Naftopidil induces apoptosis in malignant mesothelioma cell lines independently of α1-adrenoceptor blocking

Anticancer Research

Volumn 33, Issue 3, 2013, Pages 887-894

  Masachika, Eriko ^a   Kanno, Takeshi ^a   Nakano, Takashi ^a   Gotoh, Akinobu ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

1 Adrenoceptor blocker; Apoptosis; Caspase; Malignant mesothelioma; MSTO 211H; NCI H2052; NCI H2452; NCI H28

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CASPASE 3; CASPASE 8; CASPASE 9; NAFTOPIDIL; PRAZOSIN; PROTEIN KINASE C; SMALL INTERFERING RNA;

ADRENERGIC RECEPTOR BLOCKING; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALIGNANT MESOTHELIOMA; PRIORITY JOURNAL;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; HUMANS; MESOTHELIOMA; NAPHTHALENES; PIPERAZINES;

EID: 84875899823     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Brede M, Philipp M, Knaus A, Muthig V and Hein L: α2- Adrenergic receptor subtypes-novel functions uncovered in genetargeted mouse models. Biol Cell 96: 343-348, 2004.
2. Kaumann AJ and Molenaar P: Modulation of human cardiac function through 4β-adrenoceptor populations. Naunyn Schmiedebergs Arch Pharmacol 355: 667-681, 1997.
3. Zhong H and Minneman KP: α1-Adrenoceptor subtypes. Eur J Pharmacol 375: 261-276, 1999.
4. Alberti C: Apoptosis induction by quinazoline-derived α1- blockers in prostate cancer cells: biomolecular implications and clinical relevance. Eur Rev Med Pharmacol Sci 11: 59-64, 2007.
5. Anglin IE, Glassman DT and Kyprianou N: Induction of prostate apoptosis by α1-adrenoceptor antagonists: Mechanistic significance of the quinazoline component. Prostate Cancer Prostatic Dis 5: 88-95, 2002.
6. Benning CM and Kyprianou N: Quinazoline-derived α1-Adrenoceptor antagonists induce prostate cancer cell apoptosis via an α1- adrenoceptor-independent action. Cancer Res 62: 597-602, 2002.
7. Cuellar DC, Rhee J and Kyprianou N: α1-Adrenoceptor antagonists radiosensitize prostate cancer cells via apoptosis induction. Anticancer Res 22: 1673-1679, 2002.
8. Desiniotis A and Kyprianou N: Advances in the design and synthesis of prazosin derivatives over the last ten years. Expert Opin Ther Targets 15: 1405-1418, 2011.
9. Garrison JB and Kyprianou N: Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptormediated pathway. Cancer Res 66: 464-472, 2006.
10. Harris AM, Warner BW, Wilson JM, Becker A, Rowland RG, Conner W, Lane M, Kimbler K, Durbin EB, Baron AT and Kyprianou N: Effect of α1-adrenoceptor antagonist exposure on prostate cancer incidence: An observational cohort study. J Urol 178: 2176-2180, 2007.
11. Keledjian K and Kyprianou N: Anoikis induction by quinazoline based α1-adrenoceptor antagonists in prostate cancer cells: Antagonistic effect of Bcl-2. J Urol 169: 1150-1156, 2003.
12. Kyprianou N: Doxazosin and terazosin suppress prostate growth by inducing apoptosis: Clinical significance. J Urol 169: 1520-1525, 2003.
13. Kyprianou N and Benning CM: Suppression of human prostate cancer cell growth by α1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. Cancer Res 60: 4550-4555, 2000.
14. Kyprianou N and Jacobs SC: Induction of apoptosis in the prostate by α1-adrenoceptor antagonists: A novel effect of "old" drugs. Curr Urol Rep 1: 89-96, 2000.
15. Kyprianou N, Vaughan TB and Michel MC: Apoptosis induction by doxazosin and other quinazoline α1-adrenoceptor antagonists: A new mechanism for cancer treatment? Naunyn Schmiedebergs Arch Pharmacol 380: 473-477, 2009.
16. Lin SC, Chueh SC, Hsiao CJ, Li TK, Chen TH, Liao CH, Lyu PC and Guh JH: Prazosin displays anticancer activity against human prostate cancers: Targeting DNA and cell cycle. Neoplasia 9: 830-839, 2007.
17. Liou SF, Lin HH, Liang JC, Chen IJ and Yeh JL: Inhibition of human prostate cancer cells proliferation by a selective α1- adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis. Toxicology 256: 13-24, 2009.
18. Partin JV, Anglin IE and Kyprianou N: Quinazoline-based α1- adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-β signalling and IκBα induction. Br J Cancer 88: 1615-1621, 2003.
19. Siddiqui EJ, Shabbir M, Thompson CS, Mumtaz FH and Mikhailidis DP: Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved? Anticancer Res 25: 4281-4286, 2005.
20. Walden PD, Globina Y and Nieder A: Induction of anoikis by doxazosin in prostate cancer cells is associated with activation of caspase-3 and a reduction of focal adhesion kinase. Urol Res 32: 261-265, 2004.
21. Keledjian K, Borkowski A, Kim G, Isaacs JT, Jacobs SC and Kyprianou N: Reduction of human prostate tumor vascularity by the α1-adrenoceptor antagonist terazosin. Prostate 48: 71-78, 2001.
22. Keledjian K, Garrison JB and Kyprianou N: Doxazosin inhibits human vascular endothelial cell adhesion, migration, and invasion. J Cell Biochem 94: 374-388, 2005.
23. Liao CH, Guh JH, Chueh SC and Yu HJ: Antiangiogenic effects and mechanism of prazosin. Prostate 71: 976-984, 2011.
24. Tahmatzopoulos A, Lagrange CA, Zeng L, Mitchell BL, Conner WT and Kyprianou N: Effect of terazosin on tissue vascularity and apoptosis in transitional cell carcinoma of bladder. Urology 65: 1019-1023, 2005.
25. Tahmatzopoulos A, Sheng S and Kyprianou N: Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis. Oncogene 24: 5375-5383, 2005.
26. Takei R, Ikegaki I, Shibata K, Tsujimoto G and Asano T: Naftopidil, a novel α1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human α1-adrenoceptors. Jpn J Pharmacol 79: 447-454, 1999.
27. Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K and Sugimura Y: Naftopidil, a selective α1- adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila) 4: 87-96, 2011.
28. Kanda H, Ishii K, Ogura Y, Imamura T, Kanai M, Arima K and Sugimura Y: Naftopidil, a selective α-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest. Int J Cancer 122: 444-451, 2008.
29. Kanda H, Ishii K, Ogura Y, Imamura T, Kanai M, Arima K and Sugimura Y: Spontaneous regression of an asymptomatic meningioma associated with discontinuation of progesterone agonist administration. Neurol Med Chir 48: 227-330, 2008.
30. Raja S, Murthy SC and Mason DP: Malignant pleural mesothelioma. Curr Oncol Rep 13: 259-264, 2011.
31. Nogi Y, Kanno T, Nakano T, Fujita Y, Tabata C, Fukuoka K, Gotoh A and Nishizaki T: AMP converted from intracellularly transported adenosine up-regulates p53 expression to induce malignant pleural mesothelioma cell apoptosis. Cell Physiol Biochem 30: 61-74, 2012.
32. Fuchs R, Schraml E, Leitinger G, Stelzer I, Allard N, Haas HS, Schauenstein K and Sadjak A: α1-Adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism. Exp Cell Res 317: 2239-2251, 2011.
33. Ashkenazi A and Dixit VM: Death receptors: Signaling and modulation. Science 281: 1305-1308, 1998.
34. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH and Peter ME: Two CD95 (APO- 1/FAS) signaling pathways. EMBO J 17: 1675-1687, 1998.
35. Micheau O and Tschopp J: Induction of TNF receptor Imediated apoptosis via two Sequential signaling complexes. Cell 114: 181-190, 2003.
36. Earnshaw WC, Martins LM and Kaufmann SH: Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68: 383-424, 1999.
37. Kuida K: Caspase-9. Int J Biochem Cell Biol 32: 121-124, 2000.
38. Zou H, Li Y, Liu X and Wang X: An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274: 11549-11556, 1999.