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Volumn 33, Issue 8, 2013, Pages 1747-1752

Superactivated platelets: Thrombus regulators, thrombin generators, and potential clinical targets

Author keywords

activation; Hemostasis; Phosphatidylserine; Platelet; Procoagulant

Indexed keywords

BLOOD CLOTTING FACTOR 10A; CALCIUM; CYCLOPHILIN D; CYCLOSPORIN; FIBRINOGEN; PROTHROMBIN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBIN; UBIQUINONE;

EID: 84881012996     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.113.301790     Document Type: Review
Times cited : (68)

References (45)
  • 2
    • 0017111599 scopus 로고
    • Immunofluorescent localization of factor VIII-related antigen, fibrinogen, and several other plasma proteins in hemostatic plugs in humans
    • Sixma JJ, Kater L, Bouma BN, Schmitz du Moulin F, De Graaf S, Tuit G. Immunofluorescent localization of factor VIII-related antigen, fibrinogen, and several other plasma proteins in hemostatic plugs in humans. J Lab Clin Med. 1976;87: 112-119.
    • (1976) J Lab Clin Med , vol.87 , pp. 112-119
    • Sixma, J.J.1    Kater, L.2    Bouma, B.N.3    Schmitz Du Moulin, F.4    De Graaf, S.5    Tuit, G.6
  • 3
    • 0018292081 scopus 로고
    • Morphology of the hemostatic plug in human skin wounds: Transformation of the plug
    • Wester J, Sixma JJ, Geuze JJ, Heijnen HF. Morphology of the hemostatic plug in human skin wounds: transformation of the plug. Lab Invest. 1979;41: 182-192.
    • (1979) Lab Invest , vol.41 , pp. 182-192
    • Wester, J.1    Sixma, J.J.2    Geuze, J.J.3    Heijnen, H.F.4
  • 5
    • 45549085611 scopus 로고    scopus 로고
    • Lactadherin blocks thrombosis and hemostasis in vivo: Correlation with platelet phosphatidylserine exposure
    • Shi J, Pipe SW, Rasmussen JT, Heegaard CW, Gilbert GE. Lactadherin blocks thrombosis and hemostasis in vivo: correlation with platelet phosphatidylserine exposure. J Thromb Haemost. 2008;6: 1167-1174.
    • (2008) J Thromb Haemost , vol.6 , pp. 1167-1174
    • Shi, J.1    Pipe, S.W.2    Rasmussen, J.T.3    Heegaard, C.W.4    Gilbert, G.E.5
  • 6
    • 38949218420 scopus 로고    scopus 로고
    • Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis
    • Jobe SM, Wilson KM, Leo L, Raimondi A, Molkentin JD, Lentz SR, Di Paola J. Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis. Blood. 2008;111: 1257-1265.
    • (2008) Blood , vol.111 , pp. 1257-1265
    • Jobe, S.M.1    Wilson, K.M.2    Leo, L.3    Raimondi, A.4    Molkentin, J.D.5    Lentz, S.R.6    Di Paola, J.7
  • 7
    • 3142674975 scopus 로고    scopus 로고
    • Platelet factor XIII and calpain negatively regulate integrin αiIbβ3 adhesive function and thrombus growth
    • Kulkarni S, Jackson SP. Platelet factor XIII and calpain negatively regulate integrin αIIbβ3 adhesive function and thrombus growth. J Biol Chem. 2004;279: 30697-30706.
    • (2004) J Biol Chem , vol.279 , pp. 30697-30706
    • Kulkarni, S.1    Jackson, S.P.2
  • 8
    • 0034161567 scopus 로고    scopus 로고
    • Surface expression and functional characterization of alpha-granule factor v in human platelets: Effects of ionophore A23187, thrombin, collagen, and convulxin
    • Alberio L, Safa O, Clemetson KJ, Esmon CT, Dale GL. Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood. 2000;95: 1694-1702.
    • (2000) Blood , vol.95 , pp. 1694-1702
    • Alberio, L.1    Safa, O.2    Clemetson, K.J.3    Esmon, C.T.4    Dale, G.L.5
  • 9
    • 0034604575 scopus 로고    scopus 로고
    • Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain
    • Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. J Biol Chem. 2000;275: 23998-24002.
    • (2000) J Biol Chem , vol.275 , pp. 23998-24002
    • Nieswandt, B.1    Bergmeier, W.2    Schulte, V.3    Rackebrandt, K.4    Gessner, J.E.5    Zirngibl, H.6
  • 10
    • 0037108427 scopus 로고    scopus 로고
    • Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen
    • Leo L, Di Paola J, Judd BA, Koretzky GA, Lentz SR. Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen. Blood. 2002;100: 2839-2844.
    • (2002) Blood , vol.100 , pp. 2839-2844
    • Leo, L.1    Di Paola, J.2    Judd, B.A.3    Koretzky, G.A.4    Lentz, S.R.5
  • 12
    • 78650420325 scopus 로고    scopus 로고
    • Properties of procoagulant platelets: Defining and characterizing the subpopulation binding a functional prothrombinase
    • Fager AM, Wood JP, Bouchard BA, Feng P, Tracy PB. Properties of procoagulant platelets: defining and characterizing the subpopulation binding a functional prothrombinase. Arterioscler Thromb Vasc Biol. 2010;30: 2400-2407.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2400-2407
    • Fager, A.M.1    Wood, J.P.2    Bouchard, B.A.3    Feng, P.4    Tracy, P.B.5
  • 13
    • 0035543352 scopus 로고    scopus 로고
    • Simultaneous engagement of thrombin and FcγRIIA receptors results in platelets expressing high levels of procoagulant proteins
    • Batar P, Dale GL. Simultaneous engagement of thrombin and FcγRIIA receptors results in platelets expressing high levels of procoagulant proteins. J Lab Clin Med. 2001;138: 393-402.
    • (2001) J Lab Clin Med , vol.138 , pp. 393-402
    • Batar, P.1    Dale, G.L.2
  • 14
    • 20444503923 scopus 로고    scopus 로고
    • Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk
    • van der Meijden PE, Feijge MA, Giesen PL, Huijberts M, van Raak LP, Heemskerk JW. Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk. Thromb Haemost. 2005;93: 1128-1136.
    • (2005) Thromb Haemost , vol.93 , pp. 1128-1136
    • Van Der Meijden, P.E.1    Feijge, M.A.2    Giesen, P.L.3    Huijberts, M.4    Van Raak, L.P.5    Heemskerk, J.W.6
  • 15
    • 0030845821 scopus 로고    scopus 로고
    • Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: Evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses
    • Heemskerk JW, Vuist WM, Feijge MA, Reutelingsperger CP, Lindhout T. Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses. Blood. 1997;90: 2615-2625.
    • (1997) Blood , vol.90 , pp. 2615-2625
    • Heemskerk, J.W.1    Vuist, W.M.2    Feijge, M.A.3    Reutelingsperger, C.P.4    Lindhout, T.5
  • 16
    • 47949132511 scopus 로고    scopus 로고
    • Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation
    • Luik RM, Wang B, Prakriya M, Wu MM, Lewis RS. Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature. 2008;454: 538-542.
    • (2008) Nature , vol.454 , pp. 538-542
    • Luik, R.M.1    Wang, B.2    Prakriya, M.3    Wu, M.M.4    Lewis, R.S.5
  • 18
    • 13244283340 scopus 로고    scopus 로고
    • Role of mitochondrial permeability transition pore in coated-platelet formation
    • Remenyi G, Szasz R, Friese P, Dale GL. Role of mitochondrial permeability transition pore in coated-platelet formation. Arterioscler Thromb Vasc Biol. 2005;25: 467-471.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 467-471
    • Remenyi, G.1    Szasz, R.2    Friese, P.3    Dale, G.L.4
  • 19
    • 67649541305 scopus 로고    scopus 로고
    • Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
    • Schoenwaelder SM, Yuan Y, Josefsson EC, et al. Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood. 2009;114: 663-666.
    • (2009) Blood , vol.114 , pp. 663-666
    • Schoenwaelder, S.M.1    Yuan, Y.2    Josefsson, E.C.3
  • 20
    • 33751016385 scopus 로고    scopus 로고
    • Bax activators potentiate coated-platelet formation
    • Dale GL, Friese P. Bax activators potentiate coated-platelet formation. J Thromb Haemost. 2006;4: 2664-2669.
    • (2006) J Thromb Haemost , vol.4 , pp. 2664-2669
    • Dale, G.L.1    Friese, P.2
  • 21
    • 0021047734 scopus 로고
    • Changes in membrane phospholipid distribution during platelet activation
    • Bevers EM, Comfurius P, Zwaal RF. Changes in membrane phospholipid distribution during platelet activation. Biochim Biophys Acta. 1983;736: 57-66.
    • (1983) Biochim Biophys Acta , vol.736 , pp. 57-66
    • Bevers, E.M.1    Comfurius, P.2    Zwaal, R.F.3
  • 22
    • 0020003387 scopus 로고
    • The nature of the binding for prothrombinase at the platelet surface as revealed by lipolytic enzymes
    • Bevers EM, Comfurius P, Zwaal RF. The nature of the binding for prothrombinase at the platelet surface as revealed by lipolytic enzymes. Eur J Biochem. 1982;122: 81-85.
    • (1982) Eur J Biochem , vol.122 , pp. 81-85
    • Bevers, E.M.1    Comfurius, P.2    Zwaal, R.F.3
  • 23
    • 0020052831 scopus 로고
    • Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets
    • Bevers EM, Comfurius P, van Rijn JL, Hemker HC, Zwaal RF. Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets. Eur J Biochem. 1982;122: 429-436.
    • (1982) Eur J Biochem , vol.122 , pp. 429-436
    • Bevers, E.M.1    Comfurius, P.2    Van Rijn, J.L.3    Hemker, H.C.4    Zwaal, R.F.5
  • 24
    • 34548080000 scopus 로고    scopus 로고
    • Scott syndrome dogs have impaired coated-platelet formation and calcein-release but normal mitochondrial depolarization
    • Brooks MB, Catalfamo JL, Friese P, Dale GL. Scott syndrome dogs have impaired coated-platelet formation and calcein-release but normal mitochondrial depolarization. J Thromb Haemost. 2007;5: 1972-1974.
    • (2007) J Thromb Haemost , vol.5 , pp. 1972-1974
    • Brooks, M.B.1    Catalfamo, J.L.2    Friese, P.3    Dale, G.L.4
  • 25
    • 12144254763 scopus 로고    scopus 로고
    • The phosphatidylserine binding site of the factor Va C2 domain accounts for membrane binding but does not contribute to the assembly or activity of a human factor Xa-factor Va complex
    • Majumder R, Quinn-Allen MA, Kane WH, Lentz BR. The phosphatidylserine binding site of the factor Va C2 domain accounts for membrane binding but does not contribute to the assembly or activity of a human factor Xa-factor Va complex. Biochemistry. 2005;44: 711-718.
    • (2005) Biochemistry , vol.44 , pp. 711-718
    • Majumder, R.1    Quinn-Allen, M.A.2    Kane, W.H.3    Lentz, B.R.4
  • 27
    • 28444488295 scopus 로고    scopus 로고
    • Two subpopulations of thrombin-activated platelets differ in their binding of the components of the intrinsic factor X-activating complex
    • Panteleev MA, Ananyeva NM, Greco NJ, Ataullakhanov FI, Saenko EL. Two subpopulations of thrombin-activated platelets differ in their binding of the components of the intrinsic factor X-activating complex. J Thromb Haemost. 2005;3: 2545-2553.
    • (2005) J Thromb Haemost , vol.3 , pp. 2545-2553
    • Panteleev, M.A.1    Ananyeva, N.M.2    Greco, N.J.3    Ataullakhanov, F.I.4    Saenko, E.L.5
  • 28
  • 31
    • 28444436585 scopus 로고    scopus 로고
    • Coated-platelets: An emerging component of the procoagulant response
    • Dale GL. Coated-platelets: an emerging component of the procoagulant response. J Thromb Haemost. 2005;3: 2185-2192.
    • (2005) J Thromb Haemost , vol.3 , pp. 2185-2192
    • Dale, G.L.1
  • 32
    • 67650082748 scopus 로고    scopus 로고
    • Coated-platelet levels are low in patients with spontaneous intracerebral hemorrhage
    • Prodan CI, Vincent AS, Padmanabhan R, Dale GL. Coated-platelet levels are low in patients with spontaneous intracerebral hemorrhage. Stroke. 2009;40: 2578-2580.
    • (2009) Stroke , vol.40 , pp. 2578-2580
    • Prodan, C.I.1    Vincent, A.S.2    Padmanabhan, R.3    Dale, G.L.4
  • 33
    • 77953158282 scopus 로고    scopus 로고
    • Coated platelet levels correlate with bleed volume in patients with spontaneous intracerebral hemorrhage
    • Prodan CI, Vincent AS, Dale GL. Coated platelet levels correlate with bleed volume in patients with spontaneous intracerebral hemorrhage. Stroke. 2010;41: 1301-1303.
    • (2010) Stroke , vol.41 , pp. 1301-1303
    • Prodan, C.I.1    Vincent, A.S.2    Dale, G.L.3
  • 34
    • 77954485879 scopus 로고    scopus 로고
    • Lower coated-platelet levels are associated with early hemorrhagic transformation in patients with nonlacunar brain infarction
    • Prodan CI, Stoner JA, Cowan LD, Dale GL. Lower coated-platelet levels are associated with early hemorrhagic transformation in patients with nonlacunar brain infarction. J Thromb Haemost. 2010;8: 1185-1190.
    • (2010) J Thromb Haemost , vol.8 , pp. 1185-1190
    • Prodan, C.I.1    Stoner, J.A.2    Cowan, L.D.3    Dale, G.L.4
  • 35
    • 52449099304 scopus 로고    scopus 로고
    • Coated-platelets in ischemic stroke - Potential insight into the etiology of stroke subtypes
    • Prodan CI, Dale GL. Coated-platelets in ischemic stroke - potential insight into the etiology of stroke subtypes. Int J Stroke. 2008;3: 249-250.
    • (2008) Int J Stroke , vol.3 , pp. 249-250
    • Prodan, C.I.1    Dale, G.L.2
  • 36
    • 79959730828 scopus 로고    scopus 로고
    • Coated-platelet levels are elevated in patients with transient ischemic attack
    • Prodan CI, Vincent AS, Dale GL. Coated-platelet levels are elevated in patients with transient ischemic attack. Transl Res. 2011;158: 71-75.
    • (2011) Transl Res , vol.158 , pp. 71-75
    • Prodan, C.I.1    Vincent, A.S.2    Dale, G.L.3
  • 37
    • 77953741267 scopus 로고    scopus 로고
    • Coated-platelet levels may explain some variability in clinical phenotypes observed with severe hemophilia
    • Saxena K, Pethe K, Dale GL. Coated-platelet levels may explain some variability in clinical phenotypes observed with severe hemophilia. J Thromb Haemost. 2010;8: 1140-1142.
    • (2010) J Thromb Haemost , vol.8 , pp. 1140-1142
    • Saxena, K.1    Pethe, K.2    Dale, G.L.3
  • 39
    • 34147109359 scopus 로고    scopus 로고
    • Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist
    • Kjalke M, Kjellev S, Rojkjaer R. Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist. J Thromb Haemost. 2007;5: 774-780.
    • (2007) J Thromb Haemost , vol.5 , pp. 774-780
    • Kjalke, M.1    Kjellev, S.2    Rojkjaer, R.3
  • 40
    • 80052768198 scopus 로고    scopus 로고
    • Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa
    • Knudsen T, Kjalke M, Tranholm M, Nichols TC, Jensen AL, Kristensen AT. Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa. Am J Vet Res. 2011;72: 1007-1014.
    • (2011) Am J Vet Res , vol.72 , pp. 1007-1014
    • Knudsen, T.1    Kjalke, M.2    Tranholm, M.3    Nichols, T.C.4    Jensen, A.L.5    Kristensen, A.T.6
  • 41
    • 0030695063 scopus 로고    scopus 로고
    • Platelet activity of high-dose factor VIIa is independent of tissue factor
    • Monroe DM, Hoffman M, Oliver JA, Roberts HR. Platelet activity of high-dose factor VIIa is independent of tissue factor. Br J Haematol. 1997;99: 542-547.
    • (1997) Br J Haematol , vol.99 , pp. 542-547
    • Monroe, D.M.1    Hoffman, M.2    Oliver, J.A.3    Roberts, H.R.4
  • 42
    • 79953329362 scopus 로고    scopus 로고
    • Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity
    • Hoffman M, Volovyk Z, Persson E, Gabriel DA, Ezban M, Monroe DM. Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity. J Thromb Haemost. 2011;9: 759-766.
    • (2011) J Thromb Haemost , vol.9 , pp. 759-766
    • Hoffman, M.1    Volovyk, Z.2    Persson, E.3    Gabriel, D.A.4    Ezban, M.5    Monroe, D.M.6
  • 43
    • 78649630259 scopus 로고    scopus 로고
    • Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: A phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
    • Wilson WH, O'Connor OA, Czuczman MS, et al. Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol. 2010;11: 1149-1159.
    • (2010) Lancet Oncol , vol.11 , pp. 1149-1159
    • Wilson, W.H.1    O'Connor, O.A.2    Czuczman, M.S.3
  • 44
    • 79959828108 scopus 로고    scopus 로고
    • BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation
    • Vogler M, Hamali HA, Sun X-M, et al. BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation. Blood. 2010;117: 7145-7154.
    • (2010) Blood , vol.117 , pp. 7145-7154
    • Vogler, M.1    Hamali, H.A.2    Sun, X.-M.3
  • 45
    • 80051606228 scopus 로고    scopus 로고
    • Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets
    • Schoenwaelder SM, Jarman KE, Gardiner EE, et al. Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood. 2011;118: 1663-1674.
    • (2011) Blood , vol.118 , pp. 1663-1674
    • Schoenwaelder, S.M.1    Jarman, K.E.2    Gardiner, E.E.3


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