Decreased generation of procoagulant platelets detected by flow cytometric analysis in patients with bleeding diathesis

Cytometry Part B - Clinical Cytometry

Volumn 86, Issue 6, 2014, Pages 397-409

  Daskalakis, Michael ^a   Colucci, Giuseppe ^a   Keller, Peter ^a   Rochat, Sophie ^a   Silzle, Tobias ^a   Biasiutti, Franziska Demarmels ^a   Barizzi, Gabriela ^a   Alberio, Lorenzo ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

bleeding diathesis; bleeding scoring system; COAT platelets; flow cytometry; platelet aggregation; platelet function

Indexed keywords

ADENOSINE DIPHOSPHATE; COLLAGEN; CONVULXIN; DUAL SPECIFICITY PHOSPHATASE 2; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB ALPHA; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; PADGEM PROTEIN; PROCOAGULANT; THROMBIN; LECTIN; SNAKE VENOM;

ADOLESCENT; ADULT; AGED; ARTICLE; BLEEDING TENDENCY; CLINICAL EVALUATION; COAT PLATELET; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; FLOW CYTOMETRY; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; SECRETORY GRANULE; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE ANOMALY; THROMBOCYTE FUNCTION; BLEEDING; BLEEDING DISORDER; BLOOD; BLOOD CLOTTING; DISEASE PREDISPOSITION; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PROCEDURES; THROMBOCYTE DISORDER; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BLOOD COAGULATION; BLOOD PLATELET DISORDERS; BLOOD PLATELETS; COLLAGEN; CROTALID VENOMS; DISEASE SUSCEPTIBILITY; FEMALE; FLOW CYTOMETRY; HEMORRHAGE; HEMORRHAGIC DISORDERS; HUMANS; LECTINS, C-TYPE; MALE; MIDDLE AGED; P-SELECTIN; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET MEMBRANE GLYCOPROTEINS; THROMBIN; YOUNG ADULT;

EID: 84926170685     PISSN: 15524949     EISSN: 15524957     Source Type: Journal    
DOI: 10.1002/cyto.b.21157     Document Type: Article

References (37)

1. Quiroga T, Goycoolea M, Panes O, Aranda E, Martinez C, Belmont S, Munoz B, Zuniga P, Pereira J, Mezzano D,. High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls. Haematologica 2007; 92: 357-365.
2. Rodeghiero F, Castaman G, Tosetto A, Batlle J, Baudo F, Cappelletti A, Casana P, De Bosch N, Eikenboom JC, Federici AB, et al. The discriminant power of bleeding history for the diagnosis of type 1 von Willebrand disease: An international, multicenter study. J Thromb Haemost 2005; 3: 2619-2626.
3. Tosetto A, Castaman G, Rodeghiero F,. Bleeding scores in inherited bleeding disorders: Clinical or research tools? Haemophilia 2008; 14: 415-422.
4. Hayward CP,. Diagnostic evaluation of platelet function disorders. Blood Rev 2011; 25: 169-173.
5. Bolton-Maggs PH, Chalmers EA, Collins PW, Harrison P, Kitchen S, Liesner RJ, Minford A, Mumford AD, Parapia LA, Perry DJ, et al. A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO. Br J Haematol 2006; 135: 603-633.
6. Cattaneo M,. Inherited platelet-based bleeding disorders. J Thromb Haemost 2003; 1: 1628-1636.
7. Di Paola J, Federici AB, Mannucci PM, Canciani MT, Kritzik M, Kunicki TJ, Nugent D,. Low platelet α2β1 levels in type I von Willebrand disease correlate with impaired platelet function in a high shear stress system. Blood 1999; 93: 3578-3582.
8. Michelson AD, Barnard MR, Krueger LA, Frelinger AL III, Furman MI,. Evaluation of platelet function by flow cytometry. Methods 2000; 21: 259-270.
9. Maurer-Spurej E, Pittendreigh C, Wu JK,. Diagnosing platelet delta-storage pool disease in children by flow cytometry. Am J Clin Pathol 2007; 127: 626-632.
10. Michelson AD,. Platelet function testing in cardiovascular diseases. Circulation 2004; 110: e489-e493.
11. Zurcher M, Sulzer I, Barizzi G, Lammle B, Alberio L,. Stability of coagulation assays performed in plasma from citrated whole blood transported at ambient temperature. Thromb Haemost 2008; 99: 416-426.
12. Favaloro EJ,. Utility of the PFA-100 for assessing bleeding disorders and monitoring therapy: A review of analytical variables, benefits and limitations. Haemophilia 2001; 7: 170-179.
13. Zhou L, Schmaier AH,. Platelet aggregation testing in platelet-rich plasma: Description of procedures with the aim to develop standards in the field. Am J Clin Pathol 2005; 123: 172-183.
14. Harrison P, Mackie I, Mumford A, Briggs C, Liesner R, Winter M, Machin S,. Guidelines for the laboratory investigation of heritable disorders of platelet function. Br J Haematol 2011; 155: 30-44.
15. Thommen D, Sulzer I, Buhrfeind E, Naef R, Furlan M, Lammle B,. Measurement of bleeding time and study of thrombocyte aggregation. Standardization of methods, normal values and results in patients with suspected hemorrhagic diathesis. Schweiz Med Wochenschr 1988; 118: 1559-1567.
16. Alberio L, Safa O, Clemetson KJ, Esmon CT, Dale GL,. Surface expression and functional characterization of α-granule factor V in human platelets: Effects of ionophore A23187, thrombin, collagen, and convulxin. Blood 2000; 95: 1694-1702.
17. Wall JE, Buijs-Wilts M, Arnold JT, Wang W, White MM, Jennings LK, Jackson CW,. A flow cytometric assay using mepacrine for study of uptake and release of platelet dense granule contents. Br J Haematol 1995; 89: 380-385.
18. Prodan CI, Joseph PM, Vincent AS, Dale GL,. Coated-platelets in ischemic stroke: Differences between lacunar and cortical stroke. J Thromb Haemost 2008; 6: 609-614.
19. Dale GL,. Coated-platelets: An emerging component of the procoagulant response. J Thromb Haemost 2005; 3: 2185-2192.
20. Nieuwenhuis HK, Akkerman JW, Sixma JJ,. Patients with a prolonged bleeding time and normal aggregation tests may have storage pool deficiency: Studies on one hundred six patients. Blood 1987; 70: 620-623.
21. Israels SJ, McNicol A, Robertson C, Gerrard JM,. Platelet storage pool deficiency: Diagnosis in patients with prolonged bleeding times and normal platelet aggregation. Br J Haematol 1990; 75: 118-121.
22. Dale GL, Friese P, Batar P, Hamilton SF, Reed GL, Jackson KW, Clemetson KJ, Alberio L,. Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature 2002; 415: 175-179.
23. Prodan CI, Vincent AS, Padmanabhan R, Dale GL,. Coated-platelet levels are low in patients with spontaneous intracerebral hemorrhage. Stroke 2009; 40: 2578-2580.
24. Prodan CI, Vincent AS, Dale GL,. Coated platelet levels correlate with bleed volume in patients with spontaneous intracerebral hemorrhage. Stroke 2010; 41: 1301-1303.
25. Prodan CI, Stoner JA, Cowan LD, Dale GL,. Lower coated-platelet levels are associated with early hemorrhagic transformation in patients with non-lacunar brain infarction. J Thromb Haemost 2010; 8: 1185-1190.
26. Prodan CI, Dale GL,. Coated-platelets in ischemic stroke-Potential insight into the etiology of stroke subtypes. Int J Stroke 2008; 3: 249-250.
27. Prodan CI, Vincent AS, Dale GL,. Coated-platelet levels are elevated in patients with transient ischemic attack. Transl Res 2011; 158: 71-75.
28. Prodan CI, Vincent AS, Kirkpatrick AC, Hoover SL, Dale GL,. Higher levels of coated-platelets are observed in patients with subarachnoid hemorrhage but lower levels are associated with increased mortality at 30 days. J Neurol Sci 2013.
29. Saxena K, Pethe K, Dale GL,. Coated-platelet levels may explain some variability in clinical phenotypes observed with severe hemophilia. J Thromb Haemost 2010; 8: 1140-1142.
30. Weiss HJ,. Scott syndrome: A disorder of platelet coagulant activity. Semin Hematol 1994; 31: 312-319.
31. Zwaal RF, Comfurius P, Bevers EM,. Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids. Biochim Biophys Acta 2004; 1636: 119-128.
32. Furihata K, Clemetson KJ, Deguchi H, Kunicki TJ,. Variation in human platelet glycoprotein VI content modulates glycoprotein VI-specific prothrombinase activity. Arterioscler Thromb Vasc Biol 2001; 21: 1857-1863.
33. Mazepa M, Hoffman M, Monroe D,. Superactivated platelets: Thrombus regulators, thrombin generators, and potential clinical targets. Arterioscler Thromb Vasc Biol 2013; 33: 1747-1752.
34. Colucci G, Stutz M, Rochat S, Conte T, Pavicic M, Reusser M, Giabbani E, Huynh A, Thürlemann C, Keller P, Alberio L,. The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT-platelets in patients with primary platelet function defects. Blood 2014; doi: 10.1182/blood-2013-04-497123.
35. Kjalke M, Kjellev S, Rojkjaer R,. Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist. J Thromb Haemost 2007; 5: 774-780.
36. Knudsen T, Kjalke M, Tranholm M, Nichols TC, Jensen AL, Kristensen AT,. Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa. Am J Vet Res 2011; 72: 1007-1014.
37. Hoffman M, Volovyk Z, Persson E, Gabriel DA, Ezban M, Monroe DM,. Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity. J Thromb Haemost 2011; 9: 759-766.