The cell-type specificity and endosomal escape of cell-penetrating peptides

Current Pharmaceutical Design

Volumn 21, Issue 10, 2015, Pages 1351-1356

  Feng, Jing ^a   Tang, Liling ^a  

^a CHONGQING UNIVERSITY   (China)

Author keywords

Cell type specificity; CPPs; Endosomal escape

Indexed keywords

CELL PENETRATING PEPTIDE; VASCULOTROPIN RECEPTOR 1; ANTINEOPLASTIC AGENT;

APOPTOSIS; ARTICLE; BONE MARROW CULTURE; CANCER CELL; CELL SPECIFICITY; ENDOCYTOSIS; ENDOSOME; HEPG2 CELL LINE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MCF 7 CELL LINE; MYELOID LEUKEMIA; OLIGOMERIZATION; PHOTOCHEMICAL INTERNALIZATION; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; TISSUE SPECIFICITY; AMINO ACID SEQUENCE; ANIMAL; CYTOSOL; DRUG EFFECTS; GENETICS; METABOLISM; MOLECULAR GENETICS; NEOPLASMS; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL-PENETRATING PEPTIDES; CYTOSOL; ENDOSOMES; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS;

EID: 84926325629     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612820666141023155017     Document Type: Article

References (60)

1. Thomas CE, Ehrhardt A, Kay MA. Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 2003; 4: 346-58.
2. Niidome T, Huang L. Gene therapy progress and prospects: nonviral vectors. Gene Ther 2002; 9: 1647-52.
3. Madani F, Lindberg S, Langel U, Futaki S, Gräslund A. Mechanisms of cellular uptake of cell-penetrating peptides. J Biophys 2011; 2011: 414729.
4. Green M, Loewenstein PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat transactivator protein. Cell 1988; 55: 1179-88.
5. Pooga M, Hällbrink M, Zorko M, Langel U. Cell penetration by transportan. FASEB J 1998; 12: 67-77.
6. Matsushita M, Tomizawa K, Moriwaki A, Li ST, Terada H, Matsui H. A high-efficiency protein transduction system demonstrating the role of PKA in long-lasting long-term potentiation. J Neurosci 2001; 21: 6000-7.
7. Nishikawa M, Otsuki T, Ota A, et al. Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice. Mol Ther 2010; 18: 421-8.
8. Lindgren M, Langel U. Classes and prediction of cell-penetrating peptides. Methods Mol Biol 2011; 683: 3-19.
9. Mäe M, Langel Ü. Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery. Curr Opin Pharmacol 2006; 6: 509-14.
10. Tan M, Lan K-H, Yao J, et al. Selective inhibition of ErbB2-overexpressing breast cancer in vivo by a novel TAT-based ErbB2-targeting signal transducers and activators of transcription 3-blocking peptide. Cancer Res 2006; 66: 3764-72.
11. Jiang T, Olson ES, Nguyen QT, Roy M, Jennings PA, Tsien RY. Tumor imaging by means of proteolytic activation of cellpenetrating peptides. Proc Natl Acad Sci USA 2004; 101: 17867-72.
12. Lee YJ, Datta S, Pellois JP. Real-Time Fluorescence Detection of Protein Transduction into Live Cells. J Am Chem Soc 2008; 130: 2398-9.
13. Ter-Avetisyan G, Tünnemann G, Nowak D, et al . Cell entry of arginine-rich peptides is independent of endocytosis. J Biol Chem 2009; 284: 3370-8.
14. Rydström A, Deshayes S, Konate K, et al. Direct translocation as major cellular uptake for CADY self-assembling peptide-based nanoparticles. PLoS One 2011; 6: e25924.
15. Bode SA, Thévenin M, Bechara C, et al. Self-assembling mini cellpenetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis. Chem Commun 2012; 48: 7179-81.
16. Rothbard JB, Jessop TC, Lewis RS, Murray BA, Wender PA. Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells. J Am Chem Soc 2004; 126: 9506-7.
17. Martín I, Teixidó M, Giralt E. Building Cell Selectivity into CPPMediated Strategies. Pharmaceuticals 2010; 3: 1456-90.
18. Patel MP, Patel RR, Patel JK. Chitosan mediated targeted drug delivery system: a review. J Pharm Pharm Sci 2010; 13: 536-57.
19. Kondo E, Saito K, Tashiro Y, et al. Tumour lineage-homing cellpenetrating peptides as anticancer molecular delivery systems. Nat Commun 2012; 3: 951.
20. Smith GP. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 1985; 228: 1315-7.
21. Elmquist A, Lindgren M, Bartfai T, Langel U. VE-cadherinderived cell-penetrating peptide, pVEC, with carrier functions. Exp Cell Res 2001; 269: 237-44.
22. Svensen N, Walton JGA, Bradley M. Peptides for cell-selective drug delivery. Trends Pharmacol Sci 2012; 33: 186-92.
23. Roberts RW. Totally in vitro protein selection using mRNA-protein fusions and ribosome display. Curr Opin Chem Biol 1999; 3: 268-73.
24. Biyani M, Husimi Y, Nemoto N. Solid-phase translation and RNAprotein fusion: a novel approach for folding quality control and direct immobilization of proteins using anchored mRNA. Nucleic Acids Res 2006; 34: e140.
25. Krumpe LRH, Mori T. The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs. Int J Pept Res Ther 2006; 12: 79-91.
26. Ruoslahti E. Targeting tumor vasculature with homing peptides from phage display. Semin Cancer Biol 2000; 10: 435-42.
27. De Jong WH, Borm PJ. Drug delivery and nanoparticles: Applications and hazards. Int J Nanomedicine 2008; 3: 133-49.
28. Aird WC. Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res 2007; 100: 158-73.
29. Aird WC. Phenotypic heterogeneity of the endothelium: II. Representative vascular beds. Circ Res 2007; 100: 174-90.
30. Tokunaga T, Oshika Y, Abe Y, et al. Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer. Br J Cancer 1998; 77: 998-1002.
31. Hofer E, Schweighofer B. Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis. Thromb Haemost 2007; 97: 355-63.
32. Muñoz-Chápuli R, Quesada AR, Angel Medina M. Angiogenesis and signal transduction in endothelial cells. Cell Mol Life Sci 2004; 61: 2224-43.
33. Fang B, Jiang L, Zhang M, Ren FZ. A novel cell-penetrating peptide TAT-A1 delivers siRNA into tumor cells selectively. Biochimie 2013; 95: 251-7.
34. Laakkonen P, Porkka K, Hoffman JA, Ruoslahti E. A tumorhoming peptide with a targeting specificity related to lymphatic vessels. Nat Med 2002; 8: 751-5.
35. Fogal V, Zhang L, Krajewski S, Ruoslahti E. Mitochondrial/cellsurface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma. Cancer Res 2008; 68: 7210-8.
36. Roth L, Agemy L, Kotamraju VR, et al. Transtumoral targeting enabled by a novel neuropilin-binding peptide. Oncogene 2012; 31: 3754-63.
37. Ren Y, Hauert S, Lo JH, Bhatia SN. Identification and characterization of receptor-specific peptides for siRNA delivery. ACS Nano 2012; 6: 8620-31.
38. Myrberg H, Zhang L, Mäe M, Langel Ü. Design of a tumorhoming cell-penetrating peptide. Bioconjug Chem 2007; 19: 70-5.
39. Bartel Y, Grez M, Wichmann C. Interference with RUNX1/ETO Leukemogenic Function by Cell-Penetrating Peptides Targeting the NHR2 Oligomerization Domain. Biomed Res Int 2013; 2013: 14 pages.
40. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 1999; 285: 1569-72.
41. Laakkonen P, Vuorinen K. Homing peptides as targeted delivery vehicles. Integr Biol (Camb) 2010; 2: 326-37.
42. Sugahara KN, Teesalu T, Karmali PP, et al. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 2010; 328: 1031-5.
43. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002; 415: 389-95.
44. Brogden KA. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol 2005; 3: 238-50.
45. Salomone F, Cardarelli F, Luca M Di. A novel chimeric cellpenetrating peptide with membrane-disruptive properties for efficient endosomal escape. J Control 2012; 163: 293-303.
46. Salomone F, Cardarelli F, Signore G, Boccardi C, Beltram F. In vitro efficient transfection by CM18-Tat11hybrid peptide: a new tool for gene-delivery applications. PLoS One 2013; 8: e70108.
47. Taupiac MP, Bébien M, Alami M, Beaumelle B. A deletion within the translocation domain of Pseudomonas exotoxin A enhances translocation efficiency and cytotoxicity concomitantly. Mol Microbiol 1999; 31: 1385-93.
48. Mohammed A, Abdul-Wahid A. The Pseudomonas aeruginosa exotoxin A translocation domain facilitates the routing of CPPprotein cargos to the cytosol of eukaryotic cells. J Control 2012; 164: 58-64.
49. Berg K, Selbo PK, Prasmickaite L, et al. Photochemical internalization: a novel technology for delivery of macromolecules into cytosol. Cancer Res 1999; 59: 1180-3.
50. Weyergang A, Selbo PK, Berstad MEB, Bostad M, Berg K. Photochemical internalization of tumor-targeted protein toxins. Lasers Surg Med 2011; 43: 721-33.
51. Selbo PK, Sivam G, Fodstad O, Sandvig K, Berg K. In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy. Int J Cancer 2001; 92: 761-6.
52. Norum O-J, Giercksky K-E, Berg K. Photochemical internalization as an adjunct to marginal surgery in a human sarcoma model. Photochem Photobiol Sci 2009; 8: 758-62.
53. Mellert K, Lamla M, Scheffzek K, Wittig R, Kaufmann D. Enhancing endosomal escape of transduced proteins by photochemical internalisation. PLoS One 2012; 7: e52473.
54. Räägel H, Hein M, Kriiska A, Säälik P. Cell-penetrating peptide secures an efficient endosomal escape of an intact cargo upon a brief photo-induction. Cell Mol 2013; 70: 4825-39.
55. Serresi M, Bizzarri R, Cardarelli F, Beltram F. Real-time measurement of endosomal acidification by a novel genetically encoded biosensor. Anal Bioanal Chem 2009; 393: 1123-33.
56. Wadia JS, Stan R V, Dowdy SF. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med 2004; 10: 310-5.
57. Lee YJ, Johnson G, Peltier GC, Pellois JP. A HA2-Fusion tag limits the endosomal release of its protein cargo despite causing endosomal lysis. Biochim Biophys Acta-Gen Subj 2011; 1810: 752-8.
58. Kumar S, Harrison N, Richards-Kortum R, Sokolov K. Plasmonic nanosensors for imaging intracellular biomarkers in live cells. Nano Lett 2007; 7: 1338-43.
59. Kaplan IM, Wadia JS, Dowdy SF. Cationic TAT peptide transduction domain enters cells by macropinocytosis. J Control Release 2005; 102: 247-53.
60. El-Andaloussi S, Johansson HJ, Lundberg P, Langel U. Induction of splice correction by cell-penetrating peptide nucleic acids. J Gene Med 2006; 8: 1262-73.