Effect of poly-hydroxy aliphatic ester polymer type on amoxycillin release from cylindrical compacts

International Journal of Pharmaceutics

Volumn 268, Issue 1-2, 2003, Pages 71-79

  Mollo, A Rosario ^a   Corrigan, Owen I ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Amoxycillin; Amphoteric drugs; Drug degradation; Glass transition temperature; Poly (D,L lactide co glycolyde) (PLGA); Polymer degradation controlled release

Indexed keywords

AMOXICILLIN; AMPHOLYTE; COPOLYMER; POLYGLACTIN; POLYLACTIDE; RG 203; RG 503; RG 504; RG 755;

ARTICLE; CHEMICAL COMPOSITION; CONTROLLED DRUG RELEASE; DIFFUSION; DISSOLUTION; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG STABILITY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; VISCOSITY;

EID: 0344845212     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.09.003     Document Type: Article

References (20)

1. Cha Y., Pitt C.G. The acceleration of degradation-controlled drug delivery from polyester microspheres. J. Control Release. 8:1989;259-265.
2. Dunne M., Corrigan O.I., Ramtoola Z. Influence of particle size and dissolution conditions on the degradation properties of polylactide - co-glycolide particles. Biomaterials. 21:2000;1659-1668.
3. Fitzgerald, J.F., Corrigan, O.I., 1993. Mechanisms governing drug release from poly-alpha-hydroxy aliphatic esters, diltiazem base release from poly-lactide-co-glycolide delivery systems. In: El-Nokaly, M.A., Piatt, D.M., Charpentier, B.A. (Eds.), Polymeric Delivery Systems, Properties and Applications. ACS Symposium Series 520, American Chemical Society, Washington, DC, pp. 311-326.
4. Fitzgerald J.F., Corrigan O.I. Investigation of the mechanisms governing the release of levamisole from poly-lactide-co-glycolide delivery systems. J. Control Release. 42:1996;125-132.
5. Gallagher K.M., Corrigan O.I. Mechanistic aspects of the release of levamisole hydrochloride from biodegradable polymers. J. Control Release. 69:2000;261-272.
6. Kenley R.A., Lee M.O., Mahoney T.R., Sanders L.M. Poly(lactide-co- glycolide) decomposition kinetics in vivo and in vitro. Macromolecules. 20:1987;2398-2403.
7. Min Y.G., Kim Y.K., Choi Y.S., Shin J.S., Kuhun S.K. Mucociliary activity and histopathology of sinus mucosa in experimental maxillary sinusitis: a comparison of systemic administration of antibiotic and antibiotic delivery by polylactic acid polymer. Laryngoscope. 105:1995;835-842.
8. Miyajima M., Koshika A., Okada J., Kusai A., Ikeda M. The effects of drug physico-chemical properties on release from copoly (lactic/glycolic acid) matrix. Int. J. Pharm. 169:1998;255-263.
9. Mollo A.R., Corrigan O.I. An investigation of the mechanism of release of the amphoteric drug amoxycillin from poly(D,L-lactide-co-glycolide) matrices. Pharm. Dev. Tech. 7:2002;333-343.
10. Painter, P.C., Coleman, M.M., 1994. Fundamentals of Polymer Science, An Introductory Text.
11. Paul M., Laatiris A., Boulard Y., Durand R., Deniau M., Astier A. Pentamidine-loaded poly(D,L-lactide) nanoparticles: physicochemical properties and stability work. Int. J. Pharm. 159:1997;223-232.
12. Ramtoola Z., Corrigan O.I., Bourke E. Characterization of biodegradable microspheres containing dihydro-iso-androsterone. Drug. Dev. Ind. Pharm. 17:1991;1857-1873.
13. Ramtoola Z., Corrigan O.I., Barrett C.J. Release kinetics of fluphenazine from biodegradable microspheres. J. Microencapsulation. 9:1992;415-423.
14. Ritger P.L., Peppas N.A. A simple equation for the description of solute release I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J. Control Release. 5:1987;23-36.
15. Sanders L.M., Kell B.A., McRae G.I., Whitehead G.W. Prolonged controlled-release of nafarelin, a luteinizing hormone-releasing hormone analogue, from biodegradable polymeric implants: influence of composition and molecular weight of polymer. J. Pharm. Sci. 75:1986;356-360.
16. Setterstrom, J.A., Van Hamont, J.E., Reid, R.H., Jacob, E., Jeyanthi, R., Boedeker, E.C., McQueen, C.E., Jarboe, D.L., Cassels, F., Brown, W., Thies, C, Tice, T.R., Roberts, F.D., Friden, P., 2001. Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix. United States Patent, 6,309,669, October 30.
17. Scientist User Handbook, 1995. Micromath Scientific Software, Utah, USA.
18. Shih C. Chain-end scission in acid catalyzed hydrolysis of poly(D,L-lactide) in solution. J. Control Release. 34:1995;9-15.
19. USP XXIII, 1995. United States Pharmacopeial Convention Inc., MD 20852, USA.
20. Zhang X., Wyss U.P., Pichora D., Goosen M.F.A. Biodegradable controlled antibiotic release devices for osteomyelitis: optimization of release properties. J. Pharm. Pharmacol. 46:1994;714-724.