HUHS1015 induces necroptosis and caspase-independent apoptosis of MKN28 human gastric cancer cells in association with AMID accumulation in the nucleus

Anti-Cancer Agents in Medicinal Chemistry

Volumn 15, Issue 2, 2015, Pages 242-247

  Kaku, Yoshiko ^a   Tsuchiya, Ayako ^a   Kanno, Takeshi ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

AMID; Caspase independent apoptosis; HUHS1015; MKN28 gastric cancer cell; Necroptosis

Indexed keywords

APOPTOSIS INDUCING FACTOR; APOPTOSIS INDUCING FACTOR HOMOLOGOUS MITOCHONDRION ASSOCIATED INDUCER OF DEATH PROTEIN; CASPASE; CASPASE 3; CASPASE 4; CASPASE 8; CASPASE 9; HUHS1015; PIPERAZINE DERIVATIVE; PROTEIN; UNCLASSIFIED DRUG; 1-(2-(2-METHOXYPHENYLAMINO)ETHYLAMINO)-3-(NAPHTHALENE-1-YLOXY)PROPAN-2-OL; AIFM2 PROTEIN, HUMAN; ANILINE DERIVATIVE; APOPTOSIS REGULATORY PROTEIN; LIPOCORTIN 5; MITOCHONDRIAL PROTEIN; PROPANOLAMINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; MTT ASSAY; NECROPTOSIS; NUCLEAR LOCALIZATION SIGNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; WESTERN BLOTTING; CELL NUCLEUS; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; MITOCHONDRION; NECROSIS; STOMACH NEOPLASMS; TUMOR CELL LINE;

ANILINE COMPOUNDS; ANNEXIN A5; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASES; CELL DEATH; CELL LINE, TUMOR; CELL NUCLEUS; G1 PHASE; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NECROSIS; PROPANOLAMINES; STOMACH NEOPLASMS;

EID: 84926150693     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520614666140922122700     Document Type: Article

References (20)

1. Gotoh, A.; Nagaya, H.; Kanno, T.; Nishizaki, T. Antitumor action of α1-adrenoceptor blockers on human bladder, prostate and renal cancer cells. Pharmacology, 2012, 90, 242-246.
2. Masachika, E.; Kanno, T.; Nakano, T.; Gotoh, A.; Nishizaki, T. Naftopidil induces apoptosis in malignant mesothelioma cell lines independently of α1-adrenoceptor blocking. Anticancer Res., 2013, 33, 887-894.
3. Kanno, T.; Tanaka, A.; Shimizu, T.; Nakano, T.; Nishizaki, T. 1-2-(2-Methoxyphenylamino) ethylamino]-3-(naphthalene-1-yloxy) propan-2-ol as a potential anticancer drug. Pharmacology, 2013, 91, 339-345.
4. Kaku, Y.; Nagaya, H.; Tsuchiya, A.; Kanno, T.; Gotoh, A.; Tanaka, A.; Shimizu, T.; Nakao, S.; Tabata, C.; Nakano, T.; Nishizaki, T. Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma. Cancer Sci., 2014, doi: 10.1111/ cas.12429.
5. Yang, D.; Yaguchi, Y.; Nagata, T.; Gotoh, A.; Dovat, S.; Song, C.; Nishizaki, T. AMID mediates adenosine-induced caspase-independent HuH-7 cell apoptosis. Cell. Physiol. Biochem., 2011, 27, 37-44.
6. Vanags, D.M.; Pörn-Ares, M.I.; Coppola, S.; Burgess, D.H.; Orrenius, S. Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. J. Biol. Chem., 1996, 271, 31075-31085.
7. Pietra, G.; Mortarini, R.; Parmiani, G.; Anichini, A. Phases of apoptosis of melanoma cells, but not of normal melanocytes, differently affect maturation of myeloid dendritic cells. Cancer Res., 2001, 61, 8218-8226.
8. Degterev, A.; Huang, Z.; Boyce, M.; Li, Y.; Jagtap, P.; Mizushima, N.; Cuny, G.D.; Mitchison, T.J.; Moskowitz, M.A.; Yuan, J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol., 2005, 1, 112-119.
9. Cande, C.; Cecconi, F.; Dessen, P.; Kroemer, G. Apoptosisinducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J. Cell Sci., 2002, 115, 4727-4734.
10. Daugas, E.; Susin, S.A.; Zamzami, N.; Ferri, K.F.; Irinopoulou, T.; Larochette, N.; Prévost, M.C.; Leber, B.; Andrews, D.; Penninger, J.; Kroemer, G. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J., 2000, 14, 729-739.
11. Ye, H.; Cande, C.; Stephanou, N.C.; Jiang, S.; Gurbuxani, S.; Larochette, N. Daugas, E.; Garrido, C.; Kroemer, G.; Wu, H. DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat. Struct. Biol., 2002, 9, 680-684.
12. Bilyy, R.; Kit, Y.; Hellman, U.; Stoika, R. AMID: New insights on its intracellular localization and expression at apoptosis. Apoptosis, 2008, 13, 729-732.
13. Li, W.; Sun, L.; Liang, Q.; Wang, J.; Mo, W.; Zhou, B. Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol. Biol. Cell,2006, 17, 1802-1811.
14. Marshall, K.R.; Gong, M.; Wodke, L.; Lamb, J.H.; Jones, D.J.; Farmer, P.B.; Scrutton, N.S.; Munro, A.W. The human apoptosisinducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity. J. Biol. Chem., 2005, 280, 30735-30740.
15. Ohiro, Y.; Garkavtsev, I.; Kobayashi, S.; Sreekumar, K.R.; Nantz, R.; Higashikubo, B.T.; Duffy, S.L.; Higashikubo, R.; Usheva, A.; Gius, D.; Kley, N.; Horikoshi, N. A novel p53- inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). FEBS Lett., 2002, 524, 163-171.
16. Varecha, M.; Amrichova, J.; Zimmermann, M.; Ulman, V.; Lukasova, E.; Kozubek, M. Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells. Apoptosis, 2007, 12, 1155-1171.
17. Wu, M.; Xu, L.G.; Li, X.; Zhai, Z.; Shu, H.B. AMID, an apoptosisinducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J. Biol. Chem., 2002, 277, 25617-25623.
18. Christofferson, D.E.; Yuan, J. Necroptosis as an alternative form of programmed cell death. Curr. Opin. Cell Biol., 2010, 22, 263-268.
19. Wu, M.; Xu, L.G.; Su, T.; Tian, Y.; Zhai, Z.; Shu, H.B. AMID is a p53-inducible gene downregulated in tumors. Oncogene, 2004, 23, 6815-6819.
20. Vaseva, A.V.; Marchenko, N.D.; Ji, K.; Tsirka, S.E.; Holzmann, S.; Moll, U.M. p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell, 2012, 149, 1536-1548.