Efficiency, thermodynamic and kinetic stability of marketed gadolinium chelates and their possible clinical consequences: A critical review

BioMetals

Volumn 21, Issue 4, 2008, Pages 469-490

  Port, Marc ^a   Idée, Jean Marc ^a   Medina, Christelle ^a   Robic, Caroline ^a   Sabatou, Monique ^a   Corot, Claire ^a  

^a Laboratoire Guerbet   (France)

Author keywords

Contrast agents; Gadolinium; Kinetic stability; Magnetic resonance imaging; Nephrogenic systemic fibrosis; Osmolality; Relaxivity; Thermodynamic stability; Viscosity

Indexed keywords

CALCIUM; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE; GADOBENATE DIMEGLUMINE; GADOBUTROL; GADODIAMIDE; GADOFOSVESET; GADOLINIUM; GADOLINIUM CHLORIDE; GADOLINIUM PENTETATE; GADOTERATE MEGLUMINE; GADOTERIDOL; GADOVERSETAMIDE; GADOXETIC ACID; ZINC;

BINDING AFFINITY; BIOCOMPATIBILITY; CHELATION; CLINICAL TRIAL; DRUG CONFORMATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG RELEASE; DRUG RESEARCH; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG TOLERABILITY; ENZYME ACTIVITY; HUMAN; KUPFFER CELL; LD 50; LIPOPHILICITY; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSMOLALITY; PROTEIN BINDING; PROTEIN EXPRESSION; REVIEW; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; TISSUE DISTRIBUTION; VISCOSITY;

CHELATING AGENTS; CONTRAST MEDIA; GADOLINIUM; GADOLINIUM DTPA; KINETICS; MAGNETIC RESONANCE IMAGING; MOLECULAR STRUCTURE; OSMOLAR CONCENTRATION; THERMODYNAMICS; VISCOSITY;

EID: 45849113240     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-008-9135-x     Document Type: Review

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