Insulin priming effect on estradiol-induced breast cancer metabolism and growth

Cancer Biology and Therapy

Volumn 16, Issue 3, 2015, Pages 484-492

  Wairagu, Peninah M ^a   Phan, Ai N H ^a   Kim, Min Kyu ^a   Han, Jeongwoo ^a   Kim, Hyun Won ^a   Choi, Jong Whan ^a   Kim, Ki Woo ^a   Cha, Seung Kuy ^a   Park, Kwang Hwa ^a   Jeong, Yangsik ^a  

^a Yonsei University Wonju College of Medicine   (South Korea)

Author keywords

Breast cancer; Diabetes; Estradiol; Estrogen receptor; iInsulin priming; MCF 7; Metformin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CYCLIN A; CYCLIN B; ESTRADIOL; ESTROGEN RECEPTOR; GLUCOSE; INSULIN; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; PENTOSE PHOSPHATE; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; SERINE; 1,3 BUTADIENE DERIVATIVE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; ESTROGEN RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 3; MORPHOLINE DERIVATIVE; NITRILE; ONCOPROTEIN;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; DIABETES MELLITUS; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LONG TERM EXPOSURE; MACROMOLECULE; MCF 7 CELL LINE; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CELL PROLIFERATION; CHEMICALLY INDUCED; COMPLICATION; DIABETES COMPLICATIONS; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; RISK FACTOR;

BREAST NEOPLASMS; BUTADIENES; CELL PROLIFERATION; CHROMONES; DIABETES COMPLICATIONS; DIABETES MELLITUS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; HUMANS; INSULIN; MCF-7 CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MORPHOLINES; NITRILES; ONCOGENE PROTEIN V-AKT; RISK FACTORS;

EID: 84926334376     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.1080/15384047.2015.1016660     Document Type: Article

References (36)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: Cancer J Clin 2011; 61:69-90; PMID:21296855
2. Hulka BS, Moorman PG. Breast cancer: hormones and other risk factors. Maturitas 2001; 38:103-13; discussion 13-6; PMID:11311599; http://dx.doi.org/10.1016/S0378-5122(00)00196-1
3. Kaplan MA, Pekkolay Z, Kucukoner M, Inal A, Urakci Z, Ertugrul H, Akdogan R, Firat U, Yildiz I, Isikdogan A. Type 2 diabetes mellitus and prognosis in early stage breast cancer women. Med Oncol 2012; 29:1576-80; PMID:22083554; http://dx.doi.org/10.1007/s12032-011-0109-4
4. Cadoo KA, Fornier MN, Morris PG. Biological subtypes of breast cancer: current concepts and implications for recurrence patterns. Q J Nucl Med Mol Imag: Off Pub Ital Assoc Nucl Med 2013; 57:312-21; PMID:24322788
5. Lipscombe LL, Goodwin PJ, Zinman B, McLaughlin JR, Hux JE. The impact of diabetes on survival following breast cancer. Br Cancer Res Treat 2008; 109:389-95; PMID:17659440; http://dx.doi.org/10.1007/s10549-007-9654-0
6. Shanik MH, Xu Y, Skrha J, Dankner R, Zick Y, Roth J. Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse? Diabetes Care 2008; 31 Suppl 2:S262-8; PMID:18227495; http://dx.doi.org/10.2337/dc08-s264
7. Michels KB, Solomon CG, Hu FB, Rosner BA, Hankinson SE, Colditz GA, Manson JE, Nurses' Health Study. Type 2 diabetes and subsequent incidence of breast cancer in the Nurses' Health Study. Diabetes Care 2003; 26:1752-8; PMID:12766105; http://dx.doi.org/10.2337/diacare.26.6.1752
8. Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GY, Xue X, Anderson GL, et al. Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 2009; 101:48-60; PMID:19116382; http://dx.doi.org/10.1093/jnci/djn415
9. He X, Esteva FJ, Ensor J, Hortobagyi GN, Lee MH, Yeung SC. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer. Ann Oncol: Off J Eur Soc Med Oncol/ESMO 2012; 23:1771-80; PMID:22112968; http://dx.doi.org/10.1093/annonc/mdr534
10. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D. Diabetes and cancer: a consensus report. CA: Cancer J Clin 2010; 60:207-21; PMID:20554718
11. Sachdev D, Yee D. The IGF system and breast cancer. Endocr-relat Cancer 2001; 8:197-209; PMID: 11566611; http://dx.doi.org/10.1677/erc.0.0080197
12. Yee D, Lee AV. Crosstalk between the insulin-like growth factors and estrogens in breast cancer. J Mammary Gland Biol 2000; 5:107-15; PMID:10791773; http://dx.doi.org/10.1023/A:1009575518338
13. Mawson A, Lai A, Carroll JS, Sergio CM, Mitchell CJ, Sarcevic B. Estrogen and insulin/IGF-1 cooperatively stimulate cell cycle progression in MCF-7 breast cancer cells through differential regulation of c-Myc and cyclin D1. Mol Cell Endocrinol 2005; 229:161-73; PMID:15607540; http://dx.doi.org/10.1016/j.mce.2004.08.002
14. Belfiore A, Frasca F. IGF and insulin receptor signaling in breast cancer. J Mammary Gland Biol Neoplasia 2008; 13:381-406; PMID:19016312; http://dx.doi.org/10.1007/s10911-008-9099-z
15. Bartella V, De Marco P, Malaguarnera R, Belfiore A, Maggiolini M. New advances on the functional cross-talk between insulin-like growth factor-I and estrogen signaling in cancer. Cell Signalling 2012; 24:1515-21; PMID:22481093; http://dx.doi.org/10.1016/j.cellsig.2012.03.012
16. Hawsawi Y, El-Gendy R, Twelves C, Speirs V, Beattie J. Insulin-like growth factor - oestradiol crosstalk and mammary gland tumourigenesis. Biochimica et Biophysica Acta 2013; 1836:345-53; PMID:24189571
17. Fox EM, Miller TW, Balko JM, Kuba MG, Sanchez V, Smith RA, Liu S, González-Angulo AM, Mills GB, Ye F, et al. A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res 2011; 71:6773-84; PMID:21908557; http://dx.doi.org/10.1158/0008-5472.CAN-11-1295
18. Madak-Erdogan Z, Lupien M, Stossi F, Brown M, Katzenellenbogen BS. Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. Mol Cell Biol 2011; 31:226-36; PMID:20956553; http://dx.doi.org/10.1128/MCB.00821-10
19. Marquez DC, Pietras RJ. Membrane-associated binding sites for estrogen contribute to growth regulation of human breast cancer cells. Oncogene 2001; 20:5420-30; PMID:11571639; http://dx.doi.org/10.1038/sj.onc.1204729
20. Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, Imai Y, Rimm DL, Liu XS, Brown M. Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell 2011; 20:119-31; PMID:21741601; http://dx.doi.org/10.1016/j.ccr.2011.05.026
21. Peters AA, Buchanan G, Ricciardelli C, Bianco-Miotto T, Centenera MM, Harris JM, Jindal S, Segara D, Jia L, Moore NL, et al. Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Res 2009; 69:6131-40; PMID:19638585; http://dx.doi.org/10.1158/0008-5472.CAN-09-0452
22. Doane AS, Danso M, Lal P, Donaton M, Zhang L, Hudis C, Gerald WL. An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene 2006; 25:3994-4008; PMID:16491124; http://dx.doi.org/10.1038/sj.onc.1209415
23. Chan SC, Li Y, Dehm SM. Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal. J Biol Chem 2012; 287:19736-49; PMID:22532567; http://dx.doi.org/10.1074/jbc.M112.352930
24. Bjornstrom L, Sjoberg M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol 2005; 19:833-42; PMID:15695368; http://dx.doi.org/10.1210/me.2004-0486
25. Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer 2011; 11:85-95; PMID:21258394; http://dx.doi.org/10.1038/nrc2981
26. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33; PMID:19460998; http://dx.doi.org/10.1126/science.1160809
27. Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008; 452:181-6; PMID:18337815; http://dx.doi.org/10.1038/nature06667
28. Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 2005; 202:654-62; PMID:15389572; http://dx.doi.org/10.1002/jcp.20166
29. Miller RA, Chu QW, Xie JX, Foretz M, Viollet B, Birnbaum MJ. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 2013; 494:256-60; PMID:23292513; http://dx.doi.org/10.1038/nature11808
30. Viollet B, Guigas B, Sanz Garcia N, Leclerc J, Foretz M, Andreelli F. Cellular and molecular mechanisms of metformin: an overview. Clin Sci 2012; 122:253-70; PMID:22117616; http://dx.doi.org/10.1042/CS20110386
31. Klip A, Leiter LA. Cellular mechanism of action of metformin. Diabetes Care 1990; 13:696-704; PMID:2162756; http://dx.doi.org/10.2337/diacare.13.6.696
32. Vigneri P, Frasca F, Sciacca L, Pandini G, Vigneri R. Diabetes and cancer. Endocr-Relat Cancer 2009; 16:1103-23; PMID:19620249; http://dx.doi.org/10.1677/ERC-09-0087
33. Iwase H, Kobayashi M, Nakajima M, Takatori T. The ratio of insulin to C-peptide can be used to make a forensic diagnosis of exogenous insulin overdosage. Forensic Sci Int 2001; 115:123-7; PMID:11056282; http://dx.doi.org/10.1016/S0379-0738(00)00298-X
34. Diaz-Delfin J, Morales M, Caelles C. Hypoglycemic action of thiazolidinediones/peroxisome proliferator-activated receptor gamma by inhibition of the c-Jun NH2-terminal kinase pathway. Diabetes 2007; 56:1865-71; PMID:17416798; http://dx.doi.org/10.2337/db06-1293
35. Jeong Y, Xie Y, Lee W, Bookout AL, Girard L, Raso G, Behrens C, Wistuba II, Gadzar AF, Minna JD, et al. Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer. Mol Endocrinol 2012; 26:1443-54; PMID:22700587; http://dx.doi.org/10.1210/me.2011-1382
36. Bookout AL, Cummins CL, Mangelsdorf DJ, Pesola JM, Kramer MF. High-throughput real-time quantitative reverse transcription PCR. Current Protocols in Molecular Biology, edited by Frederick M Ausubel [et al] 2006; Chapter 15:Unit 15 8. PMID:18265376; doi:10.1002/0471142727.mb1508s73