Electrolytic Macrocyclizations: Scalable Synthesis of a Diazonamide-Based Drug Development Candidate

Angewandte Chemie - International Edition

Volumn 54, Issue 16, 2015, Pages 4818-4822

  Ding, Hui ^a   DeRoy, Patrick L ^b   Perreault, Christian ^b   Larivée, Alexandre ^b   Siddiqui, Arshad ^b   Caldwell, Charles G ^c   Harran, Susan ^c   Harran, Patrick G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c Joyant Pharmaceuticals   (United States)

Author keywords

anodic oxidation; electrosynthesis; macrocycles; natural products; oxazoles

Indexed keywords

DEHYDROGENATION; DISEASES; SURFACE REACTIONS; SYNTHESIS (CHEMICAL);

CLINICAL DEVELOPMENT; ELECTROCHEMICAL METHODS; ELECTROSYNTHESIS; GRAPHITE SURFACES; MACROCYCLES; NATURAL PRODUCTS; OXAZOLES; SCALABLE SYNTHESIS;

ANODIC OXIDATION;

AMIDE; AZO COMPOUND; DRUG; DZ-2384; GRAPHITE; MACROCYCLIC LACTAM; OXAZOLE DERIVATIVE;

CHEMISTRY; CONFORMATION; CYCLIZATION; OXIDATION REDUCTION REACTION; SURFACE PROPERTY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

AMIDES; AZO COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; GRAPHITE; LACTAMS, MACROCYCLIC; MOLECULAR CONFORMATION; OXAZOLES; OXIDATION-REDUCTION; PHARMACEUTICAL PREPARATIONS; SURFACE PROPERTIES;

EID: 84926452522     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201411663     Document Type: Article

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