High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men

Sexually Transmitted Infections

Volumn 90, Issue 4, 2014, Pages 337-343

  Grabowski, Mary K ^a   Gray, Ronald H ^a,b   Serwadda, David ^b,c   Kigozi, Godfrey ^b   Gravitt, Patti E ^a,d   Nalugoda, Fred ^b   Reynolds, Steven J ^a,b,e,f   Wawer, Maria J ^a,b   Watya, Stephen ^g   Quinn, Thomas C ^b,e,f   Tobian, Aaron A R ^b,f  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b RAKAI HEALTH SCIENCES PROGRAM   (Uganda)

^c MAKERERE UNIVERSITY SCHOOL OF PUBLIC HEALTH   (Uganda)

^d PERDANA UNIVERSITY   (Malaysia)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g MAKERERE UNIVERSITY   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ASSOCIATION; BEHAVIOR; CIRCUMCISION; FOLLOW UP; GENOTYPE; HETEROSEXUAL MALE; HIGH RISK HUMAN PAPILLOMAVIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; UGANDA; VIRUS LOAD; VIRUS TRANSMISSION; WART VIRUS;

AFRICA; CIRCUMCISION; HIV; HPV;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; GENOTYPE; HETEROSEXUALITY; HIV INFECTIONS; HUMAN PAPILLOMAVIRUS 16; HUMAN PAPILLOMAVIRUS 18; HUMAN PAPILLOMAVIRUS 31; HUMANS; MALE; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PENIS; SEXUAL BEHAVIOR; UGANDA; VIRAL LOAD; YOUNG ADULT;

EID: 84901952098     PISSN: 13684973     EISSN: 14723263     Source Type: Journal    
DOI: 10.1136/sextrans-2013-051230     Document Type: Article

References (29)

1. Tobian AA, Gray RH. Male foreskin and oncogenic human papillomavirus infection in men and their female partners. Future Microbiol 2011;6:739-45.
2. Partridge JM, Koutsky LA. Genital human papillomavirus infection in men. Lancet Infect Dis 2006;6:21-3.
3. Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. New Eng J Med 2003;348:518-27. (Pubitemid 36159887)
4. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.
5. Gravitt PE, Kovacic MB, Herrero R, et al. High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident disease. Int J Cancer 2007;121:2787-93. (Pubitemid 350136428)
6. Xi LF, Hughes JP, Edelstein ZR, et al. Human papillomavirus (HPV) type 16 and type 18 DNA loads at baseline and persistence of type-specific infection during a 2-year follow-up. J Infect Dis 2009;200:1789-97.
7. Dalstein V, Riethmuller D, Pretet JL, et al. Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions: a longitudinal French cohort study. Int J Cancer 2003;106:396-403.
8. Tobian AA, Graowski MK, Kigozi G, et al. Human papilloma virus clearance among males is associated with HIV acquisition and increased dendritic cell density in the foreskin. J Infect Dis 2013;207:1713-22.
9. Smith JS, Moses S, Hudgens MG, et al. Increased risk of HIV acquisition among Kenyan men with human papillomavirus infection. J Infect Dis 2010;201:1677-85.
10. Backes DM, Bleeker MC, Meijer CJ, et al. Male circumcision is associated with a lower prevalence of human papillomavirus-associated penile lesions among Kenyan men. Int J Cancer 2012;130:1888-97.
11. Giuliano AR, Lu B, Nielson CM, et al. Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men. J Infect Dis 2008;198:827-35.
12. Giuliano AR, Lee JH, Fulp W, et al. Incidence and clearance of genital human papillomavirus infection in men (HIM): a cohort study. Lancet 2011;377:932-40.
13. Tobian AA, Kigozi G, Gravitt PE, et al. Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in Rakai, Uganda. AIDS 2012;26:1555-65.
14. Flores R, Lu B, Nielson C, et al. Correlates of human papillomavirus viral load with infection site in asymptomatic men. Cancer Epidemiol Biomarkers Prev 2008;17:3573-6.
15. Bleeker MC, Hogewoning CJ, Voorhorst FJ, et al. HPV-associated flat penile lesions in men of a non-STD hospital population: less frequent and smaller in size than in male sexual partners of women with CIN. Int J Cancer 2005;113:36-41. (Pubitemid 39507308)
16. Bleeker MC, Berkhof J, Hogewoning CJ, et al. HPV type concordance in sexual couples determines the effect of condoms on regression of flat penile lesions. Br J Cancer 2005;92:1388-92. (Pubitemid 40705004)
17. Widdice L, Ma Y, Jonte J, et al. Concordance and transmission of human papillomavirus within heterosexual couples observed over short intervals. J Infect Dis 2013;207:1286-94.
18. Tobian AA, Serwadda D, Quinn TC, et al. Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. N Engl J Med 2009;360:1298-309.
19. Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet 2007;369:657-66.
20. Nowak RG, Gravitt PE, Morrison CS, et al. Increases in human papillomavirus detection during early HIV infection among women in Zimbabwe. J Infect Dis 2011;203:1182-91.
21. Gravitt PE, Peyton CL, Apple RJ, et al. Genotyping of 27 human papillomavirus types by using L1 consensus PCR products by a single-hybridization, reverse line blot detection method. J Clin Microbiol 1998;36:3020-7. (Pubitemid 28429431)
22. Wilson L, Gravitt P, Tobian A, et al. Male circumcision reduces penile high risk human papillomavirus (HPV) viral load in a randomized clinical trial in Rakai, Uganda. Sex Transm Infect 2013;89:262-6.
23. Wentzensen N, Gravitt PE, Long R, et al. Human papillomavirus load measured by linear array correlates with quantitative PCR in cervical cytology specimens. J Clin Microbiol 2012;50:1564-70.
24. Marks M, Gravitt PE, Utaipat U, et al. Kinetics of DNA load predict HPV 16 viral clearance. J Clin Virol 2011;51:44-9.
25. Monnier-Benoit S, Dalstein V, Riethmuller D, et al. Dynamics of HPV16 DNA load reflect the natural history of cervical HPV-associated lesions. J Clin Virol 2006;35:270-7. (Pubitemid 43188972)
26. Gravitt PE, Rositch AF, Silver MI, et al. A cohort effect of the sexual revolution may be masking an increase in human papillomavirus detection at menopause in the United States. J Infect Dis 2013;207:272-80.
27. Xi LF, Hughes JP, Castle PE, et al. Viral load in the natural history of human papillomavirus type 16 infection: a nested case-control study. J Infect Dis 2011;203:1425-33.
28. Stanley M. Immune responses to human papillomavirus. Vaccine 2006;24(Suppl 1):S16-22.
29. Strickler HD, Burk RD, Fazzari M, et al. Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst 2005;97:577-86. (Pubitemid 40723785)