Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly

Biological Psychiatry

Volumn 77, Issue 9, 2015, Pages 805-815

  Aceti, Massimiliano ^a   Creson, Thomas K ^a   Vaissiere, Thomas ^a   Rojas, Camilo ^a   Huang, Wen Chin ^a   Wang, Ya Xian ^b   Petralia, Ronald S ^b   Page, Damon T ^a   Miller, Courtney A ^a   Rumbaugh, Gavin ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

Author keywords

Autism spectrum disorder; Development; Epilepsy; Intellectual disability; Mouse model; Synapse; Syngap1

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; BRAIN DISEASE; DENDRITE; DENDRITIC SPINE; ENDOPHENOTYPE; FOREBRAIN; GENE; GENETIC DAMAGE; HAPLOINSUFFICIENCY; INTELLECTUAL IMPAIRMENT; MORPHOGENESIS; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; POSTNATAL DEVELOPMENT; PRIMARY SOMATOSENSORY CORTEX; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SPINE; SYNAPTOGENESIS; SYNGAP1 GENE; ABNORMALITIES; ANIMAL; BRAIN CORTEX; CONDITIONING; DEFICIENCY; EXPLORATORY BEHAVIOR; FEAR; GENETICS; GROWTH, DEVELOPMENT AND AGING; HIPPOCAMPUS; MAZE TEST; NERVE TRACT; NEWBORN; PATHOLOGY; PHYSIOLOGY; SENSORY DEPRIVATION; TRANSGENIC MOUSE; VIBRISSA;

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; SYNGAP1 PROTEIN, MOUSE;

ANIMALS; ANIMALS, NEWBORN; CEREBRAL CORTEX; CONDITIONING (PSYCHOLOGY); DENDRITIC SPINES; ENDOPHENOTYPES; EXPLORATORY BEHAVIOR; FEAR; HAPLOINSUFFICIENCY; HIPPOCAMPUS; MAZE LEARNING; MICE, TRANSGENIC; NEURAL PATHWAYS; PYRAMIDAL CELLS; RAS GTPASE-ACTIVATING PROTEINS; SENSORY DEPRIVATION; VIBRISSAE;

EID: 84926330893     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.08.001     Document Type: Article

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