Increased blastomere number in cleavage-stage embryos is associated with higher aneuploidy

Fertility and Sterility

Volumn 103, Issue 3, 2015, Pages 694-698

  Kroener, Lindsay L ^a,b   Ambartsumyan, Gayane ^a,b   Pisarska, Margareta D ^a,b   Briton Jones, Christine ^c   Surrey, Mark ^c   Hill, David ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c Southern California Reproductive Center   (United States)

Author keywords

aneuploidy; blastomere number; Cleavage stage embryo; comparative genomic hybridization; embryo progression; in vitro fertilization

Indexed keywords

ADULT; ANEUPLOIDY; ARTICLE; BLASTOCYST; BLASTOMA; CELL COUNT; CELL DIVISION; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; DISEASE ASSOCIATION; EMBRYO; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMAN; MAJOR CLINICAL STUDY; PREGNANCY RATE; PRIORITY JOURNAL; COHORT ANALYSIS; CYTOLOGY; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; OOCYTE CLEAVAGE; PREGNANCY; PRENATAL DIAGNOSIS; YOUNG ADULT;

ADULT; ANEUPLOIDY; BLASTOCYST; BLASTOMERES; CELL COUNT; CLEAVAGE STAGE, OVUM; COHORT STUDIES; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; HUMANS; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; PREGNANCY; PREIMPLANTATION DIAGNOSIS; YOUNG ADULT;

EID: 84926176855     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.12.090     Document Type: Article

References (31)

1. E. Fragouli, D. Wells, A. Thornhill, P. Serhal, M.J. Faed, and J.C. Harper Comparative genomic hybridization analysis of human oocytes and polar bodies Hum Reprod 21 2006 2319 2328
2. F. Pellestor, B. André, F. Arnal, C. Humeau, and J. Demaille Maternal aging and chromosomal abnormalities: new data drawn from in vitro unfertilized human oocytes Hum Genet 112 2003 195 203
3. N.R. Treff, B. Levy, J. Su, L.E. Northrop, X. Tao, and R.T. Scott Jr. SNP microarray-based 24 chromosome aneuploidy screening is significantly more consistent than FISH Mol Hum Reprod 16 2010 583 589
4. J.M. Franasiak, E.J. Forman, K.H. Hong, M.D. Werner, K.M. Upham, and N.R. Treff The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening Fertil Steril 101 2014 656 663.e1
5. E. Fragouli, M. Katz-Jaffe, S. Alfarawati, J. Stevens, P. Colls, and N.N. Goodall Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure Fertil Steril 94 2010 875 887
6. M.C. Magli, L. Gianaroli, A.P. Ferraretti, M. Lappi, A. Ruberti, and V. Farfalli Embryo morphology and development are dependent on the chromosomal complement Fertil Steril 87 2007 534 541
7. S. Munné, G. Tomkin, and J. Cohen Selection of embryos by morphology is less effective than by a combination of aneuploidy testing and morphology observations Fertil Steril 91 2009 943 945
8. D.K. Gardner, W.B. Schoolcraft, L. Wagley, T. Schlenker, J. Stevens, and J. Hesla A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization Hum Reprod 13 1998 3434 3440
9. D. Glujovsky, D. Blake, C. Farquhar, and A. Bardach Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology Cochrane Database Syst Rev 2012 CD002118
10. J. Fenwick, P. Platteau, A.P. Murdoch, and M. Herbert Time from insemination to first cleavage predicts developmental competence of human preimplantation embryos in vitro Hum Reprod 17 2002 407 412
11. K. Lundin, C. Bergh, and T. Hardarson Early embryo cleavage is a strong indicator of embryo quality in human IVF Hum Reprod 16 2001 2652 2657
12. B.S. Shapiro, D.C. Harris, and K.S. Richter Predictive value of 72-hour blastomere cell number on blastocyst development and success of subsequent transfer based on the degree of blastocyst development Fertil Steril 73 2000 582 586
13. J.H. Check, D. Summers-Chase, W. Yuan, D. Horwath, and C. Wilson Effect of embryo quality on pregnancy outcome following single embryo transfer in women with a diminished egg reserve Fertil Steril 87 2007 749 756
14. M. Luna, A.B. Copperman, M. Duke, D. Ezcurra, B. Sandler, and J. Barritt Human blastocyst morphological quality is significantly improved in embryos classified as fast on day 3 (≥10 cells), bringing into question current embryological dogma Fertil Steril 89 2008 358 363
15. C. Racowsky, J.E. Stern, W.E. Gibbons, B. Behr, K.O. Pomeroy, and J.D. Biggers National collection of embryo morphology data into Society for Assisted Reproductive Technology Clinic Outcomes Reporting System: associations among day 3 cell number, fragmentation and blastomere asymmetry, and live birth rate Fertil Steril 95 2011 1985 1989
16. C.C. Wong, K.E. Loewke, N.L. Bossert, B. Behr, C.J. De Jonge, and T.M. Baer Noninvasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage Nat Biotechnol 28 2010 1115 1121
17. M. Cruz, N. Garrido, J. Herrero, I. Péez-Cano, M. Muñz, and M. Meseguer Timing of cell division in human cleavage-stage embryos is linked with blastocyst formation and quality Reprod Biomed Online 25 2012 371 381
18. J.G. Lemmen, I. Agerholm, and S. Ziebe Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes Reprod Biomed Online 17 2008 385 391
19. D.J. Kaser, and C. Racowsky Clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring: a systematic review Hum Reprod Update 20 2014 617 631
20. S.E. Moayeri, R.B. Allen, W.R. Brewster, M.H. Kim, M. Porto, and L.B. Werlin Day-3 embryo morphology predicts euploidy among older subjects Fertil Steril 89 2008 118 123
21. L. Voullaire, L. Wilton, J. McBain, T. Callaghan, and R. Williamson Chromosome abnormalities identified by comparative genomic hybridization in embryos from women with repeated implantation failure Mol Hum Reprod 8 2002 1035 1041
22. C. Racowsky, M. Vernon, J. Mayer, G.D. Ball, B. Behr, and K.O. Pomeroy Standardization of grading embryo morphology Fertil Steril 94 2010 1152 1153
23. C. Gutiérez-Mateo, P. Colls, J. Sáchez-Garcí, T. Escudero, R. Prates, and K. Ketterson Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos Fertil Steril 95 2011 953 958
24. D. Wells, T. Escudero, B. Levy, K. Hirschhorn, J.D. Delhanty, and S. Munné First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy Fertil Steril 78 2002 543 549
25. A.S. Setti D.P. de Almeida Ferreira Braga R. de Cásia Savio Figueira M. de Castro Azevedo A. Iaconelli E. Borges Are poor responders patients at higher risk for producing aneuploid embryos in vitro? J Assist Reprod Genet 2011 28 399-404.
26. M.G. Katz-Jaffe, E.S. Surrey, D.A. Minjarez, R.L. Gustofson, J.M. Stevens, and W.B. Schoolcraft Association of abnormal ovarian reserve parameters with a higher incidence of aneuploid blastocysts Obstet Gynecol 121 2013 71 77
27. M.C. Magli, L. Gianaroli, S. Munné, and A.P. Ferraretti Incidence of chromosomal abnormalities from a morphologically normal cohort of embryos in poor-prognosis patients J Assist Reprod Genet 15 1998 297 301
28. S. Munné, M. Alikani, G. Tomkin, J. Grifo, and J. Cohen Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities Fertil Steril 64 1995 382 391
29. M. Li, C.M. DeUgarte, M. Surrey, H. Danzer, A. DeCherney, and D.L. Hill Fluorescence in situ hybridization reanalysis of day-6 human blastocysts diagnosed with aneuploidy on day 3 Fertil Steril 84 2005 1395 1400
30. T.H. Taylor, S.A. Gitlin, J.L. Patrick, J.L. Crain, J.M. Wilson, and D.K. Griffin The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans Hum Reprod Update 20 2014 571 581
31. R.T. Scott Jr., K.M. Upham, E.J. Forman, T. Zhao, and N.R. Treff Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial Fertil Steril 100 2013 624 630