Interference of medical contrast media on laboratory testing

Biochemia Medica

Volumn 24, Issue 1, 2014, Pages 80-88

  Lippi, Giuseppe ^a,b,c   Daves, Massimo ^a,b,c   Mattiuzzi, Camilla ^a,b,c  

^a ACADEMIC HOSPITAL OF PARMA   (Italy)

^b San Maurizio Regional Hospital   (Italy)

^c Trento General Hospital   (Italy)

Author keywords

Analytical interference; Contrast agents; Contrast media; Errors; Gadolinium

Indexed keywords

ARSENAZO 3; BARIUM SULFATE; CALCIUM; CONTRAST MEDIUM; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE; DISULFINE BLUE; GADODIAMIDE; GADOLINIUM; GADOLINIUM PENTETATE MEGLUMINE; GADOTERIC ACID; GADOVERSETAMIDE; IODINE; IODIXANOL; IOHEXOL; IOVERSOL; MAGNESIUM; METHEMOGLOBIN; SELENIUM; TROPONIN I;

ANALYTICAL ERROR; ANGIOCARDIOGRAPHY; CAPILLARY ZONE ELECTROPHORESIS; COLORIMETRY; DIAGNOSTIC IMAGING; GLOMERULUS FILTRATION RATE; HEART MUSCLE REVASCULARIZATION; HUMAN; IMMUNOASSAY; IRON BINDING CAPACITY; LABORATORY TEST; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE IMAGING; PULSE OXIMETRY; REVIEW;

ANALYTICAL INTERFERENCE; CONTRAST AGENTS; CONTRAST MEDIA; ERRORS; GADOLINIUM;

BLOOD CHEMICAL ANALYSIS; CONTRAST MEDIA; DIAGNOSTIC ERRORS; HUMANS;

EID: 84893620570     PISSN: 13300962     EISSN: None     Source Type: Journal    
DOI: 10.11613/BM.2014.010     Document Type: Review

References (54)

1. Lippi G, Plebani M, Simundic AM. Quality in laboratory diagnostics: from theory to practice. Biochem Med 2010;20:126-130. http://dx.doi.org/10.11613/BM.2010.014.
2. Simundic AM, Lippi G. Preanalytical phase - A continuous challenge for laboratory professionals. Biochem Med 2012;22:145-149. http://dx.doi.org/10.11613/BM.2012.017.
3. Lippi G, Becan-McBride K, Behúlová D, Bowen RA, Church S, Delanghe J, et al. Preanalytical quality improvement: in quality we trust. Clin Chem Lab Med 2013;51:229-241. http://dx.doi.org/10.1515/cclm-2012-0597.
4. Sonntag O. Quality in the analytical phase. Biochem Med (Zagreb) 2010;20:147-53. http://dx.doi.org/10.11613/BM.2010.017.
5. Carraro P, Plebani M. Errors in a stat laboratory: types and frequencies 10 years later. Clin Chem 2007;53:1338-42. http://dx.doi.org/10.1373/clinchem.2007.088344.
6. Clinical and Laboratory Standards Institute. Interference Testing in Clinical Chemistry; Approved Guideline - Second Edition. CLSI document EP7-A2 (ISBN 1-56238-584-4). Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2005.
7. Thomas L. Haemolysis as influence and interference factor. eJIFCC vol 13 no 4. Available at: http://www.ifcc.org/ifccfi-les/docs/130401002end.pdf. Accessed: 3 July 2013.
8. Selby C. Interference in immunoassay. Ann Clin Bioch 1999;36:704-21.
9. Dimeski G. Interference Testing. Clin Biochem Rev 2008;29(Suppl 1):S43-8.
10. Simundic AM, Topic E, Nikolac N, Lippi G. Hemolysis detection and management of hemolysed specimens. Biochem Med 2010;20:154-9. http://dx.doi.org/10.11613/BM.2010.018.
11. Lippi G, Plebani M, Favaloro EJ. Interference in coagulation testing: focus on spurious hemolysis, icterus, and lipemia. Semin Thromb Hemost 2013;39:258-66.
12. Calmarza P, Cordero J. Lipemia interferences in routine clinical biochemical tests. Biochem Med 2011;21:160-6. http://dx.doi.org/10.11613/BM.2011.025.
13. Sturgeon CM, Viljoen A. Analytical error and interference in immunoassay: minimizing risk. Ann Clin Biochem 2011;48:418-32. http://dx.doi.org/10.1258/acb.2011.011073.
14. Bolstad N, Warren DJ, Bjerner J, Kravdal G, Schwettmann L, Olsen KH, et al. Heterophilic antibody interference in commercial immunoassays; a screening study using paired native and pre-blocked sera. Clin Chem Lab Med 2011;49:2001-6. http://dx.doi.org/10.1515/CCLM.2011.702.
15. Caleffi A, Rosso R, Lippi G. Interferences in red blood cell counting in urinalysis using evacuated tubes. Clin Chem Lab Med 2010;48:1681-2. http://dx.doi.org/10.1515/CCLM.2010.312.
16. Lippi G, Mattiuzzi C, Banfi G. Controlling sources of preanalytical variability in doping samples: challenges and solutions. Bioanalysis 2013;5:1571-82. http://dx.doi.org/10.4155/bio.13.110.
17. Lippi G, Avanzini R, Sandei F, Aloe R, Cervellin G. Blood sample contamination by glucose-containing solutions: effects and identification. Br J Biomed Sci 2013;70:180-3.
18. Lippi G, Romero A, Cervellin G, Mercadanti M. Unusual false-positive case of urinary screening for buprenorphine. J Clin Lab Anal 2011;25:244-5. http://dx.doi.org/10.1002/jcla.20466.
19. Bickham P, Golembiewski J. Contrast media use in the operating room. J Perianesth Nurs 2010;25:94-103. http://dx.doi.org/10.1016/j.jopan.2010.01.013.
20. Bellin MF, Van Der Molen AJ. Extracellular gadolinium-based contrast media: an overview. Eur J Radiol 2008;66:160-7. http://dx.doi.org/10.1016/j.ejrad.2008.01.023.
21. Stratta P, Quaglia M, Airoldi A, Aime S. Structure-function relationships of iodinated contrast media and risk of nephrotoxicity. Curr Med Chem 2012;19:736-43. http://dx.doi. org/10.2174/092986712798992084.
22. Spiritus T, Zaman Z, Desmet W. Iodinated contrast media interfere with gel barrier formation in plasma and serum separator tubes. Clin Chem 2003;49:1187-9. http://dx.doi. org/10.1373/49.7.1187.
23. Kaleta EJ, Jaffe AS, Baumann NA, Block DR. A case of floating gel. Clin Chem 2012;58:1604-5. http://dx.doi.org/10.1373/clinchem.2012.188862.
24. Daves M, Lippi G, Cosio G, Raffagnini A, Peer E, Dangella A, et al. An unusual case of a primary blood collection tube with floating separator gel. J Clin Lab Anal 2012;26:246-7. http://dx.doi.org/10.1002/jcla.21512.
25. Lin CT, Lee HC, Voon WC, Yen HW, Tang MH, Chin TT, et al. Positive interference from contrast media in cardiac troponin I immunoassays. Kaohsiung J Med Sci 2006;22:107-13. http://dx.doi.org/10.1016/S1607-551X(09)70229-3.
26. Bossuyt X, Mewis A, Blanckaert N. Interference of radio-opaque agents in clinical capillary zone electrophoresis. Clin Chem 1999;45:129-31.
27. Arranz-Peña ML, González-Sagrado M, Olmos-Linares AM, Fernández-García N, Martín-Gil FJ. Interference of iodinated contrast media in serum capillary zone electrophoresis. Clin Chem 2000;46:736-7.
28. van der Watt G, Berman P. Pseudoparaproteinemia after iopamidol infusion for coronary angiography. Clin Chem 2005;51:273-4. http://dx.doi.org/10.1373/clinchem.2004.043505.
29. Vermeersch P, Mariën G, Bossuyt X. Pseudoparaproteinemia related to iomeprol administration after angiocardiography: Detection in the beta fraction by capillary zone electrophoresis. Clin Chem 2006;52:2312-3. http://dx.doi.org/10.1373/clinchem.2006.078584.
30. Cho SY, Kim Y, Lee A, Park TS, Lee HJ, Suh JT. Three Cases Showing False Results in the Detection of Monoclonal Components Using Capillary Electrophoresis. Lab Medicine 2011;42:602-6. http://dx.doi.org/10.1309/LMHZLI-MXVYLWT7SQ.
31. Potter JL, Timmons GD, Kofron WG. Radiocontrast interference in screening tests for genetic-metabolic diseases. Clin Chim Acta 1999;281:71-6. http://dx.doi.org/10.1016/S0009-8981(98)00207-1.
32. Normann PT, Frøysa A, Svaland M. Interference of gadodiamide injection (OMNISCAN) on the colorimetric determination of serum calcium. Scand J Clin Lab Invest 1995;55:421-6. http://dx.doi.org/10.3109/00365519509104981.
33. Lin J, Idee JM, Port M, Diai A, Berthommier C, Robert M, et al. Interference of magnetic resonance imaging contrast agents with the serum calcium measurement technique using colorimetric reagents. J Pharm Biomed Anal 1999;21:931-43. http://dx.doi.org/10.1016/S0731-7085(99)00188-0.
34. Prince MR, Erel HE, Lent RW, Blumenfeld J, Kent KC, Bush HL, Wang Y. Gadodiamide administration causes spurious hypocalcemia. Radiology 2003;227:639-46. http://dx.doi. org/10.1148/radiol.2273012007.
35. Doorenbos CJ, Ozyilmaz A, van Wijnen M. Severe pseudohypocalcemia after gadolinium-enhanced magnetic resonance angiography. N Engl J Med 2003;349:817-8. http://dx.doi.org/10.1056/NEJM200308213490822.
36. Decupere M, Ooms V, Oyen R, Kuypers DR, Claes K. Artifactual hypocalcaemia after intravenous administration of gadodiamide (Omniscan). Nephrol Dial Transplant 2005;20:1516-7. http://dx.doi.org/10.1093/ndt/gfh902.
37. Williams SF, Meek SE, Moraghan TJ. Spurious hypocalcemia after gadodiamide administration. Mayo Clin Proc 2005;80:1655-7. http://dx.doi.org/10.4065/80.12.1655.
38. Kang HP, Scott MG, Joe BN, Narra V, Heiken J, Parvin CA. Model for predicting the impact of gadolinium on plasma calcium measured by the o-cresolphthalein method. Clin Chem 2004;50:741-6. http://dx.doi.org/10.1373/clinchem.2003.028886.
39. Proctor KA, Rao LV, Roberts WL. Gadolinium magnetic resonance contrast agents produce analytic interference in multiple serum assays. Am J Clin Pathol 2004;121:282-92. http://dx.doi.org/10.1309/MGA3LC4X8CGLX9CH.
40. Löwe A, Balzer T, Hirt U. Interference of gadolinium-containing contrast-enhancing agents with colorimetric calcium laboratory testing. Invest Radiol 2005;40:521-5. http://dx.doi.org/10.1097/01.rli.0000170447.45577.5e.
41. Brown JJ, Hynes MR, Wible JH Jr. Measurement of serum calcium concentration after administration of four gadolinium-based contrast agents to human volunteers. AJR Am J Roentgenol 2007;189:1539-44. http://dx.doi.org/10.2214/AJR.07.2464.
42. Datta P, Dasgupta A. New method for calcium on the AD-VIA analyzer is free from interference of gadolinium-type contrast agents. J Clin Lab Anal 2009;23:399-403. http://dx.doi.org/10.1002/jcla.20353.
43. Löwe A, Breuer J, Palkowitsch P. Evaluation of the effect of two gadolinium-containing contrast-enhancing agents, gadobutrol and gadoxetate disodium, on colorimetric calcium determinations in serum and plasma. Invest Radiol 2011;46:366-9. http://dx.doi.org/10.1097/RLI.0b013e318209ed6f.
44. Gandhi MJ, Narra VR, Brown JJ, Guo A, Grosu DS, Parvin CA, Scott MG. Clinical and economic impact of falsely decreased calcium values caused by gadoversetamide interference. AJR Am J Roentgenol 2008;190:W213-7. http://dx.doi.org/10.2214/AJR.07.2923.
45. Haylor J, Vickers ME, Morcos SK. Interference of gadolinium-based contrast agents with the measurement of serum creatinine by the Jaffe reaction. Br J Radiol 2009;82:438-9. http://dx.doi.org/10.1259/bjr/13806057.
46. Walter A, Nelms S, Harrington CF, Taylor A. Interference of gadolinium on the measurement of selenium in human serum by inductively coupled plasma-quadrupole mass spectrometry. Ann Clin Biochem 2011;48:2176-7. http://dx.doi.org/10.1258/acb.2010.010030.
47. Haque SH, Nossaman BD. Dyed but not dead. Ochsner J 2012;12:135-40.
48. Darby D, Broomhead C. Interference with serum indices measurement, but not chemical analysis, on the Roche Modular by Patent Blue V. Ann Clin Biochem 2008;45:289-92. http://dx.doi.org/10.1258/acb.2007.007176.
49. McTaggart MP, Cannon LP, Kearney EM. Effect of Patent Blue V(®) dye on sample interference indices on the Abbott Architect. Ann Clin Biochem 2012;49:510-1. http://dx.doi. org/10.1258/acb.2012.012044.
50. Lai HC, Hsu HM, Cherng CH, Lin SL, Wu CT, Yu JC, Yeh CC. Interference of patent blue dye with pulse oximetry readings, methemoglobin measurements, and blue urine in sentinel lymph node mapping: a case report and review of the literature. Acta Anaesthesiol Taiwan 2011;49:162-4. http://dx.doi.org/10.1016/j.aat.2011.11.004.
51. Lippi G, Simundic AM, Mattiuzzi C. Overview on patient safety in healthcare and laboratory diagnostics. Biochem Med 2010;20:131-43. http://dx.doi.org/10.11613/BM.2010.015.
52. Lukasiewicz A, Lebkowska U, Galar M. Effect of iodinated low-osmolar contrast media on the hemostatic system after intraarterial and intravenous contrast administration. Adv Med Sci 2012;57:341-7. http://dx.doi.org/10.2478/v10039-012-0045-3.
53. Lippi G, Cervellin G, Franchini M, Favaloro EJ. Biochemical markers for the diagnosis of venous thromboembolism: the past, present and future. J Thromb Thrombolysis 2010;30:459-71. http://dx.doi.org/10.1007/s11239-0100460-x.
54. European Society of Urogenital Radiology (ESUR). ESUR Guidelines on Contrast Media. Available at: http://www.esur.org/guidelines/en/index.php. Accessed: 3 July 2013.