Large-Scale Chemical Similarity Networks for Target Profiling of Compounds Identified in Cell-Based Chemical Screens

PLoS Computational Biology

Volumn 11, Issue 3, 2015, Pages

  Lo, Yu Chen ^a   Senese, Silvia ^a   Li, Chien Ming ^b   Hu, Qiyang ^a   Huang, Yong ^b   Damoiseaux, Robert ^a   Torres, Jorge Z ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ANALYSIS; CYTOLOGY; DISEASE CONTROL; KNOWLEDGE BASED SYSTEMS; PATTERN RECOGNITION; SEARCH ENGINES;

CELL-BASED; CHEMICAL SIMILARITY; CHEMOTYPES; DRUG TARGETS; IDENTIFICATION METHOD; LARGE-SCALES; PULLDOWN; SIMILARITY NETWORK; TARGET PREDICTION; TARGET'S IDENTIFICATIONS;

LIGANDS;

CYCLIN DEPENDENT KINASE 2; DIMETHYL SULFOXIDE; DIPEPTIDYL CARBOXYPEPTIDASE; HEAT SHOCK PROTEIN 90; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PACLITAXEL; RNA DIRECTED DNA POLYMERASE; VINBLASTINE; LIGAND;

ANALYTIC METHOD; ARTICLE; CHEMICAL DATABASE; CHEMICAL SIMILARITY NETWORK ANALYSIS PULLDOWN; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; HELA CELL LINE; HIGH THROUGHPUT SCREENING; MATHEMATICAL COMPUTING; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; PREDICTION; SIMILARITY ENSEMBLE APPROACH; VALIDATION STUDY; ALGORITHM; BINDING SITE; BIOLOGY; DRUG DESIGN; FACTUAL DATABASE; HUMAN; PROCEDURES;

ALGORITHMS; BINDING SITES; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS;

EID: 84926392822     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004153     Document Type: Article

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