Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450

European Journal of Pharmaceutical Sciences

Volumn 73, Issue , 2015, Pages 49-56

  Bojić, Mirza ^a   Sedgeman, Carl A ^a   Nagy, Leslie D ^a   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aromatic hydroxylation; Aspirin (acetylsalicylic acid); Cytochromes; P450; Salicylic acid

Indexed keywords

ACETYLSALICYLIC ACID; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEFEROXAMINE; GENTISIC ACID; OXYGEN RADICAL; SALICYLIC ACID; 2,4-DIHYDROXYBENZALDEHYDE 4-PHOSPHATE; BENZALDEHYDE DERIVATIVE; CYTOCHROME P450 INHIBITOR; ENZYME INHIBITOR; ISOENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ORGANOPHOSPHATE; REACTIVE OXYGEN METABOLITE; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; DRUG METABOLISM; FLUORESCENCE; HUMAN; HUMAN CELL; HYDROXYLATION; MICROSOME; OXIDATION; PRIORITY JOURNAL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANTAGONISTS AND INHIBITORS; BIOTRANSFORMATION; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; LIVER MICROSOME; METABOLISM; OXIDATION REDUCTION REACTION;

ASPIRIN; BENZALDEHYDES; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; DEFEROXAMINE; ENZYME INHIBITORS; HUMANS; HYDROXYLATION; ISOENZYMES; MICROSOMES, LIVER; NADP; ORGANOPHOSPHATES; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; SALICYLIC ACID;

EID: 84926436248     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.03.015     Document Type: Article

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