Garcia-Espana A, Chung PJ, Sarkar IN, Stiner E, Sun TT, Desalle R. Appearance of new tetraspanin genes during vertebrate evolution. Genomics. 2008;91(4):326-34.
4. Garcia-Espana A, Chung PJ, Zhao X, Lee A, Pellicer A, Yu J, Sun TT, Desalle R. Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: implications for uroplakin structure and function. Mol Phylogenet Evol. 2006;41(2):355-67.
5. Kitadokoro K, Bordo D, Galli G, Petracca R, Falugi F, Abrignani S, Grandi G, Bolognesi M. CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. EMBO J. 2001;20(1-2):12-8.
6. Hemler ME. Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol. 2005;6(10):801-11.
7. Levy S, Shoham T. The tetraspanin web modulates immunesignalling complexes. Nat Rev Immunol. 2005;5(2):136-48.
8. Nydegger S, Khurana S, Krementsov DN, Foti M, Thali M. Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1. J Cell Biol. 2006;173(5):795-807.
9. Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J Immunol. 1992;149(9):2841-50.
10. Fournier M, Peyrou M, Bourgoin L, Maeder C, Tchou I, Foti M. CD4 dimerization requires two cysteines in the cytoplasmic domain of the molecule and occurs in microdomains distinct from lipid rafts. Mol Immunol. 2010;47(16):2594-603.
11. Imai T, Kakizaki M, Nishimura M, Yoshie O. Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. J Immunol. 1995;155(3): 1229-39.
12. Todd SC, Lipps SG, Crisa L, Salomon DR, Tsoukas CD. CD81 expressed on human thymocytes mediates integrin activation and interleukin 2-dependent proliferation. J Exp Med. 1996;184(5): 2055-60.
13. Charrin S, Manie S, Billard M, Ashman L, Gerlier D, Boucheix C, Rubinstein E. Multiple levels of interactions within the tetraspanin web. Biochem Biophys Res Commun. 2003;304(1): 107-12.
14. Berditchevski F, Tolias KF, Wong K, Carpenter CL, Hemler ME. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem. 1997;272(5):2595-8.
15. Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME. Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). J Immunol. 1996;157(5):2039-47.
16. Stipp CS, Kolesnikova TV, Hemler ME. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem. 2001;276(44):40545-54.
17. Charrin S, Le Naour F, Labas V, Billard M, Le Caer JP, Emile JF, Petit MA, Boucheix C, Rubinstein E. EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. Biochem J. 2003;373(Pt 2):409-21.
18. Sala-Valdes M, Ursa A, Charrin S, Rubinstein E, Hemler ME, Sanchez-Madrid F, Yanez-Mo M. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. J Biol Chem. 2006;281(28):19665-75.
19. Coffey G, Rajapaksa R, Liu R, Sharpe O, Kuo C-C, Krauss S, Sagi Y, Davis R, Staudt L, Sharman J, Robinson W, Levy S. Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin. J Cell Sci. 2009;122(Pt 17):3137-44.
20. Gordon-Alonso M, Sala-Valdes M, Rocha-Perugini V, Perez-Hernandez D, Lopez-Martin S, Ursa A, Alvarez S, Kolesnikova TV, Vazquez J, Sanchez-Madrid F, Yanez-Mo M. EWI-2 association with alpha-actinin regulates T cell immune synapses and HIV viral infection. J Immunol. 2012;189(2):689-700.
21. Fearon DT, Carroll MC. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu Rev Immunol. 2000;18:393-422.
22. Dempsey PW, Allison ME, Akkaraju S, Goodnow CC, Fearon DT. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science. 1996;271(5247):348-50.
23. Mattila PK, Feest C, Depoil D, Treanor B, Montaner B, Otipoby KL, Carter R, Justement LB, Bruckbauer A, Batista FD. The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. Immunity. 2013;38(3): 461-74.
24. Matsumoto AK, Martin DR, Carter RH, Klickstein LB, Ahearn JM, Fearon DT. Functional dissection of the CD21/CD19/TAPA- 1/Leu-13 complex of B lymphocytes. J Exp Med. 1993;178(4): 1407-17.
25. Maecker HT, Levy S. Normal lymphocyte development but delayed humoral immune response in CD81-null mice. J Exp Med. 1997;185(8):1505-10.
26. Miyazaki T, Muller U, Campbell KS. Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J. 1997;16(14):4217-25.
27. Tsitsikov EN, Gutierrez-Ramos JC, Geha RS. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci USA. 1997;94(20):10844-9.
28. van Zelm MC, Smet J, Adams B, Mascart F, Schandene L, Janssen F, Ferster A, Kuo CC, Levy S, van Dongen JJ, van der Burg M. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest. 2010;120(4):1265-74 PMCID: PMC2846042.
29. Shoham T, Rajapaksa R, Boucheix C, Rubinstein E, Poe JC, Tedder TF, Levy S. The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. J Immunol. 2003;171(8):4062-72.
30. Shoham T, Rajapaksa R, Kuo CC, Haimovich J, Levy S. Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments. Mol Cell Biol. 2006;26(4):1373-85 PMCID: 1367195.
31. Schick M, Nguyen V, Levy S. Anti-TAPA-1 antibodies induce protein tyrosine phosphorylation that is prevented by increasing intracellular thiol levels. J Immunol (Baltimore, MD: 1950). 1993;151(4):1918-25.
32. Cherukuri A, Shoham T, Sohn H, Levy S, Brooks S, Carter R, Pierce S. The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts. J Immunol (Baltimore, MD: 1950). 2004;172(1):370-80.
33. Sanyal M, Fernandez R, Levy S. Enhanced B cell activation in the absence of CD81. Int Immunol. 2009;21(11):1225-37.
34. Schick MR, Levy S. The TAPA-1 molecule is associated on the surface of B cells with HLA-DR molecules. J Immunol. 1993;151(8):4090-7.
35. Rubinstein E, Le Naour F, Lagaudriere-Gesbert C, Billard M, Conjeaud H, Boucheix C. CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLADR and VLA integrins. Eur J Immunol. 1996;26(11):2657-65.
36. Angelisova P, Hilgert I, Horejsi V. Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins. Immunogenetics. 1994;39: 249-56.
37. Szollosi J, Horejsi V, Bene L, Angelisova P, Damjanovich S. Supramolecular complexes of MHC class I, MHC class II, CD20, and teraspan molecules (CD53, CD81 and CD82) at the surface of a B cell line JY. J Immunol. 1996;157:2939-46.
38. Hoorn T, Paul P, Janssen L, Janssen H, Neefjes J. Dynamics within tetraspanin pairs affect MHC class II expression. J Cell Sci. 2012;125(Pt 2):328-39.
39. Fukudome K, Furuse M, Imai T, Nishimura M, Takagi S, Hinuma Y, Yoshie O. Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells. J Virol. 1992;66(3):1394-401 PMCID: PMC240862.
40. Gordon-Alonso M, Yanez-Mo M, Barreiro O, Alvarez S, Munoz-Fernandez MA, Valenzuela-Fernandez A, Sanchez-Madrid F. Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusion. J Immunol. 2006;177(8):5129-37.
41. Rubinstein E, Ziyyat A, Prenant M, Wrobel E, Wolf J-P, Levy S, Le Naour Fß, Boucheix C. Reduced fertility of female mice lacking CD81. Dev Biol. 2006;290(2):351-8.
42. Charrin S, Latil M, Soave S, Polesskaya A, Chretien F, Boucheix C, Rubinstein E. Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81. Nat Commun. 2013;4:1674.
43. Potel J, Rassam P, Montpellier C, Kaestner L, Werkmeister E, Tews BA, Couturier C, Popescu CI, Baumert TF, Rubinstein E, Dubuisson J, Milhiet PE, Cocquerel L. EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry. Cell Microbiol. 2013;15(7):1234-52.
44. Boismenu R, Rhein M, Fischer WH, Havran WL. A role for CD81 in early T cell development. Science. 1996;271(5246): 198-200.
45. Maecker H, Todd S, Kim E, Levy S. Differential expression of murine CD81 highlighted by new anti-mouse CD81 monoclonal antibodies. Hybridoma. 2000;19(1):15-22.
46. Witherden DA, Boismenu R, Havran WL. CD81 and CD28 costimulate T cells through distinct pathways. J Immunol. 2000;165(4):1902-9.
47. Sagi Y, Landrigan A, Levy R, Levy S. Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81. Proc Natl Acad Sci USA. 2012;109(5):1613-8.
48. Soldaini E, Wack A, D'Oro U, Nuti S, Ulivieri C, Baldari CT, Abrignani S. T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck. Eur J Immunol. 2003;33(2):455-64.
49. Crotta S, Stilla A, Wack A, D'Andrea A, Nuti S, D'Oro U, Mosca M, Filliponi F, Brunetto RM, Bonino F, Abrignani S, Valiante NM. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med. 2002;195(1):35-41.
50. Crotta S, Ronconi V, Ulivieri C, Baldari CT, Valiante NM, Abrignani S, Wack A. Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells. Eur J Immunol. 2006;36(4):919-29.
51. Tseng CT, Klimpel GR. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med. 2002;195(1):43-9.
52. Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC. PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. J Immunol. 2001;167(9):5115-21.
53. Clark KL, Oelke A, Johnson ME, Eilert KD, Simpson PC, Todd SC. CD81 associates with 14-3-3 in a redox-regulated palmi-toylation- dependent manner. J Biol Chem. 2004;279(19): 19401-6.
54. Mittelbrunn M, Yanez-Mo M, Sancho D, Ursa A, Sanchez-Madrid F. Cutting edge: dynamic redistribution of tetraspanin CD81 at the central zone of the immune synapse in both T lymphocytes and APC. J Immunol. 2002;169(12):6691-5.
55. Rocha-Perugini V, Zamai M, Gonzalez-Granado JM, Barreiro O, Tejera E, Yanez-Mo M, Caiolfa VR, Sanchez-Madrid F. CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses. Mol Cell Biol. 2013;33(18):3644-58 PMCID: PMC3753866.
56. Secrist H, Levy S, DeKruyff R, Umetsu D. Ligation of TAPA-1 (CD81) or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4 + T cells. Eur J Immunol. 1996;26(7):1435-42.
57. Maecker H, Do M, Levy S. CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses. Proc Natl Acad Sci USA. 1998;95(5):2458-62.
58. Deng J, Yeung V, Tsitoura D, DeKruyff R, Umetsu D, Levy S. Allergen-induced airway hyperreactivity is diminished in CD81- deficient mice. J Immunol (Baltimore, MD: 1950). 2000;165(9): 5054-61.
59. Deng J, Dekruyff R, Freeman G, Umetsu D, Levy S. Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses. Int Immunol. 2002;14(5):513-23.