Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 93, Issue , 2015, Pages 110-117

  Pradal, Julie ^a   Zuluaga, Maria Fernanda ^a   Maudens, Pierre ^a   Waldburger, Jean Marc ^c   Seemayer, Christian Alexander ^b   Doelker, Eric ^a   Gabay, Cem ^c   Jordan, Olivier ^a   Allémann, Eric ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c University Hospital of Psychiatry   (Switzerland)

Author keywords

Drug delivery system; Intra articular; Liposomes; Long term release; Microparticles; P38 MAPK inhibitors; PLA; PLGA

Indexed keywords

5 (2,6 DICHLOROPHENYL) 2 (2,4 DIFLUOROPHENYLTHIO)PYRIMIDO[1,6 B]PYRIDAZIN 6 ONE; DEXAMETHASONE; INTERLEUKIN 6; LIPOSOME; MITOGEN ACTIVATED PROTEIN KINASE 14; ANTIINFLAMMATORY AGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER; MITOGEN ACTIVATED PROTEIN KINASE P38; POLYMER; PROTEIN KINASE INHIBITOR; PYRIDAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; VX-745;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; BIOCOMPATIBILITY; BIOLOGICAL ACTIVITY; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG RELEASE; EMULSION; EVAPORATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PAIN; PARTICLE SIZE; PRESSURE; PROTEIN BLOOD LEVEL; SYNOVIOCYTE; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, EXPERIMENTAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG EFFECTS; ENZYMOLOGY; HUMAN; IMMUNOLOGY; INTRAARTICULAR DRUG ADMINISTRATION; JOINT; KINETICS; MEDICINAL CHEMISTRY; METABOLISM; PATHOLOGY; PHARMACEUTICS; PROCEDURES; SOLUBILITY; SYNOVIUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; HUMANS; INJECTIONS, INTRA-ARTICULAR; JOINTS; KINETICS; MALE; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARTICLE SIZE; POLYMERS; PROTEIN KINASE INHIBITORS; PYRIDAZINES; PYRIMIDINES; SOLUBILITY; SYNOVIAL MEMBRANE; TECHNOLOGY, PHARMACEUTICAL;

EID: 84926307785     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.03.017     Document Type: Article

References (32)

1. F.G. Salituro, J.P. Duffy, V.P. Galullo, E.M. Harrington, S. Pazhanisamy, P.J. Ford, K.L. Cepek, Y.-M.C. Wang, S.F. Bellon, G. Ku, K.P. Wilson, M.S.-S. Su, Structure, synthesis, and biological activity of VX-745: a novel, orally bioavailable and selective p38 kinase inhibitor, in: New Targets in Arthritis: Signal Transduction and Transcriptional Regulation, in: Institut Pasteur Euroconferences, Paris, France, 2001.
2. D.F.M. Weisman, M. Schiff, R. Kauffman, E. Merica, S. Martin-Munley, A double-blind, placebo-controlled trial of VX-745, an oral p38 mitogen activated protein kinase (MAPK) inhibitor, in patients with rheumatoid arthritis (RA), in: 2002 annual European Congress of Rheumatology, Stockholm, Sweden, 2002, pp. 12-15.
3. D.M. Friedman, and M.E. Moore The efficacy of intraarticular steroids in osteoarthritis: a double-blind study J. Rheumatol. 6 7 1980 850 856
4. J.L. Hollander, E.M. Brown Jr., R.A. Jessar, and C.Y. Brown Hydrocortisone and cortisone injected into arthritic joints; comparative effects of and use of hydrocortisone as a local antiarthritic agent J. Am. Med. Assoc. 17 147 1951 1629 1635
5. H. Derendorf, H. Mollmann, A. Gruner, D. Haack, and G. Gyselby Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra-articular administration Clin. Pharmacol. Ther. 3 39 1986 313 317
6. D. Brackertz, G.F. Mitchell, and I.R. Mackay Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice Arthritis Rheum. 3 20 1977 841 850
7. C. Witschi, and E. Doelker Influence of the microencapsulation method and peptide loading on poly(lactic acid) and poly(lactic-co-glycolic acid) degradation during in vitro testing J. Control. Release 2-3 51 1998 327 341
8. M. Lasa, S.M. Abraham, C. Boucheron, J. Saklatvala, and A.R. Clark Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38 Mol. Cell. Biol. 22 22 2002 7802 7811
9. E. Horisawa, K. Kubota, I. Tuboi, K. Sato, H. Yamamoto, H. Takeuchi, and Y. Kawashima Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium Pharm. Res. 2 19 2002 132 139
10. C. Berkland, M. King, A. Cox, K. Kim, and D.W. Pack Precise control of PLG microsphere size provides enhanced control of drug release rate J. Control. Release 1 82 2002 137 147
11. K. Elkharraz, N. Faisant, C. Guse, F. Siepmann, B. Arica-Yegin, J.M. Oger, R. Gust, A. Goepferich, J.P. Benoit, and J. Siepmann Paclitaxel-loaded microparticles and implants for the treatment of brain cancer: preparation and physicochemical characterization Int. J. Pharm. 2 314 2006 127 136
12. M. Wacker Nanocarriers for intravenous injection - the long hard road to the market Int. J. Pharm. 1 457 2013 50 62
13. A. Kumari, S.K. Yadav, and S.C. Yadav Biodegradable polymeric nanoparticles based drug delivery systems Colloids Surf. B Biointerf. 1 75 2010 1 18
14. M.A. Tracy, K.L. Ward, L. Firouzabadian, Y. Wang, N. Dong, R. Qian, and Y. Zhang Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro Biomaterials 11 20 1999 1057 1062
15. H.B. Ravivarapu, K. Burton, and P.P. DeLuca Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres Eur. J. Pharm. Biopharm. 2 50 2000 263 270
16. B.S. Zolnik, and D.J. Burgess Evaluation of in vivo-in vitro release of dexamethasone from PLGA microspheres J. Control. Release 2 127 2008 137 145
17. F. Alexis Factors affecting the degradation and drug-release mechanism of poly(lactic acid) and poly[(lactic acid)-co-(glycolic acid)] Polym. Int. 1 54 2005 36 46
18. G. Gasparini, S.R. Kosvintsev, M.T. Stillwell, and R.G. Holdich Preparation and characterization of PLGA particles for subcutaneous controlled drug release by membrane emulsification Colloids Surf. B Biointerf. 2 61 2008 199 207
19. R.T. Liggins, and H.M. Burt Paclitaxel loaded poly(l-lactic acid) microspheres: properties of microspheres made with low molecular weight polymers Int. J. Pharm. 1 222 2001 19 33
20. M. Li, O. Rouaud, and D. Poncelet Microencapsulation by solvent evaporation: state of the art for process engineering approaches Int. J. Pharm. 1-2 363 2008 26 39
21. H. Jeffery, S.S. Davis, and D.T. O'Hagan The preparation and characterisation of poly(lactide-co-glycolide) microparticles. I: Oil-in-water emulsion solvent evaporation Int. J. Pharm. 2-3 77 1991 169 175
22. H.S. Choi, S.-A. Seo, G. Khang, J.M. Rhee, and H.B. Lee Preparation and characterization of fentanyl-loaded PLGA microspheres: in vitro release profiles Int. J. Pharm. 1-2 234 2002 195 203
23. S. Mao, Y. Shi, L. Li, J. Xu, A. Schaper, and T. Kissel Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method Eur. J. Pharm. Biopharm. 2 68 2008 214 223
24. S. Fredenberg, M. Wahlgren, M. Reslow, and A. Axelsson The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems - a review Int. J. Pharm. 1-2 415 2011 34 52
25. S. D'Souza, J. Faraj, and P. DeLuca A model-dependent approach to correlate accelerated with real-time release from biodegradable microspheres AAPS PharmSciTech 4 6 2005 E553 E564
26. A.R. Mollo, and O.I. Corrigan Effect of poly-hydroxy aliphatic ester polymer type on amoxycillin release from cylindrical compacts Int. J. Pharm. 1-2 268 2003 71 79
27. J. Wang, B.M. Wang, and S.P. Schwendeman Characterization of the initial burst release of a model peptide from poly(d,l-lactide-co-glycolide) microspheres J. Control. Release 2-3 82 2002 289 307
28. A. Porjazoska, K. Goracinova, K. Mladenovska, M. Glavas, M. Simonovska, E.I. Janjevic, and M. Cvetkovska Poly(lactide-co-glycolide) microparticles as systems for controlled release of proteins - preparation and characterization Acta Pharm. 3 54 2004 215 229
29. B.S. Zolnik, P.E. Leary, and D.J. Burgess Elevated temperature accelerated release testing of PLGA microspheres J. Control. Release 3 112 2006 293 300
30. R. Jalil, and J.R. Nixon Microencapsulation using poly(l-lactic acid) I: Microcapsule properties affected by the preparative technique J. Microencaps. 4 6 1989 473 484
31. R. Jalil, and J.R. Nixon Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties J. Microencaps. 3 7 1990 297 325
32. A. Shenderova, T. Burke, and S. Schwendeman The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins Pharm. Res. 2 16 1999 241 248