Dopaminergic signaling within the primary cilia in the renovascular system

Frontiers in Physiology

Volumn 6, Issue MAR, 2015, Pages

  Atkinson, Kimberly F ^a   Kathem, Sarmed H ^a   Jin, Xingjian ^b   Muntean, Brian S ^b   AbouAlaiwi, Wissam A ^b   Nauli, Andromeda M ^c   Nauli, Surya M ^a  

^a CHAPMAN UNIVERSITY   (United States)

^b UNIVERSITY OF TOLEDO   (United States)

^c CALIFORNIA NORTHSTATE UNIVERSITY   (United States)

Author keywords

Blood pressure; Ciliopathy; Ciliotherapy; Cilium; Polycystic kidney disease

Indexed keywords

CALCIUM; DOPAMINE; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR 5; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CARDIOVASCULAR SYSTEM; CELL ORGANELLE; CYTOPLASM; DOPAMINERGIC ACTIVITY; DOPAMINERGIC SIGNALING; ENDOTHELIUM CELL; EPITHELIUM CELL; HUMAN; NATRIURESIS; NONHUMAN; PRIMARY CILIUM; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RENOVASCULAR SYSTEM; SHEAR STRESS; VASODILATATION;

EID: 84926454710     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2015.00103     Document Type: Article

References (22)

1. Abdul-Majeed, S., Moloney, B., and Nauli, S. (2012). Mechanisms regulating cilia growth and cilia function in endothelial cells. Cellular and Molecular Life Sciences 69, 165-173.
2. Abdul-Majeed, S., and Nauli, S.M. (2011). Dopamine Receptor Type 5 in the Primary Cilia Has Dual Chemo- and Mechano-Sensory Roles. Hypertension 58, 325-331.
3. Aboualaiwi, W.A., Takahashi, M., Mell, B.R., Jones, T.J., Ratnam, S., Kolb, R.J., and Nauli, S.M. (2009). Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades. Circulation Research 104, 860-869
4. Avasthi, P., Marley, A., Lin, H., Gregori-Puigjane, E., Shoichet, B.K., Von Zastrow, M., and Marshall, W.F. (2012). A chemical screen identifies class A G-protein coupled receptors as regulators of cilia. ACS Chemical Biology 7, 911-919.
5. Jin, X., Muntean, B.S., Aal-Aaboda, M.S., Duan, Q., Zhou, J., and Nauli, S.M. (2014). Ltype calcium channel modulates cystic kidney phenotype. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842, 1518-1526.
6. Kathem, S.H., Mohieldin, A.M., Abdul-Majeed, S., Ismail, S.H., Altaei, Q.H., Alshimmari, I.K., Alsaidi, M.M., Khammas, H., Nauli, A.M., Joe, B., and Nauli, S.M. (2014). Ciliotherapy: a novel intervention in polycystic kidney disease. Journal of Geriatric Cardiology: JGC 11, 63-73.
7. Lorthioir, A., Joannides, R., Remy-Jouet, I., Freguin-Bouilland, C., Iacob, M., Roche, C., Monteil, C., Lucas, D., Renet, S., Audrezet, M.-P., Godin, M., Richard, V., Thuillez, C., Guerrot, D., and Bellien, J. (2015). Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans. Kidney Int 87, 465-472.
8. Marshall, W.F., and Nonaka, S. (2006). Cilia: Tuning in to the Cell's Antenna. Current Biology 16, R604-R614.
9. Mohieldin, A.M., Haymour, H.S., Lo, S.T., Aboualaiwi, W.A., Atkinson, K.F., Ward, C.J., Gao, M., Wessely, O., and Nauli, S.M. (2015). Protein composition and movements of membrane swellings associated with primary cilia. Cell Mol Life Sci.
10. Muntean, B.S., Jin, X., Williams, F.E., and Nauli, S.M. (2014). Primary cilium regulates CaV1.2 expression through Wnt signaling. J Cell Physiol 229, 1926-1934.
11. Nauli, S.M., Alenghat, F.J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A.E.H., Lu, W., Brown, E.M., Quinn, S.J., Ingber, D.E., and Zhou, J. (2003). Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33, 129-137.
12. Nauli, S.M., Kawanabe, Y., Kaminski, J.J., Pearce, W.J., Ingber, D.E., and Zhou, J. (2008). Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1. Circulation 117, 1161-1171.
13. Nauli, S.M., Rossetti, S., Kolb, R.J., Alenghat, F.J., Consugar, M.B., Harris, P.C., Ingber, D.E., Loghman-Adham, M., and Zhou, J. (2006). Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol 17, 1015- 1025.
14. Pazour, G.J., San Agustin, J.T., Follit, J.A., Rosenbaum, J.L., and Witman, G.B. (2002). Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr Biol 12, R378-380.
15. Rbaibi, Y., Cui, S., Mo, D., Carattino, M., Rohatgi, R., Satlin, L.M., Szalinski, C.M., Swanhart, L.M., Fölsch, H., Hukriede, N.A., and Weisz, O.A. (2012). OCRL1 Modulates Cilia Length in Renal Epithelial Cells. Traffic 13, 1295-1305.
16. Tomer, A.-R., Andreia, M.M., Edmund, K., Andrey, P., Thomas, K., Shankar, S., and Charles, S.Z. (2004). Decoding Cilia Function: Defining Specialized Genes Required for Compartmentalized Cilia Biogenesis. Cell 117.
17. Upadhyay, V.S., Muntean, B.S., Kathem, S.H., Hwang, J.J., Aboualaiwi, W.A., and Nauli, S.M. (2014). Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells. Frontiers in Physiology 5, 72.
18. Verghese, E., Weidenfeld, R., Bertram, J.F., Ricardo, S.D., and Deane, J.A. (2008). Renal cilia display length alterations following tubular injury and are present early in epithelial repair. Nephrology Dialysis Transplantation 23, 834-841.
19. Verleyen, D., Luyten, F.P., and Tylzanowski, P. (2014). Orphan G-Protein Coupled Receptor 22 (Gpr22) Regulates Cilia Length and Structure in the Zebrafish Kupffer's Vesicle. PLoS ONE 9, e110484.
20. Wang, S., Wei, Q., Dong, G., and Dong, Z. (2013). ERK-mediated suppression of cilia in cisplatin-induced tubular cell apoptosis and acute kidney injury. Biochim Biophys Acta 1832, 1582-1590.
21. Winyard, P., and Jenkins, D. (2011). Putative roles of cilia in polycystic kidney disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812, 1256- 1262.
22. Yoder, B.K., Hou, X., and Guay-Woodford, L.M. (2002). The Polycystic Kidney Disease Proteins, Polycystin-1, Polycystin-2, Polaris, and Cystin, Are Co-Localized in Renal Cilia. Journal of the American Society of Nephrology 13, 2508-2516.