Chlamydia trachomatis load in population-based screening and STI-clinics: Implications for screening policy

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Dirks, Jeanne A M C ^a,b   Wolffs, Petra F G ^a   Dukers Muijrers, Nicole H T M ^a,b   Brink, Antoinette A T P ^a,d   Speksnijder, Arjen G C L ^c,e   Hoebe, Christian J P A ^a,b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b South Limburg Public Health Service   (Netherlands)

^c DEPARTMENT OF INFECTIOUS DISEASES   (Netherlands)

^d PathoFinder BV   (Netherlands)

^e NATURALIS BIODIVERSITY CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BACTERIAL LOAD; CELL COUNT; CHLAMYDIA TRACHOMATIS; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; HEALTH CARE POLICY; HEALTH CENTER; HIGH RISK POPULATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; NONHUMAN; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; SEXUALLY TRANSMITTED DISEASE; URETHRAL DISCHARGE; URINALYSIS; UTERINE CERVIX CYTOLOGY; CHLAMYDIA INFECTIONS; ISOLATION AND PURIFICATION; MICROBIOLOGY; ORGANIZATION AND MANAGEMENT; ORGANIZATIONAL POLICY; OUTPATIENT DEPARTMENT; SEXUALLY TRANSMITTED DISEASES; YOUNG ADULT;

BACTERIA (MICROORGANISMS); CHLAMYDIA TRACHOMATIS;

ADOLESCENT; ADULT; AMBULATORY CARE FACILITIES; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; FEMALE; HUMANS; MALE; MASS SCREENING; ORGANIZATIONAL POLICY; SEXUALLY TRANSMITTED DISEASES; YOUNG ADULT;

EID: 84926442172     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121433     Document Type: Article

References (51)

1. Soetens LC, Koedijk FDH, van den Broek IVF, Vriend HJ, Op de Coul ELM, van Sighem AI, et al. Sexually transmittted infections including HIV in the Netherlands in 2012. Bilthoven: National Institute for Public Health and the Environment; 2013.
2. Bender N, Herrmann B, Andersen B, Hocking JS, van Bergen J, Morgan J, et al. Chlamydia infection, pelvic inflammatory disease, ectopic pregnancy and infertility: cross-national study. Sexually transmitted infections. 2011 Dec; 87(7):601-8. PMID: 22028428. Epub 2011/10/27.eng. doi: 10.1136/ sextrans-2011-050205
3. Incidence, Prevalence and Cost of Sexually Transmitted Infections in the United States. Centers for Disease Control Fact Sheet [Internet]. 2013 February 2013; Available: http://www.cdc.gov/std/stats/sti-estimates-fact-sheet-feb-2013.pdf. Accessed 2013 Dec 12.
4. Stamm WE. Chlamydia trachomatis infections: progress and problems. The Journal of infectious diseases. 1999 Mar; 179 Suppl 2:S380-3. PMID: 10081511. Epub 1999/03/19.eng.
5. Trienekens SCN, Koedijk FDH, van den Broek IVF, Vriend HJ, Op de Coul ELM, van Veen MG, et al. Sexually transmitted infections including HIV in the Netherlands in 2011. Bilthoven: National Institute for Public Health and the Environment; 2012.
6. van den Broek IV, Verheij RA, van Dijk CE, Koedijk FD, van der Sande MA, van Bergen JE. Trends in sexually transmitted infections in the Netherlands, combining surveillance data from general practices and sexually transmitted infection centers. BMC family practice. 2010; 11:39. PMID: 20487552. Pubmed Central PMCID: PMC2886004. Epub 2010/05/22.eng. doi: 10.1186/1471-2296-11-39
7. van Bergen J, Gotz HM, Richardus JH, Hoebe CJ, Broer J, Coenen AJ. Prevalence of urogenital Chlamydia trachomatis increases significantly with level of urbanisation and suggests targeted screening approaches: results from the first national population based study in the Netherlands. Sexually transmitted infections. 2005 Feb; 81(1):17-23. PMID: 15681716. Pubmed Central PMCID: PMC1763744. Epub 2005/02/01.eng.
8. Gotz H, Lindback J, Ripa T, Arneborn M, Ramsted K, Ekdahl K. Is the increase in notifications of Chlamydia trachomatis infections in Sweden the result of changes in prevalence, sampling frequency or diagnostic methods? Scandinavian journal of infectious diseases. 2002; 34(1):28-34. PMID: 11874161. Epub 2002/03/05.eng.
9. Low N. Screening programmes for chlamydial infection: when will we ever learn? Bmj. 2007 Apr 7; 334 (7596):725-8. PMID: 17413173. Pubmed Central PMCID: 1847869.
10. Brunham RC, Pourbohloul B, Mak S, White R, Rekart ML. The unexpected impact of a Chlamydia trachomatis infection control program on susceptibility to reinfection. The Journal of infectious diseases. 2005 Nov 15; 192(10):1836-44. PMID: 16235186.
11. Brunham RC, Rey-Ladino J. Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nature reviews Immunology. 2005 Feb; 5(2):149-61. PMID: 15688042.
12. Carey AJ, Beagley KW. Chlamydia trachomatis, a hidden epidemic: effects on female reproduction and options for treatment. American journal of reproductive immunology. 2010 Jun; 63(6):576-86. PMID: 20192953. doi: 10.1111/j.1600-0897.2010.00819.x
13. Lorimer K, Hart GJ. Knowledge of Chlamydia trachomatis among men and women approached to participate in community-based screening, Scotland, UK. BMC public health. 2010; 10:794. PMID: 21192793. Pubmed Central PMCID: 3022863. doi: 10.1186/1471-2458-10-794
14. Buhrer-Skinner M, Muller R, Buettner PG, Gordon R, Debattista J. Reducing barriers to testing for Chlamydia trachomatis by mailed self-collected samples. Sexual health. 2013 Mar; 10(1):32-8. PMID: 23158104. Epub 2012/11/20.eng. doi: 10.1071/SH11065
15. Land JA, Van Bergen JE, Morre SA, Postma MJ. Epidemiology of Chlamydia trachomatis infection in women and the cost-effectiveness of screening. Human reproduction update. 2010 Mar-Apr; 16 (2):189-204. PMID: 19828674. doi: 10.1093/humupd/dmp035
16. Vodstrcil LA, McIver R, Huston WM, Tabrizi SN, Timms P, Hocking JS. The epidemiology of organism load in genital Chlamydia trachomatis infection - a systematic review. The Journal of infectious diseases. 2014 Dec 9. PMID: 25492913. Epub 2014/12/11.Eng.
17. West SK, Munoz B, Mkocha H, Holland MJ, Aguirre A, Solomon AW, et al. Infection with Chlamydia trachomatis after mass treatment of a trachoma hyperendemic community in Tanzania: a longitudinal study. Lancet. 2005 Oct 8; 366(9493):1296-300. PMID: 16214600.
18. Pal S, Hui W, Peterson EM, de la Maza LM. Factors influencing the induction of infertility in a mouse model of Chlamydia trachomatis ascending genital tract infection. Journal of medical microbiology. 1998 Jul; 47(7):599-605. PMID: 9839564.
19. Pal S, Peterson EM, de la Maza LM. Susceptibility of mice to vaginal infection with Chlamydia trachomatis mouse pneumonitis is dependent on the age of the animal. Infection and immunity. 2001 Aug; 69 (8):5203-6. PMID: 11447208. Pubmed Central PMCID: 98622.
20. Wiggins R, Graf S, Low N, Horner PJ, Group CSSS. Real-time quantitative PCR to determine chlamydial load in men and women in a community setting. Journal of clinical microbiology. 2009 Jun; 47 (6):1824-9. PMID: 19357201. Pubmed Central PMCID: 2691069. doi: 10.1128/JCM.00005-09
21. van den Broek IV, van Bergen JE, Brouwers EE, Fennema JS, Gotz HM, Hoebe CJ, et al. Effectiveness of yearly, register based screening for chlamydia in the Netherlands: controlled trial with randomised stepped wedge implementation. Bmj. 2012; 345:e4316. PMID: 22767614. Pubmed Central PMCID: 3390168. doi: 10.1136/bmj.e4316
22. Linssen CF, Jacobs JA, Stelma FF, van Mook WN, Terporten P, Vink C, et al. Herpes simplex virus load in bronchoalveolar lavage fluid is related to poor outcome in critically ill patients. Intensive care medicine. 2008 Dec; 34(12):2202-9. PMID: 18679655. Epub 2008/08/06.eng. doi: 10.1007/s00134-008-1231-4
23. Vliegen I, Duijvestijn A, Stassen F, Bruggeman C. Murine cytomegalovirus infection directs macrophage differentiation into a pro-inflammatory immune phenotype: implications for atherogenesis. Microbes and infection / Institut Pasteur. 2004 Oct; 6(12):1056-62. PMID: 15380774.
24. Jalal H, Stephen H, Curran M, Burton J, Bradley M, Carne C. Development and validation of a rotorgene real-time PCR assay for detection, identification, and quantification of Chlamydia trachomatis in a single reaction. Journal of clinical microbiology. 2006 Jan; 44(1):206-13. PMID: 16390971. Pubmed Central PMCID: 1351959.
25. van der Helm JJ, Sabajo LO, Grunberg AW, Morre SA, Speksnijder AG, de Vries HJ. Point-of-care test for detection of urogenital chlamydia in women shows low sensitivity. A performance evaluation study in two clinics in Suriname. PLOS ONE. 2012; 7(2):e32122. PMID: 22393383. Pubmed Central PMCID: 3290553. doi: 10.1371/journal.pone.0032122
26. Sambrook J, Fritsch E, Maniatis T. Molecular cloning: a laboratory manual: Cold Spring Harbor Laboratory Press; 1989.
27. Hornung RW, Reed LD. Estimation of Average Concentration in the Presence of Nondetectable Values. Applied Occupational and Environmental Hygiene. 1990 1990/01/01; 5(1):46-51.
28. Carey AJ, Cunningham KA, Hafner LM, Timms P, Beagley KW. Effects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice. Immunology and cell biology. 2009 May-Jun; 87(4):337-43. PMID: 19204735. doi: 10.1038/icb.2009.3
29. Hisada M, Chatterjee N, Kalaylioglu Z, Battjes RJ, Goedert JJ. Hepatitis C virus load and survival among injection drug users in the United States. Hepatology. 2005 Dec; 42(6):1446-52. PMID: 16317675.
30. Powers KA, Poole C, Pettifor AE, Cohen MS. Rethinking the heterosexual infectivity of HIV-1: a systematic review and meta-analysis. The Lancet Infectious diseases. 2008 Sep; 8(9):553-63. PMID: 18684670. Pubmed Central PMCID: 2744983. doi: 10.1016/S1473-3099(08)70156-7
31. Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. The New England journal of medicine. 2000 Mar 30; 342(13):921-9. PMID: 10738050.
32. Grabowski MK, Gray RH, Serwadda D, Kigozi G, Gravitt PE, Nalugoda F, et al. High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men. Sexually transmitted infections. 2014 Jun; 90(4):337-43. PMID: 24482488. Pubmed Central PMCID: 4030299. doi: 10.1136/sextrans-2013-051230
33. Price MJ, Ades AE, Angelis DD, Welton NJ, Macleod J, Soldan K, et al. Mixture-of-exponentials models to explain heterogeneity in studies of the duration of Chlamydia trachomatis infection. Statistics in medicine. 2013 Apr 30; 32(9):1547-60. PMID: 22949217. doi: 10.1002/sim.5603
34. Wilson DP, Bowlin AK, Bavoil PM, Rank RG. Ocular pathologic response elicited by Chlamydia organisms and the predictive value of quantitative modeling. The Journal of infectious diseases. 2009 Jun 15; 199(12):1780-9. PMID: 19419335. Epub 2009/05/08.eng. doi: 10.1086/599093
35. Jalal H, Verlander N, Kumar N, Bentley N, Carne C, Sonnex C. Genital chlamydial infection: association between clinical features, organism genotype and load. Journal of medical microbiology. 2011 Jul; 60 (Pt 7):881-8. PMID: 21415209.
36. Michel CE, Sonnex C, Carne CA, White JA, Magbanua JP, Nadala EC Jr., et al. Chlamydia trachomatis load at matched anatomic sites: implications for screening strategies. Journal of clinical microbiology. 2007 May; 45(5):1395-402. PMID: 17376879. Pubmed Central PMCID: 1865904.
37. Stephens RS. The cellular paradigm of chlamydial pathogenesis. Trends in microbiology. 2003 Jan; 11 (1):44-51. PMID: 12526854. Epub 2003/01/16.eng.
38. Rasmussen SJ. Chlamydia immunology. Current opinion in infectious diseases. 1998 Feb; 11(1):37-41. PMID: 17033365. Epub 2006/10/13.eng.
39. Wiggins R, Horner PJ, Whittington K, Holmes CH. Quantitative analysis of epithelial cells in urine from men with and without urethritis: implications for studying epithelial: pathogen interactions in vivo. BMC research notes. 2009; 2:139. PMID: 19607670. Pubmed Central PMCID: Pmc2719657. Epub 2009/07/18.eng. doi: 10.1186/1756-0500-2-139
40. Horner PJ, Thomas B, Gilroy CB, Egger M, Taylor-Robinson D. Do all men attending departments of genitourinary medicine need to be screened for non-gonococcal urethritis? International journal of STD & AIDS. 2002 Oct; 13(10):667-73. PMID: 12396535. Epub 2002/10/25.eng.
41. Gillespie CW, Manhart LE, Lowens MS, Golden MR. Asymptomatic urethritis is common and is associated with characteristics that suggest sexually transmitted etiology. Sexually transmitted diseases. 2013 Mar; 40(3):271-4. PMID: 23407472. Epub 2013/02/15.eng. doi: 10.1097/OLQ. 0b013e31827c9e42
42. Gomes JP, Borrego MJ, Atik B, Santo I, Azevedo J, Brito de Sa A, et al. Correlating Chlamydia trachomatis infectious load with urogenital ecological success and disease pathogenesis. Microbes and infection / Institut Pasteur. 2006 Jan; 8(1):16-26. PMID: 16289001.
43. Twin J, Moore EE, Garland SM, Stevens MP, Fairley CK, Donovan B, et al. Chlamydia trachomatis genotypes among men who have sex with men in Australia. Sexually transmitted diseases. 2011 Apr; 38 (4):279-85. PMID: 21085058. doi: 10.1097/OLQ.0b013e3181fc6944
44. Verweij SP, Quint KD, Bax CJ, AP VANL, Mutsaers JA, Jansen CL, et al. Serogroup distribution of urogenital Chlamydia trachomatis in urban ethnic groups in The Netherlands. Epidemiology and infection. 2013 Apr 24:1-6. PMID: 23611401.
45. Wisniewski CA, White JA, Michel CE, Mahilum-Tapay L, Magbanua JP, Nadala EC Jr., et al. Optimal method of collection of first-void urine for diagnosis of Chlamydia trachomatis infection in men. Journal of clinical microbiology. 2008 Apr; 46(4):1466-9. PMID: 18234860. Pubmed Central PMCID: 2292916. doi: 10.1128/JCM.02241-07
46. Op de Coul EL, Gotz HM, van Bergen JE, Fennema JS, Hoebe CJ, Koekenbier RH, et al. Who participates in the Dutch Chlamydia screening? A study on demographic and behavioral correlates of participation and positivity. Sexually transmitted diseases. 2012 Feb; 39(2):97-103. PMID: 22249297. doi: 10.1097/OLQ.0b013e3182383097
47. Walker J, Tabrizi SN, Fairley CK, Chen MY, Bradshaw CS, Twin J, et al. Chlamydia trachomatis incidence and re-infection among young women-behavioural and microbiological characteristics. PLOS ONE. 2012; 7(5):e37778. PMID: 22662220. Pubmed Central PMCID: 3360595. doi: 10.1371/journal. pone.0037778
48. Christerson L, de Vries HJ, Klint M, Herrmann B, Morre SA. Multilocus sequence typing of urogenital Chlamydia trachomatis from patients with different degrees of clinical symptoms. Sexually transmitted diseases. 2011 Jun; 38(6):490-4. PMID: 21301388. doi: 10.1097/OLQ.0b013e31820b8be0
49. Caldwell HD, Wood H, Crane D, Bailey R, Jones RB, Mabey D, et al. Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates. The Journal of clinical investigation. 2003 Jun; 111(11):1757-69. PMID: 12782678. Pubmed Central PMCID: PMC156111. Epub 2003/06/05.eng.
50. Hogan RJ, Mathews SA, Mukhopadhyay S, Summersgill JT, Timms P. Chlamydial persistence: beyond the biphasic paradigm. Infection and immunity. 2004 Apr; 72(4):1843-55. PMID: 15039303. Pubmed Central PMCID: PMC375192. Epub 2004/03/25.eng.
51. Althaus CL, Heijne JC, Low N. Towards more robust estimates of the transmissibility of Chlamydia trachomatis. Sexually transmitted diseases. 2012 May; 39(5):402-4. PMID: 22504608. doi: 10.1097/OLQ. 0b013e318248a550