Comparison of X-ray powder diffraction and solid-state nuclear magnetic resonance in estimating crystalline fraction of tacrolimus in sustained-release amorphous solid dispersion and development of discriminating dissolution method

Journal of Pharmaceutical Sciences

Volumn 104, Issue 5, 2015, Pages 1777-1786

  Rahman, Ziyaur ^a   Bykadi, Srikant ^a   Siddiqui, Akhtar ^a   Khan, Mansoor A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Dissolution; Partial least squares; Principal component analysis; Solid dispersion; Solid state NMR; X ray powder diffractometry

Indexed keywords

TACROLIMUS; DELAYED RELEASE FORMULATION;

ARTICLE; CHEMOMETRICS; COMPARATIVE STUDY; CRYSTALLIZATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID STATE NUCLEAR MAGNETIC RESONANCE; SUSTAINED DRUG RELEASE; X RAY POWDER DIFFRACTION; CHEMISTRY; DELAYED RELEASE FORMULATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POWDER DIFFRACTION; PROCEDURES; SOLUBILITY; X RAY DIFFRACTION;

CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; MAGNETIC RESONANCE SPECTROSCOPY; POWDER DIFFRACTION; SOLUBILITY; TACROLIMUS; X-RAY DIFFRACTION;

EID: 84926392272     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24400     Document Type: Article

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