Analysis and pharmacokinetics studies of gastrodin and p-hydroxybenzyl alcohol in dogs using ultra fast liquid chromatography-tandem mass spectrometry method

Journal of Pharmaceutical and Biomedical Analysis

Volumn 99, Issue , 2014, Pages 83-88

  Jia, Yuanwei ^a,b   Li, Xin ^a   Xie, Haitang ^b   Shen, Jie ^b   Luo, Jun ^a   Wang, Junsong ^c   Wang, Kelvin D G ^a   Liu, Qingwang ^a   Kong, Lingyi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b WANNAN MEDICAL COLLEGE   (China)

^c NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Gastrodin; Metabolite; p Hydroxybenzyl alcohol; Pharmacokinetics; UFLC ESI MS MS

Indexed keywords

4 HYDROXYBENZYL ALCOHOL; BENZYL ALCOHOL DERIVATIVE; DRUG METABOLITE; GASTRODIN; UNCLASSIFIED DRUG; 4-HYDROXYBENZYL ALCOHOL; GLUCOSIDE;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BEAGLE; CALIBRATION; DRUG BLOOD LEVEL; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RELIABILITY; SENSITIVITY ANALYSIS; STANDARD; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; DOG; DOSE RESPONSE; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; ORAL DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY;

ADMINISTRATION, ORAL; ANIMALS; BENZYL ALCOHOLS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; GLUCOSIDES; LIMIT OF DETECTION; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84926329380     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.07.004     Document Type: Article

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