Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats

British Journal of Pharmacology

Volumn 170, Issue 6, 2013, Pages 1233-1241

  Tanaka, Junichi ^a,b   Seki, Yukari ^a   Ishikura, Hiroyasu ^b   Tsubota, Maho ^a   Sekiguchi, Fumiko ^a   Yamaguchi, Kaoru ^a   Murai, Akira ^b   Umemura, Takehiro ^b   Kawabata, Atsufumi ^a  

^a KINKI UNIVERSITY   (Japan)

^b FUKUOKA UNIVERSITY HOSPITAL   (Japan)

Author keywords

edema; high mobility group box 1 (HMGB1); hyperalgesia; lipopolysaccharide; pain; thrombomodulin

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; RECOMBINANT THROMBOMODULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; HYPERALGESIA; MALE; MOLECULAR PATHOLOGY; NONHUMAN; PAIN THRESHOLD; PAW EDEMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RAT; SPINAL GANGLION; TISSUE LEVEL; WESTERN BLOTTING;

EDEMA; HIGH-MOBILITY GROUP BOX 1 (HMGB1); HYPERALGESIA; LIPOPOLYSACCHARIDE; PAIN; THROMBOMODULIN;

ANIMALS; FOOT; GANGLIA, SPINAL; HMGB1 PROTEIN; HYPERALGESIA; MALE; RATS; RATS, WISTAR; RECEPTORS, IMMUNOLOGIC; RECOMBINANT PROTEINS; RNA, MESSENGER; THROMBOMODULIN; TOLL-LIKE RECEPTOR 4;

EID: 84886781376     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12396     Document Type: Article

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