Analytical interference in serum iron determination reveals iron versus gadolinium transmetallation with linear gadolinium-based contrast agents

Investigative Radiology

Volumn 49, Issue 12, 2014, Pages 766-772

  Fretellier, Nathalie ^a   Poteau, Nathalie ^a   Factor, Cécile ^a   Mayer, Jean François ^a   Medina, Christelle ^a   Port, Marc ^a   Idée, Jean Marc ^a   Corot, Claire ^a  

^a Laboratoire Guerbet   (France)

Author keywords

Gadolinium based contrast agents; Interference; Iron; Mass spectrometry; Transmetallation

Indexed keywords

CALCIUM DIETHYLENE TRIAMINE PENTAACETIC ACID BISMETHYLAMIDE; CONTRAST MEDIUM; GADOBENIC ACID; GADOBUTROL; GADODIAMIDE; GADOLINIUM; GADOPENTETIC ACID; GADOTERIC ACID; IRON; PENTETIC ACID; UNCLASSIFIED DRUG; GADOLINIUM PENTETATE; MEGLUMINE; ORGANOMETALLIC COMPOUND;

AQUEOUS SOLUTION; ARTICLE; COLORIMETRY; CONCENTRATION RESPONSE; ELECTROSPRAY MASS SPECTROMETRY; IRON BLOOD LEVEL; METALLATION; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TIME OF FLIGHT MASS SPECTROMETRY; TRANSMETALLATION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; COMPARATIVE STUDY; HUMAN; MASS SPECTROMETRY; PROCEDURES; WISTAR RAT;

ANIMALS; COLORIMETRY; CONTRAST MEDIA; GADOLINIUM; GADOLINIUM DTPA; HUMANS; IRON; MASS SPECTROMETRY; MEGLUMINE; ORGANOMETALLIC COMPOUNDS; RATS; RATS, WISTAR;

EID: 84925954214     PISSN: 00209996     EISSN: 15360210     Source Type: Journal    
DOI: 10.1097/rli.0000000000000081     Document Type: Article

References (26)

1. Hao D, Ai T, Goerner F, et al. MRI contrast agents: basic chemistry and safety. J Magn Reson Imaging. 2012;36:1060-1071.
2. Lippi G, Daves M, Mattiuzzi C. Interference of medical contrast media on laboratory testing. Biochem Med (Zagreb). 2014;24:80-88.
3. Lin J, Idee JM, Port M, et al. Interference of magnetic resonance imaging contrast agents with the serum calcium measurement technique using colorimetric reagents. J Pharm Biomed Anal. 1999;21:931-943.
4. Lowe A, Balzer T, Hirt U. Interference of gadolinium-containing contrastenhancing agents with colorimetric calcium laboratory testing. Invest Radiol. 2005;40:521-525.
5. Normann PT, Froysa A, Svaland M. Interference of gadodiamide injection (OMNISCAN) on the colorimetric determination of serum calcium. Scand J Clin Lab Invest. 1995;55:421-426.
6. Haylor J, Vickers ME, Morcos SK. Interference of gadolinium-based contrast agents with the measurement of serum creatinine by the Jaffe reaction. Br J Radiol. 2009;82:438-439.
7. Proctor KA, Rao LV, Roberts WL. Gadolinium magnetic resonance contrast agents produce analytic interference in multiple serum assays. Am J Clin Pathol. 2004;121:282-292.
8. Zhang HL, Ersoy H, Prince MR. Effects of gadopentetate dimeglumine and gadodiamide on serum calcium, magnesium, and creatinine measurements. J Magn Reson Imaging. 2006;23:383-387.
9. Port M, Idee JM, Medina C, et al. Efficiency, thermodynamic and kinetic stability of marketed gadolinium chelates and their possible clinical consequences: a critical review. Biometals. 2008;21:469-490.
10. Laurent S, Vander Elst L, Henoumont C, et al. How to measure the transmetallation of a gadolinium complex. Contrast Media Mol Imaging. 2010;5:305-308.
11. Idee JM, Port M, Raynal I, et al. Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging: a review. Fundam Clin Pharmacol. 2006;20:563-576.
12. Tweedle M, Hagan J, Kumar K, et al. Reaction of gadolinium chelates with endogenously available ions. Magn Reson Imaging. 1991;9:409-415.
13. Laurent S, Elst LV, Copoix F, et al. Stability of MRI paramagnetic contrast media: a proton relaxometric protocol for transmetallation assessment. Invest Radiol. 2001;36:115-122.
14. Laurent S, Elst LV, Muller RN. Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents. Contrast Media Mol Imaging. 2006;1:128-137.
15. Robic C, Catoen S, De Goltstein MC, et al. The role of phosphate on Omniscan ((R)) dechelation: an in vitro relaxivity study at pH 7. Biometals. 2011;24:759-768.
16. Fretellier N, Idee J, Bruneval P, et al. Hyperphosphataemia sensitizes renally impaired rats to the profibrotic effects of gadodiamide. Br J Pharmacol. 2012;165:1151-1162.
17. Centers for Disease Control and Prevention (CDC) (2) Centers for Medicare & Medicaid Services (CMS), HHS. Medicare, Medicaid, and CLIA programs; laboratory requirements relating to quality systems and certain personnel qualifications. Final rule. Fed Regist. 2003;68:3639-3714.
18. Idee JM, Port M, Robic C, et al. Role of thermodynamic and kinetic parameters in gadolinium chelate stability. J Magn Reson Imaging. 2009;30:1249-1258.
19. Le Mignon MM, Chambon C, Warrington S, et al. Gd-DOTA. Pharmacokinetics and tolerability after intravenous injection into healthy volunteers. Invest Radiol. 1990;25:933-937.
20. Frenzel T, Lengsfeld P, Schirmer H, et al. Stability of gadolinium-based magnetic resonance imaging contrast agents in human serum at 37 degrees C. Invest Radiol. 2008;43:817-828.
21. Joffe P, Thomsen HS, Meusel M. Pharmacokinetics of gadodiamide injection in patients with severe renal insufficiency and patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis. Acad Radiol. 1998;5:491-502.
22. Swaminathan S, Horn TD, Pellowski D, et al. Nephrogenic systemic fibrosis, gadolinium, and iron mobilization. N Engl J Med. 2007;357:720-722.
23. de Haen C, Cabrini M, Akhnana L, et al. Gadobenate dimeglumine 0.5 M solution for injection (MultiHance) pharmaceutical formulation and physicochemical properties of a new magnetic resonance imaging contrast medium. J Comput Assist Tomogr. 1999;23(suppl 1):S161-S168.
24. Clarcke ET, Martell AE. Stabilities of trivalent metal ion complexes of the tetracetate derivatives of 12-, 13- and 14-membered tetrazamacrocycles. Inorg Chim Acta. 1991;190:37-46.
25. Martell AE, Smith RM. Critical Stability Constants. New York: Plenum Press; 1974.
26. Telgmann L, Wehe CA, Kunnemeyer J, et al. Speciation of Gd-based MRI contrast agents and potential products of transmetalation with iron ions or parenteral iron supplements. Anal Bioanal Chem. 2012;404:2133-2141.